(77 nodes) Propanoate metabolism network (Penicillium flavigenum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1V6TWI6	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
	A0A1V6TVR0	Uncharacterized protein. (352 aa)
	A0A1V6TSI9	Uncharacterized protein. (673 aa)
	A0A1V6TSB5	Uncharacterized protein. (489 aa)
	A0A1V6TS01	Uncharacterized protein. (1146 aa)
	A0A1V6TRQ9	Transket_pyr domain-containing protein. (386 aa)
	A0A1V6TQ58	Uncharacterized protein. (272 aa)
	A0A1V6TQ32	Uncharacterized protein. (469 aa)
	A0A1V6TP94	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (293 aa)
	A0A1V6TLY9	Uncharacterized protein. (238 aa)
	A0A1V6TK21	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa)
	A0A1V6TJD8	Uncharacterized protein. (326 aa)
	A0A1V6TIU6	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (329 aa)
	A0A1V6TIU5	PKS_ER domain-containing protein. (447 aa)
	A0A1V6TI39	Epimerase domain-containing protein. (328 aa)
	A0A1V6TI00	Epimerase domain-containing protein. (331 aa)
	A0A1V6THZ5	Uncharacterized protein. (273 aa)
	A0A1V6TH90	Epimerase domain-containing protein. (346 aa)
	A0A1V6TGZ1	Uncharacterized protein. (199 aa)
	A0A1V6TGS3	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (498 aa)
	A0A1V6TF28	Aldedh domain-containing protein. (88 aa)
	A0A1V6TDQ7	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (695 aa)
	A0A1V6TCE7	AB hydrolase-1 domain-containing protein. (553 aa)
	A0A1V6TBJ8	Uncharacterized protein. (428 aa)
	A0A1V6TBA1	Uncharacterized protein. (372 aa)
	A0A1V6TB76	Uncharacterized protein. (350 aa)
	A0A1V6TAB9	Uncharacterized protein. (334 aa)
	A0A1V6TA77	Uncharacterized protein. (345 aa)
	A0A1V6T968	3Beta_HSD domain-containing protein. (347 aa)
	A0A1V6T8Y2	Uncharacterized protein. (360 aa)
	A0A1V6T875	Uncharacterized protein. (426 aa)
	A0A1V6TR27	Epimerase domain-containing protein. (334 aa)
	A0A1V6S5I0	Uncharacterized protein. (395 aa)
	A0A1V6SA14	Uncharacterized protein. (833 aa)
	A0A1V6SDI2	Uncharacterized protein. (354 aa)
	A0A1V6SFS3	Epimerase domain-containing protein. (352 aa)
	A0A1V6SGG6	Uncharacterized protein. (568 aa)
	A0A1V6SH58	Epimerase domain-containing protein. (334 aa)
	A0A1V6SHK3	Uncharacterized protein. (1506 aa)
	A0A1V6SIF6	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (280 aa)
	A0A1V6SIQ8	Uncharacterized protein. (172 aa)
	A0A1V6SJV8	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (456 aa)
	A0A1V6SKF7	Uncharacterized protein. (405 aa)
	A0A1V6SMB1	Aldedh domain-containing protein. (522 aa)
	A0A1V6SN71	Epimerase domain-containing protein. (341 aa)
	A0A1V6SPN5	Probable acetate kinase. (431 aa)
	A0A1V6SQ10	Aldedh domain-containing protein. (589 aa)
	A0A1V6SQC3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (678 aa)
	A0A1V6SRC5	Uncharacterized protein. (548 aa)
	A0A1V6SS28	Uncharacterized protein. (491 aa)
	A0A1V6SS75	Epimerase domain-containing protein. (347 aa)
	A0A1V6SSN2	Uncharacterized protein. (312 aa)
	A0A1V6SSS7	SET domain-containing protein. (428 aa)
	A0A1V6STQ6	Uncharacterized protein. (305 aa)
	A0A1V6STW0	MaoC-like domain-containing protein. (901 aa)
	A0A1V6SU87	Uncharacterized protein. (2009 aa)
	A0A1V6SUI5	Uncharacterized protein. (234 aa)
	A0A1V6SUU0	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	A0A1V6SVP3	Uncharacterized protein. (719 aa)
	A0A1V6SW12	CoA_binding domain-containing protein. (676 aa)
	A0A1V6SWE4	Uncharacterized protein. (536 aa)
	A0A1V6SYH4	Dihydrolipoyl dehydrogenase. (512 aa)
	A0A1V6SZV5	Aldedh domain-containing protein. (527 aa)
	A0A1V6T0A7	Uncharacterized protein. (2273 aa)
	A0A1V6T0T9	Uncharacterized protein. (148 aa)
	A0A1V6T192	Uncharacterized protein. (323 aa)
	A0A1V6T328	Uncharacterized protein. (679 aa)
	A0A1V6T422	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (476 aa)
	A0A1V6T4D1	Acetyl-coenzyme A synthetase. (669 aa)
	A0A1V6T4E5	Uncharacterized protein. (576 aa)
	A0A1V6T4V7	ATP-grasp domain-containing protein. (416 aa)
	A0A1V6T503	Uncharacterized protein. (1466 aa)
	A0A1V6T5D2	Uncharacterized protein. (583 aa)
	A0A1V6T786	Pyr_redox_2 domain-containing protein. (327 aa)
	A0A1V6U2W9	PKS_ER domain-containing protein. (357 aa)
	A0A1V6U2C2	Uncharacterized protein. (385 aa)
	A0A1V6TWV4	Uncharacterized protein. (305 aa)

