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| | Rxyl_2835 | KEGG: chy:CHY_1067 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | Rxyl_3176 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding Domain of unknown function DUF1730; KEGG: xcv:XCV2606 putative iron-sulfur cluster-binding protein. (380 aa) |
| | Rxyl_3166 | PFAM: DNA-directed DNA polymerase 3'-5' exonuclease; KEGG: tpv:TP01_0386 hypothetical protein. (582 aa) |
| | Rxyl_3120 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (183 aa) |
| | Rxyl_3115 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; KEGG: gvi:gll0969 UDP-glucose dehydrogenase. (459 aa) |
| | Rxyl_3106 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (278 aa) |
| | Rxyl_3054 | KEGG: mma:MM1616 phosphoribosylaminoimidazole carboxylase. (253 aa) |
| | Rxyl_3050 | Pyruvate dehydrogenase (lipoamide); PFAM: dehydrogenase, E1 component; KEGG: tte:TTE0186 Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit. (332 aa) |
| | Rxyl_3032 | TIGRFAM: Twin-arginine translocation pathway signal; KEGG: rru:Rru_A2511 putative diguanylate cyclase (GGDEF domain). (348 aa) |
| | Rxyl_3015 | PFAM: CobB/CobQ-like glutamine amidotransferase; KEGG: tte:TTE0007 predicted glutamine amidotransferase. (249 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (339 aa) |
| | Rxyl_2984 | KEGG: fra:Francci3_3104 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC, C subunit-like UvrB/UvrC protein Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease. (560 aa) |
| | Rxyl_2847 | PFAM: aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: pfu:PF0599 aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (339 aa) |
| | tdk | PFAM: thymidine kinase; KEGG: bsu:BG10419 thymidine kinase. (202 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (502 aa) |
| | Rxyl_2792 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (213 aa) |
| | Rxyl_2791 | KEGG: mta:Moth_0867 phosphomethylpyrimidine kinase; TIGRFAM: Phosphomethylpyrimidine kinase type-2; PFAM: Phosphomethylpyrimidine kinase type-1. (264 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa) |
| | thiE-2 | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (208 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (314 aa) |
| | Rxyl_2784 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (223 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (577 aa) |
| | Rxyl_2746 | KEGG: gka:GK1423 dihydropyrimidinase; TIGRFAM: D-hydantoinase; PFAM: amidohydrolase Amidohydrolase 3. (475 aa) |
| | Rxyl_2744 | PFAM: cobalamin synthesis protein, P47K cobalamin synthesis CobW-like; KEGG: mag:amb2306 putative GTPase. (328 aa) |
| | Rxyl_2644 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sco:SCO4436 lyase. (136 aa) |
| | Rxyl_2634 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (282 aa) |
| | Rxyl_2633 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (262 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | Rxyl_2617 | Putative S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (365 aa) |
| | Rxyl_2579 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa) |
| | Rxyl_2576 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: csa:Csal_1177 hypothetical protein. (125 aa) |
| | Rxyl_2559 | KEGG: mta:Moth_0566 metal dependent phosphohydrolase; TIGRFAM: conserved hypothetical protein uncharacterized domain HDIG; PFAM: metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD region. (200 aa) |
| | Rxyl_2558 | TIGRFAM: Competence-damaged protein; PFAM: molybdopterin binding domain CinA-like; KEGG: tte:TTE1375 predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA. (420 aa) |
| | Rxyl_2531 | PFAM: AMP-dependent synthetase and ligase; KEGG: chy:CHY_0572 acetyl-coenzyme A synthetase family protein. (537 aa) |
| | folD3 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (318 aa) |
| | Rxyl_2480 | PFAM: dehydrogenase, E1 component; KEGG: bha:BH2763 branched-chain alpha-keto acid dehydrogenase E1. (333 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (567 aa) |
| | Rxyl_2406 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (337 aa) |
| | Rxyl_2403 | Pyruvate dehydrogenase (lipoamide); PFAM: dehydrogenase, E1 component; KEGG: bur:Bcep18194_A5140 pyruvate dehydrogenase (lipoamide). (331 aa) |
| | thiG | Thiamine biosynthesis protein ThiS; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (291 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (252 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (229 aa) |
| | Rxyl_2365 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: gvi:gll0669 RNA polymerase sigma-70 factor. (298 aa) |
