STRINGSTRING
NFA_10210 NFA_10210 NFA_10220 NFA_10220 NFA_10230 NFA_10230 NFA_10370 NFA_10370 NFA_10740 NFA_10740 fadA4 fadA4 gnd gnd NFA_12770 NFA_12770 NFA_13030 NFA_13030 NFA_13270 NFA_13270 NFA_16040 NFA_16040 aceE aceE NFA_16180 NFA_16180 sucB sucB gcvT gcvT NFA_17130 NFA_17130 metF metF NFA_17920 NFA_17920 ilvA ilvA pykA pykA ppc ppc fadB2 fadB2 fadB3 fadB3 NFA_22240 NFA_22240 echA12 echA12 NFA_23660 NFA_23660 NFA_24050 NFA_24050 NFA_24060 NFA_24060 NFA_24790 NFA_24790 gcvH gcvH gcvP gcvP glcB glcB katB katB NFA_27350 NFA_27350 fadA fadA fadB fadB fumA fumA NFA_32320 NFA_32320 NFA_32330 NFA_32330 NFA_33580 NFA_33580 fadA6 fadA6 folD folD NFA_34660 NFA_34660 NFA_34670 NFA_34670 acn acn acsA acsA NFA_35730 NFA_35730 tal tal zwf zwf pgl pgl tpi tpi pgk pgk gap gap rpe rpe NFA_36600 NFA_36600 NFA_36610 NFA_36610 mdh mdh NFA_37580 NFA_37580 fadB4 fadB4 mqo mqo NFA_41510 NFA_41510 NFA_41910 NFA_41910 serA serA pfkA pfkA serB serB NFA_44640 NFA_44640 NFA_45820 NFA_45820 NFA_47090 NFA_47090 NFA_48000 NFA_48000 fumC fumC glyA glyA fadA10 fadA10 eno eno prsA prsA fadA2 fadA2 sucD sucD sucC sucC pgi pgi NFA_50380 NFA_50380 NFA_51510 NFA_51510 fadA3 fadA3 gpmA gpmA NFA_51900 NFA_51900 NFA_5210 NFA_5210 fadB5 fadB5 aceA aceA NFA_52650 NFA_52650 NFA_53290 NFA_53290 ackA ackA pta pta fba fba NFA_54450 NFA_54450 gnd2 gnd2 fadA11 fadA11 katC katC NFA_56020 NFA_56020 NFA_56030 NFA_56030 serC serC gltA gltA NFA_6610 NFA_6610 NFA_9230 NFA_9230 sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC NFA_9890 NFA_9890 NFA_9940 NFA_9940
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFA_10210Putative branched-chain alpha-keto acid dehydrogenase component. (370 aa)
NFA_10220Putative branched-chain alpha-keto acid dehydrogenase component. (324 aa)
NFA_10230Putative branched-chain alpha-keto acid dehydrogenase component. (510 aa)
NFA_10370Putative methylmalonic acid semialdehyde dehydrogenase. (510 aa)
NFA_10740Hypothetical protein. (162 aa)
fadA4Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
gndPutative 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (480 aa)
NFA_12770Putative dehydrogenase. (365 aa)
NFA_13030Putative amino acid deaminase. (320 aa)
NFA_13270Putative ribose 5-phosphate isomerase. (157 aa)
NFA_16040Putative dehydrogenase. (376 aa)
aceEPutative pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (927 aa)
NFA_16180Putative acyl-CoA carboxylase. (477 aa)
sucBPutative dihydrolipoamide succinyltransferase. (587 aa)
gcvTPutative glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (366 aa)
NFA_17130Putative sugar kinase. (333 aa)
metFPutative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (321 aa)
NFA_17920Putative acyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (651 aa)
ilvAPutative threonine dehydratase. (451 aa)
pykAPutative pyruvate kinase; Belongs to the pyruvate kinase family. (473 aa)
ppcPutative phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (923 aa)
fadB2Putative 3-hydroxyacyl-CoA dehydrogenase. (347 aa)
fadB3Putative 3-hydroxyacyl-CoA dehydrogenase. (293 aa)
NFA_22240Putative alcohol dehydrogenase. (430 aa)
echA12Putative enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
NFA_23660Putative kinase. (171 aa)
NFA_24050Putative acyl-CoA synthetase. (543 aa)
NFA_24060Hypothetical protein. (155 aa)
NFA_24790Putative acyl-CoA oxidase. (643 aa)
gcvHPutative glycine cleavage system protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (132 aa)
gcvPPutative glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (934 aa)
glcBPutative malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (726 aa)
katBPutative catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (719 aa)
NFA_27350Putative phosphoglycerate mutase. (234 aa)
fadAPutative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
fadBPutative 3-hydroxyacyl-CoA dehydrogenase. (716 aa)
fumAPutative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (558 aa)
NFA_32320Putative transketolase. (289 aa)
NFA_32330Putative transketolase. (329 aa)
NFA_33580Hypothetical protein. (163 aa)
fadA6Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
folDPutative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
NFA_34660Putative methylmalonyl-CoA mutase alpha subunit. (760 aa)
