(38 nodes) E-box binding network (Tupaia chinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTF1A	Pancreas transcription factor 1 subunit alpha. (211 aa)
	L9LGA0_TUPCH	Histone deacetylase 2. (126 aa)
	SAMD12	Myb-binding protein 1A. (612 aa)
	L9LEC8_TUPCH	Transcription factor AP-4. (340 aa)
	L9LC81_TUPCH	Transcription factor 12. (516 aa)
	L9LC80_TUPCH	Aryl hydrocarbon receptor nuclear translocator-like protein 2. (245 aa)
	L9LBV3_TUPCH	Aryl hydrocarbon receptor nuclear translocator-like protein 2. (220 aa)
	ASCL2	Achaete-scute like protein 2. (193 aa)
	L9LAL3_TUPCH	Aryl hydrocarbon receptor nuclear translocator-like protein 1. (571 aa)
	L9L8N6_TUPCH	Transcription factor 4. (517 aa)
	L9L7F1_TUPCH	Protein max. (151 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (298 aa)
	BHLHE40	Class E basic helix-loop-helix protein 40. (412 aa)
	HES3	Transcription factor HES-3. (171 aa)
	TCF21	Transcription factor 21. (179 aa)
	PRMT5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (700 aa)
	HAND2	Heart-and neural crest derivatives-expressed protein 2. (66 aa)
	SREBF2	Sterol regulatory element-binding protein 2. (991 aa)
	PER1	Period circadian protein like protein 1. (1429 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (363 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (612 aa)
	L9JWX2_TUPCH	Neurogenic differentiation factor 2. (253 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	L9JHC0_TUPCH	Zinc finger E-box-binding homeobox 1. (1148 aa)
	L9JE93_TUPCH	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (509 aa)
	MYOG	Myogenin. (224 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (375 aa)
	L9J913_TUPCH	Microphthalmia-associated transcription factor. (394 aa)
	TAL1	T-cell acute lymphocytic leukemia protein 1. (262 aa)
	ATOH8	Protein atonal like protein 8. (313 aa)
	MYBBP1A	Myb-binding protein 1A. (1274 aa)
	L8Y8V2_TUPCH	Aryl hydrocarbon receptor. (657 aa)
	CIART	Uncharacterized protein. (386 aa)
	L8Y7F7_TUPCH	Histone deacetylase 1. (131 aa)
	SNAI2	Zinc finger protein SNAI2. (257 aa)
	L8Y326_TUPCH	Transcription factor E2-alpha. (833 aa)
	L8Y162_TUPCH	Cryptochrome-1. (463 aa)
	L8XZG1_TUPCH	Transcription factor HES-1. (222 aa)

Your Current Organism:

Tupaia chinensis

NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL2	L8XZG1_TUPCH	L9LB69	L8XZG1	Achaete-scute like protein 2.	Transcription factor HES-1.	0.709
ASCL2	L8Y326_TUPCH	L9LB69	L8Y326	Achaete-scute like protein 2.	Transcription factor E2-alpha.	0.783
ASCL2	L9L8N6_TUPCH	L9LB69	L9L8N6	Achaete-scute like protein 2.	Transcription factor 4.	0.801
ASCL2	L9LC81_TUPCH	L9LB69	L9LC81	Achaete-scute like protein 2.	Transcription factor 12.	0.801
BHLHE40	L8Y162_TUPCH	L9L5L1	L8Y162	Class E basic helix-loop-helix protein 40.	Cryptochrome-1.	0.630
BHLHE40	L9LAL3_TUPCH	L9L5L1	L9LAL3	Class E basic helix-loop-helix protein 40.	Aryl hydrocarbon receptor nuclear translocator-like protein 1.	0.680
BHLHE40	L9LBV3_TUPCH	L9L5L1	L9LBV3	Class E basic helix-loop-helix protein 40.	Aryl hydrocarbon receptor nuclear translocator-like protein 2.	0.420
BHLHE40	L9LC80_TUPCH	L9L5L1	L9LC80	Class E basic helix-loop-helix protein 40.	Aryl hydrocarbon receptor nuclear translocator-like protein 2.	0.420
BHLHE40	NR1D1	L9L5L1	L9K0E0	Class E basic helix-loop-helix protein 40.	Nuclear receptor subfamily 1 group D member 1.	0.577
BHLHE40	PER1	L9L5L1	L9KQY1	Class E basic helix-loop-helix protein 40.	Period circadian protein like protein 1.	0.448
CIART	L9LAL3_TUPCH	L8Y8S4	L9LAL3	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator-like protein 1.	0.461
CIART	PER1	L8Y8S4	L9KQY1	Uncharacterized protein.	Period circadian protein like protein 1.	0.437
GATA3	HAND2	L9KQM1	L9KY53	Trans-acting T-cell-specific transcription factor GATA-3.	Heart-and neural crest derivatives-expressed protein 2.	0.577
GATA3	L8Y326_TUPCH	L9KQM1	L8Y326	Trans-acting T-cell-specific transcription factor GATA-3.	Transcription factor E2-alpha.	0.649
GATA3	L8Y7F7_TUPCH	L9KQM1	L8Y7F7	Trans-acting T-cell-specific transcription factor GATA-3.	Histone deacetylase 1.	0.506
GATA3	L9JE93_TUPCH	L9KQM1	L9JE93	Trans-acting T-cell-specific transcription factor GATA-3.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.506
GATA3	L9L8N6_TUPCH	L9KQM1	L9L8N6	Trans-acting T-cell-specific transcription factor GATA-3.	Transcription factor 4.	0.530
GATA3	L9LC81_TUPCH	L9KQM1	L9LC81	Trans-acting T-cell-specific transcription factor GATA-3.	Transcription factor 12.	0.530
GATA3	L9LGA0_TUPCH	L9KQM1	L9LGA0	Trans-acting T-cell-specific transcription factor GATA-3.	Histone deacetylase 2.	0.506
GATA3	TAL1	L9KQM1	L8YD74	Trans-acting T-cell-specific transcription factor GATA-3.	T-cell acute lymphocytic leukemia protein 1.	0.852