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dnaE dnaE BP0025 BP0025 BP0122 BP0122 metG metG BP0331 BP0331 cspA cspA rne rne rimO rimO BP0637 BP0637 aspS aspS pnp pnp BP0932 BP0932 rpsA rpsA infA infA lysS lysS tex tex nusA nusA rho rho ugpC ugpC recG recG rlmD rlmD cspA-2 cspA-2 cspA-3 cspA-3 BP1783 BP1783 BP1930 BP1930 efp efp BP2100 BP2100 BP2317 BP2317 BP2429 BP2429 BP2556 BP2556 pheT pheT BP2642 BP2642 rsgA rsgA BP2757 BP2757 priB priB BP3002 BP3002 BP3199 BP3199 ruvA ruvA rnr rnr ligA ligA rpsL rpsL rplB rplB rpsQ rpsQ infA-2 infA-2 ssb ssb BP3871 BP3871
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaESimilar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. (1163 aa)
BP0025Putative racemase (Pseudogene); Pseudogene. This CDS is disrupted by the insertion of IS481 element. Similar to Rhodococcus spAD45 putative racemase IsoG TR:Q9RBP6 (EMBL:AJ249207) (405 aa) fasta scores: E(): 3.3e-16, 45.370% id in 108 aa, and to Thermoplasma volcanium L-carnitine dehydratase TVG1215416 TR:BAB60328 (EMBL:AP000995) (399 aa) fasta scores: E(): 1.7e-14, 41.509% id in 106 aa. Similar to N-terminal regions of several CDSs including BP0416, BP3709, BP0253, BP3318, BP0199. (144 aa)
BP0122Sugar ABC transporter, ATP-binding protein; Similar to Thermococcus litoralis trehalose/maltose transport ATP-hydrolyzing subunit MalK TR:Q9V306 (EMBL:AF126010) (372 aa) fasta scores: E(): 7.4e-44, 45.205% id in 365 aa, and to Rhizobium meliloti probable glycerol-3-phosphate ABC transporter ATP-binding protein TR:CAC48805 (EMBL:AL603643) (349 aa) fasta scores: E(): 2.1e-49, 50.000% id in 352 aa. (346 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (692 aa)
BP0331Similar to Methanococcus jannaschii hypothetical protein Mj1552 TR:Q58947 (EMBL:U67596) (141 aa) fasta scores: E(): 4.3e-07, 36.842% id in 95 aa, and to Archaeoglobus fulgidus conserved hypothetical protein TR:O29957 (EMBL:AE001085) (165 aa) fasta scores: E(): 2.2e-06, 25.424% id in 118 aa. Also similar to BP0932, 50.400% identity (50.806% ungapped) in 125 aa overlap. (137 aa)
cspACold shock protein; Similar to Escherichia coli cold shock protein CspA or B3556 SW:CSPA_ECOLI (P15277) (69 aa) fasta scores: E(): 9.5e-12, 55.385% id in 65 aa, and to Bordetella pertussis cold shock-like protein CspA SW:CSPA_BORPE (Q9Z5R4) (67 aa) fasta scores: E(): 2.9e-16, 68.657% id in 67 aa. Also similar to BP1770 (68.657% identity in 67 aa overlap), BP1772 (71.186% identity in 59 aa overlap), BP2757 (61.905% identity in 63 aa overlap), and to BP3871 (54.545% identity in 66 aa overlap). (67 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1042 aa)
rimOConserved hypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (439 aa)
BP0637Similar to Thermoplasma volcanium hypothetical protein Tvg0142586 TR:Q97CG7 (EMBL:AP000991) (135 aa) fasta scores: E(): 1.1e-07, 36.522% id in 115 aa, and to Archaeoglobus fulgidus conserved hypothetical protein Af0284 TR:O29957 (EMBL:AE001085) (165 aa) fasta scores: E(): 2.2e-06, 29.091% id in 110 aa. (133 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (719 aa)
BP0932Conserved hypothetical protein; Similar to Methanothermobacter thermautotrophicus conserved protein Mth1398 TR:O27449 (EMBL:AE000902) (133 aa) fasta scores: E(): 1.1e-07, 35.398% id in 113 aa, and to Archaeoglobus fulgidus conserved hypothetical protein Af2417 TR:O30254 (EMBL:AE001108) (122 aa) fasta scores: E(): 2.2e-07, 37.349% id in 83 aa. (140 aa)
rpsA30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (576 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (87 aa)
lysSSimilar to Escherichia coli lysyl-tRNA synthetase LysS or HerC or AsuD or B2890 SW:SYK1_ECOLI (P13030) (504 aa) fasta scores: E(): 3.6e-115, 59.43% id in 498 aa, and to Neisseria meningitidis lysyl-tRNA synthetase LysS or Nma1638 TR:Q9JTT7 (EMBL:AL162756) (503 aa) fasta scores: E(): 1e-126, 62.32% id in 507 aa; Belongs to the class-II aminoacyl-tRNA synthetase family. (506 aa)
texTranscription accessory protein; Transcription accessory protein. Exact function not known. (791 aa)
nusAN utilization substance protein A; Participates in both transcription termination and antitermination. (492 aa)
rhoConserved hypothetical protein (Pseudogene); Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa)
ugpCSn-glycerol-3-phosphate transport ATP-binding protein; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (362 aa)
recGATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (656 aa)
rlmDConserved hypothetical protein; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (466 aa)
cspA-2Cold shock-like protein; Identical to the previously sequenced Bordetella pertussis cold shock-like protein CspA SW:CSPA_BORPE (Q9Z5R4) (67 aa) fasta scores: E(): 3.4e-26, 100% id in 67 aa, and similar to Ralstonia solanacearum probable cold shock-like CspC transcription regulator protein CspC TR:CAD16944 (EMBL:AL646074) (67 aa) fasta scores: E(): 5.5e-17, 67.69% id in 65 aa. (67 aa)
