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| | Mbur_2004 | RNA-directed DNA polymerase; Evidence code ER4; reverse transcriptase. (576 aa) |
| | Mbur_2015 | TIM alpha/beta barrel protein; Evidence code ER4. (298 aa) |
| | Mbur_2016 | Transposase; Evidence code ER4. (372 aa) |
| | radA | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (325 aa) |
| | Mbur_2035 | Protein with PRC-barrel domain; Evidence code ER4. (90 aa) |
| | Mbur_2039 | RNA-directed DNA polymerase; Evidence code ER4; reverse transcriptase. (592 aa) |
| | Mbur_2043 | Protoporphyrinogen oxidase; Evidence code ER3. (476 aa) |
| | Mbur_2062 | DsbD-like protein; Evidence code ER4. (325 aa) |
| | Mbur_2072 | NADH pyrophosphatase; Evidence code ER2; NUDIX hydrolase domain. (281 aa) |
| | Mbur_2075 | Protein with dinitrogenase iron-molybdenum cofactor biosynthesis-like domain; Evidence code ER4. (126 aa) |
| | Mbur_2079 | Protein with dinitrogenase iron-molybdenum cofactor biosynthesis-like domain; Evidence code ER4. (126 aa) |
| | Mbur_2080 | Protein with dinitrogenase iron-molybdenum cofactor biosynthesis-like domain; Evidence code ER4. (137 aa) |
| | mtbA-2 | Methylamine-specific methylcobamide:CoM methyltransferase; Evidence code ER2. (344 aa) |
| | pylB | Radical SAM family protein, pyrrolysine biosynthesis; Evidence code ER4. (350 aa) |
| | rps8e | SSU ribosomal protein S8E; Evidence code ER2. (125 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (305 aa) |
| | Mbur_2112 | HTH DNA-binding domain protein; Evidence code ER4. (164 aa) |
| | Mbur_2121 | HD domain containing protein, metal dependent phosphohydrolase; Evidence code ER4. (616 aa) |
| | radB | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (225 aa) |
| | Mbur_2139 | Hypothetical protein; Evidence code ER5. (234 aa) |
| | Mbur_2142 | Protein of unknown function DUF134; Evidence code ER4; Belongs to the UPF0251 family. (107 aa) |
| | Mbur_2143 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (370 aa) |
| | Mbur_2162 | Helicase-like protein. (1065 aa) |
| | nth-2 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa) |
| | dbh-2 | UmuC like DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (364 aa) |
| | priL | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (364 aa) |
| | asd-2 | Phosphatidylserine decarboxylase-family protein; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. (208 aa) |
| | argD | Acetylornithine/acetyl-lysine aminotransferase; Evidence code ER2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | rfcL | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (497 aa) |
| | ilvD | Dihydroxyacid dehydratase; Evidence code ER2; Belongs to the IlvD/Edd family. (553 aa) |
| | Mbur_2253 | Hypothetical protein; Evidence code ER5. (264 aa) |
| | rps24e | SSU ribosomal protein S24E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eS24 family. (102 aa) |
| | Mbur_2322 | Ribulose-1,5-bisphosphate carboxylase-oxygenase type III; Evidence code ER2; RubisCO. (474 aa) |
| | rps3ae | SSU ribosomal protein S3Ae; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eS1 family. (235 aa) |
| | rps15p | SSU ribosomal protein S15P; Evidence code ER2. (152 aa) |
| | Mbur_2353 | Thioredoxin family protein; Evidence code ER3. (165 aa) |
| | Mbur_2354 | Cytochrome c-type biogenesis protein ccdA; Evidence code ER3. (214 aa) |
| | Mbur_2367 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (190 aa) |
| | Mbur_2384 | Hypothetical protein; Evidence code ER5. (91 aa) |
| | rpl18e | LSU ribosomal protein L18E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eL18 family. (126 aa) |
| | rps9p | SSU ribosomal protein S9P; Evidence code ER2; Belongs to the universal ribosomal protein uS9 family. (134 aa) |
| | rps2p | SSU ribosomal protein S2P; Evidence code ER2; Belongs to the universal ribosomal protein uS2 family. (214 aa) |
