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dnaE-2 dnaE-2 glnD glnD dacA-2 dacA-2 rfbA rfbA Bd1820 Bd1820 Bd1799 Bd1799 neuA neuA fic fic Bd1685 Bd1685 rnpO rnpO Bd1567 Bd1567 pnp pnp ribC ribC Bd1464 Bd1464 Bd1434 Bd1434 holB holB rpoN rpoN cks cks polA polA rfaE rfaE ppaT ppaT Bd0385 Bd0385 dnaE dnaE pleD pleD dinP dinP Bd0344 Bd0344 dnaG dnaG pcnB pcnB glmU glmU dnaN dnaN Bd0153 Bd0153 glnE glnE fliA fliA rfaE-2 rfaE-2 polC-2 polC-2 Bd3125 Bd3125 rpoB rpoB rpoC rpoC Bd3531 Bd3531 dnaX dnaX Bd3766 Bd3766 galF galF cdsA cdsA polC-3 polC-3 rsfS rsfS rpoA rpoA manC manC Bd2894 Bd2894 rph rph Bd2547 Bd2547 lplA lplA lig-2 lig-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaE-2DNA polymerase III alpha subunit. (1179 aa)
glnDprotein-P-II uridylyltransferase; InterPro: HD domain,; hypothetical protein. (769 aa)
dacA-2Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (269 aa)
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (295 aa)
Bd1820Poly A polymerase; Region start changed from 1747279 to 1747288 (-9 bases); Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (397 aa)
Bd1799Conserved hypothetical protein. (499 aa)
neuAProbable acylneuraminate cytidylyltransferase. (230 aa)
ficCell filamentation protein. (195 aa)
Bd1685Mannose-1-phosphate guanyltransferase; InterPro: ADP-glucose pyrophosphorylase; hypothetical protein. (350 aa)
rnpOPutative DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (79 aa)
Bd1567Unnamed protein product; hypothetical protein. (292 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (697 aa)
ribCRiboflavin kinase / FAD synthase ribC; Belongs to the ribF family. (314 aa)
Bd1464DNA polymerase III, delta subunit. (336 aa)
Bd1434GGDEF domain protein; InterPro: Domain of unknown function DUF9; hypothetical protein. (408 aa)
holBDNA polymerase III delta' subunit; InterPro: AAA ATPase superfamily; hypothetical protein. (314 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (478 aa)
cks3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (247 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (863 aa)
rfaEADP-heptose synthase; Carbohydrate kinase, PfkB family; hypothetical protein. (342 aa)
ppaTPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
Bd0385Hypothetical protein predicted by Glimmer/Critica. (420 aa)
dnaEDNA polymerase III, alpha chain; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1061 aa)
pleDTwo-component response regulator with GGDEF domain; hypothetical protein. (343 aa)
dinPDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (356 aa)
Bd0344Putative translation factor related to Sua5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (338 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (622 aa)
pcnBInterPro: Poly A polymerase family; hypothetical protein; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (409 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase / diamine N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexap [...] (466 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa)
Bd0153Mannose-1-phosphate guanyltransferase; hypothetical protein. (329 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (766 aa)
fliARNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (261 aa)
rfaE-2ADP-heptose synthase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (155 aa)
polC-2DNA polymerase III alpha subunit; InterPro: Exonuclease; hypothetical protein. (276 aa)
Bd3125Sensor histidine kinase; InterPro: Domain of unknown function DUF9; hypothetical protein. (496 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1422 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1375 aa)
Bd3531Conserved hypothetical protein; DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog. (618 aa)
dnaXDNA polymerase III gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (621 aa)
Bd3766Conserved hypothetical protein; Putative Cyclic nucleotide phosphodiesterase, putative; hypothetical protein. (627 aa)
galFUTP-glucose-1-phosphate uridylyltransferase; InterPro: ADP-glucose pyrophosphorylase; hypothetical protein. (294 aa)
cdsACytidylyltransferase family, phosphatidate cytidylyltransferase; hypothetical protein. (278 aa)
polC-3InterPro: Exonuclease, DNA polymerase III polC-type; hypothetical protein. (217 aa)
rsfSProbable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). Belongs to the Iojap/RsfS family. (342 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa)
manCMannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase(MANC), InterPro: Mannose-6-phosphate isomerase type II; hypothetical protein. (464 aa)
Bd2894Putative phosphatidate cytidiltransferase; InterPro: Putative integral membrane protein; hypothetical protein. (314 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa)
Bd2547Hypothetical protein predicted by Glimmer/Critica. (468 aa)
lplALipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. (339 aa)
lig-2Lig protein; InterPro: ATP-dependent DNA ligase; hypothetical protein. (740 aa)
Your Current Organism:
Bdellovibrio bacteriovorus HD100
NCBI taxonomy Id: 264462
Other names: B. bacteriovorus HD100, Bdellovibrio bacteriovorus DSM 50701, Bdellovibrio bacteriovorus str. HD100, Bdellovibrio bacteriovorus strain HD100
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