STRINGSTRING
TGFA TGFA STOX1 STOX1 DRD2 DRD2 L9KSW1_TUPCH L9KSW1_TUPCH L9KSZ2_TUPCH L9KSZ2_TUPCH L9KT43_TUPCH L9KT43_TUPCH L9KT64_TUPCH L9KT64_TUPCH L9KT72_TUPCH L9KT72_TUPCH L9KTA7_TUPCH L9KTA7_TUPCH CCND3 CCND3 L9KTT3_TUPCH L9KTT3_TUPCH L9KU64_TUPCH L9KU64_TUPCH L9KU93_TUPCH L9KU93_TUPCH ADRB2 ADRB2 L9L0F8_TUPCH L9L0F8_TUPCH L9L093_TUPCH L9L093_TUPCH L9KZK2_TUPCH L9KZK2_TUPCH GPRC5C GPRC5C L9KZ86_TUPCH L9KZ86_TUPCH L9KZ25_TUPCH L9KZ25_TUPCH MLST8 MLST8 L9KYL3_TUPCH L9KYL3_TUPCH L9KYJ6_TUPCH L9KYJ6_TUPCH L9KYJ2_TUPCH L9KYJ2_TUPCH L9KYG7_TUPCH L9KYG7_TUPCH L9KYF3_TUPCH L9KYF3_TUPCH TELO2 TELO2 AXIN2 AXIN2 AXIN1 AXIN1 GPRC5B GPRC5B L9KXK2_TUPCH L9KXK2_TUPCH LEP LEP EMP2 EMP2 L9KXG1_TUPCH L9KXG1_TUPCH L9KXB5_TUPCH L9KXB5_TUPCH SIRT1 SIRT1 L9KWW6_TUPCH L9KWW6_TUPCH L9KWW0_TUPCH L9KWW0_TUPCH L9KWE4_TUPCH L9KWE4_TUPCH IFNG IFNG RAP1A RAP1A L9KV25_TUPCH L9KV25_TUPCH L9KV14_TUPCH L9KV14_TUPCH ERP29 ERP29 JTB JTB L9KUM6_TUPCH L9KUM6_TUPCH L9KUL3_TUPCH L9KUL3_TUPCH L9KUB7_TUPCH L9KUB7_TUPCH IL18 IL18 XRCC6 XRCC6 CLU CLU L9KMV3_TUPCH L9KMV3_TUPCH EFNA1 EFNA1 MOB1A MOB1A L9KME4_TUPCH L9KME4_TUPCH L9KMB7_TUPCH L9KMB7_TUPCH TAOK3 TAOK3 PTK2 PTK2 L9KL94_TUPCH L9KL94_TUPCH GHRL GHRL L9KKU6_TUPCH L9KKU6_TUPCH L9KKR7_TUPCH L9KKR7_TUPCH CAMK1 CAMK1 MAP3K4 MAP3K4 MAS1 MAS1 L9KKA5_TUPCH L9KKA5_TUPCH L9KK38_TUPCH L9KK38_TUPCH IQGAP1 IQGAP1 CIB1 CIB1 L9KJY3_TUPCH L9KJY3_TUPCH ADRA2C ADRA2C L9KJP7_TUPCH L9KJP7_TUPCH BMPR2 BMPR2 L9KJI9_TUPCH L9KJI9_TUPCH L9KJI0_TUPCH L9KJI0_TUPCH L9KJ46_TUPCH L9KJ46_TUPCH L9KJ03_TUPCH L9KJ03_TUPCH STRADB STRADB PDE5A PDE5A ADRA1A ADRA1A L9KI32_TUPCH L9KI32_TUPCH PTK2B PTK2B L9KHR2_TUPCH L9KHR2_TUPCH IL6R IL6R L9KHJ0_TUPCH L9KHJ0_TUPCH L9KHH5_TUPCH L9KHH5_TUPCH TNF TNF CDK5R1 CDK5R1 L9KH08_TUPCH L9KH08_TUPCH L9KG55_TUPCH L9KG55_TUPCH MMD MMD NCF1 NCF1 L9KFU4_TUPCH L9KFU4_TUPCH KITLG KITLG NOD2 NOD2 ECT2 ECT2 L9K5T0_TUPCH L9K5T0_TUPCH L9K5S5_TUPCH L9K5S5_TUPCH CDK4 CDK4 CCND2 CCND2 PIK3CG PIK3CG MST1R MST1R CCND1 CCND1 L8Y076_TUPCH L8Y076_TUPCH PHB2 PHB2 L8Y0S8_TUPCH L8Y0S8_TUPCH PRKCD PRKCD L8Y1X6_TUPCH L8Y1X6_TUPCH CARTPT CARTPT L8Y298_TUPCH L8Y298_TUPCH L8Y2R5_TUPCH L8Y2R5_TUPCH ADIPOQ ADIPOQ L8Y391_TUPCH L8Y391_TUPCH CD4 CD4 NTF3 NTF3 L8Y4C1_TUPCH L8Y4C1_TUPCH L8Y4D3_TUPCH L8Y4D3_TUPCH L8Y4U5_TUPCH L8Y4U5_TUPCH CCL25 CCL25 L8Y520_TUPCH L8Y520_TUPCH CCNT2 CCNT2 L8Y5I6_TUPCH L8Y5I6_TUPCH ADRA2B ADRA2B SRCIN1 SRCIN1 L8Y5X8_TUPCH L8Y5X8_TUPCH L8Y603_TUPCH L8Y603_TUPCH SLC22A14 SLC22A14 FLT1 FLT1 L8Y6H4_TUPCH L8Y6H4_TUPCH L8Y6I0_TUPCH L8Y6I0_TUPCH L8Y6N1_TUPCH L8Y6N1_TUPCH UNC119 UNC119 B9D2 B9D2 BMP2 BMP2 L8Y7F9_TUPCH L8Y7F9_TUPCH CDKN1B CDKN1B L8Y812_TUPCH L8Y812_TUPCH MOB3C MOB3C L8Y8Z7_TUPCH L8Y8Z7_TUPCH TNFSF11 TNFSF11 PRNP PRNP L8Y9H9_TUPCH L8Y9H9_TUPCH L8Y9M2_TUPCH L8Y9M2_TUPCH PHB