STRINGSTRING
CDK4 CDK4 GLI1 GLI1 CCND2 CCND2 GNG7 GNG7 KNG1 KNG1 FADD FADD CCND1 CCND1 L8Y026_TUPCH L8Y026_TUPCH GNB3 GNB3 PGF PGF FOS FOS CXCR4 CXCR4 GLI2 GLI2 FGF6 FGF6 FGF23 FGF23 FGF3 FGF3 FGF4 FGF4 LRP5L LRP5L ADCY6 ADCY6 RHOA RHOA PTCH1 PTCH1 GADD45B GADD45B SKP1 SKP1 NOS2 NOS2 FGF10 FGF10 L8Y574_TUPCH L8Y574_TUPCH RPS6KB2 RPS6KB2 RAC2 RAC2 RALB RALB FZD1 FZD1 GSTA1 GSTA1 ELK1 ELK1 L8Y6U3_TUPCH L8Y6U3_TUPCH WNT1 WNT1 BMP2 BMP2 CDKN1B CDKN1B MGST1 MGST1 ABL1 ABL1 L8Y8G7_TUPCH L8Y8G7_TUPCH IL3RA IL3RA BIRC7 BIRC7 HRAS HRAS L8Y8R7_TUPCH L8Y8R7_TUPCH L8Y906_TUPCH L8Y906_TUPCH DVL1 DVL1 NFKB2 NFKB2 GNA12 GNA12 SUFU SUFU WNT5B WNT5B IKBKG IKBKG GADD45A GADD45A ARAF ARAF CDKN2B CDKN2B IL13 IL13 L8YAT7_TUPCH L8YAT7_TUPCH IL12B IL12B GNGT2 GNGT2 ITGA3 ITGA3 VEGFD VEGFD LRP6 LRP6 WNT7B WNT7B L8YCB0_TUPCH L8YCB0_TUPCH LAMC3 LAMC3 HES5 HES5 CCNE2 CCNE2 LAMB1 LAMB1 MSH6 MSH6 PIK3R3 PIK3R3 IL12A IL12A L8YEC2_TUPCH L8YEC2_TUPCH L8YEE1_TUPCH L8YEE1_TUPCH CASP7 CASP7 CALMODULIN CALMODULIN PTGS2 PTGS2 EPOR EPOR KEAP1 KEAP1 RASGRP4 RASGRP4 CALML6 CALML6 WNT2 WNT2 ALK ALK GNG2 GNG2 BMP4 BMP4 RAF1 RAF1 BDKRB2 BDKRB2 PTGER2 PTGER2 FGF21 FGF21 EPAS1 EPAS1 TGFBR2 TGFBR2 SMO SMO RAD51 RAD51 PLCB2 PLCB2 CSF3R CSF3R HEYL HEYL CALML3 CALML3 CALML5 CALML5 DLL4 DLL4 CASP3 CASP3 ITGB1 ITGB1 BAX BAX RPS6KA5 RPS6KA5 CALM1 CALM1 COL4A1 COL4A1 DDB2 DDB2 RUNX1T1 RUNX1T1 FGF9 FGF9 GNG11 GNG11 WNT9B WNT9B CDH1 CDH1 HDAC2 HDAC2 GNGT1 GNGT1 WNT8B WNT8B L9JKE7_TUPCH L9JKE7_TUPCH TGFB3 TGFB3 MYC MYC ADCY8 ADCY8 GNG3 GNG3 PTGER4 PTGER4 IL7R IL7R ERBB2 ERBB2 RARA RARA STAT5A STAT5A JUP JUP STAT3 STAT3 LPAR4 LPAR4 EPO EPO GNB2 GNB2 CDK6 CDK6 TRAF1 TRAF1 CTNNB1 CTNNB1 WNT7A WNT7A ARHGEF11 ARHGEF11 KITLG KITLG ADCY5 ADCY5 CCNA1 CCNA1 GADD45G GADD45G SLC2A1 SLC2A1 PTCH2 PTCH2 IL6R IL6R FZD7 FZD7 PML PML CALML4 CALML4 CCNA2 CCNA2 CASP8 CASP8 PLCG2 PLCG2 KIF7 KIF7 FZD9 FZD9 EGLN3 EGLN3 CBL CBL CKS2 CKS2 FOXO1 FOXO1 PTK2 PTK2 VHL VHL ROCK1 ROCK1 PLD2 PLD2 FZD3 FZD3 JAG1 JAG1 SOS1 SOS1 AGTR1 AGTR1 CSF1R CSF1R PDGFRB PDGFRB L9KPS3_TUPCH L9KPS3_TUPCH BIRC2 BIRC2 L9KPZ4_TUPCH L9KPZ4_TUPCH BIRC3 BIRC3 DVL2 DVL2 GSTM1 GSTM1 PRKACB PRKACB FGF20 FGF20 WNT2B WNT2B NRAS NRAS CTNNA3 CTNNA3 TGFA TGFA HSP90AB1 HSP90AB1 ZBTB16 ZBTB16 WNT16 WNT16 TCF7L1 TCF7L1 FGF16 FGF16 VEGFA VEGFA CCND3 CCND3 L9KTW8_TUPCH L9KTW8_TUPCH IL4R IL4R PIM1 PIM1 MAPK3 MAPK3 IL15RA IL15RA PLCB3 PLCB3 CXCL12 CXCL12 IFNG IFNG GNAI3 GNAI3 GSTM3 GSTM3 LPAR2 LPAR2 FZD10 FZD10 NCOA1 NCOA1 RET RET ADCY3 ADCY3 STK4 STK4 IL12RB1 IL12RB1 PIK3R2 PIK3R2 GNA13 GNA13 AXIN1 AXIN1 AXIN2 AXIN2 PRKCB PRKCB GNG13 GNG13 BIRC5 BIRC5 EGLN1 EGLN1 L9KZP9_TUPCH L9KZP9_TUPCH RAC3 RAC3 GNAQ GNAQ PIK3CD PIK3CD FZD6 FZD6 FZD4 FZD4 E2F2 E2F2 CDC42 CDC42 F2RL3 F2RL3 CASP9 CASP9 WNT3A WNT3A FGF1 FGF1 MGST2 MGST2 ADCY4 ADCY4 IFNGR1 IFNGR1 BAK1 BAK1 HEY2 HEY2 CTBP2 CTBP2 LAMC2 LAMC2 E2F1 E2F1 GRB2 GRB2 CKS1B CKS1B LAMC1 LAMC1 SHH SHH PDGFRA PDGFRA KIT KIT ADCY2 ADCY2 MTOR MTOR EDNRA EDNRA RALA RALA COL4A5 COL4A5 CXCL8 CXCL8 RXRB RXRB RXRG RXRG ARHGEF1 ARHGEF1 MGST3 MGST3 DAPK2 DAPK2 BBC3 BBC3 FH FH DCC DCC L9L999_TUPCH L9L999_TUPCH ITGA6 ITGA6 COL4A4 COL4A4 EDN1 EDN1 IGF1 IGF1 HSP90B1 HSP90B1 IKBKB IKBKB LPAR1 LPAR1 ROCK2 ROCK2 IGF2 IGF2 EGLN2 EGLN2 COL4A3 COL4A3 CRKL CRKL L9LC88_TUPCH L9LC88_TUPCH L9LCE4_TUPCH L9LCE4_TUPCH ESR1 ESR1 TCEB1 TCEB1 ADCY9 ADCY9 L9LFI5_TUPCH L9LFI5_TUPCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CDK4Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (1129 aa)
GLI1Zinc finger protein GLI1. (1104 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KNG1Kininogen-1. (447 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
L8Y026_TUPCHGlutathione S-transferase P. (235 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (342 aa)
PGFRibosomal protein S6 kinase-like 1; Belongs to the PDGF/VEGF growth factor family. (1082 aa)
