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Moth_0376 Moth_0376 Moth_0033 Moth_0033 Moth_0034 Moth_0034 Moth_0377 Moth_0377 Moth_0064 Moth_0064 Moth_0269 Moth_0269 Moth_2283 Moth_2283 Moth_2282 Moth_2282 Moth_2276 Moth_2276 leuA leuA Moth_2251 Moth_2251 Moth_2179 Moth_2179 Moth_2170 Moth_2170 Moth_2166 Moth_2166 Moth_1985 Moth_1985 Moth_1984 Moth_1984 Moth_1938 Moth_1938 Moth_1926 Moth_1926 Moth_1924 Moth_1924 Moth_1923 Moth_1923 Moth_1922 Moth_1922 Moth_1921 Moth_1921 pckA2 pckA2 Moth_1867 Moth_1867 ldh ldh Moth_1776 Moth_1776 Moth_1763 Moth_1763 Moth_1678 Moth_1678 Moth_1593 Moth_1593 Moth_1592 Moth_1592 Moth_1591 Moth_1591 Moth_1525 Moth_1525 Moth_1524 Moth_1524 Moth_1260 Moth_1260 Moth_1259 Moth_1259 acyP acyP Moth_1181 Moth_1181 ackA ackA Moth_0934 Moth_0934 Moth_0864 Moth_0864 Moth_0732 Moth_0732 Moth_0729 Moth_0729 pckA1 pckA1 Moth_0607 Moth_0607 Moth_0552 Moth_0552 Moth_0401 Moth_0401 Moth_0380 Moth_0380 Moth_0379 Moth_0379 Moth_0378 Moth_0378
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Moth_0376Pyruvate ferredoxin oxidoreductase, gamma subunit. (182 aa)
Moth_0033Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (363 aa)
Moth_00342-oxoglutarate synthase. (264 aa)
Moth_03772-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate. (89 aa)
Moth_0064Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...] (1171 aa)
Moth_0269Beta-lactamase-like protein. (297 aa)
Moth_2283Fumarase alpha subunit. (281 aa)
Moth_2282Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region. (219 aa)
Moth_2276Pyruvate ferredoxin/flavodoxin oxidoreductase. (192 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
Moth_22512-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
Moth_2179(NiFe) hydrogenase maturation protein HypF. (767 aa)
Moth_2170Acetyl-coenzyme A synthetase. (329 aa)
Moth_2166Transcriptional regulator, CopG family. (91 aa)
Moth_19852-oxoglutarate ferredoxin oxidoreductase, beta subunit. (281 aa)
Moth_19842-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (390 aa)
Moth_1938Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa)
Moth_1926Conserved hypothetical protein. (429 aa)
Moth_1924Pyruvate ferredoxin oxidoreductase, gamma subunit. (195 aa)
Moth_19232-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate. (96 aa)
Moth_1922Pyruvate ferredoxin oxidoreductase, alpha subunit. (391 aa)
Moth_1921Pyruvate ferredoxin oxidoreductase, beta subunit. (273 aa)
pckA2Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (526 aa)
Moth_1867Pyruvate kinase; Belongs to the pyruvate kinase family. (582 aa)
ldhMalate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
Moth_1776Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (291 aa)
Moth_1763Dihydrolipoamide dehydrogenase. (459 aa)
Moth_1678Beta-lactamase-like protein. (207 aa)
Moth_15932-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria. (315 aa)
Moth_1592Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria. (395 aa)
Moth_1591Pyruvate ferredoxin oxidoreductase, beta subunit; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria. (314 aa)
Moth_1525acetyl-CoA carboxylase, biotin carboxyl carrier protein. (643 aa)
Moth_1524acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
Moth_1260acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Moth_1259Propionate CoA-transferase; Belongs to the 3-oxoacid CoA-transferase family. (527 aa)
acyPAcylphosphatase. (93 aa)
Moth_1181Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (204 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
Moth_0934Pyruvate ferredoxin/flavodoxin oxidoreductase. (192 aa)
Moth_0864Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (200 aa)
Moth_0732Putative transcriptional regulator, CopG family. (134 aa)
Moth_0729Conserved hypothetical protein. (427 aa)
pckA1Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (525 aa)
Moth_0607Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (884 aa)
Moth_0552Isopropylmalate/homocitrate/citramalate synthases-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (184 aa)
Moth_0401Malate dehydrogenase (oxaloacetate decarboxylating). (407 aa)
Moth_0380CoA-binding protein. (707 aa)
Moth_0379Ketoisovalerate ferredoxin oxidoreductase, beta subunit. (288 aa)
Moth_0378Pyruvate ferredoxin oxidoreductase, alpha subunit. (405 aa)
Your Current Organism:
Moorella thermoacetica
NCBI taxonomy Id: 264732
Other names: M. thermoacetica ATCC 39073, Moorella thermoacetica ATCC 39073, Moorella thermoacetica str. ATCC 39073, Moorella thermoacetica strain ATCC 39073
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