| | Rxyl_2364 | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: tfu:Tfu_0093 hypothetical protein. (131 aa) |
| | Rxyl_2342 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: gka:GK1485 acetoacetyl-CoA synthetase. (660 aa) |
| | Rxyl_2338 | PFAM: 2-phosphosulfolactate phosphatase; KEGG: mta:Moth_0119 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (254 aa) |
| | pdhA | Pyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (353 aa) |
| | Rxyl_2316 | PFAM: bifunctional deaminase-reductase-like; KEGG: bce:BC3158 pyrimidine reductase. (179 aa) |
| | sigA-2 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (366 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (178 aa) |
| | Rxyl_2300 | TIGRFAM: Orotidine 5'-phosphate decarboxylase subfamily 2; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: sru:SRU_1735 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (280 aa) |
| | Rxyl_2279 | PFAM: AMP-dependent synthetase and ligase; KEGG: nfa:nfa12430 putative acyl-CoA synthetase. (543 aa) |
| | Rxyl_2267 | KEGG: mta:Moth_1807 hypothetical protein. (741 aa) |
| | Rxyl_2186 | KEGG: tte:TTE2394 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (189 aa) |
| | Rxyl_2184 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa) |
| | Rxyl_2183 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: xoo:XOO2365 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine. (165 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (264 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (176 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1141 aa) |
| | rpoC | DNA-directed RNA polymerase, subunit beta-prime; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1295 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (208 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (313 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (509 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | Rxyl_2094 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: dps:DP1622 probable indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (255 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gsu:GSU2378 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (206 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (257 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | Rxyl_2085 | KEGG: bce:BC0745 hydroxymethylpyrimidine-binding protein. (328 aa) |
| | Rxyl_2043 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: mca:MCA0497 pterin-4-alpha-carbinolamine dehydratase. (107 aa) |
| | Rxyl_2025 | KEGG: sth:STH848 DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: DNA-directed DNA polymerase 5'-3' exonuclease; SMART: Helix-hairpin-helix motif, class 2. (843 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (455 aa) |
| | Rxyl_1980 | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase, N-terminal domain; KEGG: pca:Pcar_3066 siroheme synthase, N-terminal domain protein. (194 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (422 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (305 aa) |
| | Rxyl_1977 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Uroporphyrinogen III synthase HEM4; KEGG: mta:Moth_1248 uroporphyrin-III C-methyltransferase. (513 aa) |
| | Rxyl_1976 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mta:Moth_1246 porphobilinogen synthase; Belongs to the ALAD family. (326 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mta:Moth_1244 glutamate-1-semialdehyde-2,1-aminomutase. (439 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa) |
| | Rxyl_1961 | KEGG: gsu:GSU2230 DNA polymerase III, delta prime subunit. (359 aa) |
| | Rxyl_1947 | PFAM: tyrosinase; KEGG: nmu:Nmul_A2156 tyrosinase/peptidase. (279 aa) |
| | Rxyl_1922 | KEGG: sth:STH1885 DNA polymerase III alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP-like nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: Phosphoesterase PHP-like; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1084 aa) |
| | Rxyl_1917 | KEGG: mta:Moth_1807 hypothetical protein. (759 aa) |
| | Rxyl_1846 | Hypothetical protein; KEGG: eba:c1A97 putative subunit of acetophenone carboxylase; Belongs to the uroporphyrinogen decarboxylase family. (302 aa) |
| | Rxyl_1813 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (304 aa) |
| | Rxyl_1759 | TIGRFAM: Benzoate-CoA ligase family; PFAM: AMP-dependent synthetase and ligase; KEGG: gme:Gmet_2143 benzoate-CoA ligase family. (527 aa) |
| | Rxyl_1711 | PFAM: AMP-dependent synthetase and ligase; KEGG: dra:DR0460 acetyl-CoA synthase. (653 aa) |
