87 items (Tupaia chinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TREX1	Three prime repair exonuclease 1. (303 aa)
	P4HA1	Prolyl 4-hydroxylase subunit alpha-1. (474 aa)
	EMC6	Transmembrane protein 93. (110 aa)
	RPN1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (536 aa)
	SSR4	Translocon-associated protein subunit delta. (165 aa)
	PIGM	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (434 aa)
	L8Y823_TUPCH	Antigen peptide transporter 2. (722 aa)
	L8YAB5_TUPCH	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	ORMDL2	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	PIGS	GPI transamidase component PIG-S. (555 aa)
	L8YAU6_TUPCH	Protein disulfide-isomerase A3; Belongs to the protein disulfide isomerase family. (562 aa)
	OSTC	Oligosaccharyltransferase complex subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All s [...] (162 aa)
	L8YC20_TUPCH	N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein. (371 aa)
	FAM167A	Protein FAM167A. (202 aa)
	L8YCS5_TUPCH	Glucosidase 2 subunit beta. (590 aa)
	ASNA1	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (348 aa)
	L8YDT1_TUPCH	TNF receptor-associated factor. (477 aa)
	TAP1	Antigen peptide transporter 1. (660 aa)
	SELENOS	Selenoprotein S. (172 aa)
	L8YFZ6_TUPCH	Serine palmitoyltransferase 1. (305 aa)
	SEC61B	Protein transport protein Sec61 subunit beta. (96 aa)
	L8YGL5_TUPCH	Glycosylphosphatidylinositol anchor attachment 1 protein. (958 aa)
	CALR	Calreticulin. (417 aa)
	RYR1	Ryanodine receptor 1. (4763 aa)
	HSD17B12	Estradiol 17-beta-dehydrogenase 12. (105 aa)
	L9JCA6_TUPCH	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B. (631 aa)
	HIGD2A	FAS-associated factor 2. (408 aa)
	L9JE00_TUPCH	Exostosin-2; Belongs to the glycosyltransferase 47 family. (740 aa)
	L9JER6_TUPCH	E3 ubiquitin-protein ligase RNF139. (100 aa)
	RNF139	E3 ubiquitin-protein ligase RNF139. (221 aa)
	PIGH	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H. (129 aa)
	L9JHM8_TUPCH	Serine palmitoyltransferase 2. (505 aa)
	L9JKG2_TUPCH	UBX domain-containing protein 7. (446 aa)
	L9JL22_TUPCH	Protein sel-1 like protein 1. (826 aa)
	L9JPU6_TUPCH	Small subunit of serine palmitoyltransferase A. (116 aa)
	UBXN1	UBX domain-containing protein 1. (324 aa)
	GANAB	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (1248 aa)
	MZB1	Plasma cell-induced resident endoplasmic reticulum protein. (191 aa)
	ORMDL3	ORM1-like protein 3. (257 aa)
	UGT3A2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (511 aa)
	L9K8Z7_TUPCH	Mitogen-activated protein kinase kinase kinase 6. (1201 aa)
	L9KFK3_TUPCH	Signal peptidase complex subunit 2. (175 aa)
	PIGT	GPI transamidase component PIG-T. (605 aa)
	KRTCAP2	Keratinocyte-associated protein 2. (137 aa)
	EMC8	Neighbor of COX4. (210 aa)
	L9KJV3_TUPCH	Hypoxia up-regulated protein 1. (1024 aa)
	MLEC	Malectin. (794 aa)
	L9KN07_TUPCH	FAS-associated factor 2. (185 aa)
	L9KNA0_TUPCH	Centromere/kinetochore protein zw10 like protein. (767 aa)
	L9KP54_TUPCH	Ubiquitin fusion degradation protein 1 like protein. (327 aa)
	L9KQ93_TUPCH	E3 ubiquitin-protein ligase synoviolin. (563 aa)
	L9KQQ6_TUPCH	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (245 aa)
	AUP1	Ancient ubiquitous protein 1. (450 aa)
	MAGT1	Magnesium transporter protein 1. (362 aa)
	ABCB9	ATP-binding cassette sub-family B member 9. (766 aa)
	L9KSW2_TUPCH	Magnesium transporter protein 1. (311 aa)
	SREBF2	Sterol regulatory element-binding protein 2. (991 aa)
	L9KU93_TUPCH	Serine/threonine-protein kinase/endoribonuclease IRE2. (871 aa)
	L9KUM2_TUPCH	E3 ubiquitin-protein ligase AMFR. (861 aa)
	FAF1	FAS-associated factor 1. (618 aa)
	L9KWQ5_TUPCH	RAD50-interacting protein 1. (796 aa)
	L9KX52_TUPCH	Calreticulin. (436 aa)
	L9KZ26_TUPCH	Nuclear protein localization protein 4 like protein. (420 aa)
	PRR35	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q. (1708 aa)
	WRB	Tryptophan-rich protein. (246 aa)
	L9KZR9_TUPCH	Protein disulfide-isomerase; Belongs to the protein disulfide isomerase family. (749 aa)
	L9L034_TUPCH	EMC1_C domain-containing protein. (893 aa)
	L9L0C9_TUPCH	Nuclear protein localization protein 4 like protein. (277 aa)
	EMC9	UPF0172 protein FAM158A. (206 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1375 aa)
	L9L347_TUPCH	Phosphatidylinositol glycan anchor biosynthesis class U protein. (418 aa)
	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (134 aa)
	INSIG1	Insulin-induced 1 protein. (480 aa)
	SPTLC3	Serine palmitoyltransferase 3. (554 aa)
	DAD1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (1258 aa)
	PIGC	Phosphatidylinositol N-acetylglucosaminyltransferase subunit C. (297 aa)
	RPN2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (672 aa)
	L9L8K0_TUPCH	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (271 aa)
	NBAS	Neuroblastoma-amplified sequence. (1642 aa)
	L9LAK1_TUPCH	FAS-associated factor 1. (138 aa)
	L9LAN0_TUPCH	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (183 aa)
	EI24	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A. (1161 aa)
	L9LB32_TUPCH	Signal peptidase complex subunit 2. (120 aa)
	L9LBH3_TUPCH	Neuroblastoma-amplified sequence. (851 aa)
	L9LDP5_TUPCH	Signal peptidase complex catalytic subunit SEC11C. (211 aa)
	L9LFI1_TUPCH	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (253 aa)

