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phoR phoR htpG htpG BP0157 BP0157 mutL mutL BP0501 BP0501 BP0571 BP0571 BP0992 BP0992 cheA cheA BP1092 BP1092 glnL glnL bvgS bvgS BP2206 BP2206 kdpD kdpD BP2548 BP2548 BP2935 BP2935 BP3137 BP3137 BP3223 BP3223 BP3535 BP3535 BP3866 BP3866
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phoRSimilar to Escherichia coli phosphate regulon sensor protein PhoR or NmpB or B0400 SW:PHOR_ECOLI (P08400) (431 aa) fasta scores: E(): 1e-55, 41.458% id in 439 aa, and to Klebsiella pneumoniae phosphate regulon sensor protein PhoR SW:PHOR_KLEPN (P45608) (431 aa) fasta scores: E(): 3.2e-55, 40.961% id in 437 aa. (436 aa)
htpGtRNA-Leu; Molecular chaperone. Has ATPase activity. (635 aa)
BP0157Two-component sensor kinase; Member of a two-component regulatory system. (465 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (629 aa)
BP0501C-terminal region of two component sensor kinase (partial); Partial. This CDS is the C-terminal region of BP3351 which was disrupted by the integration of a prophage. Similar to Salmonella enterica TctE TR:Q9FA47 (EMBL:AF020810) (488 aa) fasta scores: E(): 1.5e-21, 30.079% id in 379 aa, and to Pseudomonas aeruginosa probable two-component sensor Pa0757 TR:Q9I5H2 (EMBL:AE004510) (460 aa) fasta scores: E(): 4.6e-24, 37.500% id in 376 aa. (425 aa)
BP0571Putative two-component sensor kinase; Similar to Azorhizobium caulinodans nitrogen regulation protein NtrY SW:NTRY_AZOCA (Q04850) (771 aa) fasta scores: E(): 8.8e-14, 29.107% id in 773 aa, and to Neisseria meningitidis nitrogen regulation protein NtrY, putative Nmb0114 TR:Q9K1K3 (EMBL:AE002370) (706 aa) fasta scores: E(): 6.2e-41, 37.748% id in 755 aa. (769 aa)
BP0992Tw-component sensor kinase; Similar to Azorhizobium caulinodans sensor protein FixL SW:FIXL_AZOCA (P26489) (504 aa) fasta scores: E(): 1.7e-37, 47.893% id in 261 aa, and to Caulobacter crescentus sensory box histidine kinase FixL Cc0759 TR:Q9AA47 (EMBL:AE005751) (504 aa) fasta scores: E(): 2.4e-35, 45.059% id in 253 aa. (584 aa)
cheAChemotaxis protein CheY (Pseudogene); HMMPfam hit to PF00072, Response regulator receiver domain. (685 aa)
BP1092Probable two-component histidine kinase; Similar to Escherichia coli sensor protein KdpD or B0695 SW:KDPD_ECOLI (P21865) (894 aa) fasta scores: E(): 6.1e-11, 30.9% id in 233 aa, and to Pseudomonas aeruginosa hypothetical protein Pa1433 TR:Q9I3R4 (EMBL:AE004573) (650 aa) fasta scores: E(): 2.9e-27, 24.77% id in 654 aa. (949 aa)
glnLSimilar to Escherichia coli nitrogen regulation protein NR(II) GlnL or NtrB or GlnR or B3869 or Z5405 or Ecs4791 SW:NTRB_ECOLI (P06712) (349 aa) fasta scores: E(): 2.4e-37, 41.42% id in 350 aa, and to Herbaspirillum seropedicae histidine kinase NtrB TR:O86056 (EMBL:AF082873) (364 aa) fasta scores: E(): 3e-55, 48.59% id in 356 aa. (358 aa)
bvgSVirulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals. (1238 aa)
BP2206Putative two-component response regulator (pseudogene); 20 bp deletion in pertussis, relative to parapertussis and bronchiseptica, following this codon. (449 aa)
kdpDSimilar to Escherichia coli sensor protein KdpD or b0695 SW:KDPD_ECOLI (P21865) (894 aa) fasta scores: E(): 1.2e-68, 46.35% id in 863 aa and to Burkholderia solanacearum probable two-component sensor kinase KdpD transcription regulator protein TR:CAD16882 (EMBL:AL646075) (937 aa) fasta scores: E(): 1.6e-84, 58.87% id in 885 aa. (904 aa)
BP2548Similar to several two-component system, histidine kinases e.g. Rhizobium loti Mll7952 TR:Q984L4 (EMBL:AP003013) (452 aa) fasta scores: E(): 1.3e-44, 37.360% id in 447 aa and Salmonella typhi TctE TR:O68289 (EMBL:AF029846) (439 aa) fasta scores: E(): 1.2e-29, 32.576% id in 396 aa. (452 aa)
BP2935Similar to many two component system histidine kinases including: Xylella fastidiosa two-component system Xf2577 TR:Q9PAE1 (EMBL:AE004064) (405 aa) fasta scores: E(): 2.1e-72, 52.76% id in 398 aa and to Rhodobacter sphaeroides sensor histidine kinase RegB or PrrB SW:REGB_RHOSH (Q53068) (462 aa) fasta scores: E(): 1.6e-15, 29.06% id in 406 aa. (403 aa)
BP3137Putative two-component system sensor protein; Similar to Pseudomonas aeruginosa probable two-component sensor PA4380 TR:Q9HW22 (EMBL:AE004854) (426 aa) fasta scores: E(): 2.4e-23, 29.38% id in 439 aa. (440 aa)
BP3223Similar to Pseudomonas aeruginosa two-component sensor EnvZ or PA5199 TR:Q9HTZ0 (EMBL:AE004932) (439 aa) fasta scores: E(): 5.9e-24, 31.87% id in 480 aa, and to Bordetella pertussis, Bordetella bronchiseptica, Bordetella avium, and Bordetella parapertussis RisS protein TR:O88100 (EMBL:AJ224799) (474 aa) fasta scores: E(): 4.6e-22, 34.2% id in 307 aa. (474 aa)
BP3535Sensor kinase protein; Two-component regulatory system family, sensor kinase protein. No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Escherichia coli sensor protein BasS SW:BASS_ECOLI (P30844) (363 aa) fasta scores: E(): 5.4e-19, 32.29% id in 288 aa, and Rhizobium loti two-component system, sensor protein MLL7952 TR:Q984L4 (EMBL:AP003013) (452 aa) fasta scores: E(): 3.9e-28, 38.83% id in 291 aa. (372 aa)
BP3866Two-component regulatory system family, sensor kinase protein. Similar to Burkholderia solanacearum putative transmembrane sensor kinase transcription regulator protein RSC2936 TR:CAD16643 (EMBL:AL646072) (500 aa) fasta scores: E(): 2e-59, 45.27% id in 466 aa, and to Pseudomonas aeruginosa probable two-component sensor PA0757 TR:Q9I5H2 (EMBL:AE004510) (460 aa) fasta scores: E(): 2.8e-41, 36.2% id in 453 aa. (487 aa)
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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