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L9KYI8_TUPCH L9KYI8_TUPCH PRKAA2 PRKAA2 WIPI1 WIPI1 TFEB TFEB L9KXV9_TUPCH L9KXV9_TUPCH SIRT1 SIRT1 L9KW24_TUPCH L9KW24_TUPCH L9KVS3_TUPCH L9KVS3_TUPCH L9KVF4_TUPCH L9KVF4_TUPCH KAT5 KAT5 L9KUQ8_TUPCH L9KUQ8_TUPCH MAPK3 MAPK3 XBP1 XBP1 L9KU03_TUPCH L9KU03_TUPCH SREBF2 SREBF2 L9KT72_TUPCH L9KT72_TUPCH WNT2B WNT2B L9KRF2_TUPCH L9KRF2_TUPCH L9KQV0_TUPCH L9KQV0_TUPCH L9KQT0_TUPCH L9KQT0_TUPCH BHLHA15 BHLHA15 AOC1 AOC1 BRSK1 BRSK1 COMT COMT L9KPG8_TUPCH L9KPG8_TUPCH ATF4 ATF4 ATF2 ATF2 ACAT1 ACAT1 L9KN58_TUPCH L9KN58_TUPCH L9KMI2_TUPCH L9KMI2_TUPCH RNF167 RNF167 L9KM90_TUPCH L9KM90_TUPCH L9KLY0_TUPCH L9KLY0_TUPCH GCN1 GCN1 L9KLC2_TUPCH L9KLC2_TUPCH FOXO1 FOXO1 L9KL56_TUPCH L9KL56_TUPCH L9KKU5_TUPCH L9KKU5_TUPCH GABARAPL2 GABARAPL2 CBL CBL L9KJU1_TUPCH L9KJU1_TUPCH BMPR2 BMPR2 L9KI54_TUPCH L9KI54_TUPCH SLC2A1 SLC2A1 L9KH05_TUPCH L9KH05_TUPCH BCAS3 BCAS3 L9KEP6_TUPCH L9KEP6_TUPCH RRAGD RRAGD L9K749_TUPCH L9K749_TUPCH L9K3M0_TUPCH L9K3M0_TUPCH HCRT HCRT KRT20 KRT20 L9JWD5_TUPCH L9JWD5_TUPCH BECN1 BECN1 SSTR3 SSTR3 L9JRF6_TUPCH L9JRF6_TUPCH ATG5 ATG5 PDK4 PDK4 L9JIA0_TUPCH L9JIA0_TUPCH SESN1 SESN1 PIK3R4 PIK3R4 RNF152 RNF152 L9JGL2_TUPCH L9JGL2_TUPCH EIF2S1 EIF2S1 MAP1LC3C MAP1LC3C BECN2 BECN2 L9JFF0_TUPCH L9JFF0_TUPCH UCN3 UCN3 CPEB4 CPEB4 L9JCA3_TUPCH L9JCA3_TUPCH NUAK2 NUAK2 GAS6 GAS6 L9J9U2_TUPCH L9J9U2_TUPCH L9J8P4_TUPCH L9J8P4_TUPCH SREBF1 SREBF1 L8YFR0_TUPCH L8YFR0_TUPCH L8YF26_TUPCH L8YF26_TUPCH TTC5 TTC5 PFKFB1 PFKFB1 ATF3 ATF3 L8YD61_TUPCH L8YD61_TUPCH FLCN FLCN L8YC42_TUPCH L8YC42_TUPCH PPARA PPARA MFSD2A MFSD2A L8YBJ0_TUPCH L8YBJ0_TUPCH HFE HFE MYBBP1A MYBBP1A ADM ADM HMGCS2 HMGCS2 L8Y9D9_TUPCH L8Y9D9_TUPCH NIM1K NIM1K PLIN2 PLIN2 L8Y8J4_TUPCH L8Y8J4_TUPCH NPRL2 NPRL2 L8Y7K6_TUPCH L8Y7K6_TUPCH FAM65A FAM65A INHBB INHBB L8Y725_TUPCH L8Y725_TUPCH L8Y6K8_TUPCH L8Y6K8_TUPCH GIP GIP L8Y5J2_TUPCH L8Y5J2_TUPCH L8Y4G5_TUPCH L8Y4G5_TUPCH L8Y3W3_TUPCH L8Y3W3_TUPCH L8Y359_TUPCH L8Y359_TUPCH DDIT3 DDIT3 CARTPT CARTPT NUAK1 NUAK1 PLIN3 PLIN3 UPP1 UPP1 L9LFX4_TUPCH L9LFX4_TUPCH SAMD12 SAMD12 UCP2 UCP2 L9LCR8_TUPCH L9LCR8_TUPCH L9LCR0_TUPCH L9LCR0_TUPCH L9LC06_TUPCH L9LC06_TUPCH ZFP36 ZFP36 FOXA3 FOXA3 JMY JMY L9L8C3_TUPCH L9L8C3_TUPCH WIPI2 WIPI2 FOXK1 FOXK1 PCK1 PCK1 L9L7P5_TUPCH L9L7P5_TUPCH L9L7F1_TUPCH L9L7F1_TUPCH GLUL GLUL MYOD1 MYOD1 L9L6W1_TUPCH L9L6W1_TUPCH PCK2 PCK2 L9L5Q1_TUPCH L9L5Q1_TUPCH MTOR MTOR L9L533_TUPCH L9L533_TUPCH DAP DAP L9L4M5_TUPCH L9L4M5_TUPCH MAP1LC3A MAP1LC3A L9L2X1_TUPCH L9L2X1_TUPCH L9L2T4_TUPCH L9L2T4_TUPCH MAP3K5 MAP3K5 L9L0Q4_TUPCH L9L0Q4_TUPCH L9KZP6_TUPCH L9KZP6_TUPCH KLF10 KLF10 L9KZK2_TUPCH L9KZK2_TUPCH L9KZI1_TUPCH L9KZI1_TUPCH MTMR3 MTMR3 L9KZF0_TUPCH L9KZF0_TUPCH GNPAT GNPAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
