STRINGSTRING
fhaL fhaL rpoB rpoB BP0119 BP0119 BP0122 BP0122 BP0546 BP0546 BP0649 BP0649 bfrF bfrF bfrE bfrE prn prn BP1139 BP1139 BP1155 BP1155 livF-2 livF-2 livJ livJ fim3 fim3 BP1675 BP1675 bvgS bvgS bvgA bvgA fimD fimD fhaC fhaC bfrI bfrI BP2226 BP2226 BP2227 BP2227 alr alr BP2229 BP2229 brpL brpL bscN bscN bscL bscL bscK bscK bscJ bscJ bopB bopB bopD bopD bcrH1 bcrH1 bsp22 bsp22 bopN bopN BP2258 BP2258 BP2259 BP2259 BP2260 BP2260 bcrD bcrD bscE bscE bscF bscF BP2265 BP2265 fhaS fhaS putA putA BP3568 BP3568 BP3577 BP3577 rpsL rpsL rpoA rpoA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fhaLAdhesin; Similar to Bordetella bronchiseptica adhesin FhaB or BP1879 TR:Q9JP78 (EMBL:AF111796) (3634 aa)fasta scores: E(): 9e-125, 33.527% id in 2750 aa and to Bordetella pertussis filamentous hemagglutinin fhaB SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 1.4e-123, 33.67% id in 2705 aa. The product of this CDS is also similar to B. pertussis BP2667 E(): 7.1e-117, 37.949% identity in 2672 aa. (4196 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1370 aa)
BP0119Inner membrane component of binding-protein-dependent transport system; Similar to Thermotoga maritima sugar ABC transporter, permease protein Tm0598 TR:Q9WZ67 (EMBL:AE001734) (277 aa) fasta scores: E(): 3.9e-36, 43.860% id in 228 aa, and to Rhizobium meliloti putative sugar ABC transporter permease protein Smb20233 TR:CAC48624 (EMBL:AL603642) (282 aa) fasta scores: E(): 2.5e-30, 34.717% id in 265 aa. (266 aa)
BP0122Sugar ABC transporter, ATP-binding protein; Similar to Thermococcus litoralis trehalose/maltose transport ATP-hydrolyzing subunit MalK TR:Q9V306 (EMBL:AF126010) (372 aa) fasta scores: E(): 7.4e-44, 45.205% id in 365 aa, and to Rhizobium meliloti probable glycerol-3-phosphate ABC transporter ATP-binding protein TR:CAC48805 (EMBL:AL603643) (349 aa) fasta scores: E(): 2.1e-49, 50.000% id in 352 aa. (346 aa)
BP0546Bacterioferritin; Similar to Azotobacter vinelandii bacterioferritin Bfr SW:BFR_AZOVI (P22759) (156 aa) fasta scores: E(): 3.5e-05, 30.345% id in 145 aa, and to Pseudomonas aeruginosa probable bacterioferritin Pa4880 TR:Q9HUT3 (EMBL:AE004901) (177 aa) fasta scores: E(): 3.7e-41, 71.084% id in 166 aa. (189 aa)
BP0649Conserved hypothetical protein (Pseudogene); (CGCGG)2 in pertussis; (CGCGG)3 in bronchiseptica. (323 aa)
bfrFSimilar to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or B0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 7.8e-38, 40.000% id in 725 aa, and to Pseudomonas aeruginosa probable hydroxamate-type ferrisiderophore receptor Pa0470 TR:Q9I648 (EMBL:AE004484) (802 aa) fasta scores: E(): 1.4e-103, 40.000% id in 815 aa. (814 aa)
bfrEProbable TonB-dependent receptor for iron transport; Similar to Pseudomonas aeruginosa hydroxamate-type ferrisiderophore receptor PiuA or Fiu or Pa4514 TR:O68590 (EMBL:AF051690) (753 aa) fasta scores: E(): 3.4e-106, 43.742% id in 775 aa, and to Escherichia coli probable TonB-dependent receptor YbiL precursor YbiL or B0805 SW:YBIL_ECOLI (P75780) (760 aa) fasta scores: E(): 7.2e-50, 35.058% id in 773 aa. (752 aa)
prnPertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. (910 aa)
