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BP0134 BP0134 bfr bfr bhuV bhuV bhuU bhuU bhuT bhuT bhuS bhuS bhuR bhuR hurR hurR hurI hurI bfrF bfrF BP0737 BP0737 bfrE bfrE BP0902 BP0902 BP0903 BP0903 fecI fecI fecR fecR bfrH bfrH BP1139 BP1139 BP1141 BP1141 apbE apbE BP1211 BP1211 BP1212 BP1212 BP1213 BP1213 nodI nodI nodJ nodJ BP1216 BP1216 BP1558 BP1558 BP1560 BP1560 BP1561 BP1561 BP1760 BP1760 brfB brfB BP2017 BP2017 BP2414 BP2414 fauA fauA BP2772 BP2772 pntB pntB bfeA bfeA BP2902 BP2902 BP2921 BP2921 bfrG bfrG BP2923 BP2923 BP3339 BP3339 BP3340 BP3340 BP3529 BP3529 tonB tonB exbB exbB exbD exbD BP3596 BP3596 bfrC bfrC BP3664 BP3664
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
BP0134Similar to Azotobacter vinelandii bacterioferritin-associated ferredoxin Bfd TR:Q9Z5W9 (EMBL:AF121138) (73 aa) fasta scores: E(): 0.004, 40.426% id in 47 aa, and to Neisseria meningitidis putative ferredoxin Nma0965 or Nmb0752 TR:Q9JQR7 (EMBL:AL162754) (66 aa) fasta scores: E(): 4.5e-08, 53.704% id in 54 aa. (100 aa)
bfrBacterioferritin; Iron-storage protein. (158 aa)
bhuVPutative ATP-binding component of hemin transport system; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (262 aa)
bhuUPutative hemin permease; Similar to Yersinia enterocolitica hemin permease HemU TR:P74980 (EMBL:X77867) (334 aa) fasta scores: E(): 4.8e-47, 50.000% id in 286 aa, and to Yersinia pestis hemin transport system permease protein HmuU SW:HMUU_YERPE (Q56992) (334 aa) fasta scores: E(): 7.3e-47, 49.141% id in 291 aa. Also similar to BP3340, 40.256% identity (42.568% ungapped) in 313 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (311 aa)
bhuTSimilar to Yersinia enterocolitica hemin binding protein HemT TR:P74979 (EMBL:X77867) (279 aa) fasta scores: E(): 8.2e-29, 37.638% id in 271 aa, and to Yersinia pestis hemin-binding periplasmic protein HmuT precursor SW:HMUT_YERPE (Q56991) (279 aa) fasta scores: E(): 9.4e-29, 37.638% id in 271 aa. (289 aa)
bhuSSimilar to Yersinia pestis hemin transport protein HmuS SW:HMUS_YERPE (Q56990) (345 aa) fasta scores: E(): 1.1e-46, 42.486% id in 346 aa, and to Yersinia enterocolitica hemin transport protein HemS SW:HEMS_YEREN (P31517) (345 aa) fasta scores: E(): 1.2e-46, 43.413% id in 334 aa. (348 aa)
bhuROuter membrane heme receptor; Previously sequenced as Bordetella pertussis outer membrane heme receptor BhuR TR:AAK38153 (EMBL:AY032627) (149 aa) fasta scores: E(): 2.7e-49, 100.000% id in 149 aa. Similar to Rhizobium meliloti putative iron transport protein Smc02726 TR:CAC46967 (EMBL:AL591790) (743 aa) fasta scores: E(): 4.6e-37, 37.630% id in 768 aa. (845 aa)
hurRHeme uptake transmembrane sensor; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 1e-22, 32.459% id in 305 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa1911 TR:Q9I2J3 (EMBL:AE004617) (316 aa) fasta scores: E(): 2.4e-32, 41.118% id in 304 aa. (305 aa)
hurIHeme uptake regulator; Similar to Escherichia coli probable RNA polymerase sigma factor FecI or B4293 SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 1.2e-26, 50.649% id in 154 aa, and to Pseudomonas aeruginosa putative RNA polymerase sigma factor Pa1912 TR:Q9I2J2 (EMBL:AE004617) (168 aa) fasta scores: E(): 8.9e-31, 55.689% id in 167 aa. Also similar to BP1136, 46.875% identity in 160 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (169 aa)
bfrFSimilar to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or B0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 7.8e-38, 40.000% id in 725 aa, and to Pseudomonas aeruginosa probable hydroxamate-type ferrisiderophore receptor Pa0470 TR:Q9I648 (EMBL:AE004484) (802 aa) fasta scores: E(): 1.4e-103, 40.000% id in 815 aa. (814 aa)
