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| | sphB1 | Previously sequenced as Bordetella pertussis autotransporter subtilisin-like protease SphB1 TR:CAC44081 (EMBL:AJ318229) (1039 aa) fasta scores: E(): 0, 100.000% id in 932 aa, and dimilar to Xylella fastidiosa serine protease Xf1026 TR:Q9PEK2 (EMBL:AE003939) (905 aa) fasta scores: E(): 1.1e-45, 31.919% id in 943 aa. (932 aa) |
| | BP0499 | Hypothetical protein; No significant database matches. (132 aa) |
| | BP0500 | Hypothetical protein; No significant database matches. (656 aa) |
| | BP0535 | Probable carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (111 aa) |
| | BP0704 | N-terminal region of TonB dependent receptor protein (Pseudogene); Inverted repeat for IS481 element. (316 aa) |
| | cyaC | Cyclolysin-activating lysine-acyltransferase; Involved in fatty acylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP; Belongs to the RTX toxin acyltransferase family. (185 aa) |
| | cyaA | Bifunctional hemolysin-adenylate cyclase precursor; This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function; In the C-terminal section; belongs to the RTX prokaryotic toxin family. (1706 aa) |
| | cyaB | Cyclolysin secretion ATP-binding protein; Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family. (712 aa) |
| | cyaD | Cyclolysin secretion protein; CyaD is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (440 aa) |
| | cyaE | Cyclolysin secretion protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (474 aa) |
| | BP0825 | Similar to Vibrio cholerae hypothetical protein Vc2666 TR:Q9KNR5 (EMBL:AE004332) (205 aa) fasta scores: E(): 2.1e-30, 43.781% id in 201 aa, and to Bacillus halodurans Bh3429 protein Bh3429 TR:Q9K7D5 (EMBL:AP001518) (215 aa) fasta scores: E(): 3.8e-14, 31.818% id in 198 aa. (223 aa) |
| | BP0826 | Outer membrane component of multidrug efflux system; Similar to Pseudomonas aeruginosa mexE, mexF & oprN genes OprN TR:P95423 (EMBL:X99514) (472 aa) fasta scores: E(): 5e-47, 39.703% id in 471 aa, and to Xanthomonas maltophilia (Pseudomonas maltophilia) (Stenotrophomonas SmeC TR:Q9RBY7 (EMBL:AF173226) (471 aa) fasta scores: E(): 1.1e-31, 33.612% id in 479 aa. (497 aa) |
| | BP0827 | Integral membrane component of multidrug efflux system; Similar to Pseudomonas aeruginosa probable Rnd efflux transporter Pa4207 TR:Q9HWH4 (EMBL:AE004837) (1029 aa) fasta scores: E(): 0, 69.697% id in 1023 aa, and to Vibrio cholerae multidrug resistance protein, putative Vc0164 TR:Q9KVI2 (EMBL:AE004106) (1036 aa) fasta scores: E(): 3.4e-183, 48.309% id in 1035 aa; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1037 aa) |
| | BP0828 | Probable HlyD-family secretion protein; Similar to Pseudomonas aeruginosa probable Rnd efflux membrane fusion protein precursor Pa4206 TR:Q9HWH5 (EMBL:AE004837) (370 aa) fasta scores: E(): 4.6e-48, 48.011% id in 352 aa, and to Vibrio cholerae hypothetical protein Vc0165 TR:Q9KVI1 (EMBL:AE004106) (368 aa) fasta scores: E(): 1.7e-30, 36.593% id in 317 aa. (368 aa) |
| | BP0829 | Putative transcriptional regulator; Similar to Streptomyces lipmanii StgU TR:O88133 (EMBL:AJ006517) (210 aa) fasta scores: E(): 7.2e-21, 41.743% id in 218 aa, and to Streptomyces coelicolor hypothetical 23.3 kDa protein Sc2h4.05 TR:O86588 (EMBL:AL031514) (216 aa) fasta scores: E(): 1.1e-19, 39.524% id in 210 aa. (222 aa) |
| | BP0830 | Transposase for IS481 element. (316 aa) |
| | betT-2 | Similar to Escherichia coli high-affinity choline transport protein BetT or B0314 or Z0401 or Ecs0360 SW:BETT_ECOLI (P17447) (677 aa) fasta scores: E(): 2.1e-92, 42.249% id in 658 aa, and to Pseudomonas aeruginosa probable choline transporter Pa5291 TR:Q9HTR3 (EMBL:AE004941) (661 aa) fasta scores: E(): 2.5e-188, 74.732% id in 653 aa. Also similar to BP0804, 37.348% identity (38.522% ungapped) in 656 aa overlap; Belongs to the BCCT transporter (TC 2.A.15) family. (652 aa) |
| | bfrD | Probable TonB-dependent receptor for iron transport; Probably involved in iron transport; Belongs to the TonB-dependent receptor family. (743 aa) |
| | acrB | Acriflavine resistance protein a precursor (Pseudogene); Large deletion in pertussis relative to parapertussis and bronchiseptica following this codon. (1059 aa) |
