33 items (Myxococcus xanthus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	rplE	Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (174 aa)
	infC	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (247 aa)
	MXAN_1025	Identified by similarity to SP:O52788; match to protein family HMM PF02706. (710 aa)
	pyrG	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (546 aa)
	rpmA	Ribosomal protein L27; Identified by match to protein family HMM PF01016; match to protein family HMM TIGR00062; Belongs to the bacterial ribosomal protein bL27 family. (91 aa)
	MXAN_1915	Polysaccharide biosynthesis/export protein; Identified by match to protein family HMM PF02563. (204 aa)
	rplM	Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (151 aa)
	rpsI	Ribosomal protein S9; Identified by similarity to SP:P02363; match to protein family HMM PF00380; Belongs to the universal ribosomal protein uS9 family. (133 aa)
	smpB	SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (162 aa)
	pgk	Phosphoglycerate kinase; Identified by similarity to SP:P40924; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (395 aa)
	rplK	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (148 aa)
	rplL	Ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
	rpoB	DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1408 aa)
	rpsJ	Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
	rplD	Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa)
	rpsS	Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (95 aa)
	rpsC	Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (220 aa)
	rplP	Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
	rplN	Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
	rplF	Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (188 aa)
	rpsE	Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (173 aa)
	rpsM	Ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (127 aa)
	rpsK	Ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (146 aa)
	rplC	Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (224 aa)
	rplS	Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (127 aa)
	rplT	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (115 aa)
	dnaG	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (606 aa)
	frr	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
	tsf	Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (217 aa)
	rpsB	Ribosomal protein S2; Identified by similarity to SP:P21464; match to protein family HMM PF00318; match to protein family HMM TIGR01011; Belongs to the universal ribosomal protein uS2 family. (312 aa)
	MXAN_7416	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943. (490 aa)
	MXAN_7421	Chain length determinant family protein; Identified by match to protein family HMM PF02706. (507 aa)
	MXAN_7442	Putative membrane protein. (508 aa)

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_1025	MXAN_1915	MXAN_1025	MXAN_1915	Identified by similarity to SP:O52788; match to protein family HMM PF02706.	Polysaccharide biosynthesis/export protein; Identified by match to protein family HMM PF02563.	0.991
MXAN_1025	MXAN_7416	MXAN_1025	MXAN_7416	Identified by similarity to SP:O52788; match to protein family HMM PF02706.	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943.	0.772
MXAN_1025	MXAN_7442	MXAN_1025	MXAN_7442	Identified by similarity to SP:O52788; match to protein family HMM PF02706.	Putative membrane protein.	0.614
MXAN_1915	MXAN_1025	MXAN_1915	MXAN_1025	Polysaccharide biosynthesis/export protein; Identified by match to protein family HMM PF02563.	Identified by similarity to SP:O52788; match to protein family HMM PF02706.	0.991
MXAN_1915	MXAN_7421	MXAN_1915	MXAN_7421	Polysaccharide biosynthesis/export protein; Identified by match to protein family HMM PF02563.	Chain length determinant family protein; Identified by match to protein family HMM PF02706.	0.663
MXAN_7416	MXAN_1025	MXAN_7416	MXAN_1025	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943.	Identified by similarity to SP:O52788; match to protein family HMM PF02706.	0.772
MXAN_7416	MXAN_7421	MXAN_7416	MXAN_7421	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943.	Chain length determinant family protein; Identified by match to protein family HMM PF02706.	0.927
MXAN_7416	MXAN_7442	MXAN_7416	MXAN_7442	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943.	Putative membrane protein.	0.628
MXAN_7421	MXAN_1915	MXAN_7421	MXAN_1915	Chain length determinant family protein; Identified by match to protein family HMM PF02706.	Polysaccharide biosynthesis/export protein; Identified by match to protein family HMM PF02563.	0.663
MXAN_7421	MXAN_7416	MXAN_7421	MXAN_7416	Chain length determinant family protein; Identified by match to protein family HMM PF02706.	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943.	0.927
MXAN_7421	MXAN_7442	MXAN_7421	MXAN_7442	Chain length determinant family protein; Identified by match to protein family HMM PF02706.	Putative membrane protein.	0.535
MXAN_7442	MXAN_1025	MXAN_7442	MXAN_1025	Putative membrane protein.	Identified by similarity to SP:O52788; match to protein family HMM PF02706.	0.614
MXAN_7442	MXAN_7416	MXAN_7442	MXAN_7416	Putative membrane protein.	Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943.	0.628
MXAN_7442	MXAN_7421	MXAN_7442	MXAN_7421	Putative membrane protein.	Chain length determinant family protein; Identified by match to protein family HMM PF02706.	0.535
dnaG	frr	MXAN_5203	MXAN_5341	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	0.631
dnaG	infC	MXAN_5203	MXAN_0581	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.	0.583
dnaG	pgk	MXAN_5203	MXAN_2816	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	Phosphoglycerate kinase; Identified by similarity to SP:P40924; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family.	0.522
dnaG	pyrG	MXAN_5203	MXAN_1096	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.661
dnaG	rplC	MXAN_5203	MXAN_3370	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	0.573
dnaG	rplD	MXAN_5203	MXAN_3300	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.	0.520