| | Mbur_2406 | CTP:2, 3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase; Evidence code ER3. (199 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (362 aa) |
| | rpl3p | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (337 aa) |
| | rpl23p | LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (82 aa) |
| | rps19p | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (137 aa) |
| | rpl22p | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (151 aa) |
| | rps3p | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (304 aa) |
| | rpl29p | LSU ribosomal protein L29P; Evidence code ER2; Belongs to the universal ribosomal protein uL29 family. (67 aa) |
| | rps17p | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (109 aa) |
| | rpl14p | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa) |
| | rpl24p | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (117 aa) |
| | rps4e | SSU ribosomal protein S4E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eS4 family. (236 aa) |
| | rpl5p | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (169 aa) |
| | rps14p | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (50 aa) |
| | rps8p | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6p | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rpl32e | LSU ribosomal protein L32E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eL32 family. (148 aa) |
| | rpl19e | LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa) |
| | rpl18p | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (173 aa) |
| | rps5p | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (211 aa) |
| | truB | tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (331 aa) |
| | Mbur_0033 | HAD-superfamily hydrolase; Evidence code ER4. (221 aa) |
| | rps13p | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (148 aa) |
| | rps4p | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (184 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa) |
| | Mbur_0061 | ATP dependent DNA helicase RecQ; Evidence code ER2. (647 aa) |
| | Mbur_0067 | Cell surface glycoprotein; Evidence code ER4; S-layer protein. (302 aa) |
| | Mbur_0068 | Plasma-membrane proton-efflux P-type ATPase; Evidence code ER2. (815 aa) |
| | bcp | Thiol peroxidase; Evidence code ER2; hydroperoxide peroxidase. (160 aa) |
| | Mbur_0092 | Protein with rubredoxin and glutamine synthase domains; Evidence code ER3; Belongs to the glutamate synthase family. (496 aa) |
| | Mbur_0094 | Protein with C-terminal fumarate reductase-like domain; Evidence code ER4. (180 aa) |
| | Mbur_0096 | Metallo-beta-lactamase family RNA-degradation protein; Evidence code ER3. (411 aa) |
| | ftsY | Signal recognition docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (366 aa) |
| | rplX | LSU ribosomal protein LX; Evidence code ER2. (58 aa) |
| | rpl31e | LSU ribosomal protein L31E; Evidence code ER2; Belongs to the ribosomal protein L31e family. (88 aa) |
| | rps19e | SSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (149 aa) |
| | Mbur_0129 | Hypothetical protein; Evidence code ER5. (171 aa) |
| | dbh | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (354 aa) |
| | rps17e | SSU ribosomal protein S17E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eS17 family. (64 aa) |
| | Mbur_0187 | RNA-binding protein, containing PUA domain; Evidence code ER3. (182 aa) |
| | Mbur_0189 | ZPR1-like zinc finger protein; Evidence code ER3. (221 aa) |
| | rpl15e | LSU ribosomal protein L15E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eL15 family. (197 aa) |
| | Mbur_0197 | Ancient conserved region within archaeal exosome superoperon, UPF0023 domain protein; Evidence code ER4. (230 aa) |
| | rpl37ae | LSU ribosomal protein L37Ae; Binds to the 23S rRNA. (95 aa) |