PHB L8Y9X5_TUPCH L8Y9X5_TUPCH L8YAA3_TUPCH L8YAA3_TUPCH L8YAY3_TUPCH L8YAY3_TUPCH L8YB66_TUPCH L8YB66_TUPCH ROBO1 ROBO1 IL12B IL12B GPRC5D GPRC5D L8YBM3_TUPCH L8YBM3_TUPCH GPRC5A GPRC5A TENM1 TENM1 L8YCG1_TUPCH L8YCG1_TUPCH L8YCM6_TUPCH L8YCM6_TUPCH RASSF2 RASSF2 TCL1B TCL1B L8YDN5_TUPCH L8YDN5_TUPCH L8YDT1_TUPCH L8YDT1_TUPCH NTRK3 NTRK3 AFAP1L2 AFAP1L2 L8YEE1_TUPCH L8YEE1_TUPCH BMPR1A BMPR1A GAS6 GAS6 L9JA47_TUPCH L9JA47_TUPCH L9J9E4_TUPCH L9J9E4_TUPCH MAP3K5 MAP3K5 L9L346_TUPCH L9L346_TUPCH L9L3T7_TUPCH L9L3T7_TUPCH L9L433_TUPCH L9L433_TUPCH MMD2 MMD2 L9L4D9_TUPCH L9L4D9_TUPCH CKS1B CKS1B DUSP19 DUSP19 KIT KIT L9L5F2_TUPCH L9L5F2_TUPCH L9L5N4_TUPCH L9L5N4_TUPCH AREG AREG L9L6B4_TUPCH L9L6B4_TUPCH AKAP13 AKAP13 CCL21 CCL21 L9L6L4_TUPCH L9L6L4_TUPCH L9L6M2_TUPCH L9L6M2_TUPCH L9L711_TUPCH L9L711_TUPCH DAXX DAXX L9L7D7_TUPCH L9L7D7_TUPCH L9L7S7_TUPCH L9L7S7_TUPCH L9L8B0_TUPCH L9L8B0_TUPCH PARP16 PARP16 L9L8P9_TUPCH L9L8P9_TUPCH L9L916_TUPCH L9L916_TUPCH SLC8A2 SLC8A2 L9L952_TUPCH L9L952_TUPCH L9L9E0_TUPCH L9L9E0_TUPCH EDN1 EDN1 IGF1 IGF1 NEDD9 NEDD9 L9L9X0_TUPCH L9L9X0_TUPCH CSF1R CSF1R PDGFRB PDGFRB L9KPF1_TUPCH L9KPF1_TUPCH L9KPJ3_TUPCH L9KPJ3_TUPCH L9KPK2_TUPCH L9KPK2_TUPCH L9KPU0_TUPCH L9KPU0_TUPCH L9KQ67_TUPCH L9KQ67_TUPCH L9KQC0_TUPCH L9KQC0_TUPCH PAK1 PAK1 PDCD10 PDCD10 L9KQR2_TUPCH L9KQR2_TUPCH L9KQT0_TUPCH L9KQT0_TUPCH MAP3K11 MAP3K11 DVL2 DVL2 CAMKK2 CAMKK2 ADCYAP1 ADCYAP1 HNF1A HNF1A L9KRN4_TUPCH L9KRN4_TUPCH L9KRY3_TUPCH L9KRY3_TUPCH L9KS81_TUPCH L9KS81_TUPCH L9LAM1_TUPCH L9LAM1_TUPCH CALCA CALCA L9LAI5_TUPCH L9LAI5_TUPCH L9LAI1_TUPCH L9LAI1_TUPCH L9LAH7_TUPCH L9LAH7_TUPCH L9LAH6_TUPCH L9LAH6_TUPCH IGF2 IGF2 L9LAD1_TUPCH L9LAD1_TUPCH TNFSF15 TNFSF15 L9L9X6_TUPCH L9L9X6_TUPCH TGFBR2 TGFBR2 L9JBH9_TUPCH L9JBH9_TUPCH NRXN1 NRXN1 L9JBX1_TUPCH L9JBX1_TUPCH L9JC79_TUPCH L9JC79_TUPCH L9JCZ2_TUPCH L9JCZ2_TUPCH FERMT2 FERMT2 L9JDP2_TUPCH L9JDP2_TUPCH GCG GCG L9JE16_TUPCH L9JE16_TUPCH SYAP1 SYAP1 CCDC88A CCDC88A L9JFV6_TUPCH L9JFV6_TUPCH LTK LTK L9JGL6_TUPCH L9JGL6_TUPCH L9JGU4_TUPCH L9JGU4_TUPCH L9JJ46_TUPCH L9JJ46_TUPCH L9JKN9_TUPCH L9JKN9_TUPCH L9JL49_TUPCH L9JL49_TUPCH ADCY8 ADCY8 L9JLN6_TUPCH L9JLN6_TUPCH L9JLS4_TUPCH L9JLS4_TUPCH IL1B IL1B PAK2 PAK2 L9JRV1_TUPCH L9JRV1_TUPCH PRLR PRLR L9JTC1_TUPCH L9JTC1_TUPCH L9JU63_TUPCH L9JU63_TUPCH L9JUM1_TUPCH L9JUM1_TUPCH L9JV47_TUPCH L9JV47_TUPCH ERBB2 ERBB2 WIPF2 WIPF2 CCR7 CCR7 L9JZ14_TUPCH L9JZ14_TUPCH MAP3K7 MAP3K7 L9K006_TUPCH L9K006_TUPCH RGCC RGCC ITGB3 ITGB3 L9JAV3_TUPCH L9JAV3_TUPCH L9JAQ6_TUPCH L9JAQ6_TUPCH L9L1K9_TUPCH L9L1K9_TUPCH FGF1 FGF1 PRRC1 PRRC1 L9L2Q6_TUPCH L9L2Q6_TUPCH ROR2 ROR2 L8YEL0_TUPCH L8YEL0_TUPCH ANGPT4 ANGPT4 MAPRE3 MAPRE3 MAP2K3 MAP2K3 L8YGB8_TUPCH L8YGB8_TUPCH FBXW9 FBXW9 L8YGV5_TUPCH L8YGV5_TUPCH ALK ALK L9J8D2_TUPCH