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Moth_0262 Moth_0262 pgk pgk tpiA tpiA gpmI gpmI eno eno Moth_0376 Moth_0376 Moth_0377 Moth_0377 Moth_0378 Moth_0378 Moth_0379 Moth_0379 Moth_0380 Moth_0380 Moth_0421 Moth_0421 Moth_0474 Moth_0474 Moth_0508 Moth_0508 Moth_0607 Moth_0607 Moth_0609 Moth_0609 Moth_0610 Moth_0610 pckA1 pckA1 Moth_0732 Moth_0732 Moth_0832 Moth_0832 Moth_0934 Moth_0934 Moth_1024 Moth_1024 pfp pfp Moth_1591 Moth_1591 Moth_1592 Moth_1592 Moth_1593 Moth_1593 pfkA pfkA Moth_1763 Moth_1763 ldh ldh Moth_1867 Moth_1867 pfkA-2 pfkA-2 pckA2 pckA2 Moth_1921 Moth_1921 Moth_1922 Moth_1922 Moth_1923 Moth_1923 Moth_1924 Moth_1924 Moth_1984 Moth_1984 Moth_1985 Moth_1985 Moth_2166 Moth_2166 Moth_2170 Moth_2170 fbp fbp Moth_2276 Moth_2276 Moth_0033 Moth_0033 Moth_2404 Moth_2404 Moth_0034 Moth_0034 Moth_0064 Moth_0064 Moth_0092 Moth_0092
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Moth_0262Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (393 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
Moth_0376Pyruvate ferredoxin oxidoreductase, gamma subunit. (182 aa)
Moth_03772-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate. (89 aa)
Moth_0378Pyruvate ferredoxin oxidoreductase, alpha subunit. (405 aa)
Moth_0379Ketoisovalerate ferredoxin oxidoreductase, beta subunit. (288 aa)
Moth_0380CoA-binding protein. (707 aa)
Moth_0421Transcriptional regulator, MarR family. (410 aa)
Moth_0474Fructose-bisphosphate aldolase. (267 aa)
Moth_0508Glucose-6-phosphate isomerase. (244 aa)
Moth_0607Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (884 aa)
Moth_0609Fructose-bisphosphate aldolase. (284 aa)
Moth_0610Bifunctional phosphoglucose/phosphomannose isomerase. (360 aa)
pckA1Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (525 aa)
Moth_0732Putative transcriptional regulator, CopG family. (134 aa)
Moth_0832Glucokinase. (315 aa)
Moth_0934Pyruvate ferredoxin/flavodoxin oxidoreductase. (192 aa)
Moth_1024Iron-containing alcohol dehydrogenase. (366 aa)
pfpPyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (409 aa)
Moth_1591Pyruvate ferredoxin oxidoreductase, beta subunit; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria. (314 aa)
Moth_1592Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria. (395 aa)
Moth_15932-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria. (315 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (360 aa)
Moth_1763Dihydrolipoamide dehydrogenase. (459 aa)
ldhMalate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
Moth_1867Pyruvate kinase; Belongs to the pyruvate kinase family. (582 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
pckA2Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (526 aa)
Moth_1921Pyruvate ferredoxin oxidoreductase, beta subunit. (273 aa)
Moth_1922Pyruvate ferredoxin oxidoreductase, alpha subunit. (391 aa)
Moth_19232-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate. (96 aa)
Moth_1924Pyruvate ferredoxin oxidoreductase, gamma subunit. (195 aa)
Moth_19842-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (390 aa)
Moth_19852-oxoglutarate ferredoxin oxidoreductase, beta subunit. (281 aa)
Moth_2166Transcriptional regulator, CopG family. (91 aa)
Moth_2170Acetyl-coenzyme A synthetase. (329 aa)
fbpFructose-bisphosphate aldolase / D-fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (379 aa)
Moth_2276Pyruvate ferredoxin/flavodoxin oxidoreductase. (192 aa)
Moth_0033Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (363 aa)
Moth_2404Fructose-bisphosphate aldolase. (286 aa)
Moth_00342-oxoglutarate synthase. (264 aa)
Moth_0064Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...] (1171 aa)
Moth_0092RNA binding S1. (130 aa)
Your Current Organism:
Moorella thermoacetica
NCBI taxonomy Id: 264732
Other names: M. thermoacetica ATCC 39073, Moorella thermoacetica ATCC 39073, Moorella thermoacetica str. ATCC 39073, Moorella thermoacetica strain ATCC 39073
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