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| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (365 aa) |
| | Rxyl_0049 | PFAM: Transketolase-like Transketolase, central region; KEGG: ana:all4052 transketolase. (626 aa) |
| | Rxyl_0072 | PFAM: peptidase M20 peptidase dimerisation; KEGG: ade:Adeh_3828 peptidase M20. (354 aa) |
| | Rxyl_0073 | KEGG: ade:Adeh_3829 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (269 aa) |
| | Rxyl_0074 | Aminotransferase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II; KEGG: ade:Adeh_3830 aminotransferase, class I and II. (405 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (262 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (260 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | Rxyl_0098 | KEGG: deh:cbdb_A1731 aspartate kinase, monofunctional class; TIGRFAM: aspartate kinase aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase amino acid-binding ACT; Belongs to the aspartokinase family. (422 aa) |
| | leuC1 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa) |
| | trpB | Tryptophan synthase, beta chain-like protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (450 aa) |
| | Rxyl_0325 | PFAM: dihydrodipicolinate synthetase; KEGG: bja:blr3884 putative dihydrodipicolinate synthase; Belongs to the DapA family. (310 aa) |
| | Rxyl_0341 | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mca:MCA2039 glutamate synthase, large subunit. (1489 aa) |
| | Rxyl_0342 | TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mpa:MAP0173 glutamate synthase (NADPH) small chain. (475 aa) |
| | Rxyl_0412 | Aminotransferase; TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; KEGG: ava:Ava_2839 diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa) |
| | Rxyl_0463 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: noc:Noc_2604 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (327 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (474 aa) |
| | Rxyl_0618 | Aconitase; TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase-like; KEGG: tth:TTC0374 aconitate hydratase. (940 aa) |
| | Rxyl_0695 | PFAM: inositol monophosphatase; KEGG: cte:CT1430 myo-inositol-1(or 4)-monophosphatase. (259 aa) |
| | Rxyl_0725 | PFAM: amino acid-binding ACT Prephenate dehydrogenase; KEGG: dra:DR1122 prephenate dehydrogenase. (339 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: chy:CHY_1929 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | Rxyl_0727 | PFAM: Chorismate mutase; KEGG: ttj:TTHA0388 phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase. (104 aa) |
| | Rxyl_0728 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: mta:Moth_1335 phospho-2-dehydro-3-deoxyheptonate aldolase. (264 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa) |
| | Rxyl_0746 | KEGG: cyb:CYB_2315 putative cysteine synthase B; TIGRFAM: cysteine synthases; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (305 aa) |
| | Rxyl_0760 | PFAM: aminotransferase, class IV; KEGG: rru:Rru_A1131 aminotransferase, class IV. (296 aa) |
| | Rxyl_0763 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: noc:Noc_2604 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (321 aa) |
| | Rxyl_0796 | L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II; KEGG: tma:TM1744 L-allo-threonine aldolase. (340 aa) |
| | Rxyl_0835 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. (413 aa) |
| | Rxyl_0837 | KEGG: tfu:Tfu_0614 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (527 aa) |
| | Rxyl_0841 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: pto:PTO0186 methionine synthase. (385 aa) |
| | Rxyl_0843 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. (611 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | Rxyl_0913 | PFAM: pyruvate kinase; KEGG: mta:Moth_1867 pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | Rxyl_0933 | PFAM: Methionine synthase, vitamin-B12 independent Cobalamin-independent synthase MetE-like; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. (369 aa) |
| | Rxyl_0960 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: fra:Francci3_3168 argininosuccinate lyase. (505 aa) |
| | Rxyl_1031 | PFAM: glutamine synthetase, catalytic region; KEGG: mta:Moth_1764 glutamine synthetase, type I. (444 aa) |
| | Rxyl_1036 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20 peptidase dimerisation; KEGG: mlo:mlr7167 acetylornitine deacetylase. (426 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (380 aa) |
| | Rxyl_1090 | KEGG: mka:MK0109 aspartokinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (425 aa) |
| | Rxyl_1091 | PFAM: homoserine dehydrogenase homoserine dehydrogenase, NAD-binding; KEGG: xac:XAC1820 homoserine dehydrogenase / aspartate kinase. (360 aa) |
| | Rxyl_1092 | TIGRFAM: Aspartate-semialdehyde dehydrogenase, USG-1 related; PFAM: Semialdehyde dehydrogenase, NAD - binding Semialdehyde dehydrogenase, dimerisation region; KEGG: bce:BC3799 aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (327 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (413 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (216 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (418 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gox:GOX0479 imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (243 aa) |
| | Rxyl_1125 | KEGG: dde:Dde_0104 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region glutamine synthetase, beta-Grasp. (443 aa) |