| | Rxyl_1710 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: mta:Moth_1843 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (166 aa) |
| | Rxyl_1704 | PFAM: AMP-dependent synthetase and ligase; KEGG: bpm:BURPS1710b_1709 acetyl-coenzyme A synthetase. (576 aa) |
| | Rxyl_1689 | TIGRFAM: Propionate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: rso:RSc1518 PrpE protein ligase (putative propionyl-CoA synthetase). (636 aa) |
| | Rxyl_1667 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: gvi:gll2708 RNA polymerase ECF-type (group 3) sigma factor. (195 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (498 aa) |
| | Rxyl_1648 | TIGRFAM: uracil phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: sth:STH79 uracil phosphoribosyltransferase; Belongs to the UPRTase family. (212 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (258 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (107 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (174 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (179 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (526 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (146 aa) |
| | Rxyl_1599 | KEGG: mhu:Mhun_0707 hypothetical protein. (245 aa) |
| | Rxyl_1598 | KEGG: nwi:Nwi_1258 hypothetical protein. (521 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa) |
| | Rxyl_1569 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: tfu:Tfu_2245 acetoacetyl-CoA synthase. (664 aa) |
| | folD2 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (320 aa) |
| | Rxyl_1534 | FolC bifunctional protein; KEGG: ttj:TTHA0343 folyl-polyglutamate synthetase; TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases-like Mur ligase, middle region. (409 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (133 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (214 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (583 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: ccr:CC2443 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (305 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I Carbamoyl-phosphate synthase, small chain; KEGG: plt:Plut_0156 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (369 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase-like, ATP-grasp protein of unknown function DUF201 Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain, oligomerisation Carbamoyl-phosphate synthetase large chain-like MGS-like; KEGG: afu:AF1274 carbamoyl-phosphate synthase large chain. (1054 aa) |
| | Rxyl_1476 | Dihydroorotate oxidase B, electron transfer subunit; PFAM: oxidoreductase FAD/NAD(P)-binding; KEGG: tte:TTE1531 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases. (241 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (304 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (191 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (106 aa) |
| | Rxyl_1471 | TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein-like; KEGG: mta:Moth_0893 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase. (378 aa) |
| | Rxyl_1469 | TIGRFAM: primosomal protein N'; KEGG: pca:Pcar_0764 primosomal protein n'. (728 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (139 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (273 aa) |
| | Rxyl_1452 | PFAM: Thiamin pyrophosphokinase, catalytic region; KEGG: tte:TTE1305 hypothetical protein. (390 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (447 aa) |
| | cmk | KEGG: ade:Adeh_1515 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (224 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa) |
| | Rxyl_1416 | Riboflavin kinase / FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF Cytidyltransferase-related; PFAM: Riboflavin kinase / FAD synthetase; KEGG: fra:Francci3_3557 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (299 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (381 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (255 aa) |
| | Rxyl_1397 | RNA polymerase, sigma 28 subunit; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG; PFAM: sigma-70 region 3 sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: sco:SCO5621 RNA polymerase sigma factor WhiG. (264 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa) |
| | Rxyl_1358 | RNA polymerase, sigma 28 subunit; PFAM: Bacterio-opsin activator, HTH sigma-70 region 3 sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: sma:SAV3013 putative RNA polymerase sigma factor. (258 aa) |
| | Rxyl_1338 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (742 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (365 aa) |
| | queA | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (334 aa) |
