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| | hisE1 | Putative phosphoribosyl-ATP pyrophosphatase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (107 aa) |
| | mtnP | Putative 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (291 aa) |
| | eIF-2B | Translation initiation factor, aIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (374 aa) |
| | argD2 | Putative acetylornithine aminotransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (420 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (310 aa) |
| | argH | Argininosuccinate lyase, (ASAL); Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (465 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | hisE2 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase. (131 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (553 aa) |
| | fucA | L-fuculose phosphate aldolase. (228 aa) |
| | nifV | Putative homocitrate synthase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa) |
| | RPA4599 | Conserved hypothetical protein; InterPro IPR006163. (90 aa) |
| | RPA4597 | Possible seryl-tRNA synthetase. (313 aa) |
| | RPA4593 | Possible branched-chain amino acid aminotransferase. (294 aa) |
| | metY-2 | Homocysteine synthase. (434 aa) |
| | metAS | Possible homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (333 aa) |
| | RPA4568 | Putative enoyl-acyl carrier protein reductase. (253 aa) |
| | apbA/panE | Putative 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (301 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | trpG | Putative lemA protein; Authentic frameshift, lemA pseudogene. (719 aa) |
| | tyrC | Putative cyclohexadienyl dehydrogenase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (313 aa) |
| | hisC | Putative histidinol-phosphate aminotransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (400 aa) |
| | ilvE | Putative branched-chain amino acid aminotransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (370 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (280 aa) |
| | aroE | Putative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (278 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (390 aa) |
| | serA2 | Putative phosphoglycerate dehydrogenase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | RPA4297 | Putative aldose reductase. (274 aa) |
| | thrB | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. (327 aa) |
| | oahs | O-acetylhomoserine sulfhydrylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (435 aa) |
| | RPA4213 | Sulfite reductase hemoprotein subunit; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (551 aa) |
| | glnA-2 | Glutamine synthetase II; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (345 aa) |
| | RPA4178 | Conserved unknown protein; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (95 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the CarB family. (1109 aa) |
| | RPA4052 | Possible 3-dehydroquinate synthase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (372 aa) |
| | RPA4024 | Methionine synthase, vitamin-B12 independent; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (373 aa) |
| | RPA4018 | UDP-glucose-6-dehydrogenase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (436 aa) |
| | RPA3999 | Possible coenzyme PQQ synthesis protein E. (347 aa) |
| | RPA3735 | Conserved unknown protein; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (386 aa) |
| | argD1 | Putative N-acetylornithine aminotransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (463 aa) |
| | nirA | Possible ferredoxin-nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (590 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1293 aa) |
| | metF | Putative 5,10-methylenetetrahydrofolate reductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the methylenetetrahydrofolate reductase family. (295 aa) |
| | RPA3695 | Chorismate mutase/prephenate dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (280 aa) |
| | RPA3624 | Possible gluconolactonase precursor; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (309 aa) |
| | dyr | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (180 aa) |
| | ilvD1 | Dihydroxy-acid dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the IlvD/Edd family. (602 aa) |
| | RPA3464 | Conserved hypothetical protein; COGs COG2030. (294 aa) |
| | RPA3455 | Possible methylmalonyl-CoA decarboxylase alpha chain. (519 aa) |
| | RPA3436 | GCN5-related N-acetyltransferase. (169 aa) |
| | cysE2 | Serine acetyltransferase. (275 aa) |
| | his3 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (151 aa) |
| | RPA3324 | Hypothetical protein; InterPro IPR000183. (289 aa) |
| | pccB | propionyl-CoA carboxylase beta chain; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (510 aa) |
| | RPA3190 | Possible dihydrodipicoline synthase related protein; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the DapA family. (317 aa) |
| | RPA3174 | Conserved unknown protein; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family. (288 aa) |
| | yafB | Putative aldose reductase. (277 aa) |
| | panC | Putative pantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa) |
| | RPA3121 | Putative alginate o-acetyltransferase AlgI; Belongs to the membrane-bound acyltransferase family. (470 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa) |
| | RPA3085 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (413 aa) |
| | fabD | Putative malonyl CoA-acyl carrier protein transacylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (319 aa) |
| | acpP | Constitutive acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa) |
| | fabF | 3-oxoacyl-acyl carrier protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (421 aa) |
