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sphB1 sphB1 prn prn bipA bipA fim2 fim2 fim3 fim3 fhaB fhaB fimB fimB fimC fimC fimD fimD fhaC fhaC alcA alcA alcB alcB alcC alcC alcD alcD alcE alcE alcR alcR BP2467 BP2467 BP2487 BP2487 fhaS fhaS fimX fimX fhaL fhaL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
sphB1Previously sequenced as Bordetella pertussis autotransporter subtilisin-like protease SphB1 TR:CAC44081 (EMBL:AJ318229) (1039 aa) fasta scores: E(): 0, 100.000% id in 932 aa, and dimilar to Xylella fastidiosa serine protease Xf1026 TR:Q9PEK2 (EMBL:AE003939) (905 aa) fasta scores: E(): 1.1e-45, 31.919% id in 943 aa. (932 aa)
prnPertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. (910 aa)
bipASimilar to Bordetella bronchiseptica putative outer membrane ligand binding protein BipA TR:Q9APE8 (EMBL:AF304006) (1578 aa) fasta scores: E(): 0, 79.75% id in 1576 aa, and to Escherichia coli O157:H7 EDL933 putative adhesin EaeH TR:AAG54632 (EMBL:AE005207) (1417 aa) fasta scores: E(): 1.6e-17, 23.88% id in 1390 aa. Also similar to BP3204, 41.856% identity (43.284% ungapped) in 970 aa overlap. (1308 aa)
fim2Serotype 2 fimbrial subunit precursor; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (210 aa)
fim3Serotype 3 fimbrial subunit precursor; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (204 aa)
fhaBFilamentous hemagglutinin/adhesin; Evidence for a role in host-cell binding and infection. (3590 aa)
fimBFimbrial protein (pseudogene); Required for the biogenesis of the filamentous hemagglutinin and the fimbria; Belongs to the periplasmic pilus chaperone family. (244 aa)
fimCOuter membrane usher protein precursor; Probable porin-like protein necessary for the assembly of a pilin-type protein; Belongs to the fimbrial export usher family. (873 aa)
fimDFimbrial adhesin; Previously sequenced as Bordetella pertussis protein FhaE precursor FhaE or FimD SW:FHAE_BORPE (Q00879) (376 aa) fasta scores: E(): 1.9e-143, 100% id in 365 aa. (365 aa)
fhaCHemolysin activator-like protein; Member of a two partner secretion pathway (TPS) in which it mediates the secretion of filamentous hemagglutinin FHA (fhaB). Belongs to the TPS (TC 1.B.20) family. (584 aa)
alcAAlcaligin biosynthesis enzyme; Previously sequenced in Bordetella bronchiseptica alcaligin biosynthesis enzyme AlcA SW:ALCA_BORBR (Q44740) (461 aa) fasta scores: E(): 1.4e-197, 100% id in 461 aa. Also similar to Escherichia coli L-lysine 6-monooxygenase IucD or AerA SW:IUCD_ECOLI (P11295) (425 aa) fasta scores: E(): 2.5e-37, 28.97% id in 428 aa. (461 aa)
alcBAlcaligin biosynthesis protein; Previously sequenced in Bordetella bronchiseptica AlcB iron siderophore alcaligin biosynthetic protein TR:P94254 (EMBL:U61153) (201 aa) fasta scores: E(): 7.8e-87, 100% id in 201 aa. Also similar to Escherichia coli aerobactin siderophore biosynthesis protein IucB SW:IUCB_ECOLI (Q47317) (315 aa) fasta scores: E(): 1.1e-05, 24.4% id in 168 aa. (201 aa)
alcCAlcaligin biosynthesis protein; Previously sequenced in Bordetella bronchiseptica AlcC iron siderophore alcaligin biosynthesis protein TR:P94255 (EMBL:U61153) (618 aa) fasta scores: E(): 0, 99.83% id in 618 aa. Also similar to Echerichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 8.9e-46, 28.57% id in 595 aa. (618 aa)
alcDHypothetical protein; Previously sequenced in Bordetella bronchiseptica hypothetical protein AlcD predicted to be involved in the iron siderophore alcaligin biosynthesis TR:O52832 (EMBL:AJ000061) (267 aa) fasta scores: E(): 3.7e-105, 93.63% id in 267 aa. (266 aa)
alcEPutative iron-sulfur protein; Previously sequenced in Bordetella bronchiseptica AlcE, involved in the iron siderophore alcaligin biosynthesis, TR:O52833 (EMBL:AJ000061) (397 aa) fasta scores: E(): 7.3e-176, 99.74% id in 397 aa. Also similar to BP2804, 71.842% identity in 380 aa overlap. (397 aa)
alcRTranscriptional regulator; Previously sequenced Bordetella pertussis AlcR the regulator of alcaligin siderophore biosynthesis TR:O52066 (EMBL:AF018255) (324 aa) fasta scores: E(): 3.4e-130, 100% id in 324 aa. (324 aa)
BP2467Hypothetical protein; Weakly similar to Xylella fastidiosa phage-related protein Xf0485 TR:Q9PG17 (EMBL:AE003898) (181 aa) fasta scores: E(): 3e-06, 29.18% id in 185 aa. (171 aa)
BP2487Hypothetical protein; Weakly similar to Aquifex aeolicus hypothetical 30.0 kDa protein Aq_362 TR:O66687 (EMBL:AE000686) (265 aa) fasta scores: E(): 1.1e-05, 29.38% id in 211 aa. (333 aa)
fhaSAdhesin; Highly similar to Bordetella pertussis filamentous hemagglutinin FhaB or BP1879 SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 6.4e-175, 48.23% id in 2606 aa, and to Bordetella bronchiseptica adhesin FhaB TR:Q9JP78 (EMBL:AF111796) (3634 aa) fasta scores: E(): 2.7e-173, 46.99% id in 2679 aa. The product of this CDS is also similar to B. pertussis BP2907 E(): 9.8e-120 37.940% identity in 2670 aa. (2553 aa)
fimXFimbrial protein; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (201 aa)
fhaLAdhesin; Similar to Bordetella bronchiseptica adhesin FhaB or BP1879 TR:Q9JP78 (EMBL:AF111796) (3634 aa)fasta scores: E(): 9e-125, 33.527% id in 2750 aa and to Bordetella pertussis filamentous hemagglutinin fhaB SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 1.4e-123, 33.67% id in 2705 aa. The product of this CDS is also similar to B. pertussis BP2667 E(): 7.1e-117, 37.949% identity in 2672 aa. (4196 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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