L9J8D2_TUPCH L9J8M5_TUPCH L9J8M5_TUPCH ARHGEF5 ARHGEF5 L9LFR6_TUPCH L9LFR6_TUPCH L9LES0_TUPCH L9LES0_TUPCH ITGB1BP1 ITGB1BP1 L9LDK7_TUPCH L9LDK7_TUPCH L9LD92_TUPCH L9LD92_TUPCH ADNP ADNP L9LD52_TUPCH L9LD52_TUPCH L9LD08_TUPCH L9LD08_TUPCH L9LD07_TUPCH L9LD07_TUPCH L9LCN6_TUPCH L9LCN6_TUPCH L9LBK9_TUPCH L9LBK9_TUPCH RPS3 RPS3 DDR2 DDR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFAProtransforming growth factor alpha. (167 aa)
STOX1Storkhead-box protein 1. (1559 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
L9KSW1_TUPCHReceptor protein-tyrosine kinase. (1166 aa)
L9KSZ2_TUPCHMacrophage colony-stimulating factor 1 receptor. (370 aa)
L9KT43_TUPCHX-ray repair cross-complementing protein 6. (443 aa)
L9KT64_TUPCHFYVE, RhoGEF and PH domain-containing protein 2. (628 aa)
L9KT72_TUPCHCyclin-dependent kinase inhibitor 1. (284 aa)
L9KTA7_TUPCHSolute carrier family 22 member 7. (1883 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (286 aa)
L9KTT3_TUPCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (313 aa)
L9KU64_TUPCHClaspin. (1260 aa)
L9KU93_TUPCHSerine/threonine-protein kinase/endoribonuclease IRE2. (871 aa)
ADRB2Beta-2 adrenergic receptor. (448 aa)
L9L0F8_TUPCHUncharacterized protein. (287 aa)
L9L093_TUPCHActivity-dependent neuroprotector homeobox protein. (465 aa)
L9KZK2_TUPCHRegulatory-associated protein of mTOR. (1509 aa)
GPRC5CG-protein coupled receptor family C group 5 member C. (523 aa)
L9KZ86_TUPCHPolycystin-1. (2813 aa)
L9KZ25_TUPCHAxin-1. (695 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
L9KYL3_TUPCHDisks large like protein 3; Belongs to the MAGUK family. (776 aa)
L9KYJ6_TUPCHTNF receptor-associated factor 4. (249 aa)
L9KYJ2_TUPCHLymphocyte cytosolic protein 2. (411 aa)
L9KYG7_TUPCHSTE20-related kinase adapter protein alpha. (402 aa)
L9KYF3_TUPCH3-phosphoinositide-dependent protein kinase 1. (493 aa)
TELO2Telomere length regulation protein TEL2 like protein. (874 aa)
AXIN2Axin-2. (847 aa)
AXIN1Axin-1. (293 aa)
GPRC5BG-protein coupled receptor family C group 5 member B. (446 aa)
L9KXK2_TUPCHDual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (387 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
L9KXG1_TUPCHLong-chain fatty acid transport protein 1. (515 aa)
L9KXB5_TUPCHProtein FAM20A. (646 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (658 aa)
L9KWW6_TUPCHDisintegrin and metalloproteinase domain-containing protein 8. (1174 aa)
L9KWW0_TUPCHX-ray repair cross-complementing protein 6. (512 aa)
L9KWE4_TUPCH60S acidic ribosomal protein P1. (91 aa)
IFNGInterferon gamma. (202 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
L9KV25_TUPCHG1/S-specific cyclin-D2; Belongs to the cyclin family. (182 aa)
L9KV14_TUPCHProhibitin. (159 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
