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bvgA bvgA bvgR bvgR fabG-3 fabG-3 fabG-2 fabG-2 BP1352 BP1352 tcfA tcfA fabG fabG fim2 fim2 prn prn cheZ cheZ htpG htpG rubA rubA gabD gabD gabD-2 gabD-2 flhD flhD rpoH rpoH glcC glcC glcB glcB risA risA ahpC ahpC tonB tonB cpn10 cpn10 cpn60 cpn60 brkA brkA fabG-5 fabG-5 recA recA dnaK dnaK fabG-4 fabG-4 prpC prpC mdH mdH gltA gltA hfq hfq BP2094 BP2094 acnA acnA gabD-3 gabD-3 fhaB fhaB bvgS bvgS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
bvgAVirulence factors transcription regulator; Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes. (209 aa)
bvgRRegulatory protein BvgR; Previously sequenced as Bordetella pertussis BvgR TR:O85677 (EMBL:AF071567) (291 aa) fasta scores: E(): 5.1e-121, 100% id in 291 aa. (291 aa)
fabG-3Similar to Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase FabG or B1093 SW:FABG_ECOLI (P25716) (244 aa) fasta scores: E(): 3.3e-24, 36.69% id in 248 aa, and to Thermotoga maritima 3-oxoacyl-[acyl-carrier protein] reductase FabG or Tm1724 SW:FABG_THEMA (Q9X248) (246 aa) fasta scores: E(): 2.2e-27, 41.5% id in 253 aa. (258 aa)
fabG-2Similar to Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase FabG or B1093 SW:FABG_ECOLI (P25716) (244 aa) fasta scores: E(): 7.6e-21, 34.69% id in 245 aa, and to Agrobacterium tumefaciens Agr_l_2601p agr_l_2601 TR:AAK89866 (EMBL:AE008330) (246 aa) fasta scores: E(): 7.2e-29, 44.13% id in 247 aa. (251 aa)
BP1352Putative exported protein (pseudogene); Signal peptide predicted for BP1351 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.996 between residues 17 and 18. (265 aa)
tcfATracheal colonization factor precursor; Identical to the previously sequenced Bordetella pertussis tracheal colonization factor precursor Tcfa2 TR:O86135 (EMBL:AJ009785) (647 aa) fasta scores: E(): 1.7e-171, 99.84% id in 647 aa. (647 aa)
fabGSimilar to Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase FabG or B1093 SW:FABG_ECOLI (P25716) (244 aa) fasta scores: E(): 6e-23, 38.73% id in 253 aa, and to Pseudomonas aeruginosa 3-oxoacyl-[acyl-carrier protein] reductase FabG or Pa2967 SW:FABG_PSEAE (O54438) (247 aa) fasta scores: E(): 5.2e-25, 40.07% id in 252 aa. (252 aa)
fim2Serotype 2 fimbrial subunit precursor; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (210 aa)
prnPertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. (910 aa)
cheZChemotaxis protein CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (210 aa)
htpGtRNA-Leu; Molecular chaperone. Has ATPase activity. (635 aa)
rubARubredoxin; Similar to Acinetobacter calcoaceticus rubredoxin RubA SW:RUBR_ACICA (P42453) (54 aa) fasta scores: E(): 1.2e-15, 55.556% id in 54 aa, and to Pseudomonas aeruginosa rubredoxin Pa5350 TR:Q9HTK8 (EMBL:AE004947) (55 aa) fasta scores: E(): 6.2e-16, 62.963% id in 54 aa. (54 aa)
gabDTransposase (Pseudogene); Inverted repeat for IS481 element; Belongs to the aldehyde dehydrogenase family. (493 aa)
gabD-2Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or B2661 SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 1.3e-46, 35.532% id in 470 aa, and to Bacillus halodurans NADP-dependent glyceraldehyde-3-phosphate dehydrogenase Bh1738 TR:Q9KC36 (EMBL:AP001513) (482 aa) fasta scores: E(): 7.4e-67, 40.812% id in 468 aa. (484 aa)
flhDFlagellar transcriptional activator FlbB; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (107 aa)
rpoHRNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (307 aa)
glcCGntR-family transcriptional regulator (pseudogene); (A)2 in pertussis; (A)1 in parapertussis and bronchiseptica. (375 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
risASensor kinase protein (pseudogene); (C)3 in pertussis; (C)2 in parapertussis and bronchiseptica. (244 aa)
ahpCSimilar to Streptomyces coelicolor alkyl hydroperoxide reductase AhpC SWALL:Q9RN72 (EMBL:AF186371) (184 aa) fasta scores: E(): 9.6e-31, 51.09% id in 182 aa, and to Ralstonia solanacearum putative alkyl hydroperoxide reductase AhpC2 or rsc1646 or rs04022 SWALL:Q8XYW0 (EMBL:AL646065) (230 aa) fasta scores: E(): 2.4e-63, 85.16% id in 182 aa. (182 aa)
tonBSiderophore-mediated iron transport protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (266 aa)
cpn1010 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
cpn6060 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (547 aa)
brkASerum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. (1010 aa)
fabG-5Similar to Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase FabG or B1093 SW:FABG_ECOLI (P25716) (244 aa) fasta scores: E(): 3.5e-29, 41.597% id in 238 aa. (248 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
dnaKMolecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (641 aa)
fabG-43-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa)
prpCProbable methylisocitrate lyase (pseudogene); (C)4 inpertussis; (C)2 in parapertussis and bronchiseptica; Belongs to the citrate synthase family. (400 aa)
mdHMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
gltAPutative membrane protein (pseudogene); Signal peptide predicted for BP2356 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.447 between residues 33 and 34; Belongs to the citrate synthase family. (436 aa)
hfqPutative RNA-binding regulatory protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (78 aa)
BP2094Putative 3-oxoacyl-CoA or-ACP reductase; Similar to many e.g. Zoogloea ramigera acetoacetyl-CoA reductase phbB SW:PHBB_ZOORA (P23238) (241 aa) fasta scores: E(): 1.7e-24, 41.494% id in 241 aa and to Vibrio cholerae 3-oxoacyl-[acyl-carrier protein] reductase fabG or VC2021 SW:FABG_VIBCH (Q9KQH7) (244 aa) fasta scores: E(): 2.4e-23, 41.176% id in 238 aa. (240 aa)
acnAPutative aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
gabD-3Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or B2661 SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 7e-125, 66.66% id in 480 aa, and to Alcaligenes eutrophus succinate semialdehyde dehydrogenase GabD TR:Q9RBF6 (EMBL:AF175740) (483 aa) fasta scores: E(): 2.8e-127, 66.87% id in 480 aa. (489 aa)
fhaBFilamentous hemagglutinin/adhesin; Evidence for a role in host-cell binding and infection. (3590 aa)
bvgSVirulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals. (1238 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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