STRINGSTRING
PTO0042 PTO0042 PTO0043 PTO0043 PTO0044 PTO0044 PTO0148 PTO0148 PTO0150 PTO0150 PTO0168 PTO0168 PTO0169 PTO0169 PTO0170 PTO0170 PTO0171 PTO0171 PTO0225 PTO0225 acyP acyP PTO0281 PTO0281 PTO0282 PTO0282 PTO0283 PTO0283 PTO0332 PTO0332 PTO0336 PTO0336 PTO0348 PTO0348 PTO0382 PTO0382 PTO0383 PTO0383 PTO0384 PTO0384 PTO0426 PTO0426 PTO0427 PTO0427 gad gad PTO0501 PTO0501 PTO0502 PTO0502 PTO0536 PTO0536 PTO0546 PTO0546 PTO0547 PTO0547 PTO0548 PTO0548 PTO0549 PTO0549 rpiA rpiA PTO0631 PTO0631 gdh1 gdh1 PTO0675 PTO0675 tal tal PTO0690 PTO0690 PTO0691 PTO0691 gap gap PTO0756 PTO0756 PTO0791 PTO0791 fbp fbp PTO0830 PTO0830 PTO0845 PTO0845 PTO0887 PTO0887 PTO0889 PTO0889 PTO0906 PTO0906 PTO0935 PTO0935 PTO0954 PTO0954 PTO0957 PTO0957 ppcA ppcA mdh mdh PTO0995 PTO0995 PTO0996 PTO0996 PTO0997 PTO0997 PTO0998 PTO0998 PTO0999 PTO0999 PTO1000 PTO1000 sucD sucD PTO1003 PTO1003 PTO1012 PTO1012 PTO1021 PTO1021 PTO1022 PTO1022 PTO1023 PTO1023 PTO1024 PTO1024 PTO1025 PTO1025 PTO1026 PTO1026 gdh2 gdh2 PTO1175 PTO1175 PTO1187 PTO1187 PTO1188 PTO1188 PTO1189 PTO1189 PTO1216 PTO1216 PTO1226 PTO1226 eno eno PTO1259 PTO1259 apgM apgM PTO1279 PTO1279 PTO1360 PTO1360 PTO1361 PTO1361 PTO1383 PTO1383 PTO1384 PTO1384 PTO1385 PTO1385 PTO1396 PTO1396 PTO1423 PTO1423 gck gck PTO1446 PTO1446 PTO1453 PTO1453 PTO1459 PTO1459 PTO1504 PTO1504 PTO1505 PTO1505 pgk pgk PTO1517 PTO1517 PTO1519 PTO1519
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTO0042NADH oxidase. (97 aa)
PTO0043Altronate hydrolase. (393 aa)
PTO0044Altronate hydrolase. (98 aa)
PTO0148Mannonate dehydratase. (329 aa)
PTO0150Glutamate decarboxylase. (455 aa)
PTO0168Isocitrate dehydrogenase [NADP]. (392 aa)
PTO01692-methylcitrate-synthase. (365 aa)
PTO0170Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (284 aa)
PTO01712-methylisocitrate synthase. (425 aa)
PTO0225NAD-dependent aldehyde dehydrogenase. (510 aa)
acyPAcylphosphatase. (81 aa)
PTO0281Electron transfer flavoprotein beta-subunit. (233 aa)
PTO0282Electron transfer flavoprotein alpha subunit. (289 aa)
PTO0283Acetyl-coenzyme A synthetase. (650 aa)
PTO0332Succinate-semialdehyde dehydrogenase [NADP+]; NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes. (493 aa)
PTO0336Pyruvate kinase; Belongs to the pyruvate kinase family. (555 aa)
PTO0348Triosephosphate isomerase; Belongs to the HisA/HisF family. (219 aa)
PTO0382Hypothetical protein DUF35. (132 aa)
PTO0383Beta-ketoacyl synthase; Thiolase. (402 aa)
PTO03843-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. (351 aa)
PTO0426Isocitrate dehydrogenase [NADP]. (355 aa)
PTO0427Fumarate hydratase. (455 aa)
gadGluconate/galactonate dehydratase; Involved in the degradation of glucose and galactose via the nonphosphorylative variant of Entner-Doudoroff pathway. Catalyzes the dehydration of gluconate to produce 2-keto-3-deoxygluconate (KDG). It is also able to catalyze the dehydration of galactonate to produce 2- keto-3-deoxygalactonate (KDGal); Belongs to the mandelate racemase/muconate lactonizing enzyme family. GaD subfamily. (391 aa)
PTO0501Acetyl-coenzyme A synthetase. (214 aa)
PTO0502Acetyl-coenzyme A synthetase. (396 aa)
PTO0536acyl-CoA synthetase. (657 aa)
PTO0546Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (426 aa)
PTO0547Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (386 aa)
PTO0548Pyruvate dehydrogenase E1 component beta subunit. (321 aa)
PTO0549Pyruvate dehydrogenase E1 component alpha subunit. (333 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa)
PTO0631Long chain fatty acid CoA ligase. (557 aa)
gdh1Glucose-1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (352 aa)
PTO0675Transcriptional repressor/ROK family. (267 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (223 aa)
PTO0690Transketolase subunit B. (316 aa)
PTO0691Transketolase subunit A. (302 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase. (348 aa)
PTO0756Aldose1-epimerase; Mutarotase. (265 aa)
PTO07914-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa)