| | cusC | Similar to Escherichia coli probable outer membrane lipoprotein CusC precursor CusC or IbeB or B0572 SW:CUSC_ECOLI (P77211) (457 aa) fasta scores: E(): 4.9e-38, 39.655% id in 464 aa, and to Pseudomonas aeruginosa outer membrane protein OprM precursor OprM or OprK or Pa0427 SW:OPRM_PSEAE (Q51487) (485 aa) fasta scores: E(): 5.3e-67, 55.717% id in 481 aa. (460 aa) |
| | prn | Pertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. (910 aa) |
| | bipA | Similar to Bordetella bronchiseptica putative outer membrane ligand binding protein BipA TR:Q9APE8 (EMBL:AF304006) (1578 aa) fasta scores: E(): 0, 79.75% id in 1576 aa, and to Escherichia coli O157:H7 EDL933 putative adhesin EaeH TR:AAG54632 (EMBL:AE005207) (1417 aa) fasta scores: E(): 1.6e-17, 23.88% id in 1390 aa. Also similar to BP3204, 41.856% identity (43.284% ungapped) in 970 aa overlap. (1308 aa) |
| | fim2 | Serotype 2 fimbrial subunit precursor; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (210 aa) |
| | BP1188 | Hypothetical protein; Similar to the internal region of Bordetella bronchiseptica adhesin FhaB TR:Q9JP78 (EMBL:AF111796) (3634 aa) fasta scores: E(): 0.8, 28.31% id in 226 aa. (294 aa) |
| | BP1188A | Hypothetical protein; Similar to Homo sapiens MHC class III region complement C4A TR:Q30211 (EMBL:S58715) (79 aa) fasta scores: E(): 4.1, 32.87% id in 73 aa. (72 aa) |
| | bapB | Autotransporter (pseudogene); Inverted repeat for IS481 element. (316 aa) |
| | tcfA | Tracheal colonization factor precursor; Identical to the previously sequenced Bordetella pertussis tracheal colonization factor precursor Tcfa2 TR:O86135 (EMBL:AJ009785) (647 aa) fasta scores: E(): 1.7e-171, 99.84% id in 647 aa. (647 aa) |
| | BP1202 | Similar to Rhizobium loti transcriptional regulator Mll3386 TR:Q98GC7 (EMBL:AP003001) (219 aa) fasta scores: E(): 2.1e-34, 50.73% id in 205 aa, and to Mycobacterium tuberculosis CDC1551 transcriptional regulator, TetR family Mt3262 TR:AAK47601 (EMBL:AE007140) (200 aa) fasta scores: E(): 4.3e-05, 30.23% id in 172 aa. (231 aa) |
| | BP1203 | Conserved hypothetical protein; Similar to Rhizobium loti Mll9388 protein Mll9388 TR:Q981G1 (EMBL:AP003016) (408 aa) fasta scores: E(): 5.5e-89, 63.03% id in 395 aa, and to Rhizobium sp hypothetical protein Y4ou precursor Y4ou SW:Y4OU_RHISN (P55606) (402 aa) fasta scores: E(): 7.6e-88, 62.02% id in 395 aa; Belongs to the UPF0261 family. (402 aa) |
| | BP1204 | Similar to Rhizobium meliloti conserved hypothetical protein Sma1332 TR:AAK65386 (EMBL:AE007260) (280 aa) fasta scores: E(): 9.4e-70, 69.09% id in 275 aa, and to Rhizobium loti Mll9387 protein Mll9387 TR:Q981G2 (EMBL:AP003016) (285 aa) fasta scores: E(): 1.1e-69, 69.34% id in 274 aa. (276 aa) |
| | BP1205 | Conserved hypothetical protein; Similar to Rhizobium loti Mlr1698 protein Mlr1698 TR:Q98K03 (EMBL:AP002998) (147 aa) fasta scores: E(): 5.6e-16, 38.29% id in 141 aa, and to Mycobacterium tuberculosis hypothetical 16.8 kDa protein Rv1919c or Mtv050.03C TR:O53961 (EMBL:AL022020) (154 aa) fasta scores: E(): 0.046, 29.41% id in 136 aa. (150 aa) |
| | BP1251 | Putative toxin; Similar to the previously sequenced Bordetella pertussis pertussis toxin subunit 2 precursor PtxB SW:TOX2_BORPE (P04978) (226 aa) fasta scores: E(): 1.6e-06, 30.43% id in 207 aa, and to Bordetella pertussis pertussis toxin subunit 3 precursor PtxC SW:TOX3_BORPE (P04979) (227 aa) fasta scores: E(): 1.8e-06, 32.67% id in 202 aa. (241 aa) |
| | BP1252 | Putative exported protein; No significant database matches. (134 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase (Pseudogene); Pseudogene. This CDS is disrupted by the insertion of IS481 element. Similar to The C-terminal regions of Alcaligenes eutrophus oxygen-independent coproporphyrinogen III oxidase HemN SW:HEMN_ALCEU (O34162) (491 aa) fasta scores: E(): 8.1e-12, 47.27% id in 110 aa, and to Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN or B3867 SW:HEMN_ECOLI (P32131) (457 aa) fasta scores: E(): 5.2e-06, 35.35% id in 99 aa. (130 aa) |
