node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK74611.1 | ABK75676.1 | MSMEG_3470 | MSMEG_1604 | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | 0.542 |
ABK74611.1 | cyp125 | MSMEG_3470 | MSMEG_5995 | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.637 |
ABK74611.1 | cyp142 | MSMEG_3470 | MSMEG_5918 | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.412 |
ABK74611.1 | kstR2 | MSMEG_3470 | MSMEG_6009 | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | Transcriptional regulator, TetR family protein; Controls the expression of a small regulon that may play a role in the utilization of cholesterol. | 0.530 |
ABK75676.1 | ABK74611.1 | MSMEG_1604 | MSMEG_3470 | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | 0.542 |
ABK75676.1 | cyp125 | MSMEG_1604 | MSMEG_5995 | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.945 |
ABK75676.1 | cyp142 | MSMEG_1604 | MSMEG_5918 | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.926 |
ABK75676.1 | kstR | MSMEG_1604 | MSMEG_6042 | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | Transcriptional regulator, TetR family protein; Controls the expression of genes used for utilizing diverse lipids as energy sources. | 0.442 |
cyp125 | ABK74611.1 | MSMEG_5995 | MSMEG_3470 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | 0.637 |
cyp125 | ABK75676.1 | MSMEG_5995 | MSMEG_1604 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | 0.945 |
cyp125 | cyp142 | MSMEG_5995 | MSMEG_5918 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.942 |
cyp125 | kstR | MSMEG_5995 | MSMEG_6042 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | Transcriptional regulator, TetR family protein; Controls the expression of genes used for utilizing diverse lipids as energy sources. | 0.761 |
cyp125 | kstR2 | MSMEG_5995 | MSMEG_6009 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | Transcriptional regulator, TetR family protein; Controls the expression of a small regulon that may play a role in the utilization of cholesterol. | 0.680 |
cyp142 | ABK74611.1 | MSMEG_5918 | MSMEG_3470 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | NAD-dependent epimerase/dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. | 0.412 |
cyp142 | ABK75676.1 | MSMEG_5918 | MSMEG_1604 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. | 0.926 |
cyp142 | cyp125 | MSMEG_5918 | MSMEG_5995 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.942 |
cyp142 | kstR | MSMEG_5918 | MSMEG_6042 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | Transcriptional regulator, TetR family protein; Controls the expression of genes used for utilizing diverse lipids as energy sources. | 0.627 |
cyp142 | kstR2 | MSMEG_5918 | MSMEG_6009 | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | Transcriptional regulator, TetR family protein; Controls the expression of a small regulon that may play a role in the utilization of cholesterol. | 0.781 |
katG | katG-2 | MSMEG_3461 | MSMEG_3729 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.902 |
katG | katG-3 | MSMEG_3461 | MSMEG_6384 | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. | 0.902 |