BP0737Similar to Bordetella bronchiseptica putative inner membrane sensor BupR TR:Q9L429 (EMBL:AJ251793) (344 aa) fasta scores: E(): 7.6e-19, 33.025% id in 324 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa2388 TR:Q9I192 (EMBL:AE004665) (331 aa) fasta scores: E(): 3.9e-47, 44.377% id in 329 aa. (323 aa)
bfrEProbable TonB-dependent receptor for iron transport; Similar to Pseudomonas aeruginosa hydroxamate-type ferrisiderophore receptor PiuA or Fiu or Pa4514 TR:O68590 (EMBL:AF051690) (753 aa) fasta scores: E(): 3.4e-106, 43.742% id in 775 aa, and to Escherichia coli probable TonB-dependent receptor YbiL precursor YbiL or B0805 SW:YBIL_ECOLI (P75780) (760 aa) fasta scores: E(): 7.2e-50, 35.058% id in 773 aa. (752 aa)
BP0902Putative membrane protein; Similar to Caulobacter crescentus hypothetical protein Cc2926 TR:Q9A4B1 (EMBL:AE005957) (70 aa) fasta scores: E(): 0.0073, 44.231% id in 52 aa. (70 aa)
BP0903Putative membrane protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa1909 TR:Q9I2J5 (EMBL:AE004617) (383 aa) fasta scores: E(): 1.4e-72, 52.910% id in 378 aa, and to Caulobacter crescentus hypothetical protein Cc2927 TR:Q9A4B0 (EMBL:AE005957) (394 aa) fasta scores: E(): 2.4e-53, 50.681% id in 367 aa. (393 aa)
fecIECF-family sigma factor; Similar to Escherichia coli probable RNA polymerase sigma factor FecI or B4293 SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 1e-21, 43.82% id in 162 aa, and to Pseudomonas aeruginosa putative RNA polymerase sigma factor Pa3899 TR:Q9HXB4 (EMBL:AE004807) (169 aa) fasta scores: E(): 1.9e-31, 54.54% id in 165 aa. Also similar to BP0349, 46.875% identity in 160 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (177 aa)
fecRPutative signal transduction protein; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 5.3e-19, 32.17% id in 317 aa, and to Pseudomonas putida pupI and pupR genes PupR TR:Q52209 (EMBL:X77918) (324 aa) fasta scores: E(): 1.3e-28, 37.88% id in 322 aa. (320 aa)
bfrHSimilar to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or B0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 4.9e-61, 38.21% id in 717 aa, and to Burkholderia cepacia ornibactin receptor precursor OrbA TR:Q9F480 (EMBL:AF013993) (755 aa) fasta scores: E(): 6.7e-72, 36.05% id in 746 aa. (825 aa)
BP1139Putative iron uptake protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa0800 TR:Q9I5D8 (EMBL:AE004515) (177 aa) fasta scores: E(): 1.4e-08, 44.82% id in 87 aa. (102 aa)
BP1141Putative iron uptake protein (Pseudogene); TGA stop in pertussis; TGG in parapertussis and bronchiseptica. (108 aa)
apbEThiamine biosynthesis lipoprotein precursor; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family. (338 aa)
BP1211Putative exported protein; Similar to Xylella fastidiosa hypothetical protein Xf0595 TR:Q9PFR2 (EMBL:AE003905) (267 aa) fasta scores: E(): 4e-46, 50.76% id in 260 aa, and to Caulobacter crescentus hypothetical protein Cc3061 TR:Q9A3Y9 (EMBL:AE005969) (247 aa) fasta scores: E(): 7.2e-34, 49.5% id in 200 aa. (266 aa)
BP1212Putative exported protein; Similar to Caulobacter crescentus hypothetical protein Cc3060 TR:Q9A3Z0 (EMBL:AE005969) (171 aa) fasta scores: E(): 1.3e-34, 55.23% id in 172 aa, and to Xylella fastidiosa hypothetical protein Xf0596 TR:Q9PFR1 (EMBL:AE003905) (174 aa) fasta scores: E(): 1.9e-33, 52.63% id in 171 aa. (171 aa)
BP1213Putative membrane protein; Similar to Caulobacter crescentus hypothetical protein Cc3059 TR:Q9A3Z1 (EMBL:AE005969) (209 aa) fasta scores: E(): 2.7e-43, 55.92% id in 211 aa, and to Xylella fastidiosa hypothetical protein Xf0597 TR:Q9PFR0 (EMBL:AE003905) (218 aa) fasta scores: E(): 7.7e-45, 56.73% id in 208 aa. (209 aa)
nodIABC, transporter, ATP-binding protein; Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4- linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system. (315 aa)