NFA_34670Putative methylmalonyl-CoA mutase beta subunit. (621 aa)
acnPutative aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (933 aa)
acsAPutative acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
NFA_35730Putative transketolase; Belongs to the transketolase family. (713 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (380 aa)
zwfPutative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (522 aa)
pglPutative glucosamine-6-phosphate isomerase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (262 aa)
tpiPutative triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkPutative phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (410 aa)
gapPutative glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa)
rpePutative ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
NFA_36600Putative 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (662 aa)
NFA_36610Putative 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (359 aa)
mdhPutative malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (334 aa)
NFA_37580Putative polyphosphate glucokinase. (252 aa)
fadB4Putative 3-hydroxyacyl-CoA dehydrogenase. (301 aa)
mqoPutative oxidoreductase. (496 aa)
NFA_41510Putative acyl-CoA synthetase. (549 aa)
NFA_41910Putative pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1133 aa)
serAPutative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (532 aa)
pfkAPutative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (344 aa)
serBPutative phosphoserine phosphatase. (411 aa)
NFA_44640Putative amino acid deaminase. (311 aa)
NFA_45820Hypothetical protein. (63 aa)
NFA_47090Putative malate dehydrogenase. (398 aa)
NFA_48000Putative fructose-1,6-bisphosphatase. (347 aa)
fumCPutative fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
glyAPutative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
fadA10Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
prsAPutative phosphoribosyl pyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
fadA2Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
sucDPutative succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (304 aa)
sucCPutative succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
pgiPutative glucose-6-phosphate isomerase. (551 aa)
NFA_50380Putative acetyl-CoA carboxylase alpha subunit. (694 aa)
NFA_51510Hypothetical protein. (361 aa)
fadA3Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
gpmAPutative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (245 aa)
NFA_51900Putative sugar kinase. (297 aa)
NFA_5210Putative lipid-transfer protein. (390 aa)
fadB5Putative 3-hydroxyacyl-CoA dehydrogenase. (289 aa)
aceAPutative isocitrate lyase. (429 aa)
NFA_52650Putative dihydrolipoamide dehydrogenase. (467 aa)
NFA_53290Putative acetyl/propionyl-CoA carboxylase alpha subunit. (670 aa)
ackAPutative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
ptaPutative phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (695 aa)
fbaPutative fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
NFA_54450Hypothetical protein. (509 aa)
gnd2Putative 6-phosphogluconate dehydrogenase. (342 aa)
fadA11Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (440 aa)
katCPutative catalase. (553 aa)
NFA_56020Putative succinate dehydrogenase flavoprotein subunit. (646 aa)
NFA_56030Putative succinate dehydrogenase iron-sulfur subunit. (248 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (376 aa)
gltAPutative citrate synthase; Belongs to the citrate synthase family. (433 aa)
NFA_6610Putative citrate synthase; Belongs to the citrate synthase family. (382 aa)
NFA_9230Putative isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
sdhBPutative succinate dehydrogenase iron-sulfur subunit. (257 aa)
sdhAPutative succinate dehydrogenase flavoprotein subunit. (599 aa)
sdhDPutative succinate dehydrogenase membrane subunit. (143 aa)
sdhCPutative succinate dehydrogenase cytochrome b subunit. (132 aa)
NFA_9890Putative acyl-CoA carboxylase alpha subunit. (598 aa)
NFA_9940Putative acyl-CoA carboxylase beta subunit. (546 aa)
Your Current Organism:
Nocardia farcinica
NCBI taxonomy Id: 247156
Other names: N. farcinica IFM 10152, Nocardia farcinica IFM 10152, Nocardia farcinica str. IFM 10152, Nocardia farcinica strain IFM 10152
Server load: low (22%) [HD]