| | Rxyl_1328 | KEGG: mta:Moth_1699 hypothetical protein. (74 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (204 aa) |
| | pdxS | Vitamin B6 biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | Rxyl_1267 | PFAM: Quinolinate phosphoribosyl transferase; KEGG: tko:TK1676 nicotinate-nucleotide pyrophosphorylase. (377 aa) |
| | Rxyl_1244 | PFAM: prephenate dehydratase Chorismate mutase amino acid-binding ACT; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase. (371 aa) |
| | Rxyl_1231 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (294 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: chy:CHY_0955 GTP cyclohydrolase I. (198 aa) |
| | Rxyl_1163 | RNA polymerase, sigma 28 subunit; PFAM: sigma-70 region 3 sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: cyb:CYB_2489 RNA polymerase sigma factor, group 3. (257 aa) |
| | Rxyl_1132 | KEGG: hal:VNG1092C hypothetical protein. (268 aa) |
| | Rxyl_1131 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: hal:VNG1093C hypothetical protein. (253 aa) |
| | Rxyl_1096 | DNA polymerase III catalytic subunit, DnaE type; KEGG: mta:Moth_1872 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP-like nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: Phosphoesterase PHP-like. (1165 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (424 aa) |
| | Rxyl_1053 | PFAM: protein of unknown function DUF147; KEGG: mja:MJ1002 hypothetical protein. (197 aa) |
| | Rxyl_1030 | PFAM: glutamine amidotransferase class-I; KEGG: pae:PA1729 hypothetical protein. (224 aa) |
| | Rxyl_1008 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (289 aa) |
| | purH | KEGG: tfu:Tfu_2572 AICARFT/IMPCHase bienzyme; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like. (507 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (194 aa) |
| | purM | KEGG: gvi:gll0720 phosphoribosyl formylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like. (341 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (482 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (727 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (220 aa) |
| | purS | Phosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (74 aa) |
| | purC | KEGG: dra:DR0226 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (237 aa) |
| | Rxyl_0992 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: chy:CHY_1070 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | purD | KEGG: mta:Moth_2043 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase protein of unknown function DUF201; Belongs to the GARS family. (425 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | Rxyl_0960 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa) |
| | Rxyl_0940 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: sil:SPO1478 RNA polymerase sigma-70 factor, ECF family. (195 aa) |
| | Rxyl_0900 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: tfu:Tfu_1506 similar to DNA-directed RNA polymerase specialized sigma subunit sigma24 -like protein; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the t [...] (468 aa) |
| | sigA | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (365 aa) |
| | Rxyl_0863 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 sigma-70 region 4 Sigma-70, region 4 type 2; KEGG: gka:GK0150 DNA-directed RNA polymerase ECF-type sigma factor (sigma-W). (202 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (644 aa) |
| | Rxyl_0852 | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (443 aa) |
| | folD1 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (506 aa) |
| | Rxyl_0815 | TIGRFAM: IMP dehydrogenase related 2; PFAM: IMP dehydrogenase/GMP reductase; KEGG: tfu:Tfu_2595 IMP dehydrogenase related 2. (386 aa) |
| | Rxyl_0761 | Aminodeoxychorismate synthase, subunit I; KEGG: mta:Moth_2108 para-aminobenzoate synthase component I; TIGRFAM: para-aminobenzoate synthase, component I; PFAM: Anthranilate synthase component I and chorismate binding protein Anthranilate synthase component I-like. (480 aa) |
| | Rxyl_0750 | PFAM: 2-phosphosulfolactate phosphatase; KEGG: tma:TM0797 putative 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (282 aa) |
| | Rxyl_0747 | PFAM: Chlorite dismutase; KEGG: dra:DR1481 hypothetical protein. (240 aa) |
| | Rxyl_0728 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: mta:Moth_1335 phospho-2-dehydro-3-deoxyheptonate aldolase. (264 aa) |
| | Rxyl_0727 | PFAM: Chorismate mutase; KEGG: ttj:TTHA0388 phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase. (104 aa) |
| | Rxyl_0725 | PFAM: amino acid-binding ACT Prephenate dehydrogenase; KEGG: dra:DR1122 prephenate dehydrogenase. (339 aa) |
