Your Input: | |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | AEI99910.1 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (413 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (479 aa) |
| | AEI99947.1 | KEGG: rfr:Rfer_1162 F0F1 ATP synthase subunit epsilon; TIGRFAM: alternate F1F0 ATPase, F1 subunit epsilon; PFAM: ATPase, F1 complex, delta/epsilon subunit, N-terminal. (134 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (233 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (93 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (346 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (533 aa) |
| | AEI99954.1 | KEGG: dba:Dbac_0944 alternate F1F0 ATPase, F1 subunit gamma; TIGRFAM: Alternate ATPase, F1 complex, subunit gamma; PFAM: ATPase, F1 complex, gamma subunit. (315 aa) |
| | AEJ00014.1 | KEGG: nit:NAL212_0427 CinA domain-containing protein; TIGRFAM: CinA, C-terminal; PFAM: CinA, C-terminal; Belongs to the CinA family. (176 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (318 aa) |
| | AEJ00035.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (264 aa) |
| | AEJ00036.1 | HemY domain protein; PFAM: HemY, N-terminal; KEGG: nit:NAL212_0446 HemY domain-containing protein. (391 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | AEJ00047.1 | KEGG: nit:NAL212_0462 riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine-binding protein. (199 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (160 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (166 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa) |
| | AEJ00065.1 | PFAM: Transposase, IS4-like; KEGG: gur:Gura_1234 hypothetical protein. (463 aa) |
| | AEJ00070.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (363 aa) |
| | AEJ00075.1 | KEGG: nit:NAL212_2901 glycine oxidase ThiO; TIGRFAM: Glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase. (375 aa) |
| | AEJ00105.1 | CBS domain containing protein; PFAM: Cystathionine beta-synthase, core; Transporter-associated region; KEGG: nit:NAL212_0498 transporter-associated region. (282 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (218 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (226 aa) |
| | AEJ00138.1 | KEGG: nit:NAL212_2874 adenylate/guanylate cyclase with CHASE sensor; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase. (753 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa) |
| | AEJ00156.1 | Sigma-70 region 4 type 2; KEGG: wch:wcw_0673 hypothetical protein; PFAM: RNA polymerase sigma factor 70, region 4 type 2; SMART: ATPase, AAA+ type, core. (327 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (746 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (599 aa) |
| | AEJ00229.1 | TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T/DNA polymerase III; Excinuclease ABC, C subunit, N-terminal; KEGG: nit:NAL212_2527 DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC, C subunit, N-terminal. (463 aa) |
| | AEJ00230.1 | PFAM: DNA-repair protein, UmuC-like; KEGG: nit:NAL212_2528 DNA-directed DNA polymerase. (430 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (281 aa) |
| | AEJ00242.1 | KEGG: nit:NAL212_3012 transcriptional coactivator/pterin dehydratase; HAMAP: pterin-4-alpha-carbinolamine dehydratase; PFAM: Transcriptional coactivator/pterin dehydratase. (113 aa) |
| | atpB-2 | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (269 aa) |
| | atpE-2 | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (90 aa) |
| | atpF-2 | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (157 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa) |
| | atpA-2 | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD-2 | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (459 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (457 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (297 aa) |
| | AEJ00296.1 | KEGG: nit:NAL212_2708 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma factor 70, region 4 type 2. (194 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa) |
| | cmk | TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: nit:NAL212_2997 cytidylate kinase; PFAM: Cytidylate kinase region. (229 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (361 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (344 aa) |
| | AEJ00377.1 | TIGRFAM: Flagellar protein export ATPase, FliI; ATPase, type III secretion system, FliI/YscN; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; KEGG: nit:NAL212_0483 flagellar protein export ATPase FliI; SMART: ATPase, AAA+ type, core. (468 aa) |
