14 items (Mycolicibacterium smegmatis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ABK70912.1	Ppe family protein; Identified by match to protein family HMM PF00823. (523 aa)
	pE	Conserved hypothetical protein. (383 aa)
	esxA	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart. (95 aa)
	ABK70762.1	Ppe family protein; Identified by match to protein family HMM PF00823. (431 aa)
	katG-3	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. (739 aa)
	ABK71085.1	PPE family protein, putative. (473 aa)
	katG-2	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (688 aa)
	ABK70862.1	Mannose-binding lectin; Identified by match to protein family HMM PF01453; match to protein family HMM PF01476. (208 aa)
	katG	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. (748 aa)
	lprG	LprG protein; Probably helps membrane protein MSMEG_3069/MSMEI_2992 (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane (By similarity). Required for MSMEG_3069/MSMEI_2992 export activity. Export of ethidium bromide by MSMEG_3069/MSMEI_2992 can be complemented by the equivalent operon from M.tuberculosis (lprG-Rv1410c). Belongs to the LppX/LprAFG lipoprotein family. (236 aa)
	groS	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (100 aa)
	ABK74738.1	Ppe family protein. (567 aa)
	groL	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
	dnaK	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (622 aa)

Your Current Organism:

Mycolicibacterium smegmatis

NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK70762.1	esxA	MSMEG_0064	MSMEG_0066	Ppe family protein; Identified by match to protein family HMM PF00823.	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.	0.866
ABK70762.1	pE	MSMEG_0064	MSMEG_0412	Ppe family protein; Identified by match to protein family HMM PF00823.	Conserved hypothetical protein.	0.585
ABK70862.1	lprG	MSMEG_3662	MSMEG_3070	Mannose-binding lectin; Identified by match to protein family HMM PF01453; match to protein family HMM PF01476.	LprG protein; Probably helps membrane protein MSMEG_3069/MSMEI_2992 (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane (By similarity). Required for MSMEG_3069/MSMEI_2992 export activity. Export of ethidium bromide by MSMEG_3069/MSMEI_2992 can be complemented by the equivalent operon from M.tuberculosis (lprG-Rv1410c). Belongs to the LppX/LprAFG lipoprotein family.	0.405
ABK70912.1	pE	MSMEG_0619	MSMEG_0412	Ppe family protein; Identified by match to protein family HMM PF00823.	Conserved hypothetical protein.	0.584
ABK74738.1	pE	MSMEG_2737	MSMEG_0412	Ppe family protein.	Conserved hypothetical protein.	0.589
dnaK	groL	MSMEG_0709	MSMEG_0880	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.992
dnaK	groS	MSMEG_0709	MSMEG_1582	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.986
esxA	ABK70762.1	MSMEG_0066	MSMEG_0064	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.	Ppe family protein; Identified by match to protein family HMM PF00823.	0.866
esxA	groL	MSMEG_0066	MSMEG_0880	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.864
esxA	groS	MSMEG_0066	MSMEG_1582	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.473
groL	dnaK	MSMEG_0880	MSMEG_0709	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.992
groL	esxA	MSMEG_0880	MSMEG_0066	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.	0.864
groL	groS	MSMEG_0880	MSMEG_1582	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.999
groL	katG	MSMEG_0880	MSMEG_3461	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria.	0.400
groL	katG-2	MSMEG_0880	MSMEG_3729	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily.	0.409
groS	dnaK	MSMEG_1582	MSMEG_0709	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.986
groS	esxA	MSMEG_1582	MSMEG_0066	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.	0.473
groS	groL	MSMEG_1582	MSMEG_0880	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.999
groS	katG	MSMEG_1582	MSMEG_3461	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria.	0.418
groS	katG-2	MSMEG_1582	MSMEG_3729	Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily.	0.423