FOSProto-oncogene c-Fos. (400 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
GLI2Zinc finger protein GLI2. (1588 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (181 aa)
LRP5LLow-density lipoprotein receptor-related protein 5. (1462 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
RHOATransforming protein RhoA. (190 aa)
PTCH1Protein patched like protein 1. (1669 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1109 aa)
FGF10Fibroblast growth factor 10. (159 aa)
L8Y574_TUPCHGlutathione S-transferase P. (215 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (481 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
RALBRas-related protein Ral-B. (206 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (514 aa)
GSTA1Glutathione S-transferase A1. (166 aa)
ELK1ETS domain-containing protein Elk-1. (385 aa)
L8Y6U3_TUPCHGlutathione S-transferase alpha-4; Belongs to the GST superfamily. (207 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BMP2Bone morphogenetic protein 2. (240 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (185 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
ABL1Tyrosine-protein kinase ABL1. (959 aa)
L8Y8G7_TUPCHInterferon alpha-2. (102 aa)
IL3RAInterleukin-3 receptor subunit alpha. (662 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (368 aa)
HRASGTPase HRas. (187 aa)
L8Y8R7_TUPCHInterferon omega-1. (150 aa)
L8Y906_TUPCHInterferon omega-1. (187 aa)
DVL1Segment polarity protein dishevelled like protein DVL-1. (1156 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (893 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (287 aa)
SUFUSuppressor of fused like protein. (102 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (533 aa)
IKBKGNF-kappa-B essential modulator. (420 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
ARAFSerine/threonine-protein kinase A-Raf. (623 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (131 aa)
IL13Interleukin-13. (130 aa)
L8YAT7_TUPCHCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (966 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (260 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1580 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
L8YCB0_TUPCHInterferon alpha-2. (102 aa)
LAMC3Laminin subunit gamma-3. (1463 aa)
HES5Transcription factor HES-5. (168 aa)
CCNE2G1/S-specific cyclin-E2. (320 aa)
LAMB1Laminin subunit beta-1. (1821 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1306 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (426 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (213 aa)
L8YEC2_TUPCHInterferon alpha-2. (189 aa)
L8YEE1_TUPCHPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (807 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (303 aa)
CALMODULINCalmodulin; Belongs to the calmodulin family. (150 aa)
PTGS2Prostaglandin G/H synthase 2. (591 aa)
EPORErythropoietin receptor. (447 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
RASGRP4RAS guanyl-releasing protein 4. (645 aa)
CALML6Calmodulin-like protein 6. (203 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
ALKTyrosine-protein kinase receptor. (1151 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (152 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (321 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
EPAS1Endothelial PAS domain-containing protein 1. (833 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
SMOSmoothened like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (1115 aa)
RAD51Protein CASC5; Belongs to the RecA family. (1640 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1191 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (980 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (299 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CALML5Calmodulin-like protein 5. (148 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (736 aa)