L9KYI8_TUPCHProprotein convertase subtilisin/kexin type 9. (686 aa)
PRKAA2Non-specific serine/threonine protein kinase. (391 aa)
WIPI1WD repeat domain phosphoinositide-interacting protein 1. (463 aa)
TFEBTranscription factor EB. (487 aa)
L9KXV9_TUPCHProtein CLEC16A. (931 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (658 aa)
L9KW24_TUPCHTumor necrosis factor receptor superfamily member 6. (303 aa)
L9KVS3_TUPCHDEP domain-containing protein 5. (1698 aa)
L9KVF4_TUPCHEukaryotic translation initiation factor 2A. (498 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (499 aa)
L9KUQ8_TUPCHGAS2-like protein 1. (469 aa)
MAPK3Mitogen-activated protein kinase. (528 aa)
XBP1X-box-binding protein 1. (239 aa)
L9KU03_TUPCHF-box only protein 22. (251 aa)
SREBF2Sterol regulatory element-binding protein 2. (991 aa)
L9KT72_TUPCHCyclin-dependent kinase inhibitor 1. (284 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
L9KRF2_TUPCHUncharacterized protein. (295 aa)
L9KQV0_TUPCHUncharacterized protein. (1332 aa)
L9KQT0_TUPCH5'-AMP-activated protein kinase subunit gamma-2. (305 aa)
BHLHA15Class A basic helix-loop-helix protein 15. (191 aa)
AOC1Amine oxidase. (755 aa)
BRSK1BR serine/threonine-protein kinase 1. (776 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (266 aa)
L9KPG8_TUPCH5'-AMP-activated protein kinase subunit gamma-2. (977 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (529 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (696 aa)
ACAT1Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (422 aa)
L9KN58_TUPCHRas-related GTP-binding protein B. (254 aa)
L9KMI2_TUPCHInterferon-induced, double-stranded RNA-activated protein kinase; Belongs to the protein kinase superfamily. (458 aa)
RNF167E3 ubiquitin-protein ligase RNF167. (320 aa)
L9KM90_TUPCHCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (424 aa)
L9KLY0_TUPCHProtein SZT2. (3327 aa)
GCN1Translational activator GCN1. (2732 aa)
L9KLC2_TUPCHNuclear factor erythroid 2-related factor 2; Belongs to the bZIP family. (892 aa)
FOXO1Forkhead box protein O1. (399 aa)
L9KL56_TUPCHHistone-lysine N-methyltransferase EHMT1. (1301 aa)
L9KKU5_TUPCHCOBW domain-containing protein 3. (291 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (130 aa)
CBLE3 ubiquitin-protein ligase CBL. (889 aa)
L9KJU1_TUPCHWD repeat-containing protein 59. (1028 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
L9KI54_TUPCHSerine/threonine-protein kinase ULK2. (717 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (515 aa)
L9KH05_TUPCHUncharacterized protein. (433 aa)
BCAS3Breast carcinoma-amplified sequence 3. (863 aa)
L9KEP6_TUPCHTransducin beta-like protein 2. (514 aa)
RRAGDRas-related GTP-binding protein D. (437 aa)
L9K749_TUPCHPRKCA-binding protein. (447 aa)
L9K3M0_TUPCHFolliculin. (196 aa)