JTBProtein JTB. (146 aa)
L9KUM6_TUPCHMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
L9KUL3_TUPCHLinker for activation of T-cells family member 1. (226 aa)
L9KUB7_TUPCHF-box/WD repeat-containing protein 7. (737 aa)
IL18Interleukin-18. (121 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
CLUClusterin; Belongs to the clusterin family. (469 aa)
L9KMV3_TUPCHCentromere-associated protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2478 aa)
EFNA1Ephrin-A1; Belongs to the ephrin family. (208 aa)
MOB1AMps one binder kinase activator-like 1B; Belongs to the BolA/IbaG family. (278 aa)
L9KME4_TUPCHDickkopf-related protein 2. (67 aa)
L9KMB7_TUPCHDisks large like protein 4; Belongs to the MAGUK family. (780 aa)
TAOK3Serine/threonine-protein kinase TAO3. (898 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
L9KL94_TUPCHMitogen-activated protein kinase kinase kinase 4. (747 aa)
GHRLAppetite-regulating hormone. (195 aa)
L9KKU6_TUPCHCOP9 signalosome complex subunit 8. (260 aa)
L9KKR7_TUPCHTargeting protein for Xklp2. (933 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (457 aa)
MAS1Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (325 aa)
L9KKA5_TUPCHSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (439 aa)
L9KK38_TUPCHSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (466 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1658 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
L9KJY3_TUPCHInterleukin-34. (232 aa)
ADRA2CAlpha-2C adrenergic receptor. (580 aa)
L9KJP7_TUPCHSAM and SH3 domain-containing protein 1. (1257 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
L9KJI9_TUPCHVery low-density lipoprotein receptor. (954 aa)
L9KJI0_TUPCHAmino acid transporter. (501 aa)
L9KJ46_TUPCHProtein Dok-7. (504 aa)
L9KJ03_TUPCHAlsin. (1520 aa)
STRADBSTE20-related kinase adapter protein beta. (413 aa)
PDE5APhosphodiesterase. (865 aa)
ADRA1AAlpha-1A adrenergic receptor. (466 aa)
L9KI32_TUPCHProhibitin. (80 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
L9KHR2_TUPCHVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (272 aa)
IL6RInterleukin-6 receptor subunit alpha. (400 aa)
L9KHJ0_TUPCHDual specificity mitogen-activated protein kinase kinase 1. (505 aa)
L9KHH5_TUPCHDual specificity mitogen-activated protein kinase kinase 5. (318 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (328 aa)
L9KH08_TUPCHTargeting protein for Xklp2. (217 aa)
L9KG55_TUPCHAdvanced glycosylation end product-specific receptor. (431 aa)
MMDMonocyte to macrophage differentiation protein. (292 aa)
NCF1Neutrophil cytosol factor 1. (395 aa)
L9KFU4_TUPCHSignal transducer CD24. (78 aa)
KITLGKit ligand. (295 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (625 aa)