Your Current Organism:

Penicillium flavigenum

NCBI taxonomy Id: 254877
Other names: CBS 419.89, IBT 21526, IBT 3091, IBT V1035, IMI 293207, P. flavigenum

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1V6SDI2	A0A1V6SJV8	Uncharacterized protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.481
A0A1V6SDI2	A0A1V6U2W9	Uncharacterized protein.	PKS_ER domain-containing protein.	0.601
A0A1V6SGG6	A0A1V6SIF6	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.747
A0A1V6SGG6	A0A1V6SIQ8	Uncharacterized protein.	Uncharacterized protein.	0.590
A0A1V6SGG6	A0A1V6SJV8	Uncharacterized protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.631
A0A1V6SGG6	A0A1V6SMB1	Uncharacterized protein.	Aldedh domain-containing protein.	0.578
A0A1V6SGG6	A0A1V6SQ10	Uncharacterized protein.	Aldedh domain-containing protein.	0.578
A0A1V6SGG6	A0A1V6SQC3	Uncharacterized protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.590
A0A1V6SGG6	A0A1V6SS28	Uncharacterized protein.	Uncharacterized protein.	0.612
A0A1V6SGG6	A0A1V6SSN2	Uncharacterized protein.	Uncharacterized protein.	0.747
A0A1V6SGG6	A0A1V6STW0	Uncharacterized protein.	MaoC-like domain-containing protein.	0.800
A0A1V6SGG6	A0A1V6SUU0	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.753
A0A1V6SGG6	A0A1V6SVP3	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A1V6SGG6	A0A1V6SW12	Uncharacterized protein.	CoA_binding domain-containing protein.	0.549
A0A1V6SGG6	A0A1V6SYH4	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.447
A0A1V6SGG6	A0A1V6SZV5	Uncharacterized protein.	Aldedh domain-containing protein.	0.578
A0A1V6SGG6	A0A1V6T0A7	Uncharacterized protein.	Uncharacterized protein.	0.627
A0A1V6SGG6	A0A1V6T422	Uncharacterized protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.684
A0A1V6SGG6	A0A1V6T4D1	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.655
A0A1V6SGG6	A0A1V6T503	Uncharacterized protein.	Uncharacterized protein.	0.557