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| | pyk | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (477 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (571 aa) |
| | ABK71627.1 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. (564 aa) |
| | ABK73567.1 | Aspartate aminotransferase; Identified by match to protein family HMM PF00155. (424 aa) |
| | dapB-2 | Dihydrodipicolinate reductase, N-terminus domain protein; Identified by match to protein family HMM PF01113. (359 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (345 aa) |
| | ABK70464.1 | Identified by match to protein family HMM PF00583. (308 aa) |
| | ABK72063.1 | Dihydrodipicolinate synthase; Identified by match to protein family HMM PF00701; Belongs to the DapA family. (310 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (286 aa) |
| | serB | Phosphoserine phosphatase; Identified by match to protein family HMM PF00702; match to protein family HMM PF01842; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (413 aa) |
| | ABK69737.1 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. (654 aa) |
| | ABK71940.1 | Gamma-glutamylisopropylamide synthetase; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (450 aa) |
| | ABK75999.1 | Dihydrodipicolinate synthetase; Identified by match to protein family HMM PF00701; Belongs to the DapA family. (295 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (622 aa) |
| | ABK73984.1 | Tagatose-1,6-bisphosphate aldolase GatY; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167. (280 aa) |
| | ABK71806.1 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. (576 aa) |
| | ABK69695.1 | Histidinol-phosphate aminotransferase 2; Identified by match to protein family HMM PF00155. (337 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (380 aa) |
| | ABK69615.1 | Isocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF03971; match to protein family HMM TIGR00178; Belongs to the monomeric-type IDH family. (743 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (250 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | ABK75787.1 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. (260 aa) |
| | ABK74300.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity. (181 aa) |
| | ABK72539.1 | Transketolase, N- subunit; Identified by match to protein family HMM PF00456. (287 aa) |
| | ABK73739.1 | Transketoloase, C half; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780. (344 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (618 aa) |
| | ilvN | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119; Belongs to the acetolactate synthase small subunit family. (170 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (340 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (484 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | ABK73212.1 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. (369 aa) |
| | pyc | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1127 aa) |
| | ABK75619.1 | Acetylornithine deacetylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01910. (390 aa) |
| | ABK72227.1 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. (175 aa) |
| | ABK70728.1 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. (413 aa) |
| | aroQ-2 | Dehydroquinase dehydratase, type II; Identified by match to protein family HMM PF01220. (191 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolyzing); Identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536; match to protein family HMM TIGR03104. (601 aa) |
| | ABK70552.1 | Gamma-glutamylisopropylamide synthetase; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (457 aa) |
| | dapB-3 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (245 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa) |
| | ABK72081.1 | Identified by match to protein family HMM PF00583; Belongs to the acetyltransferase family. (160 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (291 aa) |
| | ABK72386.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | aroE | Shikimate-5-dehydrogenase; Identified by match to protein family HMM PF01488; match to protein family HMM TIGR01809; Belongs to the shikimate dehydrogenase family. (276 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (399 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (244 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (373 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (399 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Identified by similarity to SP:P46969; match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type I; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (340 aa) |
| | pgk | Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (371 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (696 aa) |
| | acnA | Aconitate hydratase 1; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein. Could catalyze the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate. (943 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (430 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (445 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (379 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. (206 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa) |
| | priA-2 | Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (258 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (261 aa) |
| | hisIE | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (115 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (524 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Identified by match to protein family HMM PF00218; Belongs to the TrpC family. (272 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (425 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | ABK70099.1 | Ferredoxin-dependent glutamate synthase 1; Identified by match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. (1518 aa) |
| | GltD | Glutamate synthase, NADH/nadph, small subunit; Identified by match to protein family HMM PF01266; match to protein family HMM PF07992; match to protein family HMM TIGR01317. (500 aa) |
| | pyk-2 | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (472 aa) |
| | derI1 | Ribose 5-phosphate isomerase; Catalyzes the isomerization of D-erythrulose-4P to D- erythrose-4P. Involved in the degradation pathways of erythritol and D- threitol, that allow M.smegmatis to grow on these compounds as the sole carbon source; Belongs to the LacAB/RpiB family. (153 aa) |
| | ABK72982.1 | 3-isopropylmalate dehydrogenase; Identified by match to protein family HMM PF00180. (356 aa) |