fbpDihydroorotate dehydrogenase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (378 aa)
PTO0830acyl-CoA dehydrogenase. (381 aa)
PTO0845Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa)
PTO0887Dihydrolipoamide dehydrogenase. (446 aa)
PTO0889Citrate synthase. (373 aa)
PTO0906Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (288 aa)
PTO0935Aconitate hydratase. (833 aa)
PTO0954enoyl-CoA hydratase/isomerase family. (238 aa)
PTO0957Malate oxidoreductase. (442 aa)
ppcAHypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (508 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (324 aa)
PTO0995Succinate dehydrogenase flavoprotein subunit. (560 aa)
PTO0996Succinate dehydrogenase iron-sulfur protein. (312 aa)
PTO0997Succinate dehydrogenase, subunit C. (290 aa)
PTO0998Succinate dehydrogenase, subunit D. (109 aa)
PTO09992-oxoglutarate synthase, beta chain. (306 aa)
PTO10002-oxoglutarate synthase, alpha chain. (631 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (284 aa)
PTO1003succinyl-CoA synthetase beta chain. (368 aa)
PTO1012Lactate 2-monooxygenase. (384 aa)
PTO10213-hydroxybutyryl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase. (644 aa)
PTO1022medium-chain-fatty-acid--CoA ligase. (525 aa)
PTO10233-ketoacyl-CoA thiolase. (395 aa)
PTO1024acyl-CoA dehydrogenase. (357 aa)
PTO1025acyl-CoA dehydrogenase, short-chain specific. (314 aa)
PTO10262-keto-3-deoxy gluconate aldolase. (287 aa)
gdh2Glucose-1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with D- galactose as substrate, but not with D-xylose, L-arabinose, D-ribose, D-mannose, D-allose, D-glucosamine, 2-deoxy-D-glucose, or glucose-6- phosphate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+) (20-fold higher activity). Physiologically, may be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway; Belongs to th [...] (359 aa)
PTO1175acetoacetyl-CoA synthetase. (624 aa)
PTO1187Hypothetical cytosolic protein. (147 aa)
PTO1188Beta-ketoacyl synthase; Thiolase. (415 aa)
PTO1189isovaleryl-CoA dehydrogenase. (372 aa)
PTO1216Glucokinase. (317 aa)
PTO1226Glucose/mannose-6-phosphate isomerase. (305 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (400 aa)
PTO1259Beta-galactosidase; Belongs to the glycosyl hydrolase 1 family. (453 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (402 aa)
PTO1279Dihydrodipicolinate synthase; Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy- 6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2- keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3- deoxygalactonate (KDGal). It is equally active with both D- and L- glyceraldehyde; Belongs to the DapA family. KDPG aldolase subfamily. (266 aa)
PTO1360Pyruvate ferredoxin oxidoreductase, alpha chain. (583 aa)
PTO1361Pyruvate ferredoxin oxidoreductase, beta chain. (282 aa)
PTO1383Electron transfer flavoprotein alpha and beta-subunit. (607 aa)
PTO1384FixC protein. (396 aa)
PTO1385Ferredoxin like protein. (95 aa)
PTO1396acyl-CoA dehydrogenase, short-chain specific. (377 aa)
PTO1423Phosphoglycerate mutase/fructose-2,6-bisphosphatase. (189 aa)
gckGlycerate kinase, putative; Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also partially utilize GTP, CTP or UTP as phosphate donor. (415 aa)
PTO1446Phosphoglycerate mutase family protein. (198 aa)
PTO1453Beta-galactosidase; Belongs to the glycosyl hydrolase 1 family. (495 aa)
PTO1459acyl-CoA dehydrogenase. (537 aa)
PTO15043-hydroxybutyryl-CoA dehydrogenase. (273 aa)
PTO1505acetyl-CoA acetyltransferase. (388 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (414 aa)
PTO1517Hypothetical transcriptional regulator. (224 aa)
PTO1519Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (776 aa)
Your Current Organism:
Picrophilus torridus
NCBI taxonomy Id: 263820
Other names: P. torridus DSM 9790, Picrophilus torridus DSM 9790, Picrophilus torridus DSM9790, Picrophilus torridus str. DSM 9790, Picrophilus torridus strain DSM 9790
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