| | Mbur_0203 | Archaeal exosome complex IMP4-like, brix-domain protein; Probably involved in the biogenesis of the ribosome. (155 aa) |
| | Mbur_0206 | RecJ-like protein; Evidence code ER4. (321 aa) |
| | rps28e | SSU ribosomal protein S28E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eS28 family. (71 aa) |
| | rpl24e | LSU ribosomal protein L24E; Binds to the 23S rRNA. (62 aa) |
| | rps6e | SSU ribosomal protein S6E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eS6 family. (135 aa) |
| | Mbur_0244 | Hypothetical protein with N-acetyltransferase domain; Evidence code ER4. (105 aa) |
| | Mbur_0245 | DEAD-box RNA helicase; Evidence code ER2; Belongs to the DEAD box helicase family. (463 aa) |
| | Mbur_0264 | Small redox protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. (73 aa) |
| | Mbur_0288 | Nitrogen-fixing NifU-like protein; Evidence code ER4. (211 aa) |
| | engB | GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation. (207 aa) |
| | Mbur_0303 | Oxidoreductase with FAD-binding domain; Evidence code ER4. (396 aa) |
| | Mbur_0308 | DUF124-domain protein; Evidence code ER4. (231 aa) |
| | Mbur_0318 | PRC-barrel domain protein; Evidence code ER4. (110 aa) |
| | Mbur_0334 | Ferredoxin thioredoxin reductase-related protein; Evidence code ER4. (241 aa) |
| | Mbur_0340 | UbiA prenyltransferase-family protein; Evidence code ER4. (312 aa) |
| | Mbur_0369 | Oxidoreductase with FAD-binding domain; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (408 aa) |
| | Mbur_0370 | NMD3 family protein; Evidence code ER4. (353 aa) |
| | tfe | Transcription Factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...] (165 aa) |
| | Mbur_0382 | DNA repair protein RadC; Evidence code ER3; Belongs to the UPF0758 family. (229 aa) |
| | Mbur_0396 | GTP-binding protein; Evidence code ER3. (254 aa) |
| | pdxS | Pyridoxal 5'-phosphate (Vitamin B6) synthase, lyase subunit pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | Mbur_0431 | Cation-transporter, P-type ATPase; Evidence code ER2. (871 aa) |
| | mtaA | Methanol-specific methylcobalamin:CoM methyltransferase; Evidence code ER2. (310 aa) |
| | Mbur_0472 | Protein with ADP-ribose binding-domain, UPF0189 family; Evidence code ER4. (174 aa) |
| | Mbur_0484 | Nucleic acid binding protein; Evidence code ER4. (941 aa) |
| | Mbur_0490 | FeS cluster assembly protein sufB; Evidence code ER4. (407 aa) |
| | Mbur_0514 | Aminotransferase, class V; Evidence code ER3; phosphoserine, serine/alanine glyoxylate, serine pyruvate aminotransferase. (380 aa) |
| | Mbur_0603 | Unusual protein kinase; Evidence code ER4. (549 aa) |
| | Mbur_0618 | Cation efflux family protein; Evidence code ER3. (411 aa) |
| | Mbur_0620 | FeMo cofactor biosynthesis domain protein; Evidence code ER4. (123 aa) |
| | Mbur_0621 | Protein with dinitrogenase iron-molybdenum cofactor biosynthesis-like domain; Evidence code ER4. (153 aa) |
| | Mbur_0626 | Protein of unknown function DUF92; Evidence code ER4. (470 aa) |
| | Mbur_0627 | NAD-dependent deacetylase, Sir2-like; Evidence code ER2. (245 aa) |
| | Mbur_0628 | Orn/DAP/Arg decarboxylase family / TabA-like; Evidence code ER3. (420 aa) |
| | taw2 | Methyltransferase superfamily protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (337 aa) |
| | Mbur_0663 | fatty-acid--CoA ligase; Evidence code ER3; Acyl-CoA synthetase. (547 aa) |
| | Mbur_0669 | Cell surface glycoprotein; Evidence code ER4; S-layer protein. (570 aa) |
| | Mbur_0681 | Protein with beta-lactamase-like domain; Evidence code ER4. (250 aa) |
| | Mbur_0683 | Protein of unknown function DUF124; Evidence code ER4. (259 aa) |
| | Mbur_0690 | RNA-directed DNA polymerase; Evidence code ER4; reverse transcriptase. (576 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (485 aa) |
| | Mbur_0765 | RNA-directed DNA polymerase; Evidence code ER4. (576 aa) |
