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bhuV bhuV bhuU bhuU bhuT bhuT bhuS bhuS bhuR bhuR hurR hurR hurI hurI bfrF bfrF BP0737 BP0737 bfrE bfrE fecI fecI fecR fecR bfrH bfrH BP1139 BP1139 BP1141 BP1141 BP1760 BP1760 fauA fauA BP2772 BP2772 pntB pntB bfeA bfeA BP2902 BP2902 BP2921 BP2921 bfrG bfrG BP2923 BP2923 BP3339 BP3339 BP3340 BP3340 BP3529 BP3529 BP3596 BP3596
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bhuVPutative ATP-binding component of hemin transport system; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (262 aa)
bhuUPutative hemin permease; Similar to Yersinia enterocolitica hemin permease HemU TR:P74980 (EMBL:X77867) (334 aa) fasta scores: E(): 4.8e-47, 50.000% id in 286 aa, and to Yersinia pestis hemin transport system permease protein HmuU SW:HMUU_YERPE (Q56992) (334 aa) fasta scores: E(): 7.3e-47, 49.141% id in 291 aa. Also similar to BP3340, 40.256% identity (42.568% ungapped) in 313 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (311 aa)
bhuTSimilar to Yersinia enterocolitica hemin binding protein HemT TR:P74979 (EMBL:X77867) (279 aa) fasta scores: E(): 8.2e-29, 37.638% id in 271 aa, and to Yersinia pestis hemin-binding periplasmic protein HmuT precursor SW:HMUT_YERPE (Q56991) (279 aa) fasta scores: E(): 9.4e-29, 37.638% id in 271 aa. (289 aa)
bhuSSimilar to Yersinia pestis hemin transport protein HmuS SW:HMUS_YERPE (Q56990) (345 aa) fasta scores: E(): 1.1e-46, 42.486% id in 346 aa, and to Yersinia enterocolitica hemin transport protein HemS SW:HEMS_YEREN (P31517) (345 aa) fasta scores: E(): 1.2e-46, 43.413% id in 334 aa. (348 aa)
bhuROuter membrane heme receptor; Previously sequenced as Bordetella pertussis outer membrane heme receptor BhuR TR:AAK38153 (EMBL:AY032627) (149 aa) fasta scores: E(): 2.7e-49, 100.000% id in 149 aa. Similar to Rhizobium meliloti putative iron transport protein Smc02726 TR:CAC46967 (EMBL:AL591790) (743 aa) fasta scores: E(): 4.6e-37, 37.630% id in 768 aa. (845 aa)
hurRHeme uptake transmembrane sensor; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 1e-22, 32.459% id in 305 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa1911 TR:Q9I2J3 (EMBL:AE004617) (316 aa) fasta scores: E(): 2.4e-32, 41.118% id in 304 aa. (305 aa)
hurIHeme uptake regulator; Similar to Escherichia coli probable RNA polymerase sigma factor FecI or B4293 SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 1.2e-26, 50.649% id in 154 aa, and to Pseudomonas aeruginosa putative RNA polymerase sigma factor Pa1912 TR:Q9I2J2 (EMBL:AE004617) (168 aa) fasta scores: E(): 8.9e-31, 55.689% id in 167 aa. Also similar to BP1136, 46.875% identity in 160 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (169 aa)
bfrFSimilar to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or B0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 7.8e-38, 40.000% id in 725 aa, and to Pseudomonas aeruginosa probable hydroxamate-type ferrisiderophore receptor Pa0470 TR:Q9I648 (EMBL:AE004484) (802 aa) fasta scores: E(): 1.4e-103, 40.000% id in 815 aa. (814 aa)
BP0737Similar to Bordetella bronchiseptica putative inner membrane sensor BupR TR:Q9L429 (EMBL:AJ251793) (344 aa) fasta scores: E(): 7.6e-19, 33.025% id in 324 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa2388 TR:Q9I192 (EMBL:AE004665) (331 aa) fasta scores: E(): 3.9e-47, 44.377% id in 329 aa. (323 aa)
bfrEProbable TonB-dependent receptor for iron transport; Similar to Pseudomonas aeruginosa hydroxamate-type ferrisiderophore receptor PiuA or Fiu or Pa4514 TR:O68590 (EMBL:AF051690) (753 aa) fasta scores: E(): 3.4e-106, 43.742% id in 775 aa, and to Escherichia coli probable TonB-dependent receptor YbiL precursor YbiL or B0805 SW:YBIL_ECOLI (P75780) (760 aa) fasta scores: E(): 7.2e-50, 35.058% id in 773 aa. (752 aa)
fecIECF-family sigma factor; Similar to Escherichia coli probable RNA polymerase sigma factor FecI or B4293 SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 1e-21, 43.82% id in 162 aa, and to Pseudomonas aeruginosa putative RNA polymerase sigma factor Pa3899 TR:Q9HXB4 (EMBL:AE004807) (169 aa) fasta scores: E(): 1.9e-31, 54.54% id in 165 aa. Also similar to BP0349, 46.875% identity in 160 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (177 aa)