ECT2Protein ECT2. (616 aa)
L9K5T0_TUPCHKinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1582 aa)
L9K5S5_TUPCHReceptor-type tyrosine-protein phosphatase C. (1179 aa)
CDK4Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (1129 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
MST1RMacrophage-stimulating protein receptor. (1429 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
L8Y076_TUPCHCalcium-binding protein 39. (293 aa)
PHB2Prohibitin. (89 aa)
L8Y0S8_TUPCHFibroblast growth factor receptor. (861 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
L8Y1X6_TUPCHInner centromere protein. (898 aa)
CARTPTCocaine-and amphetamine-regulated transcript protein. (116 aa)
L8Y298_TUPCHNck-associated protein 1-like protein. (885 aa)
L8Y2R5_TUPCHSerine/threonine-protein kinase 11. (274 aa)
ADIPOQAdiponectin. (244 aa)
L8Y391_TUPCHCyclin-T1. (597 aa)
CD4T-cell surface glycoprotein CD4. (459 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
L8Y4C1_TUPCHPro-neuregulin-1, membrane-bound isoform. (727 aa)
L8Y4D3_TUPCHNGFI-A-binding protein 2. (465 aa)
L8Y4U5_TUPCHLactotransferrin; Belongs to the transferrin family. (692 aa)
CCL25Dual specificity mitogen-activated protein kinase kinase 7. (586 aa)
L8Y520_TUPCHEarly growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (501 aa)
CCNT2Cyclin-T2. (300 aa)
L8Y5I6_TUPCHMelanoma-associated antigen D1. (513 aa)
ADRA2BAlpha-2B adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (823 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1084 aa)
L8Y5X8_TUPCHNeuralized-like protein 1A. (514 aa)
L8Y603_TUPCHMitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (847 aa)
SLC22A14Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1466 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1057 aa)
L8Y6H4_TUPCHCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
L8Y6I0_TUPCHCyclin-dependent kinase 5 activator 2. (180 aa)
L8Y6N1_TUPCHTyrosine-protein kinase receptor. (1246 aa)
UNC119Protein unc-119 like protein A. (184 aa)
B9D2Transforming growth factor beta-1. (477 aa)
BMP2Bone morphogenetic protein 2. (240 aa)
L8Y7F9_TUPCH60S acidic ribosomal protein P1. (225 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (185 aa)
L8Y812_TUPCHDorsal root ganglia homeobox protein. (665 aa)
MOB3CMps one binder kinase activator-like 2C. (221 aa)
L8Y8Z7_TUPCHDAZ-associated protein 2. (194 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (270 aa)
PRNPMajor prion protein; Belongs to the prion family. (262 aa)
L8Y9H9_TUPCHAngiopoietin-1. (303 aa)
L8Y9M2_TUPCHMyocyte-specific enhancer factor 2C. (336 aa)
PHBProhibitin. (280 aa)
L8Y9X5_TUPCHDNA excision repair protein ERCC-6. (487 aa)
L8YAA3_TUPCHTyrosine-protein kinase SYK. (562 aa)
L8YAY3_TUPCHT-cell leukemia/lymphoma protein 1A. (108 aa)