CASP3Long-chain-fatty-acid--CoA ligase 1. (584 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (741 aa)
BAXApoptosis regulator BAX. (173 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (729 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (217 aa)
COL4A1Collagen alpha-1(IV) chain. (1559 aa)
DDB2DNA damage-binding protein 2. (427 aa)
RUNX1T1Protein CBFA2T1. (596 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (1065 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (874 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (402 aa)
L9JKE7_TUPCHGlutathione S-transferase theta-1. (240 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (351 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (942 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (487 aa)
IL7RSperm flagellar protein 2. (2015 aa)
ERBB2Receptor protein-tyrosine kinase. (688 aa)
RARARetinoic acid receptor alpha. (462 aa)
STAT5ASignal transducer and activator of transcription 5A. (130 aa)
JUPJunction plakoglobin. (1088 aa)
STAT3Signal transducer and activator of transcription 3. (747 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
EPOZonadhesin. (2453 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (200 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CTNNB1Catenin beta-1. (832 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1533 aa)
KITLGKit ligand. (295 aa)
ADCY5Adenylate cyclase type 5. (321 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (446 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (515 aa)
PTCH2Protein patched like protein 2. (1229 aa)
IL6RInterleukin-6 receptor subunit alpha. (400 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
PMLProtein PML. (856 aa)
CALML4Calmodulin-like protein 4. (414 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (416 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (521 aa)
PLCG21-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2. (131 aa)
KIF7Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1320 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (478 aa)
EGLN3Egl nine like protein 3. (239 aa)
CBLE3 ubiquitin-protein ligase CBL. (889 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (974 aa)
FOXO1Forkhead box protein O1. (399 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (115 aa)
ROCK1Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1305 aa)
PLD2Phospholipase. (882 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (546 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
SOS1Son of sevenless like protein 1. (1385 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CSF1RReceptor protein-tyrosine kinase. (706 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
L9KPS3_TUPCHInterstitial collagenase. (466 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (597 aa)
L9KPZ4_TUPCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (257 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (599 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (744 aa)
GSTM1Glutathione S-transferase Mu 2; Belongs to the GST superfamily. (417 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (119 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
NRASGTPase NRas. (189 aa)
CTNNA3Catenin alpha-3. (188 aa)
TGFAProtransforming growth factor alpha. (167 aa)
HSP90AB1Heat shock protein HSP 90-beta. (782 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (423 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (268 aa)
TCF7L1Transcription factor 7-like 1. (492 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (155 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (286 aa)
L9KTW8_TUPCHCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IL4RInterleukin-4 receptor subunit alpha. (1448 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (379 aa)
MAPK3Mitogen-activated protein kinase. (528 aa)