nodJABC transporter, permease protein; Similar to Rhizobium sp nodulation protein J NodJ or Y4hE SW:NODJ_RHISN (P55475) (262 aa) fasta scores: E(): 2.2e-39, 42.3% id in 260 aa, and to Bradyrhizobium spWM9 probable nodulation ABC transporter permease nodJ TR:Q9AQ19 (EMBL:AF222753) (261 aa) fasta scores: E(): 3.8e-39, 44.7% id in 255 aa. (261 aa)
BP1216Putative membrane protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa5409 TR:Q9HTF5 (EMBL:AE004953) (186 aa) fasta scores: E(): 1.1e-33, 55.3% id in 179 aa, and to Rhizobium loti Mll6732 protein Mll6732 TR:Q988I2 (EMBL:AP003010) (200 aa) fasta scores: E(): 0.00082, 25.59% id in 168 aa. (186 aa)
BP1558Putative exported protein; Similar to Rhizobium loti Mlr5529 protein TR:Q98BK7 (EMBL:AP003006) (367 aa) fasta scores: E(): 8.4e-57, 45.92% id in 368 aa, and to Agrobacterium tumefaciens Agr_c_487p TR:AAK86100 (EMBL:AE007967) (364 aa) fasta scores: E(): 5e-42, 36.92% id in 371 aa. (373 aa)
BP1560Putative exported protein (Pseudogene); G(-) in pertussis; G(CCGCGCTGGCG) in bronchiseptica and parapertussis. (470 aa)
BP1561Putative exported protein; Similar to Rhizobium meliloti hypothetical signal peptide protein Smc00402 TR:CAC41759 (EMBL:AL591783) (426 aa) fasta scores: E(): 3e-56, 63.07% id in 436 aa, and to Agrobacterium tumefaciens Agr_c_493p TR:AAK86103 (EMBL:AE007967) (447 aa) fasta scores: E(): 3.2e-56, 63.69% id in 438 aa. (436 aa)
BP1760Putative exported protein; Similar to Pseudomonas aeruginosa probable siderophore receptor Pa1365 TR:Q9I3X9 (EMBL:AE004565) (813 aa) fasta scores: E(): 1.1e-08, 23.6% id in 771 aa, and to Escherichia coli hypothetical protein Yddb or B1495 SW:YDDB_ECOLI (P31827) (790 aa) fasta scores: E(): 3.1e-72, 32.65% id in 781 aa. (870 aa)
brfBSimilar to Yersinia enterocolitica ferrichrome receptor FcuA, fcuA SW:FCUA_YEREN (Q05202) (758 aa) fasta scores: E(): 5.1e-99, 40.909% id in 726 aa and to Bordetella bronchiseptica putative ferric siderophore receptor BrfB, bfrB TR:P94265 (EMBL:U77671) (734 aa) fasta scores: E(): 0, 98.638% id in 734 aa. Show to be iron-regulated in Bordetella bronchiseptica. (734 aa)
BP2017Putative haloacid-type dehydrogenase; Show weak similarity to Pseudomonas sp. 2-haloalkanoic acid dehalogenase I SW:HAD1_PSESP (P24069) (227 aa) fasta scores: E(): 2.4e-09, 28.821% id in 229 aa. Also similar to many haloacid-type hydrolases e.g. Pseudomonas aeruginosa probable haloacid dehalogenase PA0810 TR:Q9I5C9 (EMBL:AE004516) (233 aa) fasta scores: E(): 1.7e-35, 42.797% id in 236 aa. (244 aa)
BP2414Similar to Campylobacter jejuni hypothetical protein Cj1384C TR:Q9PMR6 (EMBL:AL139078) (104 aa) fasta scores: E(): 0.0014, 30.58% id in 85 aa and to Clostridium acetobutylicum predicted diverged chey-domain Cac1602 TR:Q97IN8 (EMBL:AE007670) (103 aa) fasta scores: E(): 1.4e-07, 34.06% id in 91 aa. (113 aa)
fauAPreviously sequenced Bordetella pertussis ferric alcaligin siderophore receptor FauA TR:Q9X6A5 (EMBL:AF135154) (734 aa) fasta scores: E(): 0, 100% id in 734 aa. (734 aa)
BP2772Putative membrane protein; Weakly similar to many proposed trancriptional regulators e.g. Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 4.4e-17, 30.38% id in 316 aa. (334 aa)
pntBNAD(P) transhydrogenase subunit beta (pseudogene); G in pertussis; (AC)G in parapertussis and bronchiseptica. (343 aa)
bfeAFerric enterobactin receptor; Previously sequenced as Bordetella pertussis ferric enterobactin receptor BfeA TR:Q45341 (EMBL:U13950) (735 aa) fasta scores: E(): 0, 99.72% id in 737 aa. (737 aa)
BP2902Putative exported protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa2689 SWALL:Q9I0F2 (EMBL:AE004697) (304 aa) fasta scores: E(): 2.4e-25, 39.79% id in 289 aa, and to Escherichia coli IroE protein SWALL:CAC43425 (EMBL:X16664) (318 aa) fasta scores: E(): 1.8e-16, 34.01% id in 244 aa; Weakly similar to several proteins of undefined function e.g. Pseudomonas aeruginosa hypothetical protein Pa2689 TR:Q9I0F2 (EMBL:AE004697) (304 aa) fasta scores: E(): 2.4e-25, 39.79% id in 289 aa. (303 aa)