| | BP1496 | Probable two-component response regulator; Similar to Escherichia coli capsular synthesis regulator component B RcsB or B2217 or Z3476 or Ecs3106 SW:RCSB_ECOLI (P14374) (216 aa) fasta scores: E(): 1.7e-12, 30.73% id in 205 aa, and to Pseudomonas aeruginosa probable two-component response regulator Pa3714 TR:Q9HXS7 (EMBL:AE004790) (213 aa) fasta scores: E(): 6.9e-16, 32.38% id in 210 aa. (219 aa) |
| | fim3 | Serotype 3 fimbrial subunit precursor; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (204 aa) |
| | fhaB | Filamentous hemagglutinin/adhesin; Evidence for a role in host-cell binding and infection. (3590 aa) |
| | fimB | Fimbrial protein (pseudogene); Required for the biogenesis of the filamentous hemagglutinin and the fimbria; Belongs to the periplasmic pilus chaperone family. (244 aa) |
| | fimC | Outer membrane usher protein precursor; Probable porin-like protein necessary for the assembly of a pilin-type protein; Belongs to the fimbrial export usher family. (873 aa) |
| | fimD | Fimbrial adhesin; Previously sequenced as Bordetella pertussis protein FhaE precursor FhaE or FimD SW:FHAE_BORPE (Q00879) (376 aa) fasta scores: E(): 1.9e-143, 100% id in 365 aa. (365 aa) |
| | fhaC | Hemolysin activator-like protein; Member of a two partner secretion pathway (TPS) in which it mediates the secretion of filamentous hemagglutinin FHA (fhaB). Belongs to the TPS (TC 1.B.20) family. (584 aa) |
| | BP2075 | Putative efflux system inner membrane protein; Similar to e.g. Escherichia coli acriflavine resistance protein E precursor acrE or envC or b3265 SW:ACRE_ECOLI (P24180) (385 aa) fasta scores: E(): 1.4e-43, 47.684% id in 367 aa and Neisseria gonorrhoeae membrane fusion protein MtrC precursor mtrC SW:MTRC_NEIGO (P43505) (412 aa) fasta scores: E(): 2.5e-37, 41.304% id in 414 aa. Probably attached to inner membrane; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (448 aa) |
| | BP2076 | Putative efflux system transmembrane protein; Similar to e.g. Escherichia coli acriflavine resistance protein B acrB or acrE or b0462 SW:ACRB_ECOLI (P31224) (1049 aa) fasta scores: E(): 3.1e-201, 52.073% id in 1037 aa and Neisseria gonorrhoeae rnd protein MtrD mtrD TR:Q51073 (EMBL:U60099) (1067 aa) fasta scores: E(): 3e-174, 51.873% id in 1068 aa. (1076 aa) |
| | BP2141 | Putative exported protein; Unknown function. (152 aa) |
| | BP2147 | Putative exported protein; Similar to e.g. Neisseria meningitidis hypothetical protein NMB0783 TR:Q9K039 (EMBL:AE002432) (159 aa) fasta scores: E(): 5.5e-15, 44.65% id in 159 aa and Haemophilus ducreyi hypothetical protein TR:Q9L7U8 (EMBL:AF219260) (149 aa) fasta scores: E(): 4.2e-11, 39.66% id in 121 aa. (159 aa) |
| | BP2183 | Conserved hypothetical protein (Pseudogene); Region of unusual DNA content. (99 aa) |
| | BP2226 | Similar to Bacillus subtilis anti-sigma F factor antagonist spoIIAa SW:SP21_BACSU (P10727) (116 aa) fasta scores: E(): 1.1e-06, 30.84% id in 107 aa; Belongs to the anti-sigma-factor antagonist family. (116 aa) |
| | BP2227 | Putative anti-sigma factor; Similar to Chlamydia muridarum RsbW protein, putative tc0837 TR:Q9PJJ2 (EMBL:AE002350) (152 aa) fasta scores: E(): 6.3e-05, 28.57% id in 126 aa, and to Bacillus subtilis anti-sigma b factor RsbW SW:RSBW_BACSU (P17904) (160 aa) fasta scores: E(): 0.16, 23.88% id in 134 aa. (142 aa) |
| | BP2229 | Putative inner membrane transport protein; Similar to Pseudomonas aeruginosa probable MFS transporter pa4096 TR:Q9HWT2 (EMBL:AE004826) (419 aa) fasta scores: E(): 1.1e-10, 28.57% id in 406 aa, and to Streptomyces coelicolor putative integral membrane transport protein SCI30a.30c TR:Q9S243 (EMBL:AL096811) (463 aa) fasta scores: E(): 1.6e-09, 27.27% id in 396 aa. (828 aa) |
| | BP2230 | Putative regulator; Similar to Chlamydia trachomatis sigma regulatory family protein-pp2c phosphatase rbsu or ct588 TR:O84592 (EMBL:AE001329) (650 aa) fasta scores: E(): 5e-19, 27.88% id in 373 aa, and to Bacillus subtilis sigma factor sigb regulation protein RsbU rsbU SW:RSBU_BACSU (P40399) (335 aa) fasta scores: E(): 1.1e-13, 26.51% id in 264 aa. (673 aa) |
| | BP2231 | Putative exported protein; No significant database matches. (395 aa) |
| | BP2232 | Hypothetical protein; No significant database matches. (435 aa) |
| | BP2233 | Hypothetical protein; No significant database matches. (232 aa) |
