node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK75490.1 | clpS | MSMEG_4909 | MSMEG_4910 | Conserved hypothetical protein. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.938 |
ABK75490.1 | cysM | MSMEG_4909 | MSMEG_4905 | Conserved hypothetical protein. | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | 0.933 |
clpS | ABK75490.1 | MSMEG_4910 | MSMEG_4909 | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | Conserved hypothetical protein. | 0.938 |
clpS | cysM | MSMEG_4910 | MSMEG_4905 | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | 0.865 |
clpS | whiB3 | MSMEG_4910 | MSMEG_1597 | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | Transcription factor WhiB; A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. The apo- but not holo-form probably binds DNA (By similarity). | 0.471 |
cysH | cysM | MSMEG_4528 | MSMEG_4905 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | 0.737 |
cysM | ABK75490.1 | MSMEG_4905 | MSMEG_4909 | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | Conserved hypothetical protein. | 0.933 |
cysM | clpS | MSMEG_4905 | MSMEG_4910 | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.865 |
cysM | cysH | MSMEG_4905 | MSMEG_4528 | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.737 |
cysM | rshA | MSMEG_4905 | MSMEG_1915 | Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. | Anti-sigma factor, family protein; A redox-regulated anti-sigma factor for cognate extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by an anti-sigma factor (Probable). Overexpression leads to increased susceptibility to diamide. | 0.445 |
groL | katG | MSMEG_0880 | MSMEG_3461 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | 0.400 |
groL | katG-2 | MSMEG_0880 | MSMEG_3729 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.409 |
groL | pknG | MSMEG_0880 | MSMEG_0786 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | Serine/threonine protein kinase; Identified by match to protein family HMM PF00069; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.510 |
groL | sodA | MSMEG_0880 | MSMEG_6427 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | [Mn] superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | 0.717 |
katG | groL | MSMEG_3461 | MSMEG_0880 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.400 |
katG | katG-2 | MSMEG_3461 | MSMEG_3729 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.902 |
katG | katG-3 | MSMEG_3461 | MSMEG_6384 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | 0.902 |
katG | sodA | MSMEG_3461 | MSMEG_6427 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | [Mn] superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | 0.933 |
katG | sodC | MSMEG_3461 | MSMEG_0835 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. | 0.941 |
katG | soxR | MSMEG_3461 | MSMEG_5450 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Redox-sensitive transcriptional activator SoxR; Identified by similarity to SP:P22538; match to protein family HMM PF00376; match to protein family HMM TIGR01950. | 0.540 |