26 items (Mycolicibacterium smegmatis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lprG	LprG protein; Probably helps membrane protein MSMEG_3069/MSMEI_2992 (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane (By similarity). Required for MSMEG_3069/MSMEI_2992 export activity. Export of ethidium bromide by MSMEG_3069/MSMEI_2992 can be complemented by the equivalent operon from M.tuberculosis (lprG-Rv1410c). Belongs to the LppX/LprAFG lipoprotein family. (236 aa)
	katG	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. (748 aa)
	pknG	Serine/threonine protein kinase; Identified by match to protein family HMM PF00069; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (760 aa)
	mmpL	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833. (1002 aa)
	ABK74377.1	Identified by match to protein family HMM PF00378. (250 aa)
	ABK72647.1	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family. (280 aa)
	sodA	[Mn] superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (207 aa)
	katG-3	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. (739 aa)
	phoP	DNA-binding response regulator PhoP; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (239 aa)
	secA2	ATPase SecA2; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (784 aa)
	katG-2	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (688 aa)
	ABK70001.1	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family. (263 aa)
	ndk	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
	ABK71586.1	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family. (242 aa)
	prrA	DNA-binding response regulator PrrA; Identified by similarity to SP:Q10531; match to protein family HMM PF00072; match to protein family HMM PF00486. (236 aa)
	mprA	DNA-binding response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). (230 aa)
	whiB3	Transcription factor WhiB; A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. The apo- but not holo-form probably binds DNA (By similarity). (96 aa)
	ABK70305.1	Identified by match to protein family HMM PF00378. (262 aa)
	ABK71286.1	RsbW protein. (194 aa)
	ABK71220.1	RsbW protein. (138 aa)
	secA	Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (953 aa)
	nuoG	NADH-quinone oxidoreductase, G subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (794 aa)
	fbpB	Antigen 85-C; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein. They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM (By similarity). (325 aa)
	ABK73865.1	Identified by match to protein family HMM PF00378. (260 aa)
	ABK69804.1	Identified by match to protein family HMM PF00378. (268 aa)
	ABK72105.1	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family. (289 aa)

Your Current Organism:

Mycolicibacterium smegmatis

NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK69804.1	ABK71220.1	MSMEG_2219	MSMEG_1803	Identified by match to protein family HMM PF00378.	RsbW protein.	0.760
ABK69804.1	ABK71286.1	MSMEG_2219	MSMEG_1787	Identified by match to protein family HMM PF00378.	RsbW protein.	0.814
ABK69804.1	ABK72105.1	MSMEG_2219	MSMEG_2223	Identified by match to protein family HMM PF00378.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.896
ABK69804.1	ABK72647.1	MSMEG_2219	MSMEG_6795	Identified by match to protein family HMM PF00378.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.786
ABK69804.1	ABK73865.1	MSMEG_2219	MSMEG_2218	Identified by match to protein family HMM PF00378.	Identified by match to protein family HMM PF00378.	0.913
ABK69804.1	ndk	MSMEG_2219	MSMEG_4627	Identified by match to protein family HMM PF00378.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.440
ABK70001.1	ABK71220.1	MSMEG_4020	MSMEG_1803	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	RsbW protein.	0.761
ABK70001.1	ABK71286.1	MSMEG_4020	MSMEG_1787	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	RsbW protein.	0.814
ABK70001.1	ndk	MSMEG_4020	MSMEG_4627	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.446
ABK70305.1	ABK71220.1	MSMEG_1739	MSMEG_1803	Identified by match to protein family HMM PF00378.	RsbW protein.	0.760
ABK70305.1	ABK71286.1	MSMEG_1739	MSMEG_1787	Identified by match to protein family HMM PF00378.	RsbW protein.	0.812
ABK70305.1	ABK72647.1	MSMEG_1739	MSMEG_6795	Identified by match to protein family HMM PF00378.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.790
ABK70305.1	ndk	MSMEG_1739	MSMEG_4627	Identified by match to protein family HMM PF00378.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.449
ABK70305.1	sodA	MSMEG_1739	MSMEG_6427	Identified by match to protein family HMM PF00378.	[Mn] superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.405
ABK71220.1	ABK69804.1	MSMEG_1803	MSMEG_2219	RsbW protein.	Identified by match to protein family HMM PF00378.	0.760
ABK71220.1	ABK70001.1	MSMEG_1803	MSMEG_4020	RsbW protein.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.761
ABK71220.1	ABK70305.1	MSMEG_1803	MSMEG_1739	RsbW protein.	Identified by match to protein family HMM PF00378.	0.760
ABK71220.1	ABK71586.1	MSMEG_1803	MSMEG_4775	RsbW protein.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.761
ABK71220.1	ABK72105.1	MSMEG_1803	MSMEG_2223	RsbW protein.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.760
ABK71220.1	ABK72647.1	MSMEG_1803	MSMEG_6795	RsbW protein.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.761