STRINGSTRING
tmk tmk SCE83967.1 SCE83967.1 SCE84664.1 SCE84664.1 SCE84684.1 SCE84684.1 SCE84999.1 SCE84999.1 SCE85774.1 SCE85774.1 pyrE pyrE dcd dcd SCE68406.1 SCE68406.1 SCE71023.1 SCE71023.1 SCE74989.1 SCE74989.1 SCE75347.1 SCE75347.1 SCE75446.1 SCE75446.1 SCE75462.1 SCE75462.1 SCE78769.1 SCE78769.1 pyrH pyrH SCE96225.1 SCE96225.1 SCF02088.1 SCF02088.1 SCF02246.1 SCF02246.1 SCF03209.1 SCF03209.1 SCF08001.1 SCF08001.1 SCF08709.1 SCF08709.1 SCF12814.1 SCF12814.1 SCF12827.1 SCF12827.1 SCF07021.1 SCF07021.1 groS groS SCF07321.1 SCF07321.1 SCF17429.1 SCF17429.1 SCF07634.1 SCF07634.1 SCF20615.1 SCF20615.1 SCF23237.1 SCF23237.1 SCF24934.1 SCF24934.1 SCF19090.1 SCF19090.1 SCF19756.1 SCF19756.1 SCF20096.1 SCF20096.1 SCF20113.1 SCF20113.1 SCF29744.1 SCF29744.1 SCF30696.1 SCF30696.1 pyrR pyrR pyrB pyrB pyrC pyrC carA carA carB carB pyrD pyrD pyrF pyrF SCF32209.1 SCF32209.1 SCF27621.1 SCF27621.1 tadA tadA SCF33791.1 SCF33791.1 SCF36153.1 SCF36153.1 SCF36981.1 SCF36981.1 SCF34159.1 SCF34159.1 SCF34289.1 SCF34289.1 dut dut psuG psuG SCF39663.1 SCF39663.1 nrdR nrdR SCF40047.1 SCF40047.1 thyX thyX SCF38329.1 SCF38329.1 SCF37742.1 SCF37742.1 SCF43686.1 SCF43686.1 SCF44164.1 SCF44164.1 pyrE-2 pyrE-2 SCF45180.1 SCF45180.1 cmk cmk pyrG pyrG SCF45695.1 SCF45695.1 SCF46316.1 SCF46316.1 SCF46719.1 SCF46719.1 ndk ndk
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (782 aa)
SCE83967.1Lamin Tail Domain. (151 aa)
SCE84664.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (770 aa)
SCE84684.1Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (333 aa)
SCE84999.1Protein of unknown function (DUF2786). (234 aa)
SCE85774.1Hypothetical protein. (403 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (192 aa)
SCE68406.1N-carbamoyl-L-amino-acid hydrolase. (399 aa)
SCE71023.1Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (196 aa)
SCE74989.1Uracil phosphoribosyltransferase; Belongs to the UPRTase family. (210 aa)
SCE75347.1Uridine kinase. (201 aa)
SCE75446.1Thymidine phosphorylase. (426 aa)
SCE75462.1Cytidine deaminase. (234 aa)
SCE78769.1Protein of unknown function (DUF2786). (401 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (255 aa)
SCE96225.1Hypothetical protein. (163 aa)
SCF02088.1N-carbamoyl-L-amino-acid hydrolase. (418 aa)
SCF02246.1Hypothetical protein; Belongs to the LOG family. (211 aa)
SCF03209.1Nicotinamidase-related amidase. (184 aa)
SCF08001.1Uridine kinase. (224 aa)
SCF08709.1Thymidylate kinase. (231 aa)
SCF12814.1Hypothetical protein; Belongs to the LOG family. (181 aa)
SCF12827.1Hypothetical protein. (325 aa)
SCF07021.1Uncharacterized conserved protein, DUF1015 family. (402 aa)
groSChaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (102 aa)
SCF07321.15-methylcytosine-specific restriction endonuclease McrA. (177 aa)
SCF17429.1Na+/melibiose symporter. (459 aa)
SCF07634.1AAA domain. (218 aa)
SCF20615.1Na+/melibiose symporter. (443 aa)
SCF23237.1Hypothetical protein. (208 aa)
SCF24934.1Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (401 aa)
SCF19090.12',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; Belongs to the 5'-nucleotidase family. (596 aa)
SCF19756.13-hydroxypropanoate dehydrogenase. (199 aa)
SCF20096.1MFS transporter, UMF1 family. (463 aa)
SCF20113.1Thymidine kinase. (239 aa)
SCF29744.1Cytidine deaminase. (155 aa)
SCF30696.1MFS transporter, DHA2 family, multidrug resistance protein. (543 aa)
pyrRPyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (194 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (425 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (397 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1115 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
SCF32209.1Cytidylate kinase, putative. (326 aa)
SCF27621.1Putative hydrolases of HD superfamily. (194 aa)
tadAtRNA(adenine34) deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (227 aa)
SCF33791.1Purine-nucleoside phosphorylase. (235 aa)
SCF36153.1Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. (112 aa)
SCF36981.1Hypothetical protein. (1088 aa)
SCF34159.1Protein of unknown function (DUF1524). (200 aa)
SCF34289.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (579 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (177 aa)
psuGPseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (310 aa)
SCF39663.1Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (960 aa)
nrdRTranscriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (177 aa)
SCF40047.1Hypothetical protein. (262 aa)
thyXThymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (245 aa)
SCF38329.1Hypothetical protein. (327 aa)
SCF37742.13-hydroxypropanoate dehydrogenase. (203 aa)
SCF43686.1Hypothetical protein. (145 aa)
SCF44164.1Major Facilitator Superfamily protein. (425 aa)
pyrE-2Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (172 aa)
SCF45180.1Hypothetical protein. (128 aa)
cmkCytidylate kinase. (226 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (585 aa)
SCF45695.1MFS transporter, DHA2 family, methylenomycin A resistance protein; Belongs to the major facilitator superfamily. (501 aa)
SCF46316.1Protein of unknown function (DUF222). (506 aa)
SCF46719.1Putative hydrolase of the HAD superfamily. (214 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
Your Current Organism:
Micromonospora mirobrigensis
NCBI taxonomy Id: 262898
Other names: DSM 44830, JCM 13240, LMG 22229, LMG:22229, M. mirobrigensis, Micromonospora mirobrigensis Trujillo et al. 2005, Micromonospora sp. WA201, NBRC 101890, strain WA201
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