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| | cysN-2 | Putative ATP sulfurylase large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (641 aa) |
| | cysD-2 | Putative ATP sulfurylase small subunit. (308 aa) |
| | folD | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | NFA_34960 | Hypothetical protein. (424 aa) |
| | acsA | Putative acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | metC | Putative O-acetylhomoserine sulfhydrylase. (434 aa) |
| | ggt | Putative gamma-glutamyltranspeptidase. (629 aa) |
| | metK | Putative S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (404 aa) |
| | dxs | Putative 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa) |
| | NFA_37950 | Putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (407 aa) |
| | NFA_41510 | Putative acyl-CoA synthetase. (549 aa) |
| | thiL | Putative thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (333 aa) |
| | NFA_42660 | Hypothetical protein. (337 aa) |
| | NFA_43230 | Putative 2-amino-3-ketobutyrate CoA ligase. (473 aa) |
| | NFA_44190 | Hypothetical protein. (291 aa) |
| | mtnAB | Putative initiation factor eIF-2B alpha subunit homolog; Bifunctional protein that catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1- phosphate (MTRu-1-P), and the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P); In the N-terminal section; belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (552 aa) |
| | mtnD2 | Putative oxidoreductase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (191 aa) |
| | mtnC | Hypothetical protein; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (232 aa) |
| | moeB | Putative molybdopterin biosynthesis protein. (394 aa) |
| | NFA_46400 | Hypothetical protein. (233 aa) |
| | mshB | Putative N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (298 aa) |
| | NFA_47870 | Hypothetical protein. (142 aa) |
| | metB | Putative cystathionine gamma-synthase. (381 aa) |
| | NFA_48320 | Putative cystathionine beta-synthase. (462 aa) |
| | NFA_48640 | Hypothetical protein. (342 aa) |
| | egtD | Hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (323 aa) |
| | egtC | Hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (280 aa) |
| | egtB | Hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (446 aa) |
| | gshA | Putative glutamylcysteine synthetase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (438 aa) |
| | NFA_50420 | Putative acyl-CoA synthetase. (648 aa) |
| | NFA_51510 | Hypothetical protein. (361 aa) |
| | mshA | Putative glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (451 aa) |
| | metE | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (767 aa) |
| | NFA_52620 | Hypothetical protein. (124 aa) |
| | thiC | Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (547 aa) |
| | thiD | Putative phosphomethylpyrimidine kinase. (281 aa) |
| | thiG | Putative thiamin-thiazole moiety synthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Putative sulfur transfer protein. (72 aa) |
| | NFA_53390 | Putative amino acid oxidase. (367 aa) |
| | thiE | Putative thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (232 aa) |
| | ackA | Putative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa) |
| | pta | Putative phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (695 aa) |
| | metZ | Putative O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa) |
| | mshD | Putative mycothiol synthase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (303 aa) |
| | NFA_6660 | Putative acyl-CoA synthetase. (666 aa) |
| | mtnP | Putative methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (269 aa) |
| | NFA_8460 | Hypothetical protein. (548 aa) |
| | metXA | Putative homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (412 aa) |
| | NFA_10210 | Putative branched-chain alpha-keto acid dehydrogenase component. (370 aa) |
| | thrA | Putative homoserine dehydrogenase. (451 aa) |
| | NFA_10890 | Hypothetical protein. (149 aa) |
| | NFA_10900 | Hypothetical protein. (95 aa) |
| | cysM | Putative cysteine synthase. (320 aa) |
| | NFA_12430 | Putative acyl-CoA synthetase. (536 aa) |
| | cysD | Putative sulfate adenylyltransferase subunit 2. (314 aa) |
| | cysH | Putative phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (239 aa) |
| | mtnA | Putative initiation factor eIF-2B alpha subunit homolog; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (523 aa) |
| | mtnD1 | Putative oxidoreductase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (189 aa) |
| | NFA_14600 | Putative transcriptional regulator. (201 aa) |
| | lipA | Putative lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (352 aa) |
| | metF | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (321 aa) |
| | NFA_17910 | Hypothetical protein. (155 aa) |
| | NFA_17920 | Putative acyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (651 aa) |
| | bioA | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (427 aa) |
| | bioF | Putative 8-amino-7-oxononanoate synthase. (384 aa) |
| | bioD | Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (243 aa) |
| | bioB | Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa) |
| | NFA_19030 | Hypothetical protein. (156 aa) |
| | NFA_20030 | Hypothetical protein. (404 aa) |
| | thiI | Putative thiamin biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (410 aa) |
| | NFA_20430 | Hypothetical protein. (132 aa) |
| | NFA_21300 | Hypothetical protein. (370 aa) |
| | NFA_24050 | Putative acyl-CoA synthetase. (543 aa) |
| | cysN2 | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. (612 aa) |
| | cysD2 | Putative sulfate adenylyltransferase subunit 2. (310 aa) |
| | NFA_28650 | Putative acyl-CoA synthetase. (654 aa) |
| | mshC | Putative ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (412 aa) |
| | NFA_31080 | Hypothetical protein. (137 aa) |
| | NFA_31400 | Hypothetical protein. (394 aa) |
| | asd | Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | metH | Putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1198 aa) |
