(33 nodes) Terpenoid backbone biosynthesis network (Verruconis gallopava)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	PV09_04537	Uncharacterized protein. (473 aa)
	PV09_03398	Uncharacterized protein. (759 aa)
	PV09_07145	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (462 aa)
	PV09_06454	Uncharacterized protein. (635 aa)
	PV09_06184	Uncharacterized protein. (415 aa)
	PV09_06311	Prenylcys_lyase domain-containing protein. (373 aa)
	PV09_05594	DUF2236 domain-containing protein. (304 aa)
	PV09_05016	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (496 aa)
	PV09_04272	AB hydrolase-1 domain-containing protein. (552 aa)
	PV09_03493	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (448 aa)
	PV09_01467	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (434 aa)
	PV09_01350	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (230 aa)
	PV09_09217	DUF2236 domain-containing protein. (337 aa)
	PV09_09142	Uncharacterized protein. (311 aa)
	PV09_08890	DUF2236 domain-containing protein. (316 aa)
	PV09_07968	Isopentenyl-diphosphate delta-isomerase. (268 aa)
	PV09_06900	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (533 aa)
	PV09_06545	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (346 aa)
	PV09_06197	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (493 aa)
	PV09_06210	Peptidase_M48 domain-containing protein. (346 aa)
	PV09_06249	Di-trans,poly-cis-decaprenylcistransferase. (432 aa)
	PV09_04735	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	PV09_04783	Uncharacterized protein. (369 aa)
	PV09_03886	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (390 aa)
	PV09_02639	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (465 aa)
	PV09_08448	Uncharacterized protein. (340 aa)
	PV09_07612	Prenylcys_lyase domain-containing protein. (534 aa)
	PV09_01333	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (458 aa)
	PV09_00399	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1167 aa)
	PV09_00363	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1004 aa)
	PV09_06327	Uncharacterized protein. (407 aa)
	PV09_03559	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (842 aa)
	PV09_01940	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (345 aa)

Your Current Organism:

Verruconis gallopava

NCBI taxonomy Id: 253628
Other names: ATCC 16027, CBS 437.64, CDC 45-492-62, Dactylaria gallopava, MUCL 6683, Ochroconis gallopava, Scolecobasidium gallopavum, V. gallopava, Verruconis gallopava (W.B. Cooke) Samerpitak & de Hoog, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV09_00363	PV09_07145	A0A0D2ASM4	A0A0D1YKI1	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.519
PV09_00399	PV09_01333	A0A0D2AS70	A0A0D2APF6	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.993
PV09_00399	PV09_01940	A0A0D2AS70	A0A0D2B757	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.709
PV09_00399	PV09_02639	A0A0D2AS70	A0A0D2AK95	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.669
PV09_00399	PV09_03493	A0A0D2AS70	A0A0D1YY61	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.639
PV09_00399	PV09_03886	A0A0D2AS70	A0A0D2AFU4	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.920
PV09_00399	PV09_04735	A0A0D2AS70	A0A0D2ABE8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.551
PV09_00399	PV09_05016	A0A0D2AS70	A0A0D1YST8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.695
PV09_00399	PV09_06197	A0A0D2AS70	A0A0D2A708	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.515
PV09_00399	PV09_06900	A0A0D2AS70	A0A0D2A4L0	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.925
PV09_00399	PV09_07968	A0A0D2AS70	A0A0D2A288	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Isopentenyl-diphosphate delta-isomerase.	0.775
PV09_01333	PV09_00399	A0A0D2APF6	A0A0D2AS70	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.993
PV09_01333	PV09_01467	A0A0D2APF6	A0A0D1Z3K0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.978
PV09_01333	PV09_01940	A0A0D2APF6	A0A0D2B757	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.819
PV09_01333	PV09_02639	A0A0D2APF6	A0A0D2AK95	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.565
PV09_01333	PV09_03398	A0A0D2APF6	A0A0D1XS48	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.969
PV09_01333	PV09_03493	A0A0D2APF6	A0A0D1YY61	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.634
PV09_01333	PV09_03886	A0A0D2APF6	A0A0D2AFU4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.896
PV09_01333	PV09_04272	A0A0D2APF6	A0A0D1YV60	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	AB hydrolase-1 domain-containing protein.	0.622
PV09_01333	PV09_04735	A0A0D2APF6	A0A0D2ABE8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.985

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