| | brpL | Similar to Erwinia amylovora putative RNA polymerase sigma factor HrpL SWALL:Q46616 (EMBL:U36244) (182 aa) fasta scores: E(): 5.7e-14, 37.41% id in 155 aa, and to Escherichia coli RNA polymerase sigma-E factor RpoE or SigE or B2573 or Z3855 or Ecs3439 SWALL:RPOE_ECOLI (SWALL:P34086) (191 aa) fasta scores: E(): 7.9e-14, 36.09% id in 169 aa; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa) |
| | bscC | Similar to Pseudomonas aeruginosa type II secretion protein PscC or Pa1716 SWALL:Q9I319 (EMBL:AE004598) (600 aa) fasta scores: E(): 1.6e-28, 36.15% id in 531 aa, and to Yersinia enterocolitica YscC SWALL:AAK69235 (EMBL:AF336309) (607 aa) fasta scores: E(): 4e-19, 36.21% id in 533 aa. (600 aa) |
| | bscW | Hypothetical protein; No significant database matches. (132 aa) |
| | bscU | Putative type III secretion protein; Similar to many eg. Pseudomonas aeruginosa translocation protein in type III secretion PscU or Pa1690 TR:Q9I337 (EMBL:AE004596) (349 aa) fasta scores: E(): 1.3e-46, 41.88% id in 339 aa, and to Yersinia enterocolitica YscU TR:Q56844 (EMBL:AF102990) (354 aa) fasta scores: E(): 4.7e-45, 38.96% id in 349 aa. (349 aa) |
| | bscT | Similar to Pseudomonas aeruginosa translocation protein in type III secretion PscT or pa1691 TR:Q9I336 (EMBL:AE004596) (262 aa) fasta scores: E(): 3.1e-29, 38.84% id in 242 aa, and to Yersinia pestis Yop proteins translocation protein TR:AAC62558 (EMBL:AF074612) (261 aa) fasta scores: E(): 4.8e-29, 35.45% id in 251 aa. (266 aa) |
| | bscS | Putative type III secretion protein; Similar to Bordetella bronchiseptica BscS TR:Q9L9D8 (EMBL:AF172245) (88 aa) fasta scores: E(): 3.9e-30, 97.72% id in 88 aa, and to Yersinia pestis Yop translocation protein S SW:YSCS_YERPE (P40298) (79 aa) fasta scores: E(): 3e-13, 56.57% id in 76 aa. (88 aa) |
| | bscR | Putative type III secretion protein; Similar to Bordetella bronchiseptica BscR TR:Q9L9D9 (EMBL:AF172245) (223 aa) fasta scores: E(): 1.1e-79, 99.1% id in 223 aa, and to Yersinia pestis Yop translocation protein R TR:AAC69787 (EMBL:AF020214) (217 aa) fasta scores: E(): 2.5e-40, 54.58% id in 218 aa. Also similar to BP1391, 40.625% identity (44.175% ungapped) in 224 aa overlap. (223 aa) |
| | bscQ | Putative type III secretion protein; Similar to Bordetella bronchiseptica BscQ TR:Q9L9E0 (EMBL:AF172245) (123 aa) fasta scores: E(): 3.4e-34, 98.9% id in 91 aa, and to Yersinia pestis Yop translocation protein Q SW:YSCQ_YERPE (P42713) (307 aa) fasta scores: E(): 7e-07, 46.37% id in 69 aa. (359 aa) |
| | bscP | Hypothetical protein; No significant database matches. (182 aa) |
| | bscO | Putative type III secretion protein; Similar to many eg. Bordetella bronchiseptica BscO TR:O68540 (EMBL:AF049488) (143 aa) fasta scores: E(): 3.3e-46, 97.88% id in 142 aa, and to Pseudomonas aeruginosa translocation protein in type III secretion PscO or pa1696 TR:Q9I331 (EMBL:AE004596) (158 aa) fasta scores: E(): 4.5e-05, 30.61% id in 147 aa. (169 aa) |
| | bscN | Putative ATP synthase in type III secretion system; Similar to many eg. Bordetella bronchiseptica BscN TR:O68539 (EMBL:AF049488) (444 aa) fasta scores: E(): 2.6e-162, 99.32% id in 444 aa, and to Pseudomonas aeruginosa ATP synthase in type III secretion system pa1697 TR:Q9I330 (EMBL:AE004596) (440 aa) fasta scores: E(): 1.8e-103, 68.19% id in 415 aa. (444 aa) |
| | bscL | Putative type III secretion protein; Similar to many eg. Bordetella bronchiseptica BscL TR:O68538 (EMBL:AF049488) (212 aa) fasta scores: E(): 8e-72, 98.58% id in 212 aa, and to Pseudomonas aeruginosa type III export protein PscL or pa1725 TR:Q9I312 (EMBL:AE004598) (214 aa) fasta scores: E(): 2.6e-23, 42.56% id in 195 aa. (212 aa) |
| | bscK | Conserved hypothetical protein; Similar to Bordetella bronchiseptica BscK TR:O68537 (EMBL:AF049488) (220 aa) fasta scores: E(): 9.4e-87, 98.18% id in 220 aa. (220 aa) |
| | bscJ | Putative type III secretion protein; Similar to many eg. Bordetella bronchiseptica BscJ TR:O68536 (EMBL:AF049488) (274 aa) fasta scores: E(): 4.5e-97, 98.17% id in 274 aa, and to Erwinia amylovora harpin secretion HrcJ precursor TR:Q46620 (EMBL:U56662) (260 aa) fasta scores: E(): 2.7e-29, 44.89% id in 245 aa. (274 aa) |