| | AEJ00396.1 | KEGG: nit:NAL212_0702 hopanoid biosynthesis associated radical SAM protein HpnH; TIGRFAM: Hopanoid biosynthesis associated radical SAM protein HpnH; PFAM: Radical SAM. (372 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | purM | KEGG: nit:NAL212_0709 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (352 aa) |
| | AEJ00429.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: nit:NAL212_0736 phosphoglycerate dehydrogenase. (312 aa) |
| | AEJ00447.1 | UPF0301 protein yqgE; KEGG: nit:NAL212_0755 hypothetical protein; HAMAP: Protein of unknown function DUF179; PFAM: Protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | pyrB | TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: nit:NAL212_0758 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa) |
| | AEJ00451.1 | KEGG: nit:NAL212_0759 dihydroorotase, multifunctional complex type; TIGRFAM: Dihydroorotase multifunctional complex type; PFAM: Amidohydrolase 3. (424 aa) |
| | AEJ00475.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (298 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | AEJ00491.1 | KEGG: nit:NAL212_2084 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (287 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (481 aa) |
| | AEJ00495.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (269 aa) |
| | carB | KEGG: nit:NAL212_2074 carbamoyl-phosphate synthase, large subunit; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Belongs to the CarB family. (1069 aa) |
| | carA | KEGG: nit:NAL212_2073 carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (384 aa) |
| | AEJ00503.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (473 aa) |
| | AEJ00516.1 | Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: nit:NAL212_2288 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (317 aa) |
| | AEJ00519.1 | PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: nit:NAL212_2755 UBA/ThiF-type NAD/FAD binding protein. (257 aa) |
| | AEJ00557.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (438 aa) |
| | AEJ00595.1 | KEGG: nit:NAL212_1037 cytidyltransferase-related domain-containing protein; TIGRFAM: Cytidyltransferase-related; PFAM: Cytidylyltransferase; LicD-like. (519 aa) |
| | AEJ00639.1 | KEGG: bxe:Bxe_A2479 putative cytoplasmic protein. (70 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | AEJ00678.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: nit:NAL212_2167 GCN5-like N-acetyltransferase. (145 aa) |
| | AEJ00687.1 | PFAM: Transposase, IS4-like; KEGG: gur:Gura_1234 hypothetical protein. (437 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1357 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1400 aa) |
| | AEJ00729.1 | TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: nit:NAL212_1467 DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal. (1173 aa) |
| | AEJ00742.1 | KEGG: psl:Psta_1889 limonene-12-epoxide hydrolase. (161 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (365 aa) |
| | AEJ00769.1 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (482 aa) |
| | AEJ00775.1 | KEGG: nit:NAL212_2109 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (204 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (274 aa) |
| | AEJ00816.1 | KEGG: nit:NAL212_1400 thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiamineS. (67 aa) |
| | AEJ00896.1 | PFAM: Protein of unknown function DUF2006; KEGG: nit:NAL212_0914 hydroxyneurosporene synthase. (369 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (345 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (357 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (915 aa) |
| | AEJ01155.1 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (403 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | AEJ01253.1 | PFAM: DeoxyUTP pyrophosphatase domain; KEGG: tkm:TK90_2717 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut. (121 aa) |
| | AEJ01328.1 | KEGG: nit:NAL212_2045 hypothetical protein. (870 aa) |
| | AEJ01354.1 | Nucleotide sugar dehydrogenase; KEGG: avn:Avin_27790 UDP-glucose 6-dehydrogenase; TIGRFAM: Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (446 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (370 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (403 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa) |
| | AEJ01392.1 | TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: nit:NAL212_2351 DNA polymerase III, delta prime subunit. (346 aa) |
| | AEJ01393.1 | PFAM: Protein of unknown function DUF336; KEGG: nit:NAL212_2350 hypothetical protein. (173 aa) |
| | AEJ01424.1 | PFAM: NUDIX hydrolase domain; KEGG: nit:NAL212_2038 NUDIX hydrolase. (147 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (247 aa) |
| | AEJ01453.1 | KEGG: nit:NAL212_1515 esterase/lipase/thioesterase family protein. (296 aa) |