L8YB66_TUPCHPIP49_C domain-containing protein. (403 aa)
ROBO1Roundabout like protein 1. (1344 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
GPRC5DG-protein coupled receptor family C group 5 member D. (299 aa)
L8YBM3_TUPCHT-lymphocyte activation antigen CD86. (202 aa)
GPRC5ARetinoic acid-induced protein 3. (357 aa)
TENM1Teneurin-1. (1867 aa)
L8YCG1_TUPCHReceptor tyrosine-protein kinase erbB-3. (1181 aa)
L8YCM6_TUPCHRap guanine nucleotide exchange factor 2. (2387 aa)
RASSF2Ras association domain-containing protein 2. (333 aa)
TCL1BT-cell leukemia/lymphoma protein 1B. (152 aa)
L8YDN5_TUPCHSerine/threonine-protein kinase WNK1. (489 aa)
L8YDT1_TUPCHTNF receptor-associated factor. (477 aa)
NTRK3Tyrosine-protein kinase receptor. (437 aa)
AFAP1L2Actin filament-associated protein 1-like 2. (849 aa)
L8YEE1_TUPCHPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (807 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
GAS6Growth arrest-specific protein 6. (1470 aa)
L9JA47_TUPCHCyclin-K. (339 aa)
L9J9E4_TUPCHMitogen-activated protein kinase kinase kinase. (909 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1375 aa)
L9L346_TUPCHDickkopf-related protein 1. (240 aa)
L9L3T7_TUPCHProgrammed cell death protein 10. (253 aa)
L9L433_TUPCHAngiotensinogen; Belongs to the serpin family. (634 aa)
MMD2Monocyte to macrophage differentiation factor 2. (252 aa)
L9L4D9_TUPCHTumor protein D53. (113 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
DUSP19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
L9L5F2_TUPCHPolycystin-2. (817 aa)
L9L5N4_TUPCHProepiregulin. (224 aa)
AREGAmphiregulin. (251 aa)
L9L6B4_TUPCHOxysterol-binding protein-related protein 8. (739 aa)
AKAP13A-kinase anchor protein 13. (1997 aa)
CCL21C-C motif chemokine. (249 aa)
L9L6L4_TUPCH40S ribosomal protein S3-A. (174 aa)
L9L6M2_TUPCHToll-like receptor 4. (527 aa)
L9L711_TUPCHCalcitonin. (138 aa)
DAXXDeath domain-associated protein 6. (733 aa)
L9L7D7_TUPCH26S proteasome non-ATPase regulatory subunit 10. (193 aa)
L9L7S7_TUPCHDiacylglycerol kinase. (855 aa)
L9L8B0_TUPCHCas scaffolding protein family member 4. (761 aa)
PARP16Poly [ADP-ribose] polymerase. (372 aa)
L9L8P9_TUPCHX-ray repair cross-complementing protein 5. (182 aa)
L9L916_TUPCHRAS guanyl-releasing protein 1. (661 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1267 aa)
L9L952_TUPCHTC1 domain-containing protein. (106 aa)
L9L9E0_TUPCHTumor necrosis factor receptor superfamily member 11A. (555 aa)
EDN1Endothelin-1. (200 aa)
IGF1Insulin-like growth factor I. (182 aa)
NEDD9Enhancer of filamentation 1. (860 aa)
L9L9X0_TUPCHActivity-dependent neuroprotector homeobox protein. (382 aa)
CSF1RReceptor protein-tyrosine kinase. (706 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
