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Bxe_B2552 Bxe_B2552 Bxe_A0415 Bxe_A0415 Bxe_A0473 Bxe_A0473 sucC sucC sucD sucD Bxe_A0781 Bxe_A0781 Bxe_A0797 Bxe_A0797 Bxe_A0944 Bxe_A0944 fumC fumC Bxe_A1351 Bxe_A1351 Bxe_A1362 Bxe_A1362 Bxe_A1647 Bxe_A1647 Bxe_A1703 Bxe_A1703 Bxe_A1721 Bxe_A1721 Bxe_A1907 Bxe_A1907 Bxe_A1908 Bxe_A1908 Bxe_A1994 Bxe_A1994 Bxe_A2178 Bxe_A2178 Bxe_A2184 Bxe_A2184 Bxe_A2185 Bxe_A2185 Bxe_A2219 Bxe_A2219 glcB glcB Bxe_A2716 Bxe_A2716 Bxe_A2811 Bxe_A2811 Bxe_A2812 Bxe_A2812 nuoN nuoN Bxe_A3202 Bxe_A3202 Bxe_A3203 Bxe_A3203 nuoK nuoK nuoI nuoI nuoH nuoH Bxe_A3208 Bxe_A3208 Bxe_A3210 Bxe_A3210 ppc ppc Bxe_A3413 Bxe_A3413 Bxe_A3459 Bxe_A3459 Bxe_A3839 Bxe_A3839 Bxe_A3840 Bxe_A3840 Bxe_A3977 Bxe_A3977 Bxe_A3978 Bxe_A3978 Bxe_A3997 Bxe_A3997 ubiE ubiE Bxe_A4078 Bxe_A4078 Bxe_A4148 Bxe_A4148 Bxe_A4149 Bxe_A4149 Bxe_A4150 Bxe_A4150 Bxe_A4167 Bxe_A4167 Bxe_A4170 Bxe_A4170 aceK aceK Bxe_A4333 Bxe_A4333 Bxe_B0098 Bxe_B0098 Bxe_B0201 Bxe_B0201 Bxe_B0223 Bxe_B0223 Bxe_B0325 Bxe_B0325 Bxe_B0326 Bxe_B0326 Bxe_B0327 Bxe_B0327 Bxe_B0328 Bxe_B0328 Bxe_B0329 Bxe_B0329 Bxe_B0378 Bxe_B0378 Bxe_B0532 Bxe_B0532 Bxe_B0567 Bxe_B0567 Bxe_B0773 Bxe_B0773 Bxe_B0876 Bxe_B0876 Bxe_B1057 Bxe_B1057 Bxe_B1058 Bxe_B1058 Bxe_B1077 Bxe_B1077 Bxe_B1134 Bxe_B1134 Bxe_B1374 Bxe_B1374 Bxe_B1499 Bxe_B1499 Bxe_B1533 Bxe_B1533 Bxe_B1635 Bxe_B1635 Bxe_B1636 Bxe_B1636 Bxe_B1638 Bxe_B1638 Bxe_B1667 Bxe_B1667 Bxe_B1741 Bxe_B1741 Bxe_B1742 Bxe_B1742 Bxe_B1743 Bxe_B1743 Bxe_B1751 Bxe_B1751 Bxe_B1810 Bxe_B1810 Bxe_B1811 Bxe_B1811 Bxe_B1817 Bxe_B1817 Bxe_B2064 Bxe_B2064 Bxe_B2127 Bxe_B2127 dld dld Bxe_B2301 Bxe_B2301 Bxe_B2302 Bxe_B2302 fhcC fhcC Bxe_B2465 Bxe_B2465 Bxe_B2503 Bxe_B2503 Bxe_B2551 Bxe_B2551 Bxe_B2707 Bxe_B2707 Bxe_B2714 Bxe_B2714 Bxe_B2745 Bxe_B2745 Bxe_B2890 Bxe_B2890 Bxe_B2892 Bxe_B2892 Bxe_B2893 Bxe_B2893 Bxe_B2894 Bxe_B2894 Bxe_B2895 Bxe_B2895 mdh mdh Bxe_B2900 Bxe_B2900 Bxe_B2903 Bxe_B2903 Bxe_C0080 Bxe_C0080 Bxe_C0081 Bxe_C0081 Bxe_C0168 Bxe_C0168 Bxe_C0175 Bxe_C0175 Bxe_C0176 Bxe_C0176 Bxe_C0177 Bxe_C0177 Bxe_C0178 Bxe_C0178 Bxe_C0179 Bxe_C0179 napB napB Bxe_C0529 Bxe_C0529 Bxe_C0531 Bxe_C0531 Bxe_C0779 Bxe_C0779 Bxe_C0854 Bxe_C0854 Bxe_C0986 Bxe_C0986 Bxe_C1008 Bxe_C1008
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
Bxe_B2552Formate dehydrogenase (quinone-dependent) iron-sulfur subunit. (310 aa)
Bxe_A0415Putative cytochrome B subunit transmembrane protein; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (459 aa)
Bxe_A0473Putative molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (692 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
Bxe_A0781Bifunctional -- transcriptional regulator, MerR family / Citrate synthase. (545 aa)
Bxe_A0797Isocitrate dehydrogenase (NADP). (418 aa)
Bxe_A0944Conserved hypothetical protein. (242 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
Bxe_A1351Putative FAD-binding oxidoreductase. (472 aa)
Bxe_A1362Electron transferring flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (557 aa)
Bxe_A1647Malate synthase A; Belongs to the malate synthase family. (536 aa)
Bxe_A1703Conserved hypothetical protein. (145 aa)
Bxe_A1721Excisionase/Xis, DNA-binding protein. (404 aa)
Bxe_A1907Cytochrome bd quinol oxidase subunit 2 apoprotein. (378 aa)
Bxe_A1908Cytochrome bd quinol oxidase subunit 1 apoprotein. (535 aa)
Bxe_A1994Hypothetical protein. (93 aa)
Bxe_A2178Putative transmembrane hydrogenase cytochrome B- type subunit. (208 aa)
