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| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (358 aa) |
| | AEI99937.1 | KEGG: fri:FraEuI1c_1222 6-phosphogluconate dehydrogenase, decarboxylating; TIGRFAM: 6-phosphogluconate dehydrogenase related protein; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; 6-phosphogluconate dehydrogenase, C-terminal. (340 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (474 aa) |
| | AEI99940.1 | KEGG: rfr:Rfer_1145 phosphoglucomutase; TIGRFAM: Phosphoglucomutase, alpha-D-glucose specific; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal. (588 aa) |
| | AEI99941.1 | KEGG: dat:HRM2_24160 GlgP3; TIGRFAM: Alpha-glucan phosphorylase; PFAM: Glycosyl transferase, family 35. (848 aa) |
| | AEI99955.1 | KEGG: app:CAP2UW1_3404 UTP-glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal type; PFAM: Nucleotidyl transferase. (292 aa) |
| | AEI99979.1 | PFAM: Ketopantoate reductase ApbA/PanE, C-terminal; Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: nit:NAL212_1794 ketopantoate reductase ApbA/PanE domain-containing protein. (340 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (318 aa) |
| | AEJ00035.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (264 aa) |
| | AEJ00047.1 | KEGG: nit:NAL212_0462 riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine-binding protein. (199 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (160 aa) |
| | AEJ00058.1 | KEGG: nit:NAL212_0655 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic; PFAM: Isocitrate/isopropylmalate dehydrogenase. (415 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | AEJ00070.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (363 aa) |
| | AEJ00073.1 | PFAM: DAHP synthetase I/KDSA; KEGG: nit:NAL212_2903 3-deoxy-7-phosphoheptulonate synthase. (372 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | AEJ00117.1 | KEGG: nit:NAL212_0631 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6; PFAM: FAD dependent oxidoreductase. (389 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (419 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa) |
| | AEJ00196.1 | Hypothetical protein; KEGG: sin:YN1551_1251 glyceraldehyde-3-phosphate dehydrogenase. (351 aa) |
| | AEJ00241.1 | PFAM: Peptidase M48, Ste24p; KEGG: nit:NAL212_3013 STE24 endopeptidase. (418 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (204 aa) |
| | AEJ00252.1 | TIGRFAM: Thiolase; KEGG: nit:NAL212_0503 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (297 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (451 aa) |
| | AEJ00338.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (671 aa) |
| | AEJ00339.1 | KEGG: nit:NAL212_0187 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | pgk | KEGG: nit:NAL212_0186 phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | AEJ00341.1 | KEGG: nit:NAL212_0185 pyruvate kinase; TIGRFAM: Pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. (483 aa) |
| | AEJ00342.1 | Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | argA | KEGG: nit:NAL212_2619 amino-acid N-acetyltransferase; TIGRFAM: Amino-acid N-acetyltransferase (ArgA); PFAM: GCN5-related N-acetyltransferase; Aspartate/glutamate/uridylate kinase; Belongs to the acetyltransferase family. ArgA subfamily. (447 aa) |
| | AEJ00349.1 | PFAM: Inositol monophosphatase; KEGG: nit:NAL212_2616 inositol monophosphatase. (262 aa) |
| | AEJ00391.1 | PFAM: Phosphopantetheine-binding; KEGG: nit:NAL212_0309 phosphopantetheine-binding protein. (84 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | purM | KEGG: nit:NAL212_0709 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (352 aa) |
| | AEJ00406.1 | PFAM: Aminotransferase class-III; KEGG: nit:NAL212_0712 acetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa) |
| | metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (375 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (234 aa) |
| | AEJ00429.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: nit:NAL212_0736 phosphoglycerate dehydrogenase. (312 aa) |
| | AEJ00437.1 | PFAM: O-methyltransferase, family 3; KEGG: nit:NAL212_0745 O-methyltransferase family 3. (227 aa) |
| | AEJ00445.1 | Protein of unknown function DUF224 cysteine-rich region domain protein; PFAM: Cysteine-rich region, CCG; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: nit:NAL212_0753 hypothetical protein. (428 aa) |
| | coq7 | 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (208 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (165 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (234 aa) |
| | AEJ00475.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (298 aa) |
| | AEJ00476.1 | KEGG: nit:NAL212_0784 dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (481 aa) |
| | AEJ00516.1 | Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: nit:NAL212_2288 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (317 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (249 aa) |