L9KPF1_TUPCHSTE20-related kinase adapter protein alpha. (149 aa)
L9KPJ3_TUPCHTyrosine-protein kinase. (1060 aa)
L9KPK2_TUPCHDisabled like protein 2-interacting protein. (988 aa)
L9KPU0_TUPCHPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
L9KQ67_TUPCHSerine/threonine-protein kinase PAK 1. (196 aa)
L9KQC0_TUPCHDisabled like protein 2-interacting protein. (212 aa)
PAK1Non-specific serine/threonine protein kinase. (1020 aa)
PDCD10Programmed cell death protein 10. (222 aa)
L9KQR2_TUPCHCyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (295 aa)
L9KQT0_TUPCH5'-AMP-activated protein kinase subunit gamma-2. (305 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (860 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (744 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (609 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (188 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (631 aa)
L9KRN4_TUPCHLow-density lipoprotein receptor-related protein 8. (1069 aa)
L9KRY3_TUPCHp2X purinoceptor 7. (860 aa)
L9KS81_TUPCHMacrophage colony-stimulating factor 1. (964 aa)
L9LAM1_TUPCHFrizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
CALCACalcitonin. (142 aa)
L9LAI5_TUPCHReelin. (2789 aa)
L9LAI1_TUPCHX-ray repair cross-complementing protein 5. (442 aa)
L9LAH7_TUPCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (439 aa)
L9LAH6_TUPCHPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (279 aa)
IGF2Insulin-like growth factor II. (261 aa)
L9LAD1_TUPCHG8 domain-containing protein. (1494 aa)
TNFSF15Tumor necrosis factor ligand superfamily member 15. (255 aa)
L9L9X6_TUPCHTyrosine-protein phosphatase non-receptor type 1. (598 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
L9JBH9_TUPCHProgesterone-induced-blocking factor 1. (134 aa)
NRXN1Neurexin-1-alpha. (341 aa)
L9JBX1_TUPCHProhibitin. (201 aa)
L9JC79_TUPCHProtein aurora borealis. (515 aa)
L9JCZ2_TUPCHFrizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (623 aa)
FERMT2Fermitin family like protein 2. (680 aa)
L9JDP2_TUPCHNADPH oxidase 4. (95 aa)
GCGGlucagon. (179 aa)
L9JE16_TUPCHProhibitin. (162 aa)
SYAP1Synapse-associated protein 1. (300 aa)
CCDC88AGirdin. (1812 aa)
L9JFV6_TUPCHX-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (652 aa)
LTKTyrosine-protein kinase receptor. (826 aa)
L9JGL6_TUPCHThrombospondin-1. (1181 aa)
L9JGU4_TUPCH60S acidic ribosomal protein P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (109 aa)
L9JJ46_TUPCHNatural resistance-associated macrophage protein 1. (605 aa)
L9JKN9_TUPCHSignal transducer CD24. (76 aa)
L9JL49_TUPCHAdenylate cyclase type 8. (355 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (942 aa)
L9JLN6_TUPCHAdenylate cyclase type 8. (159 aa)
