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hemE hemE aceA aceA hemH1 hemH1 hemH2 hemH2 odhA odhA cysG cysG GBAA_1631 GBAA_1631 GBAA_3124 GBAA_3124 GBAA_4313 GBAA_4313 pta pta isdG isdG hemA hemA hemC hemC hemD hemD hemB hemB GBAA_4503 GBAA_4503 gltX gltX GBAA_0537 GBAA_0537
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (348 aa)
aceAIsocitrate lyase; Identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346. (425 aa)
hemH1Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (311 aa)
hemH2Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (319 aa)
odhA2-oxoglutarate dehydrogenase, E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (955 aa)
cysGuroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. (258 aa)
GBAA_1631Putative membrane protein; Identified by match to protein family HMM PF01810. (210 aa)
GBAA_3124Putative membrane protein; Identified by match to protein family HMM PF01810. (208 aa)
GBAA_4313Transcriptional regulator, Fur family; Identified by match to protein family HMM PF01475; Belongs to the Fur family. (151 aa)
ptaPhosphate acetyltransferase; Identified by match to protein family HMM PF01515; match to protein family HMM TIGR00651. (323 aa)
isdGConserved hypothetical protein; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. (107 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (444 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa)
hemDuroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (250 aa)
hemBDelta-aminolevulinic acid dehydratase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. (329 aa)
GBAA_4503Transcriptional regulator, Fur family; Identified by match to protein family HMM PF01475. (137 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa)
GBAA_0537Transcriptional regulator, Fur family; Identified by match to protein family HMM PF01475; Belongs to the Fur family. (144 aa)
Your Current Organism:
Bacillus anthracis
NCBI taxonomy Id: 261594
Other names: B. anthracis str. 'Ames Ancestor', Bacillus anthracis str. 'Ames Ancestor', Bacillus anthracis str. Ames 0581, Bacillus anthracis str. Ames Ancestor
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