| | Rxyl_0711 | RfaE bifunctional protein, domain II; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (455 aa) |
| | Rxyl_0673 | RNA polymerase, sigma 28 subunit; PFAM: sigma-70 region 3 sigma-70 region 2 sigma-70 region 4; KEGG: tte:TTE1755 DNA-directed RNA polymerase sigma subunits (sigma70/sigma32); Belongs to the sigma-70 factor family. (274 aa) |
| | Rxyl_0652 | Adenosylcobinamide kinase; PFAM: cobalbumin biosynthesis enzyme; SMART: ATPase; KEGG: det:DET0694 cobinamide kinase/cobinamide phosphate guanylyltransferase. (187 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (301 aa) |
| | cobS | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (256 aa) |
| | cobT | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (362 aa) |
| | Rxyl_0646 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: sma:SAV6405 putative metal binding protein. (297 aa) |
| | Rxyl_0645 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: sma:SAV6406 putative precorrin-8X methylmutase. (199 aa) |
| | Rxyl_0643 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: sma:SAV6407 putative precorrin methylase. (561 aa) |
| | Rxyl_0642 | KEGG: sma:SAV6408 precorrin-6Y C5,15-methyltransferase / precorrin-8W decarboxylase; TIGRFAM: Precorrin-6y C5,15-methyltransferase, subunit CbiE; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (403 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (388 aa) |
| | Rxyl_0640 | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sma:SAV6409 putative methyltransferase. (257 aa) |
| | Rxyl_0639 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (238 aa) |
| | cobB | Hydrogenobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (450 aa) |
| | Rxyl_0637 | cob(I)yrinic acid a,c-diamide adenosyltransferase; KEGG: sma:SAV6413 putative cob(I)alamin adenolsyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. (191 aa) |
| | Rxyl_0636 | Protoporphyrin IX magnesium-chelatase; PFAM: magnesium chelatase, ChlI subunit von Willebrand factor, type A ATPase associated with various cellular activities, AAA_5; SMART: ATPase; KEGG: sco:SCO1850 putative chelatase. (616 aa) |
| | Rxyl_0635 | Hydrogenobyrinic acid a,c-diamide cobaltochelatase; TIGRFAM: Cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase; KEGG: sma:SAV6415 putative magnesium chelatase. (1237 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (499 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (290 aa) |
| | Rxyl_0486 | PFAM: PHP-like; SMART: DNA polymerase X Phosphoesterase PHP-like Helix-hairpin-helix DNA-binding, class 1; KEGG: cbu:CBU_0490 hypothetical DNA polymerase / putative histidinol phosphatase. (574 aa) |
| | Rxyl_0462 | TIGRFAM: Glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: gka:GK0623 glycine oxidase. (378 aa) |
| | Rxyl_0429 | KEGG: mlo:mll5389 hypothetical protein. (124 aa) |
| | Rxyl_0358 | Dihydropyrimidinase; PFAM: amidohydrolase; KEGG: ana:alr5010 D-hydantoinase. (483 aa) |
| | Rxyl_0354 | Hypothetical protein. (137 aa) |
| | trpB | Tryptophan synthase, beta chain-like protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (450 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (388 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | Rxyl_0236 | PFAM: carboxyl transferase; KEGG: sma:SAV5722 putative acetyl CoA carboxylase beta subunit. (502 aa) |
| | Rxyl_0230 | PFAM: PHP-like; SMART: DNA polymerase X Phosphoesterase PHP-like Helix-hairpin-helix DNA-binding, class 1; KEGG: mca:MCA1213 hypothetical protein. (569 aa) |
| | Rxyl_0219 | KEGG: gka:GK1423 dihydropyrimidinase; TIGRFAM: D-hydantoinase; PFAM: amidohydrolase Amidohydrolase 3. (467 aa) |
| | Rxyl_0212 | ATP:cob(I)alamin adenosyltransferase; TIGRFAM: ATP; PFAM: regulatory protein GntR, HTH cobalamin adenosyltransferase; KEGG: bur:Bcep18194_A3822 cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (175 aa) |
| | Rxyl_0188 | PFAM: FAD dependent oxidoreductase; KEGG: bcl:ABC0532 glycine/D-amino acid oxidase. (380 aa) |
| | Rxyl_0107 | KEGG: ade:Adeh_3566 L-aspartate oxidase; TIGRFAM: L-aspartate oxidase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein-like HI0933-like protein FAD dependent oxidoreductase FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (488 aa) |
| | Rxyl_0106 | KEGG: gsu:GSU1936 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (291 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (322 aa) |
| | Rxyl_0014 | Phosphopantothenoylcysteine decarboxylase; PFAM: flavoprotein; KEGG: ttj:TTHA1560 DNA/pantothenate metabolism flavoprotein. (189 aa) |
| | Rxyl_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (375 aa) |