L9JLS4_TUPCHPutative speedy protein-like protein 3. (296 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
PAK2Non-specific serine/threonine protein kinase. (507 aa)
L9JRV1_TUPCHPhosphoinositide 3-kinase regulatory subunit 5. (831 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (573 aa)
L9JTC1_TUPCHRapamycin-insensitive companion of mTOR. (1433 aa)
L9JU63_TUPCHPro-neuregulin-2, membrane-bound isoform. (201 aa)
L9JUM1_TUPCHProheparin-binding EGF-like growth factor. (156 aa)
L9JV47_TUPCHPhosphoinositide 3-kinase regulatory subunit 6. (591 aa)
ERBB2Receptor protein-tyrosine kinase. (688 aa)
WIPF2Cell division control protein 6 like protein. (870 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (702 aa)
L9JZ14_TUPCHProspero homeobox protein 1. (782 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
L9K006_TUPCHSorting nexin. (598 aa)
RGCCResponse to complement 32 protein. (135 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (798 aa)
L9JAV3_TUPCHCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1324 aa)
L9JAQ6_TUPCHSignal transducer CD24. (76 aa)
L9L1K9_TUPCHFrizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PRRC1Protein PRRC1. (435 aa)
L9L2Q6_TUPCHProtein ajuba. (1034 aa)
ROR2Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1023 aa)
L8YEL0_TUPCHM-phase inducer phosphatase 2. (498 aa)
ANGPT4Angiopoietin-4. (497 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3. (281 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
L8YGB8_TUPCHDeath ligand signal enhancer. (469 aa)
FBXW9F-box/WD repeat-containing protein 9. (460 aa)
L8YGV5_TUPCHPro-epidermal growth factor. (852 aa)
ALKTyrosine-protein kinase receptor. (1151 aa)
L9J8D2_TUPCHE3 ubiquitin-protein ligase ZFP91. (371 aa)
L9J8M5_TUPCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (189 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1612 aa)
L9LFR6_TUPCHReceptor tyrosine-protein kinase erbB-4. (98 aa)
L9LES0_TUPCHCalcium-binding protein 39-like protein. (518 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (216 aa)
L9LDK7_TUPCHAbl interactor 1. (637 aa)
L9LD92_TUPCHSignal transducer CD24. (75 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1190 aa)
L9LD52_TUPCHHistone-lysine N-methyltransferase EZH2. (634 aa)
L9LD08_TUPCHMucosa-associated lymphoid tissue lymphoma translocation protein 1. (727 aa)
L9LD07_TUPCHTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
L9LCN6_TUPCHReceptor tyrosine-protein kinase erbB-4. (916 aa)
L9LBK9_TUPCHDisintegrin and metalloproteinase domain-containing protein 17. (846 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
DDR2Discoidin domain-containing receptor 2. (1543 aa)
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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