| | Mbur_0797 | O-acetylhomoserine aminocarboxypropyltransferase; Evidence code ER2. (431 aa) |
| | Mbur_0800 | Transposase; Evidence code ER4. (373 aa) |
| | Mbur_0804 | MoxR-like AAA-3 family ATPase; Evidence code ER3. (324 aa) |
| | Mbur_0806 | Prephenate dehydratase; Evidence code ER2. (284 aa) |
| | Mbur_0808 | Methanol-specific methylcobalamin:CoM methyltransferase; Evidence code ER2. (338 aa) |
| | Mbur_0833 | Protein of unknown function DUF125; Evidence code ER4. (174 aa) |
| | cimA-2 | (R)-citramalate synthase; Evidence code ER2; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa) |
| | Mbur_0885 | P-type cation transporting ATPase; Evidence code ER2. (887 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (270 aa) |
| | rpl21e | LSU ribosomal protein L21E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eL21 family. (97 aa) |
| | Mbur_0939 | FAD dependent oxidoreductase; Evidence code ER4. (385 aa) |
| | tgtA | Archaeosine tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (483 aa) |
| | Mbur_0943 | Thioredoxin; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. (77 aa) |
| | mtbA | Methylcobamide:CoM methyltransferase; Evidence code ER3. (348 aa) |
| | Mbur_0961 | tRNA (guanine-N(1)-)-methyltransferase; Evidence code ER3. (331 aa) |
| | Mbur_0964 | RNA-binding protein; Evidence code ER4. (102 aa) |
| | Mbur_0989 | Hypothetical protein; Evidence code ER5. (160 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (215 aa) |
| | mtaA-2 | Methanol-specific methylcobalamin:CoM methyltransferase; Evidence code ER2. (345 aa) |
| | Mbur_1011 | Cation efflux family protein; Evidence code ER3. (289 aa) |
| | cbiXS | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (131 aa) |
| | Mbur_1038 | Nitrogenase iron protein; Evidence code ER2. (264 aa) |
| | endA | tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity). (351 aa) |
| | Mbur_1041 | Threonyl/alanyl tRNA synthetase second additional domain; Evidence code ER3; SAD domain. (234 aa) |
| | hcp | Hybrid-cluster protein with hydroxylamine reductase activity; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (539 aa) |
| | Mbur_1054 | Cupin-domain protein; Evidence code ER4. (104 aa) |
| | Mbur_1064 | Hypothetical protein; Evidence code ER5. (77 aa) |
| | Mbur_1065 | Ferritin family protein; Evidence code ER4. (89 aa) |
| | Mbur_1075 | Re-Citrate Synthase; Evidence code ER2; Belongs to the alpha-IPM synthase/homocitrate synthase family. (425 aa) |
| | Mbur_1077 | Geranylgeranyl reductase; Evidence code ER3. (399 aa) |
| | dnl1 | DNA ligase 1, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (567 aa) |
| | Mbur_1098 | 3-hydroxy-3-methylglutaryl-CoA reductase; Evidence code ER2; Belongs to the HMG-CoA reductase family. (414 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (204 aa) |
| | hel308 | DEAD/DEAH box helicase-like protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (760 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | Mbur_1149 | UPF0026, Radical SAM protein; Evidence code ER4. (326 aa) |
| | Mbur_1150 | Protein of unknown function DUF134; Evidence code ER4; Belongs to the UPF0251 family. (201 aa) |
| | rps10p | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | rps7p | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (186 aa) |
| | rps12p | SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa) |
| | rpl30e | LSU ribosomal protein L30E; Evidence code ER2. (95 aa) |
| | Mbur_1185 | SPFH domain / Band 7 family-like protein; Evidence code ER4. (316 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (449 aa) |
| | top6A | DNA topoisomerase, type VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (373 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (422 aa) |