Your Current Organism:

Tupaia chinensis

NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB9	L8Y823_TUPCH	L9KSQ0	L8Y823	ATP-binding cassette sub-family B member 9.	Antigen peptide transporter 2.	0.975
ABCB9	L8YAB5_TUPCH	L9KSQ0	L8YAB5	ATP-binding cassette sub-family B member 9.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.446
ABCB9	L8YAU6_TUPCH	L9KSQ0	L8YAU6	ATP-binding cassette sub-family B member 9.	Protein disulfide-isomerase A3; Belongs to the protein disulfide isomerase family.	0.487
ASNA1	EMC6	L8YDF6	L8Y414	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Transmembrane protein 93.	0.588
ASNA1	L9KQQ6_TUPCH	L8YDF6	L9KQQ6	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.591
ASNA1	L9LFI1_TUPCH	L8YDF6	L9LFI1	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.412
ASNA1	SEC61B	L8YDF6	L8YGH5	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Protein transport protein Sec61 subunit beta.	0.717
ASNA1	WRB	L8YDF6	L9KZH5	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Tryptophan-rich protein.	0.995
AUP1	HIGD2A	L9KS43	L9JCD7	Ancient ubiquitous protein 1.	FAS-associated factor 2.	0.544
AUP1	HSD17B12	L9KS43	L9JBW3	Ancient ubiquitous protein 1.	Estradiol 17-beta-dehydrogenase 12.	0.403
AUP1	L9JL22_TUPCH	L9KS43	L9JL22	Ancient ubiquitous protein 1.	Protein sel-1 like protein 1.	0.801
AUP1	L9KN07_TUPCH	L9KS43	L9KN07	Ancient ubiquitous protein 1.	FAS-associated factor 2.	0.544
AUP1	L9KQ93_TUPCH	L9KS43	L9KQ93	Ancient ubiquitous protein 1.	E3 ubiquitin-protein ligase synoviolin.	0.753
AUP1	L9KUM2_TUPCH	L9KS43	L9KUM2	Ancient ubiquitous protein 1.	E3 ubiquitin-protein ligase AMFR.	0.514
AUP1	L9KZR9_TUPCH	L9KS43	L9KZR9	Ancient ubiquitous protein 1.	Protein disulfide-isomerase; Belongs to the protein disulfide isomerase family.	0.418
AUP1	L9LFI1_TUPCH	L9KS43	L9LFI1	Ancient ubiquitous protein 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.633
AUP1	VCP	L9KS43	L9L6K9	Ancient ubiquitous protein 1.	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.619
CALR	GANAB	L8YGV3	L9JS92	Calreticulin.	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	0.540
CALR	L8Y823_TUPCH	L8YGV3	L8Y823	Calreticulin.	Antigen peptide transporter 2.	0.478
CALR	L8YAB5_TUPCH	L8YGV3	L8YAB5	Calreticulin.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.761