BP2921Putative exported protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa0435 TR:Q9I682 (EMBL:AE004480) (492 aa) fasta scores: E(): 1.8e-84, 51.11% id in 495 aa. (489 aa)
bfrGPutative TonB-dependent receptor; Similar to Pseudomonas aeruginosa hypothetical protein Pa0434 TR:Q9I683 (EMBL:AE004480) (730 aa) fasta scores: E(): 7.2e-136, 49.52% id in 737 aa, and to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or b0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 3.7e-14, 22.9% id in 786 aa. (732 aa)
BP2923Putative lipoprotein; No significant database hits. (145 aa)
BP3339Conserved hypothetical protein (pseudogene); 97 bp deletion in pertussis relative to parapertussis and bronchiseptica. (264 aa)
BP3340Similar to Rhizobium meliloti putative iron ABC transporter permease protein smb21430 TR:CAC49658 (EMBL:AL603646) (356 aa) fasta scores: E(): 4.7e-59, 52.41% id in 332 aa, and to Corynebacterium diphtheriae HmuU TR:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 1.4e-35, 37.69% id in 329 aa. Also similar to BP0344, 40.256% identity (42.568% ungapped) in 313 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (349 aa)
BP3529Conserved hypothetical protein; Previously sequenced as Bordetella bronchiseptica hypothetical protein TR:Q9S3N8 (EMBL:AJ132742) (226 aa) fasta scores: E(): 2e-91, 100% id in 226 aa. Similar to Pseudomonas aeruginosa hypothetical protein PA4515 TR:Q9HVQ7 (EMBL:AE004865) (226 aa) fasta scores: E(): 3.4e-61, 66.37% id in 226 aa. (226 aa)
tonBSiderophore-mediated iron transport protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (266 aa)
exbBMotA/TolQ/ExbB proton channel family protein; C-terminal region is similar to Escherichia coli inner membrane protein that maintains integrity of cell envelope and tolerance to group A colicins TolQ SW:TOLQ_ECOLI (P05828) (230 aa) fasta scores: E(): 2.1e-13, 31.87% id in 229 aa. Previously sequenced as Bordetella pertussis putative biopolymer transport protein ExbB TR:Q9S3M5 (EMBL:AJ132741) (325 aa) fasta scores: E(): 1.2e-103, 100% id in 325 aa. (325 aa)
exbDSimilar to Escherichia coli biopolymer transport protein ExbD SW:EXBD_ECOLI (P18784) (141 aa) fasta scores: E(): 2.1e-09, 31.53% id in 130 aa. Previously sequenced as Bordetella pertussis putative biopolymer transport protein ExbD TR:Q9S3M4 (EMBL:AJ132741) (155 aa) fasta scores: E(): 4.4e-53, 100% id in 155 aa. (155 aa)
BP3596Periplasmic binding protein; Similar to Salmonella typhimurium cobalamin periplasmic binding protein BtuF TR:Q9ZFP9 (EMBL:AF096877) (266 aa) fasta scores: E(): 2.9e-15, 34.66% id in 251 aa, and to Vibrio cholerae hypothetical protein VC2381 TR:Q9KPI6 (EMBL:AE004308) (276 aa) fasta scores: E(): 4e-24, 38.82% id in 255 aa. (297 aa)
bfrCFerric siderophore receptor; Similar to Vibrio anguillarum ferric anguibactin receptor precursor FatA SW:FATA_VIBAN (P11461) (726 aa) fasta scores: E(): 1.9e-33, 24.84% id in 664 aa, and to Pseudomonas aeruginosa probable TonB-dependent receptor protein PA1910 TR:Q9I2J4 (EMBL:AE004617) (804 aa) fasta scores: E(): 6.2e-37, 28.2% id in 741 aa. Highly similar to Bordetella bronchiseptica unidentified ferric siderophore receptor BfrC TR:P94274 (EMBL:U79564) (724 aa) fasta scores: E(): 0, 98.61% id in 724 aa. (729 aa)
BP3664Similar to Pseudomonas aeruginosa hypothetical protein PA4095 TR:Q9HWT3 (EMBL:AE004825) (177 aa) fasta scores: E(): 2e-14, 32.23% id in 152 aa, and to Alcaligenes sp. 2,4'-dihydroxyacetophenone dioxygenase Dad TR:Q9REI7 (EMBL:AJ133820) (176 aa) fasta scores: E(): 3.3e-12, 31.69% id in 142 aa. (172 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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