BP1139Putative iron uptake protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa0800 TR:Q9I5D8 (EMBL:AE004515) (177 aa) fasta scores: E(): 1.4e-08, 44.82% id in 87 aa. (102 aa)
BP1155Putative regulatory protein; Similar to Synechocystis sp nitrogen assimilation regulatory protein Slr1529 TR:P74210 (EMBL:D90913) (835 aa) fasta scores: E(): 1.5e-09, 26.03% id in 434 aa, and to Achromobacter cycloclastes regulatory protein NosR TR:O68476 (EMBL:AF047429) (731 aa) fasta scores: E(): 0.05, 24.9% id in 261 aa, and to Rhizobium meliloti regulatory protein NosR TR:O68483 (EMBL:AF047430) (755 aa) fasta scores: E(): 1.4, 24.9% id in 249 aa. (459 aa)
livF-2Putative aspartate racemase (Pseudogene); Pseudogene. This CDS appears to be missing the N-terminal region, this is probably due to the a large deletion immediately upstream. Similar to Shigella flexneri 2a hypothetical 25.4 kDa protein TR:AAL08433 (EMBL:AF326777) (229 aa) fasta scores: E(): 1.5e-07, 36.11% id in 108 aa, and to Pyrococcus abyssi aspartate racemase RacD-1 or pab0912 TR:Q9UYY1 (EMBL:AJ248287) (228 aa) fasta scores: E(): 9.8e-06, 31.42% id in 105 aa. Also similar to the C-terminus of BP0053, 55.140% identity (55.140% ungapped) in 107 aa overlap. (233 aa)
livJSimilar to Escherichia coli leu/ile/val-binding protein precursor LivJ or B3460 SW:LIVJ_ECOLI (P02917) (367 aa) fasta scores: E(): 7.4e-64, 48.05% id in 360 aa, and to Pseudomonas aeruginosa leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor BraC or Pa1074 SW:BRAC_PSEAE (P21175) (373 aa) fasta scores: E(): 1.6e-72, 52.02% id in 371 aa. (371 aa)
fim3Serotype 3 fimbrial subunit precursor; Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process; Belongs to the fimbrial protein family. (204 aa)
BP1675Putative exported protein; Similar to Comamonas testosteroni OrfJ protein TR:Q9RHM9 (EMBL:AB029044) (326 aa) fasta scores: E(): 4.8e-32, 34.47% id in 322 aa, and to Alcaligenes eutrophus hypothetical 35.7 kDa protein MacB TR:Q9RBG2 (EMBL:AF130250) (340 aa) fasta scores: E(): 3.3e-30, 35.87% id in 315 aa. (320 aa)
bvgSVirulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals. (1238 aa)
bvgAVirulence factors transcription regulator; Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes. (209 aa)
fimDFimbrial adhesin; Previously sequenced as Bordetella pertussis protein FhaE precursor FhaE or FimD SW:FHAE_BORPE (Q00879) (376 aa) fasta scores: E(): 1.9e-143, 100% id in 365 aa. (365 aa)
fhaCHemolysin activator-like protein; Member of a two partner secretion pathway (TPS) in which it mediates the secretion of filamentous hemagglutinin FHA (fhaB). Belongs to the TPS (TC 1.B.20) family. (584 aa)
bfrIPutative ferrisiderophore receptor; Similar to Pseudomonas aeruginosa hydroxamate-type ferrisiderophore receptor FiuA TR:O68595 (EMBL:AF051691) (802 aa) fasta scores: E(): 1.7e-71, 36.83% id in 714 aa, and to Salmonella typhimurium ferrichrome iron receptor FhuA TR:O86925 (EMBL:Y14025) (729 aa) fasta scores: E(): 2e-65, 35.72% id in 725 aa. (702 aa)
BP2226Similar to Bacillus subtilis anti-sigma F factor antagonist spoIIAa SW:SP21_BACSU (P10727) (116 aa) fasta scores: E(): 1.1e-06, 30.84% id in 107 aa; Belongs to the anti-sigma-factor antagonist family. (116 aa)