| | ABK72037.1 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | ABK70335.1 | Acetylornithine deacetylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01910. (443 aa) |
| | sdaA | L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | ABK75279.1 | Cyclohexadienyl dehydratase; Identified by match to protein family HMM PF00497. (268 aa) |
| | ABK73360.1 | Fructose-bisphosphate aldolase class-I; Identified by match to protein family HMM PF00274. (297 aa) |
| | glnA | Glutamine synthetase, catalytic domain; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (453 aa) |
| | argH | Argininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (469 aa) |
| | argG | Argininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa) |
| | argD | Acetylornithine aminotransferase; Identified by match to protein family HMM PF00202; match to protein family HMM PF01212; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (398 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) |
| | ABK70330.1 | Glutamine synthetase; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (459 aa) |
| | ectB | Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (428 aa) |
| | ABK73320.1 | Citrate synthase; Belongs to the citrate synthase family. (271 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (288 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase; Identified by match to protein family HMM PF01503. (93 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1246 aa) |
| | aroG | 3-deoxy-7-phosphoheptulonate synthase; Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate. (464 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (364 aa) |
| | asnB-2 | Asparagine synthase (glutamine-hydrolyzing); Identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536. (658 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (368 aa) |
| | glnA-2 | Glutamine synthetase, type I; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (478 aa) |
| | glnA-3 | Glutamine synthetase, type I; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation [...] (446 aa) |
| | ABK71359.1 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. (518 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (370 aa) |
| | ABK74088.1 | Transketolase; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780. (644 aa) |
| | ltaE | L-threonine aldolase, low-specificity; Identified by similarity to SP:O50584; match to protein family HMM PF00282; match to protein family HMM PF01212. (338 aa) |
| | ABK74373.1 | Acetolactate synthase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. (540 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (424 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | ABK71161.1 | Ribose 5-phosphate isomerase; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR02133. (159 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa) |
| | ABK75362.1 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. (439 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (474 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. (355 aa) |
| | dapD | Tetrahydropicolinate succinylase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (314 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (490 aa) |
| | ABK69767.1 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. (384 aa) |
| | ABK75142.1 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. (463 aa) |
| | ABK76235.1 | Glutamate--ammonia ligase; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (477 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | ABK71532.1 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. (282 aa) |
| | ABK71866.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (88 aa) |
| | gltA | Citrate synthase I; Identified by similarity to SP:P42457; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. (434 aa) |
| | ABK75407.1 | Citrate synthase; Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family. (377 aa) |
| | serC | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (370 aa) |
| | ABK69794.1 | PLP-dependent aminotransferases; Identified by match to protein family HMM PF00155; match to protein family HMM PF01212. (390 aa) |
| | cysE | Serine O-acetyltransferase. (172 aa) |
| | ABK74501.1 | Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784. (459 aa) |
| | ABK74603.1 | Cysteine synthase/cystathionine beta-synthase family protein; Identified by match to protein family HMM PF00291. (365 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | ABK73626.1 | Asparate kinase, monofunctional class; Identified by match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (421 aa) |
| | glnT | Glutamine synthetase, type III; Identified by match to protein family HMM PF00120; match to protein family HMM TIGR03105; Belongs to the glutamine synthetase family. (434 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (602 aa) |
| | ABK71789.1 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153. (314 aa) |
| | ABK70572.1 | Phosphoglycerate mutase family protein, putative; Identified by match to protein family HMM PF00300. (202 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (361 aa) |
| | pheA | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842. (310 aa) |
| | GltD-2 | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01317. (488 aa) |
| | ABK70243.1 | Ferredoxin-dependent glutamate synthase 1; Identified by match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. (1542 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (771 aa) |
| | ABK73929.1 | Citrate synthase 2; Identified by match to protein family HMM PF00285; match to protein family HMM TIGR01800; Belongs to the citrate synthase family. (376 aa) |
| | pyc-2 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa) |
| | ABK75399.1 | Glutamine synthetase III; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (461 aa) |
| | ABK75112.1 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. (270 aa) |
| | ABK72666.1 | Homoserine O-acetyltransferase; Identified by match to protein family HMM PF00561; Belongs to the AB hydrolase superfamily. MetX family. (342 aa) |
| | derI2 | Ribose 5-phosphate isomerase; Catalyzes the isomerization of D-erythrulose-4P to D- erythrose-4P. Involved in the degradation pathways of L-threitol, D- threitol and erythritol, that allow M.smegmatis to grow on these compounds as the sole carbon source; Belongs to the LacAB/RpiB family. (152 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (182 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