| | bscI | Putative type III secretion protein; Similar to Bordetella bronchiseptica BscI TR:O68535 (EMBL:AF049488) (115 aa) fasta scores: E(): 8.1e-32, 90.43% id in 115 aa, and to Pseudomonas aeruginosa type III export protein PscI or pa1722 TR:Q9I315 (EMBL:AE004598) (112 aa) fasta scores: E(): 2.1, 28.07% id in 114 aa. (135 aa) |
| | bcr4 | Hypothetical protein; No significant database matches. (173 aa) |
| | bcrH2 | Putative regulatory protein; Weakly similar to many Pseudomonas aeruginosa regulatory protein PcrH or pa1707 TR:Q9I325 (EMBL:AE004597) (167 aa) fasta scores: E(): 0.0042, 25.34% id in 146 aa, and to Yersinia pestis low calcium response locus protein H Lcrh or ypcd1.30c or y0051 SW:LCRH_YERPE (P21207) (168 aa) fasta scores: E(): 0.063, 23.81% id in 126 aa. (153 aa) |
| | bopB | Similar to Bordetella bronchiseptica outer protein B BopB TR:Q9REZ5 (EMBL:AF207789) (400 aa) fasta scores: E(): 2e-118, 96.75% id in 400 aa. (402 aa) |
| | bopD | Similar to Bordetella bronchiseptica outer protein D BopD TR:Q9REZ6 (EMBL:AF207788) (313 aa) fasta scores: E(): 3.5e-86, 98.4% id in 313 aa. (313 aa) |
| | bcrH1 | Similar to Pseudomonas aeruginosa regulatory protein PcrH or pa1707 TR:Q9I325 (EMBL:AE004597) (167 aa) fasta scores: E(): 1.4e-12, 37.41% id in 155 aa, and to Yersinia pestis low calcium response locus protein H LcrH or ypcd1.30c or y0051 SW:LCRH_YERPE (P21207) (168 aa) fasta scores: E(): 4.7e-08, 31.66% id in 120 aa. (161 aa) |
| | BP2255 | Hypothetical protein; No significant database matches. (91 aa) |
| | bsp22 | Putative secreted protein; Strongly similar to Bordetella bronchiseptica secreted protein 22 Bsp22 TR:Q9REZ7 (EMBL:AF207787) (205 aa) fasta scores: E(): 4.1e-68, 96.58% id in 205 aa. (205 aa) |
| | bopN | Putative outer protein N; Similar to many eg. Bordetella bronchiseptica outer protein N BopN TR:Q9REZ4 (EMBL:AF207790) (365 aa) fasta scores: E(): 4.3e-132, 99.17% id in 365 aa, and to Pseudomonas syringae hypersensitivity response secretion protein HrpJ SW:HRPJ_PSESY (Q05395) (346 aa) fasta scores: E(): 5e-08, 26.94% id in 308 aa. (365 aa) |
| | BP2258 | Hypothetical protein; No significant database matches. (125 aa) |
| | BP2259 | Conserved hypothetical protein; Similar to Pseudomonas aeruginosa pcr3 pcr3 or pa1701 TR:O30534 (EMBL:AF010150) (121 aa) fasta scores: E(): 0.52, 31.49% id in 127 aa. (136 aa) |
| | BP2260 | Conserved hypothetical protein; Similar to Bradyrhizobium japonicum Id192 TR:Q9ANI6 (EMBL:AF322012) (142 aa) fasta scores: E(): 0.99, 29.2% id in 113 aa, and to Chlamydia muridarum type III secretion chaperone, putative tc0546 TR:Q9PKC0 (EMBL:AE002323) (139 aa) fasta scores: E(): 5.1, 31.13% id in 106 aa. (122 aa) |
| | bcrD | Putative type III secretion pore protein; Similar to many eg. Chlamydophila caviae Cds2 protein TR:O34019 (EMBL:U88070) (709 aa) fasta scores: E(): 6e-116, 47.14% id in 700 aa, and to Salmonella typhimurium Invasion protein InvA SW:INVA_SALTY (P35657) (665 aa) fasta scores: E(): 1.4e-90, 43.96% id in 671 aa. Also similar to BP1367, 36.510% identity (38.426% ungapped) in 682 aa overlap. (699 aa) |
| | bscD | Putative type III secretion protein; Weak but full length similarity to Pseudomonas aeruginosa type III secretion protein PscD TR:P95432 (EMBL:U56077) (432 aa) fasta scores: E(): 0.00018, 25.57% id in 438 aa. (426 aa) |
| | bscE | Hypothetical protein; No significant database matches. (99 aa) |
| | bscF | Similar to Pseudomonas aeruginosa putative type III secretion protein PscF or pa1719 TR:P95434 (EMBL:U56077) (85 aa) fasta scores: E(): 0.013, 27.9% id in 86 aa. (88 aa) |
| | BP2265 | Hypothetical protein; No significant database matches. (151 aa) |
| | BP2266 | Transposase for IS481 element. (316 aa) |
| | BP2289 | Putative outer membrane protein (pseudogene); (CTGGG)2 in pertussis; (CTGGG)1 in parapertussis and bronchiseptica. (396 aa) |
| | BP2290 | Similar to Escherichia coli, and multidrug resistance protein A EmrB or b2686 or z3987 or ecs3548 SW:EMRB_ECOLI (P27304) (512 aa) fasta scores: E(): 9.4e-102, 54.72% id in 508 aa, and to Haemophilus influenzae multidrug resistance protein B homolog EmrB or hi0897 SW:EMRB_HAEIN (P44927) (510 aa) fasta scores: E(): 2.7e-98, 52.89% id in 501 aa; Belongs to the major facilitator superfamily. (528 aa) |
