STRINGSTRING
xpt xpt SJZ29589.1 SJZ29589.1 SJZ29683.1 SJZ29683.1 purF purF SJZ29833.1 SJZ29833.1 SJZ30028.1 SJZ30028.1 SJZ30145.1 SJZ30145.1 apt apt tilS tilS SJZ30927.1 SJZ30927.1 SJZ30935.1 SJZ30935.1 SJZ31431.1 SJZ31431.1 SJZ31479.1 SJZ31479.1 SJZ31484.1 SJZ31484.1 SJZ31496.1 SJZ31496.1 SJZ31562.1 SJZ31562.1 SJZ31818.1 SJZ31818.1 SJZ31864.1 SJZ31864.1 SJZ31868.1 SJZ31868.1 adk adk SJZ32325.1 SJZ32325.1 ychF ychF SJZ32646.1 SJZ32646.1 SJZ34082.1 SJZ34082.1 purC purC SJZ34559.1 SJZ34559.1 SJZ34769.1 SJZ34769.1 SJZ35769.1 SJZ35769.1 truA truA surE surE nrdR nrdR SJZ39416.1 SJZ39416.1 SJZ39427.1 SJZ39427.1 SJZ39492.1 SJZ39492.1 SJZ40148.1 SJZ40148.1 SJZ40170.1 SJZ40170.1 SJZ40180.1 SJZ40180.1 SJZ43899.1 SJZ43899.1 SJZ44759.1 SJZ44759.1 SJZ46297.1 SJZ46297.1 SJZ46332.1 SJZ46332.1 SJZ46739.1 SJZ46739.1 SJZ48787.1 SJZ48787.1 SJZ49725.1 SJZ49725.1 SJZ49856.1 SJZ49856.1 SJZ50789.1 SJZ50789.1 purD purD SJZ52052.1 SJZ52052.1 SJZ53042.1 SJZ53042.1 SJZ53526.1 SJZ53526.1 SJZ53673.1 SJZ53673.1 SJZ54745.1 SJZ54745.1 SJZ55987.1 SJZ55987.1 SJZ56395.1 SJZ56395.1 SJZ56544.1 SJZ56544.1 ndk ndk purA purA SJZ59947.1 SJZ59947.1 SJZ60026.1 SJZ60026.1 SJZ61298.1 SJZ61298.1 SJZ63901.1 SJZ63901.1 SJZ66614.1 SJZ66614.1 SJZ67316.1 SJZ67316.1 SJZ68858.1 SJZ68858.1 SJZ70116.1 SJZ70116.1 SJZ70165.1 SJZ70165.1 SJZ70887.1 SJZ70887.1 SJZ70985.1 SJZ70985.1 SJZ72182.1 SJZ72182.1 purN purN purM purM purE purE SJZ75525.1 SJZ75525.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa)
SJZ29589.1Ribonucleoside-triphosphate reductase class III catalytic subunit. (721 aa)
SJZ29683.13',5'-cyclic AMP phosphodiesterase CpdA. (367 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (461 aa)
SJZ29833.1Exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase. (509 aa)
SJZ30028.1Hypothetical protein. (224 aa)
SJZ30145.1IMP dehydrogenase. (502 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (459 aa)
SJZ30927.1GMP synthase (glutamine-hydrolysing). (625 aa)
SJZ30935.1Adenylate cyclase, class 3. (668 aa)
SJZ31431.1Predicted PurR-regulated permease PerM. (368 aa)
SJZ31479.1Phosphoribosylformylglycinamidine synthase. (1323 aa)
SJZ31484.1Nucleoid DNA-binding protein; Belongs to the bacterial histone-like protein family. (402 aa)
SJZ31496.1DNA-binding protein HU-beta; Belongs to the bacterial histone-like protein family. (91 aa)
SJZ31562.1Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (371 aa)
SJZ31818.1Tetrapyrrole methylase family protein / MazG family protein. (302 aa)
SJZ31864.1Adenylosuccinate lyase. (473 aa)
SJZ31868.1Putative GTP pyrophosphokinase. (230 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (210 aa)
SJZ32325.1Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. (713 aa)
ychFHypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (376 aa)
SJZ32646.1Pyruvate kinase; Belongs to the pyruvate kinase family. (598 aa)
SJZ34082.1Adenosine deaminase. (335 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (281 aa)
SJZ34559.1Predicted PurR-regulated permease PerM. (363 aa)
SJZ34769.1GAF domain-containing protein. (436 aa)
SJZ35769.1Type I restriction enzyme, R subunit. (815 aa)
truAtRNA pseudouridine38-40 synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (264 aa)
surE5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (254 aa)
nrdRTranscriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (153 aa)
SJZ39416.1Ribonucleoside-triphosphate reductase class III catalytic subunit. (702 aa)
SJZ39427.1Glutaredoxin. (182 aa)
SJZ39492.1XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (219 aa)
SJZ40148.1CO or xanthine dehydrogenase, Mo-binding subunit. (798 aa)
SJZ40170.1Carbon-monoxide dehydrogenase small subunit. (156 aa)
SJZ40180.1Molybdopterin dehydrogenase FAD binding domain-containing protein. (268 aa)
SJZ43899.1dGTPase; Belongs to the dGTPase family. Type 2 subfamily. (431 aa)
SJZ44759.1Adenosine deaminase. (341 aa)
SJZ46297.1Phosphoglucomutase. (587 aa)
SJZ46332.1Phosphoglucomutase. (594 aa)
SJZ46739.1Hypothetical protein. (208 aa)
SJZ48787.1Hypothetical protein. (230 aa)
SJZ49725.1Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (422 aa)
SJZ49856.1Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Belongs to the PurH family. (537 aa)
SJZ50789.1Calcineurin-like phosphoesterase. (292 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (447 aa)
SJZ52052.1ppGpp synthetase catalytic domain-containing protein (RelA/SpoT-type nucleotidyltranferase). (352 aa)
SJZ53042.1Predicted phosphoesterase. (249 aa)
SJZ53526.1ppGpp synthetase catalytic domain-containing protein (RelA/SpoT-type nucleotidyltranferase). (415 aa)
SJZ53673.1Integration host factor subunit beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (103 aa)
SJZ54745.1Adenylate cyclase, class 3. (286 aa)
SJZ55987.1tRNA(Ile)-lysidine synthase TilS/MesJ; Belongs to the TtcA family. (239 aa)
SJZ56395.1Purine-nucleoside phosphorylase. (233 aa)
SJZ56544.1HD domain-containing protein. (212 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (408 aa)
SJZ59947.1Adenylate cyclase, class 2. (200 aa)
SJZ60026.1Hypothetical protein. (229 aa)
SJZ61298.1Adenylate cyclase, class 3. (938 aa)
SJZ63901.1DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (92 aa)
SJZ66614.1Guanine deaminase. (147 aa)
SJZ67316.1IMP cyclohydrolase. (238 aa)
SJZ68858.1Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa)
SJZ70116.1Hypothetical protein. (110 aa)
SJZ70165.1O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain. (168 aa)
SJZ70887.1Uncharacterized membrane-anchored protein YitT, contains DUF161 and DUF2179 domains. (289 aa)
SJZ70985.1LysM domain-containing protein. (711 aa)
SJZ72182.1CBS domain-containing protein. (265 aa)
purNPhosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (213 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (364 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
SJZ75525.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (601 aa)
Your Current Organism:
Treponema porcinum
NCBI taxonomy Id: 261392
Other names: ATCC BAA-908, CIP 108245, JCM 12342, T. porcinum, Treponema porcinum Nordhoff et al. 2005, Treponema sp. 14V28, strain 14V28
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