Bxe_A2184Cytochrome-c oxidase; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (679 aa)
Bxe_A2185Putative cytochrome c oxidase, subunit III. (217 aa)
Bxe_A2219Glycolate oxidase subunit GlcD. (499 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa)
Bxe_A2716Putative citrate synthase. (418 aa)
Bxe_A28112-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (427 aa)
Bxe_A28122-oxoglutarate dehydrogenase E1 component. (953 aa)
nuoNNADH dehydrogenase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (490 aa)
Bxe_A3202NADH dehydrogenase subunit M. (496 aa)
Bxe_A3203NADH dehydrogenase subunit L. (692 aa)
nuoKNADH dehydrogenase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (101 aa)
nuoINADH dehydrogenase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa)
nuoHNADH dehydrogenase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (354 aa)
Bxe_A3208NADH dehydrogenase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (777 aa)
Bxe_A3210NADH dehydrogenase subunit E. (161 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (994 aa)
Bxe_A3413Putative methyltransferase. (250 aa)
Bxe_A3459Putative cytochrome B561. (177 aa)
Bxe_A3839Cytochrome bd quinol oxidase subunit 2 apoprotein. (335 aa)
Bxe_A3840Cytochrome bd quinol oxidase subunit 1 apoprotein. (462 aa)
Bxe_A3977Putative FAD-binding oxidase. (471 aa)
Bxe_A3978D-lactate dehydrogenase (cytochrome). (497 aa)
Bxe_A3997Putative cytochrome b-561 membrane protein. (186 aa)
ubiE2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (243 aa)
Bxe_A4078Putative cytochrome c oxidase, subunit I. (541 aa)
Bxe_A4148Cytochrome bd quinol oxidase subunit 1 apoprotein. (535 aa)
Bxe_A4149Cytochrome bd quinol oxidase subunit 2 apoprotein. (378 aa)
Bxe_A4150Putative exported protein. (38 aa)
Bxe_A4167Putative cytochrome c oxidase, subunit III. (285 aa)
Bxe_A4170Cytochrome-c oxidase; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (537 aa)
aceK(Isocitrate dehydrogenase (NADP+)) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (612 aa)
Bxe_A4333Putative high potential iron-sulfur protein; Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria; Belongs to the high-potential iron-sulfur protein (HiPIP) family. (103 aa)
Bxe_B0098Putative Cytochrome B561. (191 aa)
Bxe_B0201Putative cytochrome b-561 protein. (222 aa)
Bxe_B0223Putative high-potential iron-sulfur protein; Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria; Belongs to the high-potential iron-sulfur protein (HiPIP) family. (103 aa)
Bxe_B0325Putative formate hydrogenlyase subunit. (515 aa)
Bxe_B0326NADH dehydrogenase (quinone). (486 aa)
Bxe_B0327Putative membrane protein. (219 aa)
Bxe_B0328Formate hydrogenlyase subunit 4. (316 aa)
Bxe_B0329NADH dehydrogenase (quinone). (669 aa)
Bxe_B0378Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. (563 aa)
Bxe_B0532Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (742 aa)
Bxe_B0567Conserved hypothetical protein. (147 aa)
Bxe_B0773Putative FAD/FMN-containing oxidoreductase. (462 aa)
Bxe_B0876Putative ferredoxin-containing oxidase. (98 aa)
Bxe_B1057Putative alcohol dehydrogenase. (397 aa)
Bxe_B1058Conserved hypothetical protein. (129 aa)
Bxe_B1077Putative cytochrome b561. (176 aa)
Bxe_B1134Citrate synthase; Belongs to the citrate synthase family. (432 aa)
Bxe_B1374Conserved hypothetical protein. (128 aa)
Bxe_B1499Putative NAD(FAD)-dependent dehydrogenase. (104 aa)
