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hisH hisH bhuR bhuR hurR hurR cyaC cyaC cyaA cyaA cyaB cyaB cyaD cyaD cyaE cyaE prn prn bvgS bvgS fhaB fhaB bapA bapA bopB bopB bopD bopD bopN bopN fauA fauA fhaS fhaS bfeA bfeA brkA brkA ptxB ptxB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisHAmidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (225 aa)
bhuROuter membrane heme receptor; Previously sequenced as Bordetella pertussis outer membrane heme receptor BhuR TR:AAK38153 (EMBL:AY032627) (149 aa) fasta scores: E(): 2.7e-49, 100.000% id in 149 aa. Similar to Rhizobium meliloti putative iron transport protein Smc02726 TR:CAC46967 (EMBL:AL591790) (743 aa) fasta scores: E(): 4.6e-37, 37.630% id in 768 aa. (845 aa)
hurRHeme uptake transmembrane sensor; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 1e-22, 32.459% id in 305 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa1911 TR:Q9I2J3 (EMBL:AE004617) (316 aa) fasta scores: E(): 2.4e-32, 41.118% id in 304 aa. (305 aa)
cyaCCyclolysin-activating lysine-acyltransferase; Involved in fatty acylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP; Belongs to the RTX toxin acyltransferase family. (185 aa)
cyaABifunctional hemolysin-adenylate cyclase precursor; This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function; In the C-terminal section; belongs to the RTX prokaryotic toxin family. (1706 aa)
cyaBCyclolysin secretion ATP-binding protein; Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family. (712 aa)
cyaDCyclolysin secretion protein; CyaD is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (440 aa)
cyaECyclolysin secretion protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (474 aa)
prnPertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. (910 aa)
bvgSVirulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals. (1238 aa)
fhaBFilamentous hemagglutinin/adhesin; Evidence for a role in host-cell binding and infection. (3590 aa)
bapAPutative autotransporter; Previously sequenced as Bordetella pertussis BapA protein BapA TR:Q9F4B4 (EMBL:AJ277632) (903 aa) fasta scores: E(): 0, 100% id in 903 aa. (903 aa)
bopBSimilar to Bordetella bronchiseptica outer protein B BopB TR:Q9REZ5 (EMBL:AF207789) (400 aa) fasta scores: E(): 2e-118, 96.75% id in 400 aa. (402 aa)
bopDSimilar to Bordetella bronchiseptica outer protein D BopD TR:Q9REZ6 (EMBL:AF207788) (313 aa) fasta scores: E(): 3.5e-86, 98.4% id in 313 aa. (313 aa)
bopNPutative outer protein N; Similar to many eg. Bordetella bronchiseptica outer protein N BopN TR:Q9REZ4 (EMBL:AF207790) (365 aa) fasta scores: E(): 4.3e-132, 99.17% id in 365 aa, and to Pseudomonas syringae hypersensitivity response secretion protein HrpJ SW:HRPJ_PSESY (Q05395) (346 aa) fasta scores: E(): 5e-08, 26.94% id in 308 aa. (365 aa)
fauAPreviously sequenced Bordetella pertussis ferric alcaligin siderophore receptor FauA TR:Q9X6A5 (EMBL:AF135154) (734 aa) fasta scores: E(): 0, 100% id in 734 aa. (734 aa)
fhaSAdhesin; Highly similar to Bordetella pertussis filamentous hemagglutinin FhaB or BP1879 SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 6.4e-175, 48.23% id in 2606 aa, and to Bordetella bronchiseptica adhesin FhaB TR:Q9JP78 (EMBL:AF111796) (3634 aa) fasta scores: E(): 2.7e-173, 46.99% id in 2679 aa. The product of this CDS is also similar to B. pertussis BP2907 E(): 9.8e-120 37.940% identity in 2670 aa. (2553 aa)
bfeAFerric enterobactin receptor; Previously sequenced as Bordetella pertussis ferric enterobactin receptor BfeA TR:Q45341 (EMBL:U13950) (735 aa) fasta scores: E(): 0, 99.72% id in 737 aa. (737 aa)
brkASerum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. (1010 aa)
ptxBPertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. (226 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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