| | AEJ01456.1 | PFAM: ThiamineS; KEGG: neu:NE2351 hypothetical protein. (105 aa) |
| | AEJ01472.1 | KEGG: nit:NAL212_1518 queuosine biosynthesis protein QueD; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related. (149 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (490 aa) |
| | apaG | Protein ApaG; KEGG: nit:NAL212_0549 ApaG domain-containing protein; HAMAP: Protein ApaG; PFAM: ApaG. (128 aa) |
| | AEJ01516.1 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: nit:NAL212_0553 phosphomethylpyrimidine kinase. (291 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa) |
| | hemL | TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: nit:NAL212_0555 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III. (426 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (534 aa) |
| | AEJ01548.1 | PFAM: DNA-repair protein, UmuC-like; KEGG: nit:NAL212_2528 DNA-directed DNA polymerase. (465 aa) |
| | AEJ01565.1 | KEGG: nit:NAL212_1873 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; TIGRFAM: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa) |
| | AEJ01567.1 | KEGG: nit:NAL212_1279 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (458 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | AEJ01600.1 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (172 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (139 aa) |
| | AEJ01620.1 | PFAM: Transposase, IS4-like; KEGG: gur:Gura_1234 hypothetical protein. (438 aa) |
| | AEJ01634.1 | KEGG: dak:DaAHT2_2156 hypothetical protein. (538 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (542 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (225 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | AEJ01721.1 | KEGG: gvi:glr4232 hypothetical protein. (419 aa) |
| | AEJ01735.1 | PFAM: TENA/THI-4 protein/Coenzyme PQQ biosynthesis protein C; KEGG: nit:NAL212_1610 TenA/THI-4 domain-containing protein. (247 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (417 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (241 aa) |
| | AEJ01761.1 | KEGG: nit:NAL212_1015 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70 RpoE type; RNA polymerase sigma-70; PFAM: RNA polymerase sigma-70 region 2; RNA polymerase sigma factor 70, region 4 type 2. (199 aa) |
| | AEJ01762.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (532 aa) |
| | purC | TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: nit:NAL212_1554 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (299 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (335 aa) |
| | AEJ01826.1 | PFAM: DNA polymerase III chi subunit, HolC; KEGG: nit:NAL212_2233 DNA polymerase III chi subunit HolC. (140 aa) |
| | AEJ01837.1 | KEGG: rsc:RCFBP_11467 DNA primase-like protein. (162 aa) |
| | AEJ01839.1 | KEGG: rsc:RCFBP_11467 DNA primase-like protein. (360 aa) |
| | hemF | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (298 aa) |
| | AEJ01858.1 | KEGG: nit:NAL212_0888 hypothetical protein. (66 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (490 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (558 aa) |
| | AEJ01908.1 | Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (398 aa) |
| | AEJ01909.1 | Ribonucleoside-diphosphate reductase, alpha subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (954 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (728 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (238 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: nit:NAL212_1729 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like. (519 aa) |
| | purD | Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: nit:NAL212_1730 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (435 aa) |
| | AEJ02010.1 | KEGG: nit:NAL212_2375 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00701; PFAM: Uncharacterised protein family UPF0093. (145 aa) |
| | AEJ02015.1 | Purine or other phosphorylase family 1; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (248 aa) |
| | AEJ02016.1 | PFAM: Phosphoribosyltransferase; KEGG: nit:NAL212_2411 phosphoribosyltransferase. (181 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (314 aa) |
| | AEJ02040.1 | KEGG: gvi:gll1319 hypothetical protein. (420 aa) |
| | AEJ02048.1 | PFAM: Transposase, IS4-like; KEGG: gur:Gura_1234 hypothetical protein. (437 aa) |
| | AEJ02074.1 | PFAM: DNA-repair protein, UmuC-like; KEGG: nit:NAL212_2528 DNA-directed DNA polymerase. (430 aa) |
| | AEJ02075.1 | TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T/DNA polymerase III; Excinuclease ABC, C subunit, N-terminal; KEGG: nit:NAL212_2527 DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC, C subunit, N-terminal. (463 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa) |