| | RPA3040 | Unknown protein. (187 aa) |
| | argE | Possible acetylornitine deacetylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (426 aa) |
| | dapA1-2 | Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (307 aa) |
| | RPA2989 | Putative quinone oxidoreductase. (333 aa) |
| | serA1 | Putative phosphoglycerate dehydrogenase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | bioF | 8-amino-7-oxononanoate synthase. (376 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (212 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (425 aa) |
| | glnA | Glutamine synthetase I; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (469 aa) |
| | fabZ | Possible (3R)-hydroxymyristoyl-acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the TrpC family. (287 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the KdsA family. (287 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (434 aa) |
| | glyA2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa) |
| | RPA2763 | Putative O-acetylhomoserine sulfhydrylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (426 aa) |
| | fabH | 3-oxoacyl-acyl carrier protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (325 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (353 aa) |
| | glyA1 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (432 aa) |
| | acpS | Acyl carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (146 aa) |
| | dapA2-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | RPA2614 | Conserved hypothetical protein. (425 aa) |
| | lipA2 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (319 aa) |
| | RPA2578 | Possible alginate o-acetyltransferase AlgJ. (377 aa) |
| | RPA2577 | Putative alginate o-acetyltransferase AlgI; Belongs to the membrane-bound acyltransferase family. (489 aa) |
| | RPA2568 | O-acetylserine (thiol) lyase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (345 aa) |
| | RPA2565 | O-acetylserine (thiol) lyase C-terminal portion. (45 aa) |
| | RPA2538 | Putative acyl-CoA carboxylase, beta chain; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (551 aa) |
| | HDH | Putative homoserine dehydrogenase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (441 aa) |
| | argC | N-acetylglutamate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (331 aa) |
| | aroQ2 | 3-dehydroquinate dehydratase type 2; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | accB | Putative biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (164 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (788 aa) |
| | prpB | Putative carboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (305 aa) |
| | RPA2387 | Conserved hypothetical protein. (436 aa) |
| | RPA2362 | Putative O-acetylhomoserine sulfhydrylase. (437 aa) |
| | RPA2356 | Putative cystathionine beta-synthase. (465 aa) |
| | mtnD | Conserved hypothetical protein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (165 aa) |
| | metC | Putative O-acetylhomoserine sulfhydrylase. (433 aa) |
| | metY | Putative homocysteine synthase. (397 aa) |
| | ilvD | Putative dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa) |
| | RPA2325 | Possible acetylornithine deacetylase. (432 aa) |
| | RPA2181 | Possible metE (5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase); Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (340 aa) |
| | RPA2166 | Conserved hypothetical protein. (94 aa) |
| | ilvD3 | Dihydroxy-acid dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the IlvD/Edd family. (568 aa) |
| | RPA2143 | Putative acetyl/propionyl-CoA carboxylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (540 aa) |
| | nosD | Putative periplasmic ABC transport copper binding protein. (454 aa) |
| | leuI | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | bioB | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (336 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | ilvH | Acetolactate synthase (small subunit); Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (180 aa) |
| | serB | Putative phosphoserine phosphatase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (243 aa) |
| | RPA2028 | Conserved hypothetical protein. (193 aa) |
| | RPA2022 | Specialized acyl carrier protein. (93 aa) |
| | RPA2021 | 3-hydroxymyristoyl-acyl carrier protein dehydratase. (156 aa) |
| | RPA2020 | 3-oxoacyl-acyl carrier protein synthase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (402 aa) |
| | RPA2019 | 3-oxoacyl-acyl carrier protein synthase II; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (426 aa) |
| | leuA | Putative isopropyl malate synthase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the alpha-IPM synthase/homocitrate synthase family. (532 aa) |
| | cbbZ | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (225 aa) |
| | pqqE | Putative pyrroloquinoline quinone biosynthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (377 aa) |
| | pqqD | Pyrroloquinoline quinone biosynthesis protein D; Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway. (102 aa) |
| | pqqC | Pyrroloquinoline quinone biosynthesis protein C; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (254 aa) |
| | pqqB | Pyrroloquinoline quinone biosynthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm, in association with PQQ biosynthesis, but is not absolutely required for this synthesis; Belongs to the PqqB family. (308 aa) |
| | panE | Putative ketopantoate reductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (330 aa) |
| | RPA1940 | Putative quinone oxidoreductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (322 aa) |
| | RPA1890 | Hypothetical protein. (1033 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (285 aa) |
| | folB | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa) |
