STRINGSTRING
lpxC lpxC Bxe_A0684 Bxe_A0684 kdsB kdsB lpxK lpxK Bxe_A0987 Bxe_A0987 hldD hldD kdsA kdsA lpxH lpxH lpxD lpxD fabZ fabZ lpxA lpxA lpxB lpxB Bxe_A1962 Bxe_A1962 Bxe_A3286 Bxe_A3286 Bxe_A3287 Bxe_A3287 Bxe_A3288 Bxe_A3288 Bxe_A3289 Bxe_A3289 Bxe_A3291 Bxe_A3291 Bxe_A3421 Bxe_A3421 Bxe_A3698 Bxe_A3698 Bxe_A3700 Bxe_A3700 Bxe_A3714 Bxe_A3714 Bxe_A3715 Bxe_A3715 Bxe_A4014 Bxe_A4014 Bxe_A4117 Bxe_A4117 Bxe_A4118 Bxe_A4118 Bxe_A4229 Bxe_A4229 gmhA gmhA Bxe_A4372 Bxe_A4372 Bxe_B0560 Bxe_B0560 Bxe_B1103 Bxe_B1103
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
Bxe_A0684Putative ADP-heptose--LPS heptosyltransferaseII. (341 aa)
kdsB3-deoxy-D-manno- octulosonatecytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (289 aa)
lpxKlipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (338 aa)
Bxe_A0987D-alpha,beta-D-heptose 7-phosphate 1-kinase. (326 aa)
hldDADP-glyceromanno-heptose 6-epimerase precursor; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (330 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (284 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (265 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (370 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa)
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (389 aa)
Bxe_A1962Putative lipid A biosynthesis acyltransferase; Citation: Blattner,F.R., Plunkett,G. III,Bloch,C.A., et al Science 277 (5331), 1453-1474 (1997). (292 aa)
Bxe_A3286Putative lipopolysaccharide biosynthesis glycosyltransferase protein. (419 aa)
Bxe_A3287Hypothetical protein. (448 aa)
Bxe_A3288Putative lipopolysaccharide core biosynthesis glycosyltransferase protein. (375 aa)
Bxe_A3289Putative LPS biosynthesis-related protein. (358 aa)
Bxe_A3291Putative LPS biosynthesis-related protein. (253 aa)
Bxe_A3421Putative lipopolysaccharide heptosyltransferase-1. (334 aa)
Bxe_A3698Putatove 3-deoxy-D-manno-octulosonic- acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (439 aa)
Bxe_A3700Putative lipopolysaccharide heptosyltransferase-1. (333 aa)
Bxe_A3714D-alpha,beta-D-heptose 7-phosphate 1-kinase. (334 aa)
Bxe_A3715Conserved hypothetical protein. (382 aa)
Bxe_A4014D-alpha,beta-D-heptose 1,7-bisphosphate phosphatase. (184 aa)
Bxe_A4117KpsF/GutQ; Belongs to the SIS family. GutQ/KpsF subfamily. (327 aa)
Bxe_A4118Phosphatase YrbI. (186 aa)
Bxe_A4229Cytidyltransferase-related protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (160 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (195 aa)
Bxe_A4372Putative lipid A biosynthesis lauroylacyltransferase. (294 aa)
Bxe_B0560Putative heptosyltransferase. (390 aa)
Bxe_B1103Putative lipid A biosynthesis lauroylacyl transferase. (294 aa)
Your Current Organism:
Paraburkholderia xenovorans
NCBI taxonomy Id: 266265
Other names: Burkholderia cepacia LB400, Burkholderia fungorum LB400, Burkholderia sp. LB400, Burkholderia xenovorans LB400, P. xenovorans LB400, Paraburkholderia xenovorans LB400, Pseudomonas LB400, Pseudomonas sp. (strain LB400), Pseudomonas sp. LB400
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