| | vag8 | Autotransporter; Previously sequenced as Bordetella pertussis Vag8 protein Vag8-2 SWALL:Q8VV95 (EMBL:AJ420993) (915 aa) fasta scores: E(): 0, 100% id in 915 aa. (915 aa) |
| | alcA | Alcaligin biosynthesis enzyme; Previously sequenced in Bordetella bronchiseptica alcaligin biosynthesis enzyme AlcA SW:ALCA_BORBR (Q44740) (461 aa) fasta scores: E(): 1.4e-197, 100% id in 461 aa. Also similar to Escherichia coli L-lysine 6-monooxygenase IucD or AerA SW:IUCD_ECOLI (P11295) (425 aa) fasta scores: E(): 2.5e-37, 28.97% id in 428 aa. (461 aa) |
| | alcB | Alcaligin biosynthesis protein; Previously sequenced in Bordetella bronchiseptica AlcB iron siderophore alcaligin biosynthetic protein TR:P94254 (EMBL:U61153) (201 aa) fasta scores: E(): 7.8e-87, 100% id in 201 aa. Also similar to Escherichia coli aerobactin siderophore biosynthesis protein IucB SW:IUCB_ECOLI (Q47317) (315 aa) fasta scores: E(): 1.1e-05, 24.4% id in 168 aa. (201 aa) |
| | alcC | Alcaligin biosynthesis protein; Previously sequenced in Bordetella bronchiseptica AlcC iron siderophore alcaligin biosynthesis protein TR:P94255 (EMBL:U61153) (618 aa) fasta scores: E(): 0, 99.83% id in 618 aa. Also similar to Echerichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 8.9e-46, 28.57% id in 595 aa. (618 aa) |
| | alcD | Hypothetical protein; Previously sequenced in Bordetella bronchiseptica hypothetical protein AlcD predicted to be involved in the iron siderophore alcaligin biosynthesis TR:O52832 (EMBL:AJ000061) (267 aa) fasta scores: E(): 3.7e-105, 93.63% id in 267 aa. (266 aa) |
| | alcE | Putative iron-sulfur protein; Previously sequenced in Bordetella bronchiseptica AlcE, involved in the iron siderophore alcaligin biosynthesis, TR:O52833 (EMBL:AJ000061) (397 aa) fasta scores: E(): 7.3e-176, 99.74% id in 397 aa. Also similar to BP2804, 71.842% identity in 380 aa overlap. (397 aa) |
| | alcR | Transcriptional regulator; Previously sequenced Bordetella pertussis AlcR the regulator of alcaligin siderophore biosynthesis TR:O52066 (EMBL:AF018255) (324 aa) fasta scores: E(): 3.4e-130, 100% id in 324 aa. (324 aa) |
| | bcr | Putative drug resistance translocase; Previously sequenced in Bordetella bronchiseptica Bcr protein TR:O52835 (EMBL:AJ000061) (110 aa) fasta scores: E(): 4.8e-35, 96.36% id in 110 aa. Note the differing C-termini. Also similar to Escherichia coli bicyclomycin resistance protein Bcr or BicR or BicR or Sur or SuxA or b2182 SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 1.1e-25, 29.41% id in 391 aa. (407 aa) |
| | mar | Possible membrane efflux protein; Similar to many proteins involved in multiple antibiotic resistance including: Salmonella typhimurium multiple antibiotic resistance protein MarC SW:MARC_SALTY (Q56068) (221 aa) fasta scores: E(): 6.2e-17, 29.68% id in 219 aa and to Escherichia coli multiple antibiotic resistance protein MarC SW:MARC_ECOLI (P31123) (221 aa) fasta scores: E(): 1.5e-16, 30.18% id in 222 aa. Previously sequenced as Bordetella pertussis putative multiple antibiotic resistance protein Mar TR:Q9X6A6 (EMBL:AF135154) (132 aa) fasta scores: E(): 1.2e-36, 100% id in 111 aa. Note [...] (219 aa) |
| | BP2467 | Hypothetical protein; Weakly similar to Xylella fastidiosa phage-related protein Xf0485 TR:Q9PG17 (EMBL:AE003898) (181 aa) fasta scores: E(): 3e-06, 29.18% id in 185 aa. (171 aa) |
| | BP2487 | Hypothetical protein; Weakly similar to Aquifex aeolicus hypothetical 30.0 kDa protein Aq_362 TR:O66687 (EMBL:AE000686) (265 aa) fasta scores: E(): 1.1e-05, 29.38% id in 211 aa. (333 aa) |
| | fhaS | Adhesin; Highly similar to Bordetella pertussis filamentous hemagglutinin FhaB or BP1879 SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 6.4e-175, 48.23% id in 2606 aa, and to Bordetella bronchiseptica adhesin FhaB TR:Q9JP78 (EMBL:AF111796) (3634 aa) fasta scores: E(): 2.7e-173, 46.99% id in 2679 aa. The product of this CDS is also similar to B. pertussis BP2907 E(): 9.8e-120 37.940% identity in 2670 aa. (2553 aa) |
| | fimX | Fimbrial protein; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (201 aa) |