BP2227Putative anti-sigma factor; Similar to Chlamydia muridarum RsbW protein, putative tc0837 TR:Q9PJJ2 (EMBL:AE002350) (152 aa) fasta scores: E(): 6.3e-05, 28.57% id in 126 aa, and to Bacillus subtilis anti-sigma b factor RsbW SW:RSBW_BACSU (P17904) (160 aa) fasta scores: E(): 0.16, 23.88% id in 134 aa. (142 aa)
alrAlanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (387 aa)
BP2229Putative inner membrane transport protein; Similar to Pseudomonas aeruginosa probable MFS transporter pa4096 TR:Q9HWT2 (EMBL:AE004826) (419 aa) fasta scores: E(): 1.1e-10, 28.57% id in 406 aa, and to Streptomyces coelicolor putative integral membrane transport protein SCI30a.30c TR:Q9S243 (EMBL:AL096811) (463 aa) fasta scores: E(): 1.6e-09, 27.27% id in 396 aa. (828 aa)
brpLSimilar to Erwinia amylovora putative RNA polymerase sigma factor HrpL SWALL:Q46616 (EMBL:U36244) (182 aa) fasta scores: E(): 5.7e-14, 37.41% id in 155 aa, and to Escherichia coli RNA polymerase sigma-E factor RpoE or SigE or B2573 or Z3855 or Ecs3439 SWALL:RPOE_ECOLI (SWALL:P34086) (191 aa) fasta scores: E(): 7.9e-14, 36.09% id in 169 aa; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa)
bscNPutative ATP synthase in type III secretion system; Similar to many eg. Bordetella bronchiseptica BscN TR:O68539 (EMBL:AF049488) (444 aa) fasta scores: E(): 2.6e-162, 99.32% id in 444 aa, and to Pseudomonas aeruginosa ATP synthase in type III secretion system pa1697 TR:Q9I330 (EMBL:AE004596) (440 aa) fasta scores: E(): 1.8e-103, 68.19% id in 415 aa. (444 aa)
bscLPutative type III secretion protein; Similar to many eg. Bordetella bronchiseptica BscL TR:O68538 (EMBL:AF049488) (212 aa) fasta scores: E(): 8e-72, 98.58% id in 212 aa, and to Pseudomonas aeruginosa type III export protein PscL or pa1725 TR:Q9I312 (EMBL:AE004598) (214 aa) fasta scores: E(): 2.6e-23, 42.56% id in 195 aa. (212 aa)
bscKConserved hypothetical protein; Similar to Bordetella bronchiseptica BscK TR:O68537 (EMBL:AF049488) (220 aa) fasta scores: E(): 9.4e-87, 98.18% id in 220 aa. (220 aa)
bscJPutative type III secretion protein; Similar to many eg. Bordetella bronchiseptica BscJ TR:O68536 (EMBL:AF049488) (274 aa) fasta scores: E(): 4.5e-97, 98.17% id in 274 aa, and to Erwinia amylovora harpin secretion HrcJ precursor TR:Q46620 (EMBL:U56662) (260 aa) fasta scores: E(): 2.7e-29, 44.89% id in 245 aa. (274 aa)
bopBSimilar to Bordetella bronchiseptica outer protein B BopB TR:Q9REZ5 (EMBL:AF207789) (400 aa) fasta scores: E(): 2e-118, 96.75% id in 400 aa. (402 aa)
bopDSimilar to Bordetella bronchiseptica outer protein D BopD TR:Q9REZ6 (EMBL:AF207788) (313 aa) fasta scores: E(): 3.5e-86, 98.4% id in 313 aa. (313 aa)
bcrH1Similar to Pseudomonas aeruginosa regulatory protein PcrH or pa1707 TR:Q9I325 (EMBL:AE004597) (167 aa) fasta scores: E(): 1.4e-12, 37.41% id in 155 aa, and to Yersinia pestis low calcium response locus protein H LcrH or ypcd1.30c or y0051 SW:LCRH_YERPE (P21207) (168 aa) fasta scores: E(): 4.7e-08, 31.66% id in 120 aa. (161 aa)
bsp22Putative secreted protein; Strongly similar to Bordetella bronchiseptica secreted protein 22 Bsp22 TR:Q9REZ7 (EMBL:AF207787) (205 aa) fasta scores: E(): 4.1e-68, 96.58% id in 205 aa. (205 aa)