HCRTOrexin. (175 aa)
KRT20Keratin, type I cytoskeletal 20; Belongs to the intermediate filament family. (399 aa)
L9JWD5_TUPCHNon-specific serine/threonine protein kinase. (423 aa)
BECN1Beclin-1. (462 aa)
SSTR3Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (419 aa)
L9JRF6_TUPCHMyosin-13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2418 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
L9JIA0_TUPCHActivating molecule in BECN1-regulated autophagy protein 1. (1554 aa)
SESN1Sestrin-1. (631 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1443 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (203 aa)
L9JGL2_TUPCHEukaryotic translation initiation factor 2-alpha kinase 4. (1629 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
MAP1LC3CMicrotubule-associated proteins 1A/1B light chain 3C. (75 aa)
BECN2Beclin-1-like protein 1. (383 aa)
L9JFF0_TUPCHPhosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1683 aa)
UCN3Urocortin-3. (284 aa)
CPEB4Cytoplasmic polyadenylation element-binding protein 4. (732 aa)
L9JCA3_TUPCHRibonuclease ZC3H12A. (466 aa)
NUAK2NUAK family SNF1-like kinase 2. (632 aa)
GAS6Growth arrest-specific protein 6. (1470 aa)
L9J9U2_TUPCHBeclin 1-associated autophagy-related key regulator. (350 aa)
L9J8P4_TUPCHUbiquitin-like modifier-activating enzyme ATG7. (598 aa)
SREBF1Sterol regulatory element-binding protein 1. (1897 aa)
L8YFR0_TUPCHHeterogeneous nuclear ribonucleoprotein L. (473 aa)
L8YF26_TUPCHZinc transporter ZIP4. (707 aa)
TTC5Telomerase protein component 1. (3071 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. (425 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (189 aa)
L8YD61_TUPCHLa-related protein 1. (759 aa)
FLCNFolliculin. (577 aa)
L8YC42_TUPCHBR serine/threonine-protein kinase 2. (673 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
MFSD2AMajor facilitator superfamily domain-containing protein 2A. (540 aa)
L8YBJ0_TUPCHAlanine aminotransferase 1. (360 aa)
HFEHereditary hemochromatosis protein like protein; Belongs to the MHC class I family. (277 aa)
MYBBP1AMyb-binding protein 1A. (1274 aa)
ADMAdrenomedullin. (188 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (468 aa)
L8Y9D9_TUPCHDnaJ like protein subfamily C member 15. (107 aa)
NIM1KSerine/threonine-protein kinase NIM1; Belongs to the protein kinase superfamily. (436 aa)
PLIN2Perilipin; Belongs to the perilipin family. (436 aa)
L8Y8J4_TUPCH5'-AMP-activated protein kinase subunit gamma-3. (375 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
L8Y7K6_TUPCHLysosome-associated membrane glycoprotein 2. (420 aa)
FAM65AProtein FAM65A. (1246 aa)
INHBBInhibin beta B chain. (320 aa)
L8Y725_TUPCHEukaryotic translation initiation factor 2-alpha kinase 3. (726 aa)
L8Y6K8_TUPCHZinc transporter ZIP5. (557 aa)
