STRINGSTRING
cheA cheA pilB pilB grpE grpE pilT-4 pilT-4 cheB-2 cheB-2 cheB-3 cheB-3 cheR-4 cheR-4 cheR-5 cheR-5 cheW-3 cheW-3 cheR-2 cheR-2 pilT-2 pilT-2 pilT pilT cheB cheB grpE-2 grpE-2 cheW-2 cheW-2 cheR cheR cheW cheW cheR-3 cheR-3 pilT-3 pilT-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cheAChemotaxis protein CheA; Identified by similarity to SP:P29072; match to protein family HMM PF01584; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM PF02895. (862 aa)
pilBType IV-A pilus assembly ATPase PilB; Identified by match to protein family HMM PF00437; match to protein family HMM PF05157; match to protein family HMM TIGR02538. (566 aa)
grpECo-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] (255 aa)
pilT-4Twitching motility protein PilT; Identified by similarity to SP:P24559; match to protein family HMM PF00437; match to protein family HMM TIGR01420. (369 aa)
cheB-2Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (353 aa)
cheB-3Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (348 aa)
cheR-4Chemotaxis protein methyltransferase CheR; Identified by similarity to SP:P07801; match to protein family HMM PF01739. (273 aa)
cheR-5CheR methyltransferase, SAM binding domain; Identified by match to protein family HMM PF01739. (346 aa)
cheW-3Chemotaxis protein CheW; Identified by similarity to SP:P07365; match to protein family HMM PF01584. (174 aa)
cheR-2Chemotaxis protein methyltransferase CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (290 aa)
pilT-2Twitching mobility protein; Identified by similarity to SP:P24559; match to protein family HMM PF00437; match to protein family HMM TIGR01420. (491 aa)
pilTTwitching mobility protein; Identified by similarity to SP:P24559; match to protein family HMM PF00437; match to protein family HMM TIGR01420. (364 aa)
cheBProtein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (345 aa)
grpE-2Putative co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of A [...] (209 aa)
cheW-2Chemotaxis protein CheW; Identified by similarity to GB:AAM52213.1; match to protein family HMM PF01584. (194 aa)
cheRChemotaxis protein methyltransferase CheR; Identified by similarity to GB:AAM52210.1; match to protein family HMM PF01739; match to protein family HMM PF07719. (485 aa)
cheWChemotaxis coupling protein CheW; Identified by similarity to GB:AAM52209.1; match to protein family HMM PF01584. (188 aa)
cheR-3Chemotaxis protein methyltransferase CheR; Identified by similarity to GB:AAL46996.1; match to protein family HMM PF01739. (440 aa)
pilT-3Twitching motility protein PilT; Identified by similarity to SP:P24559; match to protein family HMM PF00437; match to protein family HMM TIGR01420. (372 aa)
Your Current Organism:
Myxococcus xanthus
NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.