STRINGSTRING
zapD zapD ftsZ ftsZ ftsA ftsA ftsQ ftsQ AEJ00235.1 AEJ00235.1 ftsE ftsE ftsH ftsH AEJ00521.1 AEJ00521.1 AEJ00553.1 AEJ00553.1 AEJ00563.1 AEJ00563.1 AEJ00584.1 AEJ00584.1 AEJ00589.1 AEJ00589.1 AEJ00609.1 AEJ00609.1 AEJ00633.1 AEJ00633.1 AEJ00712.1 AEJ00712.1 mrdB mrdB AEJ00884.1 AEJ00884.1 AEJ01011.1 AEJ01011.1 AEJ01198.1 AEJ01198.1 xerC xerC AEJ01606.1 AEJ01606.1 AEJ01609.1 AEJ01609.1 tig tig nagZ nagZ murA murA ftsB ftsB mpl mpl ftsH-2 ftsH-2 AEJ02238.1 AEJ02238.1 AEJ02371.1 AEJ02371.1 AEJ02389.1 AEJ02389.1 AEJ02539.1 AEJ02539.1 engB engB xerD xerD AEJ02857.1 AEJ02857.1 AEJ03142.1 AEJ03142.1 minC minC AEJ03173.1 AEJ03173.1 minE minE ftsL ftsL ftsI ftsI murE murE murF murF mraY mraY murD murD ftsW ftsW murG murG murC murC tolQ tolQ tolB tolB pal pal cpoB cpoB murB murB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
zapDUPF0289 protein yacF; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (251 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (412 aa)
ftsQCell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (258 aa)
AEJ00235.1Protein of unknown function DUF214; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (303 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (217 aa)
ftsHATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (637 aa)
AEJ00521.1PFAM: Peptidase M23; KEGG: nit:NAL212_2753 peptidase M23. (414 aa)
AEJ00553.1PFAM: Glycosyl transferase, family 4, conserved region; KEGG: nit:NAL212_0300 glycosyl transferase family 4. (330 aa)
AEJ00563.1PFAM: Peptidase M23; KEGG: nit:NAL212_2810 peptidase M23. (444 aa)
AEJ00584.1KEGG: nit:NAL212_1755 cell division protein FtsK/SpoIIIE; PFAM: Cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SMART: ATPase, AAA+ type, core. (764 aa)
AEJ00589.1PFAM: Biopolymer transport protein ExbD/TolR; KEGG: nit:NAL212_1750 biopolymer transport protein ExbD/TolR. (139 aa)
AEJ00609.1PFAM: Multicopper oxidase, type 3; Multicopper oxidase, type 2; KEGG: nit:NAL212_2028 bilirubin oxidase. (539 aa)
AEJ00633.1PFAM: Domain of unknown function DUF1731, C-terminal; NAD-dependent epimerase/dehydratase; KEGG: nit:NAL212_1241 NAD-dependent epimerase/dehydratase. (302 aa)
AEJ00712.1Peptidase M23; KEGG: nit:NAL212_2123 peptidase M23; PFAM: Peptidase M23; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding Lysin subgroup. (358 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (366 aa)
AEJ00884.1KEGG: eli:ELI_09370 ATPase, AAA family protein; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core. (684 aa)
AEJ01011.1PFAM: ATPase, AFG1-like; KEGG: nit:NAL212_1253 AFG1-family ATPase. (403 aa)
AEJ01198.1PFAM: WD40-like Beta Propeller; KEGG: nit:NAL212_2061 WD40-like beta propeller containing protein. (366 aa)
xerCTyrosine recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (297 aa)
AEJ01606.1ZipA FtsZ-binding region protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. (394 aa)
AEJ01609.1Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (99 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (434 aa)
nagZGlycoside hydrolase family 3 domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (350 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa)
ftsBCell division protein ftsB-like protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (97 aa)
mplUDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (462 aa)
ftsH-2ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (609 aa)
AEJ02238.1Sporulation domain-containing protein; PFAM: Sporulation/cell division region, bacteria; KEGG: nit:NAL212_0982 sporulation domain-containing protein. (229 aa)
AEJ02371.1Sporulation domain-containing protein; PFAM: Sporulation/cell division region, bacteria; KEGG: nit:NAL212_1354 sporulation domain-containing protein. (262 aa)
AEJ02389.1PFAM: Protein of unknown function YGGT; KEGG: nit:NAL212_1445 hypothetical protein. (191 aa)
AEJ02539.1TIGRFAM: Type IV pilus assembly protein PilM; KEGG: nit:NAL212_1167 type IV pilus assembly protein PilM. (367 aa)
engBGTP-binding protein engB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (198 aa)
xerDTyrosine recombinase xerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (303 aa)
AEJ02857.1PFAM: Peptidase M23; KEGG: nit:NAL212_2483 peptidase M23. (305 aa)
AEJ03142.1Chromosome segregation and condensation protein, ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (209 aa)
minCSeptum site-determining protein minC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (249 aa)
AEJ03173.1KEGG: nit:NAL212_3107 septum site-determining protein MinD; TIGRFAM: Septum site-determining protein MinD; PFAM: Cobyrinic acid a,c-diamide synthase. (270 aa)
minECell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (92 aa)
ftsLCell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (100 aa)
ftsIPenicillin-binding protein transpeptidase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (576 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (513 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (467 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (489 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (386 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (363 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (475 aa)
tolQProtein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (226 aa)
tolBProtein tolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (449 aa)
palPeptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (172 aa)
cpoBTol-pal system protein YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (301 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (337 aa)
Your Current Organism:
Nitrosomonas sp. Is79A3
NCBI taxonomy Id: 261292
Other names: N. sp. Is79A3
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