| | fhaL | Adhesin; Similar to Bordetella bronchiseptica adhesin FhaB or BP1879 TR:Q9JP78 (EMBL:AF111796) (3634 aa)fasta scores: E(): 9e-125, 33.527% id in 2750 aa and to Bordetella pertussis filamentous hemagglutinin fhaB SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 1.4e-123, 33.67% id in 2705 aa. The product of this CDS is also similar to B. pertussis BP2667 E(): 7.1e-117, 37.949% identity in 2672 aa. (4196 aa) |
| | BP2924 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. (98 aa) |
| | BP2925 | Similar to Rhizobium meliloti hypothetical protein Smb20529 TR:CAC48908 (EMBL:AL603643) (309 aa) fasta scores: E(): 3.9e-53, 52.76% id in 271 aa and to Caulobacter crescentus hypothetical protein Cc3255 TR:Q9A3E9 (EMBL:AE005989) (280 aa) fasta scores: E(): 1.2e-44, 48.14% id in 270 aa; Belongs to the UPF0276 family. (294 aa) |
| | BP2926 | Weakly similar to Rhizobium meliloti hypothetical protein Smb20528 TR:CAC48907 (EMBL:AL603643) (266 aa) fasta scores: E(): 3.4e-19, 35.08% id in 248 aa and to Caulobacter crescentus hypothetical protein Cc3256 TR:Q9A3E8 (EMBL:AE005989) (254 aa) fasta scores: E(): 3.3e-14, 33.07% id in 254 aa. (251 aa) |
| | BP2927 | Putative integral membrane protein; Similar in parts to Caulobacter crescentus hypothetical protein Cc3257 TR:Q9A3E7 (EMBL:AE005989) (150 aa) fasta scores: E(): 4.7e-15, 46.66% id in 135 aa and to Rhizobium meliloti hypothetical protein Smb20527 TR:CAC48906 (EMBL:AL603643) (144 aa) fasta scores: E(): 8.9e-12, 38.88% id in 144 aa. (165 aa) |
| | ompQ | Outer membrane porin protein OmpQ; Previously described as Bordetella pertussis OmpQ TR:Q45342 (EMBL:U16266) (364 aa) fasta scores: E(): 1.5e-148, 99.72% id in 364 aa. Similar to Bordetella pertussis outer membrane porin protein precursor SW:OMP_BORPE (Q04064) (385 aa) fasta scores: E(): 2.4e-13, 34.25% id in 400 aa, and to Neisseria meningitidis major outer membrane protein Porb or nma0398 SW:OMB_NEIMA (P57042) (329 aa) fasta scores: E(): 7e-05, 24.5% id in 351 aa. (364 aa) |
| | ndh | Similar to Escherichia coli NADH dehydrogenase Ndh SW:DHNA_ECOLI (P00393) (433 aa) fasta scores: E(): 1.6e-60, 43.18% id in 433 aa, and to Pseudomonas fluorescens NADH dehydrogenase II Ndh TR:Q9KGX0 (EMBL:AF281147) (432 aa) fasta scores: E(): 3.5e-68, 46.89% id in 435 aa. (439 aa) |
| | brkB | Similar to Bordetella pertussis serum resistance protein BrkB TR:Q45339 (EMBL:U12276) (296 aa) fasta scores: E(): 3.8e-111, 100% id in 296 aa. Similar to the N-terminal region of Rhizobium loti hypothetical protein MLL2378 TR:Q98IJ2 (EMBL:AP002999) (339 aa) fasta scores: E(): 3.1e-35, 39.28% id in 280 aa. (296 aa) |
| | brkA | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. (1010 aa) |
| | ptxA | Pertussis toxin subunit 1 precursor; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP- binding proteins from their membrane receptors. (269 aa) |
| | ptxB | Pertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. (226 aa) |
| | ptxD | Pertussis toxin subunit 4 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. (152 aa) |
| | ptxE | Pertussis toxin subunit 5 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. (133 aa) |
| | ptxC | Pertussis toxin subunit 3 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. (227 aa) |
| | ptlA | Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. (102 aa) |
| | ptlB | Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. (104 aa) |
| | ptlC | Putative bacterial secretion system protein; Component of the type IV secretion system ptl essential for secretion of assembled pertussis toxin (PTX) through the outer membrane. (824 aa) |
| | ptlD | Putative membrane protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. (463 aa) |
| | ptlI | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. (61 aa) |
| | ptlE | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. Could possess peptidoglycanase activity. (233 aa) |
| | ptlF | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane; Belongs to the TrbG/VirB9 family. (273 aa) |
| | ptlG | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. (374 aa) |
| | ptlH | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. (339 aa) |
| | BP3812 | Similar to Pseudomonas aeruginosa outer membrane protein precursor OprM SW:OPRM_PSEAE (Q51487) (485 aa) fasta scores: E(): 2.1e-35, 32.58% id in 488 aa, and to Pseudomonas aeruginosa probable outer membrane lipoprotein precursor PA2525 TR:Q9I0V8 (EMBL:AE004680) (498 aa) fasta scores: E(): 2e-79, 57.41% id in 479 aa. (494 aa) |
