STRINGSTRING
trpB trpB Rxyl_0725 Rxyl_0725 hisC hisC Rxyl_0727 Rxyl_0727 Rxyl_0728 Rxyl_0728 Rxyl_0761 Rxyl_0761 Rxyl_0960 Rxyl_0960 Rxyl_1244 Rxyl_1244 aroE aroE aroA aroA aroB aroB aroK aroK aroC aroC trpA trpA trpB-2 trpB-2 trpF trpF Rxyl_2094 Rxyl_2094 trpD trpD Rxyl_2096 Rxyl_2096 trpE trpE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
trpBTryptophan synthase, beta chain-like protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (450 aa)
Rxyl_0725PFAM: amino acid-binding ACT Prephenate dehydrogenase; KEGG: dra:DR1122 prephenate dehydrogenase. (339 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: chy:CHY_1929 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa)
Rxyl_0727PFAM: Chorismate mutase; KEGG: ttj:TTHA0388 phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase. (104 aa)
Rxyl_07283-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: mta:Moth_1335 phospho-2-dehydro-3-deoxyheptonate aldolase. (264 aa)
Rxyl_0761Aminodeoxychorismate synthase, subunit I; KEGG: mta:Moth_2108 para-aminobenzoate synthase component I; TIGRFAM: para-aminobenzoate synthase, component I; PFAM: Anthranilate synthase component I and chorismate binding protein Anthranilate synthase component I-like. (480 aa)
Rxyl_09603-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa)
Rxyl_1244PFAM: prephenate dehydratase Chorismate mutase amino acid-binding ACT; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase. (371 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (447 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
trpB-2Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gsu:GSU2378 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (206 aa)
Rxyl_2094PFAM: Indole-3-glycerol phosphate synthase; KEGG: dps:DP1622 probable indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (255 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa)
Rxyl_2096Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase; PFAM: glutamine amidotransferase class-I; KEGG: neu:NE0014 panthranilate synthase component II (glutamine amido-transferase) protein. (188 aa)
trpEAnthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (509 aa)
Your Current Organism:
Rubrobacter xylanophilus
NCBI taxonomy Id: 266117
Other names: R. xylanophilus DSM 9941, Rubrobacter xylanophilus DSM 9941, Rubrobacter xylanophilus str. DSM 9941, Rubrobacter xylanophilus strain DSM 9941
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