| | gpsA | KEGG: nit:NAL212_2153 NAD-dependent glycerol-3-phosphate dehydrogenase domain-containing protein; HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (330 aa) |
| | AEJ00530.1 | PFAM: Short-chain dehydrogenase/reductase SDR; KEGG: nit:NAL212_2150 enoyl-(acyl-carrier-protein) reductase (NADH). (261 aa) |
| | AEJ00536.1 | KEGG: nit:NAL212_1598 phenylacetic acid degradation-like protein; TIGRFAM: Phenylacetic acid degradation-related protein; PFAM: Thioesterase superfamily. (158 aa) |
| | AEJ00541.1 | KEGG: nit:NAL212_1602 L-serine dehydratase 1; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase single chain form; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (459 aa) |
| | AEJ00552.1 | PFAM: Aminotransferase, class V/Cysteine desulfurase; KEGG: nit:NAL212_0299 serine--pyruvate transaminase. (405 aa) |
| | AEJ00556.1 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (310 aa) |
| | AEJ00557.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | AEJ00660.1 | KEGG: nit:NAL212_2185 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (567 aa) |
| | AEJ00661.1 | Manually curated; TIGRFAM: Acetolactate synthase, small subunit; KEGG: nit:NAL212_2184 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (163 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (221 aa) |
| | AEJ00664.1 | KEGG: nit:NAL212_2181 CDP-diacylglycerol/serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (257 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (510 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (383 aa) |
| | surE | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (247 aa) |
| | AEJ00714.1 | PFAM: Aminotransferase, class I/II; KEGG: nit:NAL212_1611 aspartate transaminase. (408 aa) |
| | AEJ00715.1 | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: nit:NAL212_1612 homoserine dehydrogenase. (437 aa) |
| | AEJ00716.1 | KEGG: nit:NAL212_1613 threonine synthase; TIGRFAM: Threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (472 aa) |
| | AEJ00720.1 | KEGG: nit:NAL212_1785 succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein; PFAM: Ferredoxin. (231 aa) |
| | AEJ00722.1 | KEGG: nit:NAL212_1783 citrate synthase I; TIGRFAM: Citrate synthase, type II; PFAM: Citrate synthase-like; Belongs to the citrate synthase family. (433 aa) |
| | AEJ00723.1 | KEGG: nit:NAL212_1782 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component. (946 aa) |
| | AEJ00724.1 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (419 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (204 aa) |
| | hisE | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphatase; KEGG: nit:NAL212_0811 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase. (108 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (155 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: nit:NAL212_0814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis. (251 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa) |
| | hisB | KEGG: nit:NAL212_0816 imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisC | TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: nit:NAL212_0817 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa) |
| | AEJ00927.1 | Squalene-hopene cyclase; KEGG: nit:NAL212_0906 squalene/oxidosqualene cyclase; TIGRFAM: Hopene cyclase; Squalene cyclase; PFAM: Prenyltransferase/squalene oxidase. (669 aa) |
| | AEJ00978.1 | PFAM: Pyruvate kinase, barrel; KEGG: tau:Tola_1286 pyruvate kinase. (624 aa) |
| | aroK | Shikimate kinase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (565 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (357 aa) |
| | AEJ01001.1 | KEGG: nit:NAL212_2827 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (264 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa) |
| | AEJ01034.1 | PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; KEGG: nit:NAL212_1252 mannitol dehydrogenase. (334 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (450 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa) |
| | AEJ01096.1 | PFAM: Ribulose bisphosphate carboxylase, small chain; KEGG: nit:NAL212_0871 ribulose-bisphosphate carboxylase. (118 aa) |
| | cbbL | Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (473 aa) |
| | thrB | TIGRFAM: Homoserine kinase ThrB; HAMAP: Homoserine kinase; KEGG: nit:NAL212_1090 homoserine kinase; PFAM: Aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (316 aa) |
| | AEJ01181.1 | Aconitate hydratase 1; TIGRFAM: Aconitase/iron regulatory protein 2; KEGG: nit:NAL212_2041 aconitate hydratase 1; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (976 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa) |
| | AEJ01252.1 | PFAM: Phosphopantetheine-binding; KEGG: aae:aq_1717a acyl carrier protein. (122 aa) |
| | AEJ01339.1 | KEGG: nmu:Nmul_A1700 homospermidine synthase. (472 aa) |
| | AEJ01376.1 | PFAM: Squalene/phytoene synthase; KEGG: nit:NAL212_2368 squalene/phytoene synthase. (356 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (403 aa) |
