STRINGSTRING
groL groL abrB abrB gyrA gyrA GBAA_5701 GBAA_5701 pemK pemK spo0F spo0F glyA glyA comK comK nprB nprB GBAA_5164 GBAA_5164 spoVID spoVID safA safA splB splB spo0A spo0A GBAA_4230 GBAA_4230 codY codY polC polC cotE cotE sleL sleL GBAA_3612 GBAA_3612 dhaS dhaS amyS amyS sleB sleB iolD iolD iolC iolC GBAA_2241 GBAA_2241 GBAA_1706 GBAA_1706 flgK flgK spoIVA spoIVA comC comC sinR sinR mecA mecA GBAA_1162 GBAA_1162 bdbD bdbD purH purH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
abrBTransition state transcriptional regulatory protein AbrB; Identified by similarity to SP:P08874; match to protein family HMM PF04014; match to protein family HMM TIGR01439. (94 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (823 aa)
GBAA_5701Channel protein, hemolysin III family; Identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065. (215 aa)
pemKTranscriptional regulator, PemK family; Identified by match to protein family HMM PF02452. (116 aa)
spo0FSporulation initiation phosphotransferase F; Identified by match to protein family HMM PF00072. (122 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
comKCompetence transcription factor ComK; Identified by match to protein family HMM PF06338. (168 aa)
nprBNeutral protease B; Extracellular zinc metalloprotease. (547 aa)
GBAA_5164Conserved domain protein. (295 aa)
spoVIDPutative stage VI sporulation protein D; Identified by match to protein family HMM PF01476; match to protein family HMM TIGR02907. (327 aa)
safASpore coat assembly protein SafA; Identified by match to protein family HMM PF01476. (582 aa)
splBSpore photoproduct lyase; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR00620. (341 aa)
spo0AStage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity). (264 aa)
GBAA_4230Alpha-amylase; Identified by match to protein family HMM PF00128; match to protein family HMM PF02903; Belongs to the glycosyl hydrolase 13 family. (586 aa)
codYTranscriptional regulator CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (259 aa)
polCDNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1433 aa)
cotESpore coat protein E. (180 aa)
sleLGlycosyl hydrolase, family 18; N-acetylglucosaminidase involved in cortex peptidoglycan degradation during germination. Cleaves only partially degraded spore peptidoglycans. Recognizes muramic acid delta-lactam residues specific to spore peptidoglycans. (430 aa)
GBAA_3612Putative squalene-hopene cyclase; Identified by match to protein family HMM PF00432; match to protein family HMM TIGR01787. (617 aa)
dhaSAldehyde dehydrogenase (NAD); Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (494 aa)
amySAlpha-amylase; Identified by match to protein family HMM PF00128. (513 aa)
sleBSpore cortex-lytic enzyme prepeptide; Identified by match to protein family HMM PF01471; match to protein family HMM PF07486; match to protein family HMM TIGR02869. (253 aa)
iolDPutative iolD protein; Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG). (644 aa)
iolCPutative iolC protein; Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2- deoxy-D-gluconate (DKGP). (332 aa)
GBAA_2241Hemolysin III; Identified by similarity to SP:P54176; match to protein family HMM PF03006; match to protein family HMM TIGR01065. (218 aa)
GBAA_1706Flagellin; Identified by match to protein family HMM PF00669; match to protein family HMM PF00700. (287 aa)
flgKPutative flagellar hook-associated protein; Identified by match to protein family HMM PF06429; match to protein family HMM TIGR02492. (432 aa)
spoIVAStage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Directs the assembly of the coat and exosporium to an area around the forespore. (492 aa)
comCLate competence protein comC; Identified by match to protein family HMM PF01478; match to protein family HMM PF06750. (240 aa)
sinRTranscriptional regulator SinR; Identified by match to protein family HMM PF01381; match to protein family HMM PF08671. (107 aa)
mecANegative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC (By similarity). (217 aa)
GBAA_1162Identified by match to protein family HMM PF00128. (433 aa)
bdbDConserved hypothetical protein; May be required for disulfide bond formation in some proteins. (217 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. (511 aa)
Your Current Organism:
Bacillus anthracis
NCBI taxonomy Id: 261594
Other names: B. anthracis str. 'Ames Ancestor', Bacillus anthracis str. 'Ames Ancestor', Bacillus anthracis str. Ames 0581, Bacillus anthracis str. Ames Ancestor
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