| | Mbur_1238 | V-type ATPase subunit family/V-type ATP synthase subunit I-like protein; Evidence code ER4; Belongs to the V-ATPase 116 kDa subunit family. (646 aa) |
| | atpF | V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (99 aa) |
| | atpB | V-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (460 aa) |
| | Mbur_1260 | Metallophosphoesterase-domain protein; Evidence code ER4. (436 aa) |
| | Mbur_1287 | F420H2 dehydrogenase subunit N; Evidence code ER3. (480 aa) |
| | Mbur_1301 | Hypothetical protein; Evidence code ER5. (425 aa) |
| | Mbur_1308 | Oxidoreductase with FAD binding domain; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (406 aa) |
| | dnaJ | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] (396 aa) |
| | dnaK | Chaperone DnaK; Acts as a chaperone. (620 aa) |
| | grpE | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (191 aa) |
| | Mbur_1322 | Toprim domain protein; Evidence code ER4; topoisomerase-primase domain; Belongs to the UPF0292 family. (158 aa) |
| | Mbur_1329 | Sulfide dehydrogenase (flavoprotein) subunit SudB; Evidence code ER2. (283 aa) |
| | argJ | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (394 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa) |
| | Mbur_1344 | Hypothetical protein; Evidence code ER5. (200 aa) |
| | Mbur_1348 | Dihydrofolate reductase; Evidence code ER3. (174 aa) |
| | Mbur_1353 | Radical SAM family protein with UPF0004 and MiaB-like domains; Evidence code ER4. (430 aa) |
| | Mbur_1362 | Single-stranded DNA-binding protein; Evidence code ER3; Replication factor A; RP-A; RF-A. (426 aa) |
| | Mbur_1374 | Nucleic acid binding protein; Evidence code ER4. (450 aa) |
| | Mbur_1375 | Archaeal histone A; Evidence code ER2. (73 aa) |
| | Mbur_1378 | UPF0132 family protein; Evidence code ER3. (110 aa) |
| | priS | DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (390 aa) |
| | rpl44e | LSU ribosomal protein L44E; Binds to the 23S rRNA. (92 aa) |
| | nop10p | Ribosome biogenesis protein Nop10; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (56 aa) |
| | Mbur_1412 | HD domain containing protein, metal dependent phosphohydrolase; Evidence code ER4. (400 aa) |
| | ubiX | Phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (183 aa) |
| | rpl10ae | LSU ribosomal protein L10AE; Evidence code ER2; Belongs to the universal ribosomal protein uL16 family. (172 aa) |
| | bchI | Protoporphyrin IX magnesium-chelatase; Evidence code ER2. (337 aa) |
| | Mbur_1461 | Monovalent cation/proton antiporter family protein; Evidence code ER3. (636 aa) |
| | Mbur_1465 | Protein with PRC-barrel domain; Evidence code ER4. (90 aa) |
| | tbp | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (206 aa) |
| | Mbur_1500 | Hypothetical protein; Evidence code ER5. (258 aa) |
| | rad50 | DNA-binding Structural Maintenance of Chromosomes Protein with ATPase domain; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (888 aa) |
| | mre11 | Metallophosphoesterase domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (485 aa) |
| | rnp4 | Ribonuclease P protein component 4; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (108 aa) |
| | Mbur_1531 | Histidine triad protein; Evidence code ER2. (136 aa) |
| | Mbur_1538 | Chromosome segregation domain protein; Evidence code ER4; SMC domain. (657 aa) |
| | flpA | Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (230 aa) |
| | Mbur_1562 | Pre-mRNA processing ribonucleoprotein; Evidence code ER3. (354 aa) |
| | Mbur_1566 | DEAD/DEAH box helicase domain protein; Evidence code ER4. (726 aa) |
| | Mbur_1586 | N-acetylneuraminic acid synthase/N-acetylneuraminate-9-phosphate synthase; Evidence code ER3. (347 aa) |
| | Mbur_1608 | Glycosyl transferase, family 2; Evidence code ER4. (373 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (275 aa) |
| | Mbur_1628 | Hypothetical protein; Evidence code ER5. (170 aa) |