| | Rxyl_1244 | PFAM: prephenate dehydratase Chorismate mutase amino acid-binding ACT; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase. (371 aa) |
| | Rxyl_1270 | Arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: tth:TTC1132 arginase; Belongs to the arginase family. (306 aa) |
| | Rxyl_1297 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mta:Moth_0993 isocitrate dehydrogenase (NAD+). (336 aa) |
| | ilvD | KEGG: tth:TTC0871 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa) |
| | Rxyl_1363 | PFAM: ribulose-phosphate 3-epimerase; KEGG: gka:GK1178 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (447 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (412 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (262 aa) |
| | Rxyl_1586 | PFAM: Methionine synthase, vitamin-B12 independent Cobalamin-independent synthase MetE-like; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. (371 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa) |
| | Rxyl_1635 | PFAM: peptidase M20 peptidase dimerisation; KEGG: bcl:ABC3512 succinyl-diaminopimelate desuccinylase. (400 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa) |
| | Rxyl_1676 | KEGG: fra:Francci3_0083 citrate synthase I; TIGRFAM: Citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (445 aa) |
| | Rxyl_1692 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. (167 aa) |
| | leuC2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa) |
| | Rxyl_2005 | KEGG: tfu:Tfu_2017 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | Rxyl_2041 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1128 aa) |
| | Rxyl_2072 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pca:Pcar_0575 3-isopropylmalate dehydrogenase. (358 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (349 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gsu:GSU2378 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (206 aa) |
| | Rxyl_2094 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: dps:DP1622 probable indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (255 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | Rxyl_2096 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase; PFAM: glutamine amidotransferase class-I; KEGG: neu:NE0014 panthranilate synthase component II (glutamine amido-transferase) protein. (188 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (509 aa) |
| | hisI | PFAM: phosphoribosyl-AMP cyclohydrolase phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bha:BH3577 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (213 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa) |
| | Rxyl_2475 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20 peptidase dimerisation; KEGG: mlo:mlr1185 succinyl-diaminopimelate desuccinylase. (420 aa) |
| | Rxyl_2477 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: gka:GK0373 acetolactate synthaselarge subunit. (543 aa) |
| | Rxyl_2498 | PFAM: glutamine synthetase, catalytic region; KEGG: psp:PSPPH_2916 glutamine synthetase, type III. (446 aa) |
| | Rxyl_2541 | PFAM: fructose-bisphosphate aldolase, class-I; KEGG: bja:bll1520 fructose bisphosphate aldolase. (341 aa) |
| | Rxyl_2556 | Citrate synthase; PFAM: regulatory protein, MerR Citrate synthase; KEGG: bps:BPSL0890 putative citrate synthase. (426 aa) |
| | Rxyl_2557 | PFAM: Citrate synthase; KEGG: ccr:CC3642 citrate synthase; Belongs to the citrate synthase family. (391 aa) |
| | Rxyl_2572 | TIGRFAM: Histidinol phosphate phosphatase, HisJ; PFAM: PHP-like; KEGG: mta:Moth_0817 histidinol phosphate phosphatase, HisJ; Belongs to the PHP hydrolase family. HisK subfamily. (270 aa) |
| | Rxyl_2588 | 6-phosphofructokinase; PFAM: phosphofructokinase; KEGG: mta:Moth_1234 phosphofructokinase. (378 aa) |
| | Rxyl_2824 | Aconitase; TIGRFAM: Putative aconitate hydratase; PFAM: aconitate hydratase-like; KEGG: gme:Gmet_2763 aconitate hydratase. (660 aa) |
| | Rxyl_2877 | PFAM: GCN5-related N-acetyltransferase; KEGG: ade:Adeh_1022 tyrosine phosphatase. (147 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: syf:Synpcc7942_0009 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa) |
| | argJ | Glutamate N-acetyltransferase / N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (253 aa) |
| | argD | KEGG: mta:Moth_2287 acetylornithine and succinylornithine aminotransferases; TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | Rxyl_2889 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (317 aa) |
| | Rxyl_2948 | Phosphoglycerate mutase; KEGG: tth:TTC1888 3-phosphonopyruvate decarboxylase; TIGRFAM: phosphonopyruvate decarboxylase-related protein; PFAM: metalloenzyme. (403 aa) |
| | Rxyl_3123 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (355 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | Rxyl_3125 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: det:DET0833 acetolactate synthase, large subunit, biosynthetic type. (564 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa) |
| | ilvE | Branched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (318 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (510 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | Rxyl_3131 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: pab:PAB0894 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (520 aa) |
| | Rxyl_3192 | Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: noc:Noc_2604 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (323 aa) |
| | Rxyl_3196 | PFAM: glutamine synthetase, catalytic region; KEGG: sco:SCO1613 putative glutamine synthetase. (455 aa) |