bopNPutative outer protein N; Similar to many eg. Bordetella bronchiseptica outer protein N BopN TR:Q9REZ4 (EMBL:AF207790) (365 aa) fasta scores: E(): 4.3e-132, 99.17% id in 365 aa, and to Pseudomonas syringae hypersensitivity response secretion protein HrpJ SW:HRPJ_PSESY (Q05395) (346 aa) fasta scores: E(): 5e-08, 26.94% id in 308 aa. (365 aa)
BP2258Hypothetical protein; No significant database matches. (125 aa)
BP2259Conserved hypothetical protein; Similar to Pseudomonas aeruginosa pcr3 pcr3 or pa1701 TR:O30534 (EMBL:AF010150) (121 aa) fasta scores: E(): 0.52, 31.49% id in 127 aa. (136 aa)
BP2260Conserved hypothetical protein; Similar to Bradyrhizobium japonicum Id192 TR:Q9ANI6 (EMBL:AF322012) (142 aa) fasta scores: E(): 0.99, 29.2% id in 113 aa, and to Chlamydia muridarum type III secretion chaperone, putative tc0546 TR:Q9PKC0 (EMBL:AE002323) (139 aa) fasta scores: E(): 5.1, 31.13% id in 106 aa. (122 aa)
bcrDPutative type III secretion pore protein; Similar to many eg. Chlamydophila caviae Cds2 protein TR:O34019 (EMBL:U88070) (709 aa) fasta scores: E(): 6e-116, 47.14% id in 700 aa, and to Salmonella typhimurium Invasion protein InvA SW:INVA_SALTY (P35657) (665 aa) fasta scores: E(): 1.4e-90, 43.96% id in 671 aa. Also similar to BP1367, 36.510% identity (38.426% ungapped) in 682 aa overlap. (699 aa)
bscEHypothetical protein; No significant database matches. (99 aa)
bscFSimilar to Pseudomonas aeruginosa putative type III secretion protein PscF or pa1719 TR:P95434 (EMBL:U56077) (85 aa) fasta scores: E(): 0.013, 27.9% id in 86 aa. (88 aa)
BP2265Hypothetical protein; No significant database matches. (151 aa)
fhaSAdhesin; Highly similar to Bordetella pertussis filamentous hemagglutinin FhaB or BP1879 SW:FHAB_BORPE (P12255) (3591 aa) fasta scores: E(): 6.4e-175, 48.23% id in 2606 aa, and to Bordetella bronchiseptica adhesin FhaB TR:Q9JP78 (EMBL:AF111796) (3634 aa) fasta scores: E(): 2.7e-173, 46.99% id in 2679 aa. The product of this CDS is also similar to B. pertussis BP2907 E(): 9.8e-120 37.940% identity in 2670 aa. (2553 aa)
putABifunctional proline oxidoreductase/transcriptional repressor; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1273 aa)
BP3568Putative exported protein; N-terminus is similar to the N-terminal region of Salmonella typhimurium Leu/Ile/Val/Thr-binding protein precursor LivJ SW:LIVJ_SALTY (P17215) (365 aa) fasta scores: E(): 3.1e-06, 23.12% id in 294 aa. Full length CDS is similar to Deinococcus radiodurans branched-chain amino acid ABC transporter, periplasmic amino acid- binding protein DRA0263 TR:Q9RYP6 (EMBL:AE001863) (424 aa) fasta scores: E(): 4.5e-83, 57.25% id in 400 aa. Similar to BP1506, 52.926% identity (53.495% ungapped) in 376 aa overlap. (387 aa)
BP3577ABC transporter ATP-binding protein; Similar to Pseudomonas aeruginosa high-affinity branched-chain amino acid transport ATP-binding protein BraF SW:BRAF_PSEAE (P21629) (255 aa) fasta scores: E(): 2.7e-27, 39.84% id in 256 aa, and to Rhizobium meliloti putative ATP-binding ABC transporter protein SMC03120 TR:CAC47552 (EMBL:AL591792) (262 aa) fasta scores: E(): 4.8e-45, 57.61% id in 243 aa. (257 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (125 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (328 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.