STRINGSTRING
cotE cotE codY codY spo0A spo0A mntR mntR cymR cymR phoP phoP ccpA ccpA comK comK spoIIID spoIIID abrB abrB spoVT spoVT sinR sinR resD resD lexA lexA glnR glnR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cotESpore coat protein E. (180 aa)
codYTranscriptional regulator CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (259 aa)
spo0AStage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity). (264 aa)
mntRIron-dependent repressor family protein; Central regulator of manganese homeostasis. Belongs to the DtxR/MntR family. (142 aa)
cymRIdentified by match to protein family HMM PF02082; match to protein family HMM TIGR00738. (138 aa)
phoPDNA-binding response regulator PhoP; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (239 aa)
ccpAIdentified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481. (332 aa)
comKCompetence transcription factor ComK; Identified by match to protein family HMM PF06338. (168 aa)
spoIIIDStage III sporulation protein D; Identified by match to protein family HMM TIGR02844. (132 aa)
abrBTransition state transcriptional regulatory protein AbrB; Identified by similarity to SP:P08874; match to protein family HMM PF04014; match to protein family HMM TIGR01439. (94 aa)
spoVTStage V sporulation protein T; Identified by match to protein family HMM PF04014; match to protein family HMM TIGR01439; match to protein family HMM TIGR02851. (178 aa)
sinRTranscriptional regulator SinR; Identified by match to protein family HMM PF01381; match to protein family HMM PF08671. (107 aa)
resDDNA-binding response regulator ResD; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (238 aa)
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (206 aa)
glnRTranscriptional repressor GlnR; Transcription repressor during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high- affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site. (129 aa)
Your Current Organism:
Bacillus anthracis
NCBI taxonomy Id: 261594
Other names: B. anthracis str. 'Ames Ancestor', Bacillus anthracis str. 'Ames Ancestor', Bacillus anthracis str. Ames 0581, Bacillus anthracis str. Ames Ancestor
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