STRINGSTRING
ilvE ilvE Chro_1292 Chro_1292 acpS acpS Chro_1887 Chro_1887 Chro_1898 Chro_1898 Chro_2326 Chro_2326 coaX coaX panD panD coaE coaE Chro_2985 Chro_2985 Chro_3077 Chro_3077 Chro_3651 Chro_3651 acpS-2 acpS-2 ilvD ilvD coaD coaD Chro_4779 Chro_4779 ilvC ilvC panB panB Chro_5499 Chro_5499 panC/cmk panC/cmk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa)
Chro_1292PFAM: Protein of unknown function, DUF479; COGs: COG3124 conserved hypothetical protein; InterPro IPR007431; KEGG: cyc:PCC7424_1921 protein of unknown function DUF479; PFAM: protein of unknown function DUF479; SPTR: Putative uncharacterized protein. (205 aa)
acpSHolo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (129 aa)
Chro_1887PFAM: 4'-phosphopantetheinyl transferase superfamily; TIGRFAM: phosphopantetheine--protein transferase domain; COGs: COG2091 Phosphopantetheinyl transferase; InterPro IPR004568:IPR008278; KEGG: npu:Npun_R2089 4'-phosphopantetheinyl transferase; PFAM: 4'-phosphopantetheinyl transferase; SPTR: 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (269 aa)
Chro_1898Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: ava:Ava_3533 acetolactate synthase; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase. (547 aa)
Chro_2326PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: ava:Ava_2035 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (174 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (268 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
Chro_2985Phosphopantothenoylcysteine decarboxylase, Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa)
Chro_3077Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (322 aa)
Chro_3651PFAM: 4'-phosphopantetheinyl transferase superfamily; TIGRFAM: phosphopantetheine--protein transferase domain; holo-[acyl-carrier-protein] synthase; COGs: COG0736 Phosphopantetheinyl transferase (holo-ACP synthase); InterPro IPR004568:IPR008278; KEGG: amr:AM1_A0245 holo-acyl-carrier-protein synthase; PFAM: 4'-phosphopantetheinyl transferase; SPTR: Holo-acyl-carrier-protein synthase; Belongs to the P-Pant transferase superfamily. (137 aa)
acpS-2Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (139 aa)
ilvDPFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404:IPR002114:IPR020558:IPR000581; KEGG: cyc:PCC7424_2821 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (561 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (162 aa)
Chro_4779Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR012001:IPR012000:IPR011766:IPR000399:IPR 012846; KEGG: npu:Npun_R1735 acetolactate synthase 3 catalytic subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: [...] (632 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (258 aa)
Chro_5499PFAM: Aldehyde dehydrogenase family; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160:IPR012394:IPR015590; KEGG: npu:Npun_F0840 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (455 aa)
panC/cmkPantothenate synthetase, cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. (560 aa)
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
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