| | Mbur_1648 | ABC1 family protein; Evidence code ER4. (559 aa) |
| | Mbur_1650 | Transposase; Evidence code ER4. (372 aa) |
| | rpl40e | LSU ribosomal protein L40E; Evidence code ER2; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa) |
| | hcp-2 | Hybrid-cluster protein with hydroxylamine reductase activity; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (562 aa) |
| | Mbur_1679 | (S)-2,3-Di-O-geranylgeranyl glyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (281 aa) |
| | Mbur_1688 | DNA polymerase B, delta subunit with exonuclease activity; Evidence code ER3. (910 aa) |
| | Mbur_1692 | Cation-transporter, P-type ATPase; Evidence code ER2. (894 aa) |
| | Mbur_1695 | Sodium/hydrogen antiporter; Evidence code ER3. (390 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (887 aa) |
| | Mbur_1707 | Protease inhibitor, alpha(2)-macroglobulin -like protein; Evidence code ER3. (1403 aa) |
| | Mbur_1730 | TraB family protein; Evidence code ER3. (461 aa) |
| | Mbur_1733 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (411 aa) |
| | Mbur_1734 | Peptidase S24-like protein; Evidence code ER4. (184 aa) |
| | taw1 | Radical SAM domain and Wyosine domain-containing protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (316 aa) |
| | Mbur_1748 | Protein with peptidase family M28 domain; Evidence code ER4. (430 aa) |
| | Mbur_1764 | Single-stranded DNA-binding protein; Evidence code ER3; Replication factor A; RP-A; RF-A. (373 aa) |
| | kptA | RNA 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (216 aa) |
| | Mbur_1767 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase-like protein; Evidence code ER4. (453 aa) |
| | dnaG | Toprim domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (475 aa) |
| | Mbur_1781 | 2-isopropylmalate synthase; Evidence code ER2. (442 aa) |
| | Mbur_1782 | UbiA prenyltransferase-family protein; Evidence code ER4. (247 aa) |
| | Mbur_1804 | SPFH domain / Band 7 family integral membrane protein; Evidence code ER4. (252 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | Mbur_1852 | Metallo-beta-lactamase-like family protein; Evidence code ER4. (337 aa) |
| | Mbur_1862 | Nucleoside 2-deoxyribosyltransferase-like protein; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base; Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family. (122 aa) |
| | Mbur_1867 | Diaminopimelate decarboxylase; Evidence code ER3. (349 aa) |
| | Mbur_1881 | Phosphoesterase containing TrkA-N, DHH, and DHHA1 domains; Evidence code ER4. (498 aa) |
| | Mbur_1887 | GTP-binding domain protein; Evidence code ER4. (356 aa) |
| | fen | FEN1 flap endonuclease with 5'-3' exonuclease activity; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the ba [...] (338 aa) |
| | Mbur_1926 | UbiA prenyltransferase-family protein; Evidence code ER4. (307 aa) |
| | Mbur_1932 | 3-hydroxy-3-methylglutaryl-CoA synthase; Evidence code ER3; Belongs to the thiolase-like superfamily. UPF0219 family. (349 aa) |
| | Mbur_1934 | DUF35-domain protein; Evidence code ER4. (133 aa) |
| | Mbur_1935 | Adenylyl cyclase-family protein; Evidence code ER4. (171 aa) |
| | rpl11p | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (161 aa) |
| | rpl1p | LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (213 aa) |
| | rpl10e | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (337 aa) |
| | rpl12p | LSU ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (100 aa) |
| | Mbur_1950 | Dead box RNA helicase; Evidence code ER2; Belongs to the DEAD box helicase family. (522 aa) |
| | Mbur_1954 | Protein with beta-lactamase-like domain; Evidence code ER4. (248 aa) |
| | Mbur_1974 | F420H2:NADP+ Oxidoreductase; Evidence code ER3. (242 aa) |
| | Mbur_1985 | dCMP deaminase; Evidence code ER2. (151 aa) |
| | Mbur_1988 | Replication factor C small subunit; Evidence code ER2. (341 aa) |