Bxe_B1533Aconitase; Belongs to the aconitase/IPM isomerase family. (861 aa)
Bxe_B1635Cytochrome bo3 quinol oxidase subunit 3. (201 aa)
Bxe_B1636Cytochrome bo3 quinol oxidase subunit 1 apoprotein; Belongs to the heme-copper respiratory oxidase family. (662 aa)
Bxe_B1638NADH dehydrogenase subunit M. (518 aa)
Bxe_B1667Putative type-b cytochrome. (179 aa)
Bxe_B1741Putative membrane protein. (316 aa)
Bxe_B1742Iron-sulfur cluster-binding protein. (251 aa)
Bxe_B1743Molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (974 aa)
Bxe_B1751Conserved hypothetical protein. (210 aa)
Bxe_B1810Cytochrome bd quinol oxidase subunit 1 apoprotein. (471 aa)
Bxe_B1811Cytochrome bd quinol oxidase subunit 2 apoprotein. (334 aa)
Bxe_B1817Putative oxidoreductase. (470 aa)
Bxe_B2064Putative cytochrome b-561 membrane protein. (184 aa)
Bxe_B2127Putative oxidoreductase. (465 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (579 aa)
Bxe_B23012-methylcitrate dehydratase (trans-methylaconitate-forming). (865 aa)
Bxe_B23022-methylcitrate synthase; Belongs to the citrate synthase family. (389 aa)
fhcCFormylmethanofuran dehydrogenase, subunit C. (281 aa)
Bxe_B2465Putative cytochrome b561. (188 aa)
Bxe_B2503Putative ferredoxin. (404 aa)
Bxe_B2551Formate dehydrogenase (quinone-dependent) cytochrome b subunit. (218 aa)
Bxe_B2707Conserved hypothetical protein. (123 aa)
Bxe_B2714Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. (558 aa)
Bxe_B2745Putative cytochrome B561. (191 aa)
Bxe_B2890Citrate synthase; Belongs to the citrate synthase family. (433 aa)
Bxe_B2892Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (234 aa)
Bxe_B2893Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (591 aa)
Bxe_B2894Succinate dehydrogenase subunit D. (122 aa)
Bxe_B2895Succinate dehydrogenase subunit C. (137 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
Bxe_B29002-methylcitrate synthase; Belongs to the citrate synthase family. (395 aa)
Bxe_B2903Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
Bxe_C0080Putative cytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (680 aa)
Bxe_C0081Putative cytochrome c oxidase subunit III. (217 aa)
Bxe_C0168Putative cytochrome c oxidase subunit I; Belongs to the heme-copper respiratory oxidase family. (877 aa)
Bxe_C0175Putative NADH-ubiquinone oxidoreductase subunit. (522 aa)
Bxe_C0176NADH dehydrogenase (quinone). (486 aa)
Bxe_C0177Putative membrane protein. (219 aa)
Bxe_C0178Formate hydrogenlyase subunit 4. (316 aa)
Bxe_C0179NADH dehydrogenase (quinone). (669 aa)
napBPeriplasmic nitrate reductase subunit NapB; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (159 aa)
Bxe_C0529Putative NADH dehydrogenase subunit. (246 aa)
Bxe_C0531NAD(P)-dependent nickel-iron dehydrogenase catalytic subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (504 aa)
Bxe_C0779Conserved hypothetical protein. (103 aa)
Bxe_C0854Dihydrolipoamide acyltransferase (E2) component of 2-oxoacid dehydrogenase complexes. (428 aa)
Bxe_C0986Putative citrate synthase. (259 aa)
Bxe_C1008Citrate synthase. (429 aa)
Your Current Organism:
Paraburkholderia xenovorans
NCBI taxonomy Id: 266265
Other names: Burkholderia cepacia LB400, Burkholderia fungorum LB400, Burkholderia sp. LB400, Burkholderia xenovorans LB400, P. xenovorans LB400, Paraburkholderia xenovorans LB400, Pseudomonas LB400, Pseudomonas sp. (strain LB400), Pseudomonas sp. LB400
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