| | BP3813 | AcrB/AcrD/AcrF family protein; Similar to Escherichia coli hypothetical protein YegO SW:YEGO_ECOLI (P76399) (1025 aa) fasta scores: E(): 0, 60.8% id in 1023 aa, and to Pseudomonas aeruginosa probable RND efflux transporter PA2526 TR:Q9I0V7 (EMBL:AE004680) (1036 aa) fasta scores: E(): 0, 61.08% id in 1033 aa. Similar to BP3814, 50.193% identity (51.590% ungapped) in 1034 aa overlap; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1035 aa) |
| | BP3814 | AcrB/AcrD/AcrF family protein; Similar to Pseudomonas aeruginosa probable RND efflux transporter PA1436 TR:Q9I3R1 (EMBL:AE004573) (1036 aa) fasta scores: E(): 1.2e-171, 50.49% id in 1016 aa, and to Rhizobium loti RND efflux transporter MLL5779 TR:Q98B06 (EMBL:AP003007) (1038 aa) fasta scores: E(): 2.3e-168, 52.25% id in 1020 aa. Similar to BP3813, 50.193% identity (51.590% ungapped) in 1034 aa overlap; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1022 aa) |
| | BP3815 | HlyD family secretion protein; Similar to Pseudomonas aeruginosa probable RND efflux membrane fusion protein precursor PA2528 TR:Q9I0V5 (EMBL:AE004680) (426 aa) fasta scores: E(): 1.6e-64, 51.74% id in 402 aa, and to Burkholderia solanacearum putative resistance transmembrane protein RSP1197 TR:CAD18348 (EMBL:AL646083) (449 aa) fasta scores: E(): 1.6e-69, 51.71% id in 408 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (416 aa) |
| | zapD | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (253 aa) |
| | coaE | Putative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (214 aa) |
| | BP3818 | Type 4 prepilin-like proteins leader peptide processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (326 aa) |
| | BP3819 | Hypothetical protein; Poor database matches. Weakly similar to Vibrio cholerae lipoprotein VC1962 TR:Q9KQN6 (EMBL:AE004271) (163 aa) fasta scores: E(): 0.065, 28.36% id in 141 aa. (247 aa) |
| | BP3820 | Putative regulatory protein; Similar to the C-terminal regions of Salmonella typhimurium transcriptional regulatory protein UhpA SW:UHPA_SALTY (P27667) (196 aa) fasta scores: E(): 2.6e-05, 47.29% id in 74 aa, and Escherichia coli transcriptional regulatory protein UhpA SW:UHPA_ECOLI (P10940) (196 aa) fasta scores: E(): 6.3e-05, 45.94% id in 74 aa. (115 aa) |
| | BP3823 | Similar to Burkholderia solanacearum conserved hypothetical protein RSC2385 TR:CAD16092 (EMBL:AL646069) (62 aa) fasta scores: E(): 3.7e-09, 58.33% id in 60 aa, and to Neisseria meningitidis hypothetical protein NMA1654 TR:Q9JTS3 (EMBL:AL162756) (61 aa) fasta scores: E(): 6e-06, 44.06% id in 59 aa. (62 aa) |
| | BP3824 | Putative membrane protein; Similar to Escherichia coli multidrug resistance protein B EmrB SW:EMRB_ECOLI (P27304) (512 aa) fasta scores: E(): 1.5e-26, 28.46% id in 411 aa, and to Rhizobium loti probable transporter MLL1728 TR:Q98JY3 (EMBL:AP002998) (477 aa) fasta scores: E(): 1.7e-75, 46.96% id in 477 aa. Possible alternative translational start site; Belongs to the major facilitator superfamily. (485 aa) |
| | BP3826 | Putative membrane protein; Similar to Pseudomonas aeruginosa hypothetical protein PA0661 TR:Q9I5R0 (EMBL:AE004501) (140 aa) fasta scores: E(): 1.7e-05, 31.46% id in 143 aa, and to Rhizobium loti hypothetical protein MLL4486 TR:Q98DY7 (EMBL:AP003004) (162 aa) fasta scores: E(): 2.2e-05, 31.91% id in 141 aa. Possible alternative translational start site. (155 aa) |
| | BP3827 | Putative exported protein; Similar to Rhizobium meliloti hypothetical protein SMA1927 TR:Q92Y30 (EMBL:AE007292) (330 aa) fasta scores: E(): 1.7e-48, 44.61% id in 334 aa, and to Agrobacterium tumefaciens AGR_L_312p TR:AAK88723 (EMBL:AE008213) (329 aa) fasta scores: E(): 2.2e-45, 43.28% id in 335 aa. (340 aa) |
| | ftsE | Similar to Escherichia coli cell division ATP-binding protein FtsE SW:FTSE_ECOLI (P10115) (222 aa) fasta scores: E(): 9e-36, 50.9% id in 220 aa, and to Neisseria meningitidis ABC transporter ATP-binding protein NMA0254 TR:Q9JWT1 (EMBL:AL162752) (216 aa) fasta scores: E(): 1.6e-34, 48.83% id in 215 aa. (223 aa) |
| | BP3833 | Putative permease protein; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (302 aa) |