GIPGastric inhibitory polypeptide. (176 aa)
L8Y5J2_TUPCHSerine/threonine-protein kinase SIK1. (746 aa)
L8Y4G5_TUPCHWD repeat-containing protein mio-A. (619 aa)
L8Y3W3_TUPCHSodium-coupled neutral amino acid transporter 3. (421 aa)
L8Y359_TUPCHSodium-coupled neutral amino acid transporter 2. (440 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (172 aa)
CARTPTCocaine-and amphetamine-regulated transcript protein. (116 aa)
NUAK1NUAK family SNF1-like kinase 1. (626 aa)
PLIN3Perilipin; Belongs to the perilipin family. (436 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (297 aa)
L9LFX4_TUPCHLow-density lipoprotein receptor-related protein 11. (232 aa)
SAMD12Myb-binding protein 1A. (612 aa)
UCP2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
L9LCR8_TUPCHSerine/threonine-protein kinase 24. (537 aa)
L9LCR0_TUPCHCarbamoyl-phosphate synthase [ammonia], mitochondrial. (1438 aa)
L9LC06_TUPCHMitogen-activated protein kinase. (589 aa)
ZFP36Tristetraprolin. (377 aa)
FOXA3Hepatocyte nuclear factor 3-gamma. (347 aa)
JMYJunction-mediating and-regulatory protein. (906 aa)
L9L8C3_TUPCHHereditary hemochromatosis protein like protein; Belongs to the MHC class I family. (345 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2. (55 aa)
FOXK1Forkhead box protein K1. (649 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
L9L7P5_TUPCHF-box only protein 22. (655 aa)
L9L7F1_TUPCHProtein max. (151 aa)
GLULGlutamine synthetase. (555 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (298 aa)
L9L6W1_TUPCHGlutamine synthetase. (192 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (654 aa)
L9L5Q1_TUPCHVacuolar protein sorting-associated protein 41 like protein. (802 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (3780 aa)
L9L533_TUPCH3-oxo-5-alpha-steroid 4-dehydrogenase 1. (451 aa)
DAPDeath-associated protein 1. (314 aa)
L9L4M5_TUPCHWD repeat domain phosphoinositide-interacting protein 2. (482 aa)
MAP1LC3AMicrotubule-associated proteins 1A/1B light chain 3A. (202 aa)
L9L2X1_TUPCHNitrogen permease regulator 3-like protein. (608 aa)
L9L2T4_TUPCHPhosphatidylinositol 3-kinase catalytic subunit type 3. (782 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1375 aa)
L9L0Q4_TUPCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (829 aa)
L9KZP6_TUPCHForkhead box protein K2. (706 aa)
KLF10Krueppel-like factor 10. (478 aa)
L9KZK2_TUPCHRegulatory-associated protein of mTOR. (1509 aa)
L9KZI1_TUPCHGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (446 aa)
MTMR3Myotubularin-related protein 3. (1197 aa)
L9KZF0_TUPCHWD repeat domain phosphoinositide-interacting protein 3. (656 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (680 aa)
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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