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CDK4 CDK4 GNG7 GNG7 PIK3CG PIK3CG FADD FADD CCND1 CCND1 GNB3 GNB3 FOS FOS CCR5 CCR5 CCR4 CCR4 CCR1 CCR1 CCR3 CCR3 CSF2 CSF2 C3 C3 L8Y8G7_TUPCH L8Y8G7_TUPCH IRF7 IRF7 HRAS HRAS L8Y8R7_TUPCH L8Y8R7_TUPCH L8Y906_TUPCH L8Y906_TUPCH L8Y952_TUPCH L8Y952_TUPCH L8Y9Y1_TUPCH L8Y9Y1_TUPCH IKBKG IKBKG L8YAI9_TUPCH L8YAI9_TUPCH L8YAT7_TUPCH L8YAT7_TUPCH GNGT2 GNGT2 L8YCB0_TUPCH L8YCB0_TUPCH ICAM1 ICAM1 L8YCF9_TUPCH L8YCF9_TUPCH CCR8 CCR8 PIK3R3 PIK3R3 L8YEC2_TUPCH L8YEC2_TUPCH L8YEE1_TUPCH L8YEE1_TUPCH CALMODULIN CALMODULIN PTGS2 PTGS2 CALML6 CALML6 GNG2 GNG2 RAF1 RAF1 IKBKE IKBKE CALML3 CALML3 CALML5 CALML5 CASP3 CASP3 TLR3 TLR3 IRF3 IRF3 BAX BAX CALM1 CALM1 GNG11 GNG11 BECN2 BECN2 GNGT1 GNGT1 MYC MYC GNG3 GNG3 MAP2K4 MAP2K4 BECN1 BECN1 STAT3 STAT3 GNB2 GNB2 TRADD TRADD CDK6 CDK6 CTNNB1 CTNNB1 L9KB10_TUPCH L9KB10_TUPCH CALML4 CALML4 CASP8 CASP8 PLCG2 PLCG2 GABARAPL2 GABARAPL2 NRAS NRAS TCF7L1 TCF7L1 VEGFA VEGFA L9KTW8_TUPCH L9KTW8_TUPCH MAPK3 MAPK3 UBA52 UBA52 PIK3R2 PIK3R2 GNG13 GNG13 L9KZP9_TUPCH L9KZP9_TUPCH PPP3R2 PPP3R2 PIK3CD PIK3CD E2F2 E2F2 CASP9 CASP9 IFNGR1 IFNGR1 BAK1 BAK1 ITPR3 ITPR3 E2F1 E2F1 ITPR1 ITPR1 MTOR MTOR CXCL8 CXCL8 SRC SRC L9L999_TUPCH L9L999_TUPCH IKBKB IKBKB NFATC2 NFATC2 ATG3 ATG3 ZFP36 ZFP36 IFNB1 IFNB1 L9LC88_TUPCH L9LC88_TUPCH ITPR2 ITPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK4Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (1129 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (342 aa)
FOSProto-oncogene c-Fos. (400 aa)
CCR5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CCR1C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (129 aa)
C3Complement C3. (1697 aa)
L8Y8G7_TUPCHInterferon alpha-2. (102 aa)
IRF7Interferon regulatory factor 7. (470 aa)
HRASGTPase HRas. (187 aa)
L8Y8R7_TUPCHInterferon omega-1. (150 aa)
L8Y906_TUPCHInterferon omega-1. (187 aa)
L8Y952_TUPCHSaoe class I histocompatibility antigen, A alpha chain; Belongs to the MHC class I family. (214 aa)
L8Y9Y1_TUPCHPatr class I histocompatibility antigen, A-126 alpha chain. (136 aa)
IKBKGNF-kappa-B essential modulator. (420 aa)
L8YAI9_TUPCHHLA class I histocompatibility antigen, A-23 alpha chain; Belongs to the MHC class I family. (376 aa)
L8YAT7_TUPCHCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
L8YCB0_TUPCHInterferon alpha-2. (102 aa)
ICAM1Intercellular adhesion molecule 1. (520 aa)
L8YCF9_TUPCHPatr class I histocompatibility antigen, A-126 alpha chain. (174 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (426 aa)
L8YEC2_TUPCHInterferon alpha-2. (189 aa)
L8YEE1_TUPCHPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (807 aa)
CALMODULINCalmodulin; Belongs to the calmodulin family. (150 aa)
PTGS2Prostaglandin G/H synthase 2. (591 aa)
CALML6Calmodulin-like protein 6. (203 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (152 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon. (899 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CALML5Calmodulin-like protein 5. (148 aa)
CASP3Long-chain-fatty-acid--CoA ligase 1. (584 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (564 aa)
IRF3Interferon regulatory factor 3. (420 aa)
BAXApoptosis regulator BAX. (173 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (217 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
BECN2Beclin-1-like protein 1. (383 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (327 aa)
BECN1Beclin-1. (462 aa)
STAT3Signal transducer and activator of transcription 3. (747 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (310 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (200 aa)
CTNNB1Catenin beta-1. (832 aa)
L9KB10_TUPCH60S ribosomal protein L21. (358 aa)
CALML4Calmodulin-like protein 4. (414 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (521 aa)
PLCG21-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2. (131 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (130 aa)
NRASGTPase NRas. (189 aa)
TCF7L1Transcription factor 7-like 1. (492 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (155 aa)
L9KTW8_TUPCHCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK3Mitogen-activated protein kinase. (528 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (146 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (793 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (81 aa)
L9KZP9_TUPCHCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PPP3R2Glutamate [NMDA] receptor subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1124 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1074 aa)
E2F2Transcription factor E2F2. (442 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (403 aa)
IFNGR1Interferon gamma receptor 1. (458 aa)
BAK1Bcl-2 homologous antagonist/killer. (283 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2646 aa)
E2F1Transcription factor E2F1. (175 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (73 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (3780 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
SRCTyrosine-protein kinase. (526 aa)
L9L999_TUPCHCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (768 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (788 aa)
ATG3Autophagy-related protein 3. (240 aa)
ZFP36Tristetraprolin. (377 aa)
IFNB1Interferon beta. (187 aa)
L9LC88_TUPCHInterferon alpha-2. (189 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2231 aa)
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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