IL15RAInterleukin-2 receptor subunit alpha. (611 aa)
PLCB3Phosphoinositide phospholipase C. (1208 aa)
CXCL12Stromal cell-derived factor 1. (101 aa)
IFNGInterferon gamma. (202 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GSTM3Glutathione S-transferase. (224 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
FZD10Frizzled-10. (58 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1123 aa)
ADCY3Adenylate cyclase type 3. (300 aa)
STK4Serine/threonine-protein kinase 4. (536 aa)
IL12RB1Interleukin-12 receptor subunit beta-1. (643 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (793 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (509 aa)
AXIN1Axin-1. (293 aa)
AXIN2Axin-2. (847 aa)
PRKCBNon-specific serine/threonine protein kinase. (333 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (81 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
EGLN1Egl nine like protein 1. (464 aa)
L9KZP9_TUPCHCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RAC3Leucine-rich repeat-containing protein 45. (872 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (323 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1074 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (364 aa)
FZD4Dynein light chain roadblock-type 1. (150 aa)
E2F2Transcription factor E2F2. (442 aa)
CDC42Cell division control protein 42 like protein. (191 aa)
F2RL3Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (403 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MGST2Microsomal glutathione S-transferase 2. (229 aa)
ADCY4Guanylate cyclase. (1472 aa)
IFNGR1Interferon gamma receptor 1. (458 aa)
BAK1Bcl-2 homologous antagonist/killer. (283 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
CTBP2Uncharacterized protein. (1020 aa)
LAMC2Laminin subunit gamma-2. (1219 aa)
E2F1Transcription factor E2F1. (175 aa)
GRB2Growth factor receptor-bound protein 2. (210 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LAMC1Laminin subunit gamma-1. (456 aa)
SHHSonic hedgehog protein. (207 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
ADCY2Adenylate cyclase type 2. (116 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (3780 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (607 aa)
RALARas-related protein Ral-A. (206 aa)
COL4A5Collagen alpha-1(IV) chain. (701 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
RXRBRetinoic acid receptor RXR-beta. (408 aa)
RXRGRetinoic acid receptor RXR-gamma. (425 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1103 aa)
MGST3Microsomal glutathione S-transferase 3. (151 aa)
DAPK2Death-associated protein kinase 3. (503 aa)
BBC3Bcl-2-binding component 3. (173 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
DCCNetrin receptor DCC. (961 aa)
L9L999_TUPCHCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ITGA6Integrin alpha-6; Belongs to the integrin alpha chain family. (1126 aa)
COL4A4Collagen alpha-1(IV) chain. (1527 aa)
EDN1Endothelin-1. (200 aa)
IGF1Insulin-like growth factor I. (182 aa)
HSP90B1Endoplasmin. (805 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (768 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (287 aa)
ROCK2Rho-associated protein kinase 2. (519 aa)
IGF2Insulin-like growth factor II. (261 aa)
EGLN2Egl nine like protein 2. (403 aa)
COL4A3Mitochondrial fission factor. (409 aa)
CRKLCrk-like protein. (303 aa)
L9LC88_TUPCHInterferon alpha-2. (189 aa)
L9LCE4_TUPCHGlutathione S-transferase theta-4; Belongs to the GST superfamily. (241 aa)
ESR1Estrogen receptor. (106 aa)
TCEB1Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family. (96 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (815 aa)
L9LFI5_TUPCHGlutathione S-transferase theta-1; Belongs to the GST superfamily. (242 aa)
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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