cspA-3Cold shock-like protein; Similar to Bordetella pertussis cold shock-like protein CspA SW:CSPA_BORPE (Q9Z5R4) (67 aa) fasta scores: E(): 1.2e-15, 71.66% id in 60 aa, and to Escherichia coli cold shock protein CspA or B3556 or Z4981 or Ecs4441 or Sty4153 SW:CSPA_ECOLI (P15277) (69 aa) fasta scores: E(): 6.2e-14, 68.42% id in 57 aa. (66 aa)
BP1783Conserved hypothetical protein; Similar to Pyrococcus abyssi AcaC protein or Pab0908 TR:Q9UYY6 (EMBL:AJ248287) (134 aa) fasta scores: E(): 1.3e-05, 29.83% id in 124 aa, and to Archaeoglobus fulgidus conserved hypothetical protein Af1292 TR:O28977 (EMBL:AE001015) (136 aa) fasta scores: E(): 3.8e-05, 29.66% id in 118 aa. (143 aa)
BP1930Similar to Rhizobium loti ABC transporter, ATP-binding protein Mll2948 TR:Q98HB1 (EMBL:AP003000) (371 aa) fasta scores: E(): 3.5e-46, 43.86% id in 367 aa, and to Pseudomonas aeruginosa probable ATP-binding component of ABC transporter Pa0603 TR:Q9I5T5 (EMBL:AE004496) (369 aa) fasta scores: E(): 8.6e-46, 43.37% id in 362 aa. (363 aa)
efpPutative elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa)
BP2100Similar to Caulobacter crescentus hypothetical protein CC1431 TR:Q9A8C3 (EMBL:AE005818) (488 aa) fasta scores: E(): 3e-65, 44.136% id in 469 aa. (495 aa)
BP2317Putative ribonuclease; Similar to a family of proteins involved in processing of the 5'end of 16S rRNA and implicated in the formation of cytoplasmic axial filaments during chromosome segregation and cell division, eg. Neisseria meningitidis cytoplasmic axial filament protein nmb1791 TR:Q9JY14 (EMBL:AE002529) (509 aa) fasta scores: E(): 5.2e-111, 60.41% id in 485 aa, and to Escherichia coli, and ribonuclease G CafA or Rng or b3247 or z4605 or ecs4119 SW:RNG_ECOLI (P25537) (488 aa) fasta scores: E(): 6.6e-98, 52.24% id in 490 aa. (487 aa)
BP2429Hypothetical protein; Involved in DNA repair and RecF pathway recombination. (195 aa)
BP2556Weakly similar to many proteins of undefined function e.g. Thermoplasma acidophilum hypothetical protein Ta1457 ta1457 TR:Q9HI85 (EMBL:AL445067) (135 aa) fasta scores: E(): 0.018, 25.210% id in 119 aa. (130 aa)
pheTSimilar to Escherichia coli phenylalanyl-tRNA synthetase beta chain PheT or B1713 SW:SYFB_ECOLI (P07395) (795 aa) fasta scores: E(): 3.9e-126, 45.735% id in 809 aa. (805 aa)
BP2642Putative ABC transport protein, inner membrane component (pseudogene); (C)3 in pertussis; (C)2 in parapertussis and bronchiseptica; Belongs to the ABC transporter superfamily. (362 aa)
rsgAPutative ATP/GTP-binding protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (300 aa)
BP2757Putative cold-shock protein; Similar to Salmonella typhimurium cold shock protein CspA SW:CSPA_SALTY (P37410) (69 aa) fasta scores: E(): 8.7e-15, 66.66% id in 66 aa. Also similar to many cold shock-like proteins e.g. Stigmatella aurantiaca cold shock-like protein CspA SW:CSPA_STIAU (P72366) (68 aa) fasta scores: E(): 6.8e-17, 72.3% id in 65 aa. (81 aa)
priBPrimosomal replication protein n; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (107 aa)
BP3002Similar to Neisseria meningitidis hypothetical protein NMA2205 TR:Q9JSP1 (EMBL:AL162758) (635 aa) fasta scores: E(): 1.2e-70, 40.63% id in 598 aa, and to Neisseria meningitidis ribonuclease II-related protein NMB0282 TR:Q9K185 (EMBL:AE002385) (626 aa) fasta scores: E(): 9.7e-70, 40.13% id in 598 aa. (627 aa)
BP3199Similar to Sulfolobus solfataricus hypothetical protein SSO2626 TR:Q97VJ8 (EMBL:AE006858) (128 aa) fasta scores: E(): 3.4e-05, 28.15% id in 103 aa. (129 aa)
ruvAHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (190 aa)
rnrPutative ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (826 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (696 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (125 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (93 aa)
infA-2Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
ssbSingle-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (166 aa)
BP3871Similar to Escherichia coli cold shock-like protein CspC SW:CSPC_ECOLI (P36996) (68 aa) fasta scores: E(): 1.1e-14, 62.9% id in 62 aa, and to Salmonella typhimurium cold shock protein CspA SW:CSPA_SALTY (P37410) (69 aa) fasta scores: E(): 1.1e-14, 64.06% id in 64 aa. Similar to BP1770, 60.606% identity (60.606% ungapped) in 66 aa overlap, BP2757, 62.295% identity (62.295% ungapped) in 61 aa overlap, BP1772, 59.677% identity (59.677% ungapped) in 62 aa overlap, and to BP0426, 54.545% identity (54.545% ungapped) in 66 aa overlap. (68 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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