fecRPutative signal transduction protein; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 5.3e-19, 32.17% id in 317 aa, and to Pseudomonas putida pupI and pupR genes PupR TR:Q52209 (EMBL:X77918) (324 aa) fasta scores: E(): 1.3e-28, 37.88% id in 322 aa. (320 aa)
bfrHSimilar to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or B0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 4.9e-61, 38.21% id in 717 aa, and to Burkholderia cepacia ornibactin receptor precursor OrbA TR:Q9F480 (EMBL:AF013993) (755 aa) fasta scores: E(): 6.7e-72, 36.05% id in 746 aa. (825 aa)
BP1139Putative iron uptake protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa0800 TR:Q9I5D8 (EMBL:AE004515) (177 aa) fasta scores: E(): 1.4e-08, 44.82% id in 87 aa. (102 aa)
BP1141Putative iron uptake protein (Pseudogene); TGA stop in pertussis; TGG in parapertussis and bronchiseptica. (108 aa)
BP1760Putative exported protein; Similar to Pseudomonas aeruginosa probable siderophore receptor Pa1365 TR:Q9I3X9 (EMBL:AE004565) (813 aa) fasta scores: E(): 1.1e-08, 23.6% id in 771 aa, and to Escherichia coli hypothetical protein Yddb or B1495 SW:YDDB_ECOLI (P31827) (790 aa) fasta scores: E(): 3.1e-72, 32.65% id in 781 aa. (870 aa)
fauAPreviously sequenced Bordetella pertussis ferric alcaligin siderophore receptor FauA TR:Q9X6A5 (EMBL:AF135154) (734 aa) fasta scores: E(): 0, 100% id in 734 aa. (734 aa)
BP2772Putative membrane protein; Weakly similar to many proposed trancriptional regulators e.g. Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 4.4e-17, 30.38% id in 316 aa. (334 aa)
pntBNAD(P) transhydrogenase subunit beta (pseudogene); G in pertussis; (AC)G in parapertussis and bronchiseptica. (343 aa)
bfeAFerric enterobactin receptor; Previously sequenced as Bordetella pertussis ferric enterobactin receptor BfeA TR:Q45341 (EMBL:U13950) (735 aa) fasta scores: E(): 0, 99.72% id in 737 aa. (737 aa)
BP2902Putative exported protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa2689 SWALL:Q9I0F2 (EMBL:AE004697) (304 aa) fasta scores: E(): 2.4e-25, 39.79% id in 289 aa, and to Escherichia coli IroE protein SWALL:CAC43425 (EMBL:X16664) (318 aa) fasta scores: E(): 1.8e-16, 34.01% id in 244 aa; Weakly similar to several proteins of undefined function e.g. Pseudomonas aeruginosa hypothetical protein Pa2689 TR:Q9I0F2 (EMBL:AE004697) (304 aa) fasta scores: E(): 2.4e-25, 39.79% id in 289 aa. (303 aa)
BP2921Putative exported protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa0435 TR:Q9I682 (EMBL:AE004480) (492 aa) fasta scores: E(): 1.8e-84, 51.11% id in 495 aa. (489 aa)
bfrGPutative TonB-dependent receptor; Similar to Pseudomonas aeruginosa hypothetical protein Pa0434 TR:Q9I683 (EMBL:AE004480) (730 aa) fasta scores: E(): 7.2e-136, 49.52% id in 737 aa, and to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or b0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 3.7e-14, 22.9% id in 786 aa. (732 aa)
BP2923Putative lipoprotein; No significant database hits. (145 aa)
BP3339Conserved hypothetical protein (pseudogene); 97 bp deletion in pertussis relative to parapertussis and bronchiseptica. (264 aa)
BP3340Similar to Rhizobium meliloti putative iron ABC transporter permease protein smb21430 TR:CAC49658 (EMBL:AL603646) (356 aa) fasta scores: E(): 4.7e-59, 52.41% id in 332 aa, and to Corynebacterium diphtheriae HmuU TR:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 1.4e-35, 37.69% id in 329 aa. Also similar to BP0344, 40.256% identity (42.568% ungapped) in 313 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (349 aa)
BP3529Conserved hypothetical protein; Previously sequenced as Bordetella bronchiseptica hypothetical protein TR:Q9S3N8 (EMBL:AJ132742) (226 aa) fasta scores: E(): 2e-91, 100% id in 226 aa. Similar to Pseudomonas aeruginosa hypothetical protein PA4515 TR:Q9HVQ7 (EMBL:AE004865) (226 aa) fasta scores: E(): 3.4e-61, 66.37% id in 226 aa. (226 aa)
BP3596Periplasmic binding protein; Similar to Salmonella typhimurium cobalamin periplasmic binding protein BtuF TR:Q9ZFP9 (EMBL:AF096877) (266 aa) fasta scores: E(): 2.9e-15, 34.66% id in 251 aa, and to Vibrio cholerae hypothetical protein VC2381 TR:Q9KPI6 (EMBL:AE004308) (276 aa) fasta scores: E(): 4e-24, 38.82% id in 255 aa. (297 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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