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argC argC Mfla_0061 Mfla_0061 ilvD ilvD leuA leuA Mfla_0567 Mfla_0567 ilvE ilvE leuA-2 leuA-2 Mfla_0903 Mfla_0903 Mfla_1319 Mfla_1319 asd asd leuB leuB leuD leuD leuC leuC argD argD Mfla_1817 Mfla_1817 Mfla_2119 Mfla_2119 Mfla_2120 Mfla_2120 ilvC ilvC Mfla_2139 Mfla_2139 argJ argJ argA argA argB argB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
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Your Input:
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (350 aa)
Mfla_0061TIGRFAM: citrate synthase I; PRIAM: Citrate (Si)-synthase; PFAM: Citrate synthase; KEGG: tbd:Tbd_1187 citrate synthase I; COGs: COG0372 Citrate synthase category=C; Belongs to the citrate synthase family. (430 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; PRIAM: Dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: cvi:CV1277 dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase category=G; Belongs to the IlvD/Edd family. (616 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
Mfla_0567TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PRIAM: Aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: neu:NE2132 aspartate kinase; COGs: COG0527 Aspartokinases category=E; Belongs to the aspartokinase family. (408 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (562 aa)
Mfla_0903Aminotransferase. (429 aa)
Mfla_1319Aminotransferase. (398 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (351 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: tbd:Tbd_1851 acetylornithine and succinylornithine aminotransferase; COGs: COG4992 Ornithine/acetylornithine aminotransferase category=E; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (392 aa)
Mfla_1817Aconitase; PRIAM: Aconitate hydratase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: noc:Noc_2103 aconitate hydratase; COGs: COG1049 Aconitase B category=C; Belongs to the aconitase/IPM isomerase family. (855 aa)
Mfla_2119TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tbd:Tbd_1991 acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase] category=H. (568 aa)
Mfla_2120TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tbd:Tbd_1990 acetolactate synthase, small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit category=E. (163 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
Mfla_2139PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: tbd:Tbd_0854 isocitrate dehydrogenase (NADP); COGs: COG0538 Isocitrate dehydrogenases category=C. (413 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa)
argAN-acetylglutamate synthase / N-acetylglutamate kinase; TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; helix-turn-helix domain protein; KEGG: tbd:Tbd_0154 amino-acid N-acetyltransferase (ArgA); COGs: COG0548 Acetylglutamate kinase category=E; Belongs to the acetyltransferase family. ArgA subfamily. (521 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (294 aa)
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus KT, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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