| | AEJ01387.1 | PFAM: Aldose 1-epimerase; KEGG: nit:NAL212_2357 aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (302 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa) |
| | AEJ01459.1 | PFAM: Acyl-CoA oxidase/dehydrogenase, type 1; Acyl-CoA oxidase/dehydrogenase, central region; Acyl-CoA dehydrogenase, N-terminal; KEGG: neu:NE2348 acyl-CoA dehydrogenase. (400 aa) |
| | AEJ01475.1 | PFAM: Short-chain dehydrogenase/reductase SDR; KEGG: nit:NAL212_1521 3-oxoacyl-(acyl-carrier-protein) reductase. (246 aa) |
| | sucC-2 | Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (391 aa) |
| | sucD-2 | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (490 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (242 aa) |
| | AEJ01511.1 | KEGG: nit:NAL212_0546 ribulose-phosphate 3-epimerase; TIGRFAM: Ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | hemL | TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: nit:NAL212_0555 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III. (426 aa) |
| | AEJ01528.1 | KEGG: nit:NAL212_0568 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase; PFAM: Alcohol dehydrogenase, zinc-binding; Alcohol dehydrogenase GroES-like; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa) |
| | AEJ01543.1 | KEGG: nit:NAL212_1620 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; TIGRFAM: Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: Mannose-6-phosphate isomerase, type II, C-terminal; Nucleotidyl transferase. (479 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (464 aa) |
| | AEJ01559.1 | KEGG: nit:NAL212_0936 pyridoxal-dependent decarboxylase, exosortase system type 1 associated; TIGRFAM: Pyridoxal-dependent decarboxylase, exosortase system type 1 associated; PFAM: Orn/DAP/Arg decarboxylase 2. (411 aa) |
| | AEJ01567.1 | KEGG: nit:NAL212_1279 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (458 aa) |
| | AEJ01585.1 | KEGG: nit:NAL212_1830 UTP-glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal type; PFAM: Nucleotidyl transferase. (297 aa) |
| | cysC | Sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (636 aa) |
| | cysD | TIGRFAM: Sulphate adenylyltransferase, small subunit; HAMAP: Sulfate adenylyltransferase subunit 2; KEGG: nit:NAL212_1834 sulfate adenylyltransferase, small subunit; PFAM: Phosphoadenosine phosphosulphate reductase. (298 aa) |
| | AEJ01599.1 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: nit:NAL212_1080 ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (391 aa) |
| | AEJ01678.1 | KEGG: nit:NAL212_1513 aspartate kinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family. (409 aa) |
| | AEJ01683.1 | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal; KEGG: slt:Slit_2280 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (310 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | AEJ01686.1 | PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal; KEGG: nit:NAL212_0853 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I. (458 aa) |
| | AEJ01704.1 | Catalytic domain-containing protein of components of various dehydrogenase complexes; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (436 aa) |
| | AEJ01705.1 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (417 aa) |
| | AEJ01747.1 | KEGG: nit:NAL212_1028 dihydrolipoamide dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (486 aa) |
| | purC | TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: nit:NAL212_1554 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (299 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | AEJ01789.1 | PFAM: Aminotransferase, class I/II; KEGG: nit:NAL212_1544 aspartate transaminase. (397 aa) |
| | AEJ01823.1 | KEGG: nit:NAL212_2230 phosphoserine phosphatase SerB; TIGRFAM: Phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB, PSPase-like; PFAM: Haloacid dehalogenase-like hydrolase. (276 aa) |
| | hemF | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (298 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (487 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (289 aa) |
| | ubiC | Chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (180 aa) |
| | argH | TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: nit:NAL212_1857 argininosuccinate lyase; PFAM: Fumarate lyase. (486 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa) |
| | AEJ01912.1 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: nit:NAL212_0930 ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (390 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (412 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | AEJ01985.1 | PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: nit:NAL212_1723 deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (349 aa) |
| | AEJ01988.1 | KEGG: nit:NAL212_1726 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6; PFAM: FAD dependent oxidoreductase. (390 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: nit:NAL212_1729 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like. (519 aa) |