| | AEJ02121.1 | PFAM: Radical SAM; KEGG: nit:NAL212_2033 radical SAM domain-containing protein. (317 aa) |
| | AEJ02129.1 | PFAM: Aminotransferase, class I/II; KEGG: sat:SYN_00565 2-amino-3-ketobutyrate coenzyme A ligase. (407 aa) |
| | ctaA | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (337 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (369 aa) |
| | nadE-2 | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (680 aa) |
| | AEJ02204.1 | KEGG: tkm:TK90_2683 hypothetical protein. (195 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (506 aa) |
| | AEJ02239.1 | KEGG: nit:NAL212_0981 FolC bifunctional protein; TIGRFAM: Folylpolyglutamate synthetase; PFAM: Mur ligase, central; Mur ligase, C-terminal; Belongs to the folylpolyglutamate synthase family. (434 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (287 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: nit:NAL212_0977 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (290 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (361 aa) |
| | AEJ02366.1 | PFAM: Protein of unknown function DUF927; KEGG: pfl:PFL_4979 hypothetical protein. (951 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (68 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | AEJ02381.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | AEJ02483.1 | KEGG: nit:NAL212_0259 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta. (346 aa) |
| | AEJ02491.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | AEJ02511.1 | KEGG: rsl:RPSI07_mp0498 cob(II)yrinic acid a,c-diamide reductase (blub); TIGRFAM: Cob(II)yrinic acid a,c-diamide reductase; PFAM: Nitroreductase-like. (215 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (223 aa) |
| | bioC | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (293 aa) |
| | bioH | Carboxylesterase bioH; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (256 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (388 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa) |
| | AEJ02541.1 | Delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; KEGG: nit:NAL212_1165 porphobilinogen synthase; Belongs to the ALAD family. (321 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (244 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (334 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa) |
| | AEJ02584.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: nit:NAL212_1123 phosphoglycerate dehydrogenase. (398 aa) |
| | AEJ02627.1 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (201 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (493 aa) |
| | AEJ02629.1 | Cobalbumin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (176 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (354 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (258 aa) |
| | AEJ02656.1 | PHP domain protein; KEGG: nmu:Nmul_A0901 PHP-like; PFAM: PHP, C-terminal; SMART: DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1; Polymerase/histidinol phosphatase, N-terminal. (577 aa) |
| | AEJ02660.1 | KEGG: rfr:Rfer_0828 isochorismatase hydrolase; manually curated; PFAM: Isochorismatase-like. (194 aa) |
| | AEJ02661.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (452 aa) |
| | AEJ02793.1 | PFAM: BolA-like protein; KEGG: nit:NAL212_1373 BolA family protein; Belongs to the BolA/IbaG family. (104 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (393 aa) |
| | AEJ02833.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (461 aa) |
| | priB | Single-strand binding protein/Primosomal replication protein n; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (98 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: nit:NAL212_0573 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (278 aa) |
| | folE2 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. (268 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (614 aa) |
| | AEJ03021.1 | KEGG: nit:NAL212_0835 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma factor 70, region 4 type 2. (200 aa) |
| | AEJ03026.1 | KEGG: kse:Ksed_21480 hypothetical protein. (357 aa) |
| | AEJ03119.1 | PFAM: Protein of unknown function DUF336; KEGG: nit:NAL212_0634 hypothetical protein. (135 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | AEJ03189.1 | TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; PFAM: HemN, C-terminal; Radical SAM; KEGG: nit:NAL212_3122 coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (469 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | AEJ03220.1 | PFAM: RecF/RecN/SMC protein, N-terminal; KEGG: gvi:gll1843 hypothetical protein. (367 aa) |
| | AEJ03279.1 | KEGG: nit:NAL212_3193 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (164 aa) |
