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leuB leuB leuD-1 leuD-1 leuC-1 leuC-1 sucD sucD sucC sucC SPO0355 SPO0355 leuC-2 leuC-2 leuD-2 leuD-2 SPO1565 SPO1565 SPO2385 SPO2385 SPO2412 SPO2412 ilvB ilvB ilvN ilvN SPO2883 SPO2883 SPO2885 SPO2885 mclA mclA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (367 aa)
leuD-13-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuC-13-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
sucDsuccinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
SPO0355Hypothetical protein; Identified by similarity to GB:AAK25618.1. (342 aa)
leuC-23-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (452 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (203 aa)
SPO1565Citrate lyase, putative; Identified by similarity to SP:O53078; Belongs to the HpcH/HpaI aldolase family. (325 aa)
SPO2385Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. (576 aa)
SPO2412Aldolase, putative; Identified by similarity to GB:BAB21456.3. (231 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (583 aa)
ilvNAcetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. (186 aa)
SPO2883Thiamine pyrophosphate-binding domain protein; Identified by match to protein family HMM PF02776. (516 aa)
SPO2885Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. (539 aa)
mclAmalyl-CoA lyase; Identified by similarity to GB:AAB58884.1; match to protein family HMM TIGR01588; Belongs to the HpcH/HpaI aldolase family. (320 aa)
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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