| | folK | Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (163 aa) |
| | RPA1826 | Conserved hypothetical protein; InterPro IPR006311:IPR006626. (452 aa) |
| | RPA1745 | N-carbamoyl-beta-alanine amidohydrolase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (416 aa) |
| | serA | Possible phosphoglycerate dehydrogenase (serA), Nter fragment. (304 aa) |
| | yeaU | Putative tartrate dehydrogenase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (372 aa) |
| | RPA1726 | Putative oxidoreductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (338 aa) |
| | RPA1596 | Possible tryptophan synthase beta chain; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (122 aa) |
| | trpB-1 | Putative tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | putA | Proline dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1002 aa) |
| | RPA1569 | O-acetylhomoserine sulfhydrylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (431 aa) |
| | ilvD2 | Dihydroxy-acid dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the IlvD/Edd family. (618 aa) |
| | cysE1 | Serine acetyltransferase. (315 aa) |
| | glnAIII | Putative glutamine synthetase III. (461 aa) |
| | RPA1298 | Putative 3-oxoacyl-acyl carrier protein synthase III; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (371 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the CarA family. (397 aa) |
| | RPA1217 | Putative carboxypeptidase G2; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (376 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | RPA1199 | Enoyl-acyl carrier protein reductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (273 aa) |
| | RPA1179 | Beta-alanine-pyruvate transaminase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (484 aa) |
| | RPA1150 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (382 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (325 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (370 aa) |
| | glnA4 | Putative glutamine synthetase-like protein. (486 aa) |
| | RPA0915 | Putative NADPH quinone oxidoreductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (332 aa) |
| | dapA2 | Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa) |
| | gltD | Glutamate synthase (NADPH) small chain; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (484 aa) |
| | gltB | Glutamate synthase, large subunit; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (1575 aa) |
| | thrC | Threonine synthase. (501 aa) |
| | RPA0704 | Conserved unknown protein; InterPro IPR000379 COGs COG0429. (326 aa) |
| | badC | Putative alcohol dehydrogenase. (339 aa) |
| | argB | Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the transferase hexapeptide repeat family. (281 aa) |
| | dapE | Putative succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (387 aa) |
| | lysC | Putative aspartokinase, alpha and beta subunits; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the aspartokinase family. (417 aa) |
| | argJ | Putative glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | MLYCD, | malonyl-CoA decarboxylase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (476 aa) |
| | cysK | Cysteine synthase, cytosolic O-acetylserine(thiol)lyase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the cysteine synthase/cystathionine beta- synthase family. (332 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | aroK | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (203 aa) |
| | aroB | Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (381 aa) |
| | RPA0497 | GCN5-related N-acetyltransferase. (136 aa) |
| | PA3602 | Possible glutamate synthase; Belongs to the glutamate synthase family. (543 aa) |
| | RPA0427 | Enoyl-acyl carrier protein reductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (269 aa) |
| | fabB | beta-ketoacyl-ACP synthase I; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (408 aa) |
| | fabA | 3-hydroxydecanoyl-acyl carrier protein dehydrase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (175 aa) |
| | folD | Putative methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa) |
| | CPS1, | Putative Gly-X carboxypeptidase YSCS precursor. (493 aa) |
| | argG | Argininosuccinate synthase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (445 aa) |
| | RPA0346 | Conserved hypothetical protein. (247 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (271 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (245 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase, amidotransferase component; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. (197 aa) |
| | RPA0266 | Putative alginate o-acetyltransferase AlgI; Belongs to the membrane-bound acyltransferase family. (470 aa) |
| | RPA0256 | Putative UROPORPHYRINOGEN-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (248 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (293 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | asdB | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | leuB | Beta-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (370 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (430 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa) |
| | folC | Putative folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (442 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (327 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa) |
| | trpF | Putative N-(5'-phosphoribosyl)anthranilate isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the TrpF family. (213 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (445 aa) |
| | aroG1 | 2-dehydro-3-deoxyphosphoheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (364 aa) |
| | panE1 | Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa) |
