STRINGSTRING
ABK75676.1 ABK75676.1 ABK70656.1 ABK70656.1 ABK72635.1 ABK72635.1 ABK70902.1 ABK70902.1 ABK70591.1 ABK70591.1 ABK71760.1 ABK71760.1 ABK71075.1 ABK71075.1 ABK73174.1 ABK73174.1 ABK72155.1 ABK72155.1 ABK74355.1 ABK74355.1 ABK74503.1 ABK74503.1 ABK75204.1 ABK75204.1 ABK70837.1 ABK70837.1 ABK71566.1 ABK71566.1 ABK73925.1 ABK73925.1 ABK73207.1 ABK73207.1 ABK71225.1 ABK71225.1 cyp142 cyp142 kshA kshA ksdD ksdD cyp125 cyp125 ABK74830.1 ABK74830.1 ABK73895.1 ABK73895.1 ABK74305.1 ABK74305.1 ABK71346.1 ABK71346.1 kshB kshB ABK71264.1 ABK71264.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABK75676.1FAD dependent oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01266. (578 aa)
ABK70656.1acyl-CoA dehydrogenase, C- domain protein; Identified by match to protein family HMM PF08028. (393 aa)
ABK72635.13-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. (522 aa)
ABK70902.13-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. (558 aa)
ABK70591.1Oxygenase KshA; Identified by match to protein family HMM PF00355. (386 aa)
ABK71760.13-ketosteroid-delta4; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. (529 aa)
ABK71075.1Biphenyl-2,3-diol 1,2-dioxygenase 1; Identified by match to protein family HMM PF00903. (300 aa)
ABK73174.1Pigment production hydroxylase; Identified by match to protein family HMM PF08028. (393 aa)
ABK72155.1Oxidoreductase, NAD/FAD-binding; Identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970. (351 aa)
ABK74355.1Linalool 8-monooxygenase; Belongs to the cytochrome P450 family. (430 aa)
ABK74503.1Succinate dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. (499 aa)
ABK75204.1acyl-CoA synthase; Identified by match to protein family HMM PF00501. (503 aa)
ABK70837.13-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. (587 aa)
ABK71566.13-beta hydroxysteroid dehydrogenase/isomerase family protein; Identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993. (356 aa)
ABK73925.1Steroid delta-isomerase; Identified by match to protein family HMM PF02136. (124 aa)
ABK73207.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (411 aa)
ABK71225.1Nuclear transport factor 2 (NTF2) domain superfamily protein; Identified by match to protein family HMM PF02136. (145 aa)
cyp142P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. (401 aa)
kshARieske [2Fe-2S] domain protein; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. (383 aa)
ksdD3-ketosteroid dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to. (569 aa)
cyp125P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. (427 aa)
ABK74830.1Nitrilotriacetate monooxygenase component B; Identified by match to protein family HMM PF01613. (189 aa)
ABK73895.1Biphenyl-2,3-diol 1,2-dioxygenase; Identified by match to protein family HMM PF00903. (299 aa)
ABK74305.12-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; Identified by match to protein family HMM PF00561. (292 aa)
ABK71346.1Pigment production hydroxylase; Identified by match to protein family HMM PF08028. (396 aa)
kshBOxidoreductase, electron transfer component; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. (353 aa)
ABK71264.1Hypothetical protein; Identified by Glimmer2; putative. (128 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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