STRINGSTRING
fgd fgd pckG pckG ABK73410.1 ABK73410.1 ABK72261.1 ABK72261.1 ABK74466.1 ABK74466.1 ABK69784.1 ABK69784.1 ABK74515.1 ABK74515.1 ABK75024.1 ABK75024.1 fbiB fbiB cofD cofD ABK75334.1 ABK75334.1 ABK71939.1 ABK71939.1 ABK72991.1 ABK72991.1 ABK70230.1 ABK70230.1 ABK74121.1 ABK74121.1 FbiC FbiC ABK71229.1 ABK71229.1 ABK72942.1 ABK72942.1 ABK75053.1 ABK75053.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgdF420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Cannot use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6- phosphate or D-fructose-6-phosphate as substrate. Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family. (337 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (608 aa)
ABK73410.1Conserved hypothetical protein; Identified by match to protein family HMM PF00296. (338 aa)
ABK72261.1Monooxygenase; Identified by match to protein family HMM PF00296. (310 aa)
ABK74466.1Conserved hypothetical protein. (302 aa)
ABK69784.1Conserved hypothetical protein. (283 aa)
ABK74515.1Conserved hypothetical protein. (298 aa)
ABK75024.1Oxidoreductase; Identified by match to protein family HMM PF00296. (347 aa)
fbiBF420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] (454 aa)
cofDLppg:fo 2-phospho-l-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (327 aa)
ABK75334.1Conserved hypothetical protein TIGR00026; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. (140 aa)
ABK71939.1Conserved hypothetical protein; Identified by match to protein family HMM PF00296. (329 aa)
ABK72991.1Conserved hypothetical protein. (350 aa)
ABK70230.1Hydride transferase 1; Identified by match to protein family HMM PF00296. (327 aa)
ABK74121.1Conserved hypothetical protein. (295 aa)
FbiCFO synthase; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR00423. (874 aa)
ABK71229.1Conserved hypothetical protein; Identified by match to protein family HMM PF00296. (330 aa)
ABK72942.1Monooxygenase; Identified by match to protein family HMM PF00296. (306 aa)
ABK75053.1Oxidoreductase; Identified by match to protein family HMM PF00296. (345 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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