| | purD | Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: nit:NAL212_1730 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (435 aa) |
| | AEJ02005.1 | KEGG: nit:NAL212_1745 hypothetical protein. (97 aa) |
| | AEJ02010.1 | KEGG: nit:NAL212_2375 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00701; PFAM: Uncharacterised protein family UPF0093. (145 aa) |
| | AEJ02016.1 | PFAM: Phosphoribosyltransferase; KEGG: nit:NAL212_2411 phosphoribosyltransferase. (181 aa) |
| | ilvD | TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: nit:NAL212_2332 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (557 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (244 aa) |
| | AEJ02116.1 | PFAM: Aminotransferase, class I/II; KEGG: nit:NAL212_2291 cystathionine beta-lyase. (389 aa) |
| | ctaA | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (337 aa) |
| | AEJ02150.1 | Polyprenyl synthetase; KEGG: nit:NAL212_1045 trans-hexaprenyltranstransferase; manually curated; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (322 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (369 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (506 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (287 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: nit:NAL212_0977 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | AEJ02252.1 | KEGG: nit:NAL212_0968 hypothetical protein. (662 aa) |
| | AEJ02267.1 | TIGRFAM: Sucrose-phosphate synthase, glycosyltransferase region; HAD-superfamily hydrolase, subfamily IIB; Sucrose phosphate synthase, sucrose phosphatase-like region; KEGG: nit:NAL212_0460 sucrose-phosphate synthase; PFAM: Sucrose-6F-phosphate phosphohydrolase, plant/cyanobacteria; Glycosyl transferase, group 1. (722 aa) |
| | AEJ02268.1 | PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: nit:NAL212_0459 PfkB domain-containing protein. (304 aa) |
| | AEJ02275.1 | Transketolase; KEGG: afw:Anae109_2025 transketolase; TIGRFAM: Transketolase, bacterial-like; PFAM: Transketolase, N-terminal; Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; Belongs to the transketolase family. (697 aa) |
| | AEJ02276.1 | ROK family protein; PFAM: ROK; KEGG: nha:Nham_2098 polyphosphate glucokinase. (228 aa) |
| | zwf-2 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (472 aa) |
| | AEJ02299.1 | KEGG: nit:NAL212_2002 succinate dehydrogenase, cytochrome b556 subunit; TIGRFAM: Succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase, cytochrome b subunit. (129 aa) |
| | AEJ02300.1 | KEGG: nmu:Nmul_A0862 succinate dehydrogenase, cytochrome b subunit; TIGRFAM: Succinate dehydrogenase, hydrophobic membrane anchor; PFAM: Succinate dehydrogenase, cytochrome b subunit. (117 aa) |
| | AEJ02301.1 | KEGG: nit:NAL212_2000 succinate dehydrogenase, flavoprotein subunit; TIGRFAM: Succinate dehydrogenase, flavoprotein subunit; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (587 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa) |
| | AEJ02329.1 | ROK family protein; PFAM: ROK; KEGG: dar:Daro_0037 N-acetylglucosamine kinase. (297 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (361 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (235 aa) |
| | AEJ02446.1 | PFAM: Methyltransferase type 11; KEGG: nit:NAL212_0155 methyltransferase type 11. (184 aa) |
| | AEJ02455.1 | CoA-binding domain protein; PFAM: CoA-binding; KEGG: rfr:Rfer_1518 CoA-binding. (290 aa) |
| | AEJ02488.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1236 aa) |
| | AEJ02491.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | AEJ02492.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (160 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | AEJ02541.1 | Delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; KEGG: nit:NAL212_1165 porphobilinogen synthase; Belongs to the ALAD family. (321 aa) |
| | argG | TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: nit:NAL212_1128 argininosuccinate synthase; PFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | AEJ02580.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa) |
| | argD | TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: nit:NAL212_1126 acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (386 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa) |
| | AEJ02584.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: nit:NAL212_1123 phosphoglycerate dehydrogenase. (398 aa) |
| | AEJ02585.1 | KEGG: nit:NAL212_1122 chorismate mutase; TIGRFAM: Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT. (356 aa) |
| | hisC-2 | TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: nit:NAL212_1121 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (372 aa) |
| | AEJ02587.1 | KEGG: nmu:Nmul_A2194 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (338 aa) |
| | AEJ02588.1 | PFAM: Prephenate dehydrogenase; KEGG: nit:NAL212_1120 prephenate dehydrogenase. (295 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (320 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | AEJ02695.1 | Protein of unknown function DUF224 cysteine-rich region domain protein; PFAM: Cysteine-rich region, CCG; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: nit:NAL212_2158 hypothetical protein. (416 aa) |
| | AEJ02696.1 | PFAM: FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal; KEGG: nit:NAL212_2159 FAD linked oxidase domain-containing protein. (357 aa) |
| | AEJ02697.1 | PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; KEGG: nit:NAL212_2160 D-lactate dehydrogenase (cytochrome). (484 aa) |
| | AEJ02709.1 | PFAM: Peptidase T2, asparaginase 2; KEGG: nit:NAL212_2859 beta-aspartyl-peptidase. (324 aa) |
| | AEJ02728.1 | TIGRFAM: Thiolase; KEGG: nit:NAL212_1990 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa) |
| | AEJ02737.1 | PFAM: Phosphopantetheine-binding; KEGG: nit:NAL212_1588 phosphopantetheine-binding protein. (84 aa) |
| | glk | Glucokinase; KEGG: nit:NAL212_1341 glucokinase; TIGRFAM: Glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (334 aa) |
| | AEJ02760.1 | KEGG: nit:NAL212_1340 alpha-glucan phosphorylase; TIGRFAM: Alpha-glucan phosphorylase; PFAM: Glycosyl transferase, family 35. (850 aa) |
| | metK-2 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | glgB | 1,4-alpha-glucan-branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (735 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (439 aa) |
| | AEJ02783.1 | Domain of unknown function DUF1926; PFAM: Alpha-amylase/4-alpha-glucanotransferase, prokaryotic; Domain of unknown function DUF1925; Glycoside hydrolase, family 57, core; KEGG: nit:NAL212_2767 4-alpha-glucanotransferase. (670 aa) |
| | pgi | KEGG: nit:NAL212_2766 glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (544 aa) |
| | glgA | Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (491 aa) |
| | AEJ02786.1 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; KEGG: nit:NAL212_1391 dihydrolipoyl dehydrogenase. (471 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | AEJ02810.1 | KEGG: nit:NAL212_1335 dihydrolipoamide dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Biotin/lipoyl attachment; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (588 aa) |
| | AEJ02829.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: nit:NAL212_0587 phosphoglycerate dehydrogenase. (322 aa) |
| | AEJ02838.1 | KEGG: nit:NAL212_0575 glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal. (187 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: nit:NAL212_0573 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (278 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (346 aa) |
| | AEJ02879.1 | KEGG: nit:NAL212_0669 malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase. (314 aa) |
| | AEJ02880.1 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | AEJ02890.1 | PFAM: FAD dependent oxidoreductase; KEGG: nit:NAL212_2630 glycerol-3-phosphate dehydrogenase. (529 aa) |
| | AEJ02910.1 | MOFRL domain protein; PFAM: MOFRL; KEGG: nit:NAL212_0695 hydroxypyruvate reductase. (423 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (614 aa) |
| | AEJ02946.1 | PFAM: Polyprenyl synthetase; KEGG: nit:NAL212_2664 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. (297 aa) |
| | AEJ02967.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | cbbL-2 | Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (491 aa) |
| | AEJ02970.1 | PFAM: Ribulose bisphosphate carboxylase, small chain; KEGG: nit:NAL212_2943 ribulose-bisphosphate carboxylase. (144 aa) |
| | AEJ02973.1 | KEGG: nit:NAL212_2946 ketose-bisphosphate aldolase; TIGRFAM: Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (406 aa) |
| | ilvA | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (503 aa) |
| | cysN | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (425 aa) |
| | AEJ03109.1 | KEGG: nmu:Nmul_A1148 sulfate adenylyltransferase subunit 2; TIGRFAM: Sulphate adenylyltransferase, small subunit; PFAM: Phosphoadenosine phosphosulphate reductase. (301 aa) |
| | AEJ03120.1 | Manually curated; KEGG: nit:NAL212_0633 serine O-acetyltransferase. (317 aa) |
| | AEJ03121.1 | KEGG: nit:NAL212_0632 cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (326 aa) |
| | AEJ03143.1 | PFAM: Inositol monophosphatase; KEGG: nit:NAL212_0282 inositol-phosphate phosphatase. (273 aa) |
| | AEJ03166.1 | KEGG: nit:NAL212_3100 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (246 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (279 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | AEJ03189.1 | TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; PFAM: HemN, C-terminal; Radical SAM; KEGG: nit:NAL212_3122 coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (469 aa) |
| | AEJ03195.1 | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (255 aa) |
| | AEJ03196.1 | PFAM: Phosphatidate cytidylyltransferase; KEGG: nit:NAL212_3129 phosphatidate cytidylyltransferase; Belongs to the CDS family. (273 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (395 aa) |
| | gpmA-2 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (246 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (274 aa) |
